Archives
#ESCCongress – [Not Published Yet] Trial clarifies which patients with acute pulmonary embolism can be managed at home
6 Sep, 2020 | 21:36h | UTCNews Release: Trial clarifies which patients with acute pulmonary embolism can be managed at home – European Society of Cardiology
HESTIA Calculator: Hestia Criteria for Outpatient Pulmonary Embolism Treatment – MdCalc
sPESI Calculator: Simplified PESI (Pulmonary Embolism Severity Index) – MeCalc
Systematic review: Association between D-Dimer levels and mortality in patients with COVID-19
6 Sep, 2020 | 21:37h | UTC
Randomized trial: Negative-pressure wound therapy compared with standard dressings following surgical treatment of major trauma to the lower limb
6 Sep, 2020 | 21:33h | UTCSource: EvidenceAlerts
Commentaries on Twitter
Should we use “Negative Pressure Dressings” in high risk major trauma wounds?
Paper early 2020 in JAMA https://t.co/I3SZfy62K1
Blow-by-blow account today (all 114 pages!) https://t.co/V6UbWItCmN
Spoiler: No – no difference@BritOrthopaedic @OrthoFolks @bota_uk @JAMA_current pic.twitter.com/PUQoCwz4Zr
— Dan Perry (@MrDanPerry) August 24, 2020
https://twitter.com/NIHRevidence/status/1298609160238628865
[Abstract Only] Randomized trial: Aspirin increases major GI bleeding risk by 60% in older individuals
6 Sep, 2020 | 21:30h | UTCSource: EvidenceAlerts
Commentary on Twitter
Aspirin increases GI bleeding risk by 60% in an aspirin RCT
137 total GI bleeds in 90000 person years @Gut_BMJ https://t.co/Hb8h6kZrpo
— Elliot Tapper (@ebtapper) August 8, 2020
Randomized placebo-surgery controlled trial evaluates arthroscopic partial meniscectomy for a degenerative meniscus tear: a 5 year follow-up
6 Sep, 2020 | 21:34h | UTC
Commentary on Twitter
HOT OFF THE PRESS***
5 year follow-up results of the FIDELITY trial (arthroscopic partial meniscectomy VS placebo surgery for degenerative meniscal tears)
Another crushing blow for the #SexyScalpel? #OpenAccess by @anttimal @shamteppo & co!https://t.co/furVdovR9v pic.twitter.com/2gwNsQTk0s
— British Journal of Sports Medicine (BJSM) (@BJSM_BMJ) August 29, 2020
Meta-analysis (randomized trials + cohort studies) suggests improved outcomes with early norepinephrine for septic shock
6 Sep, 2020 | 21:27h | UTCEarly Norepinephrine for Septic Shock – JournalFeed
Original Study: Timing of norepinephrine initiation in patients with septic shock: a systematic review and meta-analysis – Critical Care
“Further randomized clinical studies should be conducted in order to confirm the results.” (from Critical Care)
‘CRISPR babies’ are still too risky, says influential panel
6 Sep, 2020 | 21:25h | UTC‘CRISPR babies’ are still too risky, says influential panel – Nature
Randomized trial: Preoperative intravenous iron to treat anemia 10–42 days before major abdominal surgery does not reduce the need for blood transfusion
6 Sep, 2020 | 21:28h | UTC
Commentary on Twitter
Startling finding. In a blinded RCT, preop iron transfusion did not ⬇️complications, or a ⬇️transfusions after major abdominal surgery. While Hb ⬆️, no real tangible benefit occurred.
Periop medicine & optimization is complicated! #colorectalsurgery https://t.co/q0HhR3JCy3— Ahmer Karimuddin (@ahmerkarimuddin) September 5, 2020
Image: SARS-CoV-2 infection of airway cells
4 Sep, 2020 | 02:15h | UTCImages in Clinical Medicine: SARS-CoV-2 Infection of Airway Cells – New England Journal of Medicine
[Abstract Only] Meta-analysis: Effect of alternate-day fasting on obesity and cardiometabolic risk
6 Sep, 2020 | 21:24h | UTCSource: EvidenceAlerts
Editorial: Are we underestimating seroprevalence of SARS-CoV-2?
4 Sep, 2020 | 02:17h | UTCAre we underestimating seroprevalence of SARS-CoV-2? – The BMJ
Commentary: Are antibody tests underestimating the spread of COVID-19? – St. George’s University of London
Review: Coagulopathy of Covid-19
4 Sep, 2020 | 02:14h | UTCCoagulopathy of Coronavirus Disease 2019 – Critical Care Medicine
Commentary on Twitter
What you need to know about #Covid19 #coagulopathy is all in one place – @CCM. This will help target your anticoagulation plans for COVID care. @SCCM https://t.co/gKUbc995ra
— Lauren R. Sorce, PhD, RN, CPNP-AC/PC, FAAN, FCCM (@SCCMPresident) September 1, 2020
Editorial: Reopening schools during COVID-19
4 Sep, 2020 | 02:16h | UTCReopening schools during COVID-19 – Science
Evolution and epidemic spread of SARS-CoV-2 in Brazil
4 Sep, 2020 | 02:11h | UTCEvolution and epidemic spread of SARS-CoV-2 in Brazil – Science
[Preprint] Diarrhea and vomiting may be a key sign of Covid-19 in children
4 Sep, 2020 | 02:12h | UTCDiarrhoea and vomiting may be key sign of Covid in children – The Guardian
Original Study: Seroprevalence of SARS-CoV-2 antibodies in children – A prospective multicentre cohort study – medRxiv
Commentary on Twitter
(1/10) Important pre-print study (interpret cautiously) of 992 UK children showing 6.9% had #SARSCoV2 antibodies, suggesting they are at similar risk of infection as adults, & that young and older children are similarly susceptible. 50% were asymptomatic.https://t.co/sUgvIlnmE0 pic.twitter.com/nxeHkAODLF
— Dr Zoë Hyde (@DrZoeHyde) September 3, 2020
Case report: Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection
4 Sep, 2020 | 02:10h | UTCCommentary: Can COVID-19 cause diabetes? – MedicalXpress
Commentary on Twitter
https://twitter.com/nresearchnews/status/1301179637704331265
COVID-19 and mRNA vaccines—first large test for a new approach
4 Sep, 2020 | 02:08h | UTCCOVID-19 and mRNA Vaccines—First Large Test for a New Approach – JAMA
Forty postmortem examinations in COVID-19 Patients: Two distinct pathologic phenotypes and correlation with clinical and radiologic findings
4 Sep, 2020 | 02:05h | UTC
Commentary on Twitter
Our COVID autopsy study is now online! We describe 2 distinct pathologic phenotypes and correlate with clinical and radiologic data. So proud of this team! 💕@ColumbiaPath @AJCPjournal #pulmpath #pathology #autopsy #NYC #COVID19 #covid https://t.co/f3xhc0v1si
— Simona De Michele, MD (@SDeMicheleMD) September 3, 2020
Opinion: Herd immunity is not a strategy
4 Sep, 2020 | 02:09h | UTCHerd Immunity Is Not a Strategy – The Atlantic
Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic
4 Sep, 2020 | 02:06h | UTC
Coalition Covid-19 Brazil – Randomized trial: Dexamethasone improves outcomes in patients with Acute Respiratory Distress Syndrome and COVID-19
3 Sep, 2020 | 11:24h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Related studies: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial – JAMA AND Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA
Commentary: Inexpensive Steroids Can Save Lives Of Seriously Ill COVID-19 Patients – NPR
Commentary on Twitter
In this RCT, IV #dexamethasone increased the number of ventilator-free days by day 28 vs standard care alone among patients with #COVID19 and moderate or severe ARDS https://t.co/RA9G6LVRlz @ICURevisited @FlaviaSepsis @israelmaia16
— JAMA (@JAMA_current) September 2, 2020
Malignant pleural effusions: New evidence on management
4 Sep, 2020 | 02:03h | UTCMalignant pleural effusions (MPE): new evidence on management – Evidently Cochrane
Original Review: Interventions for the management of malignant pleural effusions: a network meta‐analysis – Cochrane Library
Video: Corticosteroids for COVID-19 – New Evidence of Benefit
3 Sep, 2020 | 11:21h | UTCCorticosteroids for COVID-19 – New Evidence of Benefit – JAMA
Meta-analysis: Corticosteroids for critically ill patients with COVID-19
3 Sep, 2020 | 11:23h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Commentaries: Analysis of seven trials finds that corticosteroids reduce risk of death by 20 per cent in critically ill COVID-19 patients – University of Bristol AND Multiple studies confirm steroids can fight severe COVID-19 – MedicalXpress
Commentary on Twitter
1/8 Corticosteroids and COVID19
*Three* RCTs and a new @WHO meta-analysis add to #RECOVERY trial data that corticosteroids reduce mortality in critically ill #COVID19 patientshttps://t.co/H8c46Y5DTm— JAMA (@JAMA_current) September 2, 2020
Incidence of malformations after early pregnancy exposure to Modafinil
4 Sep, 2020 | 02:02h | UTCIncidence of Malformations After Early Pregnancy Exposure to Modafinil in Sweden and Norway – JAMA (free for a limited period)
Commentary: Narcolepsy drug did not increase risk of fetal malformation – Karolinska Institutet
Commentary on Twitter
Cohort study: Modafinil use during early pregnancy was not significantly associated with increased risk of major malformations (unexposed group = 2.1% vs. exposed = 2.6%; crude RR = 1.06; 0.35-3.26). 1st trimester only: RR = 0.44; 0.06-3.10 https://t.co/u4WsK2v31C
— P𝘧OL (@psychopharmacol) September 2, 2020