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Study: Children and adults equally susceptible to in-home COVID-19 spread, but children generally had less frequent and severe symptoms

15 Dec, 2020 | 01:36h | UTC

Symptoms and Transmission of SARS-CoV-2 Among Children — Utah and Wisconsin, March–May 2020 – Pediatrics

Commentaries: Study: Kids, adults equally susceptible to in-home COVID-19 spread – CIDRAP AND COVID-19 in Children: Looking Forward, Not Back

 

WHO, UNICEF Report: Almost 2 billion people depend on health care facilities without basic water services

15 Dec, 2020 | 01:33h | UTC

Almost 2 billion people depend on health care facilities without basic water services – WHO, UNICEF – World Health Organization

Report: Global progress report on WASH in health care facilities: Fundamentals first – World Health Organization

Commentary: 1.8 Billion People Struggling To Access Basic Water Services, With Countries “Significantly” Behind Goals, WHO Report Finds – Health Policy Watch

 

Brazilian Cardio-oncology Guideline – 2020

15 Dec, 2020 | 01:31h | UTC

Brazilian Cardio-oncology Guideline – 2020 – Arquivos Brasileiros de Cardiologia

 

Randomized trial: Among patients with advanced rectal cancer, short-course radiotherapy followed by chemotherapy before total mesorectal excision reduces disease-related treatment failure compared to standard treatment

15 Dec, 2020 | 01:29h | UTC

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial – The Lancet Oncology

 

Commentary on Twitter

 

AHA Scientific Statement: Menopause transition and cardiovascular disease risk

15 Dec, 2020 | 01:32h | UTC

Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association – Circulation

News release: Heart disease risk in women increases leading up to menopause; early intervention is key – American Heart Association

Top Things to Know: Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention

Commentaries: Menopause Transition and Cardiovascular Health: Time Matters – American Heart Association AND Report on latest menopause science looks at heart risks – American Heart Association AND Menopause Transition and CVD Risk: AHA Scientific Statement – American College of Cardiology

 

Critical review: “I’m upset about the RELAX trial” (study showing a lower PEEP strategy is noninferior to a higher PEEP strategy in ICU patients without ARDS)

15 Dec, 2020 | 01:27h | UTC

I’m upset about the RELAX trial – PulmCrit

Original study and commentaries: Randomized trial: Among patients in the ICU receiving invasive ventilation, a strategy with lower PEEP was noninferior to a strategy using higher PEEP

 

Commentary from the author on Twitter

 

Randomized trial: In acutely ill children, the risk of electrolyte disorders is markedly increased with plasmalike isotonic fluid therapy compared with moderately hypotonic fluid therapy containing 20 mmol/L of potassium

15 Dec, 2020 | 01:25h | UTC

Risk of Electrolyte Disorders in Acutely Ill Children Receiving Commercially Available Plasmalike Isotonic Fluids: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

Commentary: Isotonic Fluids Without Potassium Could Be Harmful for Some Acutely Ill Kids – Medscape (free registration required)

 

Commentary on Twitter

 

Randomized trial: Among women with urinary incontinence, biofeedback-mediated intensive pelvic floor training does not provide additional benefit to basic pelvic floor muscle training

15 Dec, 2020 | 01:23h | UTC

Basic versus biofeedback-mediated intensive pelvic floor muscle training for women with urinary incontinence: the OPAL RCT – Health Technology Assessment

 

Meta-analysis: Induction of labor at 41 weeks improves perinatal outcomes compared with expectant management until 42 weeks, without increasing the cesarean delivery rate

15 Dec, 2020 | 01:21h | UTC

Induction of labour at 41 weeks or expectant management until 42 weeks: A systematic review and an individual participant data meta-analysis of randomised trials – PLOS Medicine

Commentary: More support for induction at 41 weeks’ pregnancy, especially for first time mothers – University of Gothenburg

 

Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19

13 Dec, 2020 | 23:31h | UTC

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine

Commentary: Baricitinib plus remdesivir shows promise for treating COVID-19 – NIH News Releases

 

Commentary on Twitter

 

Podcast: Management of Cellulitis

15 Dec, 2020 | 01:20h | UTC

#246 Take a Bite out of Cellulitis with Dr Boghuma Titanji – The Curbsiders Internal Medicine Podcast

 

Call for action: Managing the infodemic – A global movement to promote access to health information and mitigate harm from health misinformation among online and offline communities

13 Dec, 2020 | 23:34h | UTC

Call for Action: Managing the Infodemic – World Health Organization

See also: Infodemic Management – World Health Organization AND Tips for professional reporting on COVID-19 vaccines – World Health Organization

 

Meta-analysis: Efficacy and harms of remdesivir for the treatment of COVID-19. “Until stronger evidence emerges, we cannot conclude that remdesivir is efficacious for treating COVID-19”.

13 Dec, 2020 | 23:27h | UTC

Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis – PLOS One

 

Video: Coronavirus vaccine update with Anthony Fauci

13 Dec, 2020 | 23:25h | UTC

Coronavirus Vaccine Update With Anthony Fauci – JAMA

 

A systematic review of corticosteroid treatment for noncritically ill patients with COVID-19 – corticosteroid treatment is not recommended for patients with mild or moderate COVID-19

13 Dec, 2020 | 23:26h | UTC

A systematic review of corticosteroid treatment for noncritically ill patients with COVID-19 – Scientific Reports

 

Fauci says herd immunity possible by fall, ‘normality’ by end of 2021

13 Dec, 2020 | 23:23h | UTC

Fauci says herd immunity possible by fall, ‘normality’ by end of 2021 – The Harvard Gazette

 

A doctor on 9 things that could go wrong with the new vaccines – by worrying together, we can prevent much of this from happening

13 Dec, 2020 | 23:21h | UTC

A doctor on 9 things that could go wrong with the new vaccines – Vox

 

NICE Guideline: Osteoarthritis care and management

13 Dec, 2020 | 23:19h | UTC

Osteoarthritis: care and management – National Institute for Health and Care Excellence

 

WHO calls on world leaders to “honor their pledge” to fund COVID-19 vaccines; South Africa raises specter of “vaccine apartheid”

13 Dec, 2020 | 23:22h | UTC

WHO Calls On World Leaders To “Honor Their Pledge” To Fund COVID-19 Vaccines; South Africa Raises Spectre Of “Vaccine Apartheid” – Health Policy Watch

Related: Nine out of 10 in poor nations to miss out on inoculation as west buys up Covid vaccines – The Guardian

 

Systematic review: Tourniquet use for knee replacement surgery is probably associated with an increased risk of serious adverse events

13 Dec, 2020 | 23:17h | UTC

Tourniquet use for knee replacement surgery – Cochrane Library

Commentary: Featured Review: Tourniquet in knee replacement surgery

 

Systematic review: Among patients with advanced chronic kidney disease and uremic pruritus, gabapentinoids are the most studied treatments and show the greatest reduction in itch scores

13 Dec, 2020 | 23:16h | UTC

Interventions for itch in people with advanced chronic kidney disease – Cochrane Library

Commentary: What is the best treatment for itch in people with chronic kidney disease? – Cochrane Library

 

The USPSTF draft statement recommends behavioral counseling interventions aimed at promoting healthy weight gain and preventing excess gestational weight gain in pregnancy

13 Dec, 2020 | 23:18h | UTC

Healthy Weight and Weight Gain During Pregnancy: Behavioral Counseling Interventions – U.S. Preventive Services Task Force

Commentary: USPSTF in favor of interventions for healthy weight gain in pregnancy

 

Just published: Pfizer vaccine confers 95% protection against Covid-19

11 Dec, 2020 | 09:32h | UTC

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine – New England Journal of Medicine

Editorial: SARS-CoV-2 Vaccination — An Ounce (Actually, Much Less) of Prevention

Commentary: Pfizer vaccine results published in peer-reviewed journal – MedicalXpress

Related: FDA advisory panel endorses Pfizer/BioNTech Covid-19 vaccine – STAT

 

Commentary on Twitter (Thread – Click for more)

 

Randomized trial: Trimethoprim-Sulfamethoxazole does not benefit patients with moderate and severe idiopathic pulmonary fibrosis

13 Dec, 2020 | 23:14h | UTC

Effect of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) vs Placebo on Death, Lung Transplant, or Hospital Admission in Patients With Moderate and Severe Idiopathic Pulmonary Fibrosis: The EME-TIPAC Randomized Clinical Trial – JAMA

Commentary: Idiopathic pulmonary fibrosis: Co-trimoxazole therapy did not prevent disease progression – MedicalResearch

 

Commentary on Twitter

 

Randomized trial: Budesonide orodispersible tablets maintain remission in patients with eosinophilic esophagitis

13 Dec, 2020 | 23:12h | UTC

Budesonide Orodispersible Tablets Maintain Remission in a Randomized, Placebo-Controlled Trial of Patients With Eosinophilic Esophagitis – Gastroenterology

Editorial: Maintenance Topical Steroid Therapy in Eosinophilic Esophagitis: Not So Hard to Swallow Any More?

Commentary: Budesonide for Maintaining EoE Remission – gutsandgrowth

 

Commentary on Twitter

 

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