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Lenvatinib plus either pembrolizumab or everolimus was compared with sunitinib as first-line therapy for advanced renal cell cancer. Progression-free survival was significantly longer with lenvatinib plus pembrolizumab than with sunitinib.

— NEJM (@NEJM) February 13, 2021

RCT: Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma

15 Feb, 2021 | 00:34h | UTC

Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: 2021 Genitourinary Cancers Symposium: Enfortumab Vedotin-ejfv Prolongs Survival in Patients With Metastatic Urothelial Carcinoma – The ASCO Post

RCT: A comparison of sunitinib with cabozantinib, crizotinib, and savolitinib for treatment of advanced papillary renal cell carcinoma

15 Feb, 2021 | 00:32h | UTC

A comparison of sunitinib with cabozantinib, crizotinib, and savolitinib for treatment of advanced papillary renal cell carcinoma: a randomised, open-label, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Cabozantinib most effective treatment for metastatic papillary kidney cancer – MedicalXpress

RCT: Radiopharmaceutical therapy vs. cabazitaxel in patients with metastatic castration-resistant prostate cancer

15 Feb, 2021 | 00:29h | UTC

[177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Radionuclide Tx Wins in Third-Line Metastatic CRPC – MedPage Today

Updated U.S. Recommended Adult Immunization Schedule

12 Feb, 2021 | 02:07h | UTC

Summary: Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older — United States, 2021 – Centers for Disease Control and Prevention

Long-term data: No difference in cardiovascular mortality or morbidity with transdermal estradiol vs. LHRH agonists for androgen suppression in prostate cancer

15 Feb, 2021 | 00:31h | UTC

Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme – The Lancet (link to abstract – $ for full-text)

M-A: No link between blood pressure drugs and falls

12 Feb, 2021 | 02:05h | UTC

No link between blood pressure drugs and falls, finds study – University of Oxford

Original study: Association between antihypertensive treatment and adverse events: systematic review and meta-analysis – The BMJ

Commentary on Twitter (thread – click for more)

Can #bloodpressure treatment be harmful? Our new meta-analysis suggests it is NOT linked to #falls or #fractures but may increase the risk of syncope & acute kidney injury https://t.co/H5LlsFVBXJ – see thread @RichardJMcManus @Richard_D_Riley @ebhcmedstats @JulietU_S @drandyclegg pic.twitter.com/UtWjE1BzMW

— James Sheppard (@jamessheppard48) February 10, 2021

M-A: As consumer products, E-Cigarettes are not associated with increased smoking cessation, but may improve smoking cessation rates as a prescription therapy intervention

12 Feb, 2021 | 01:52h | UTC

E-Cigarette Use and Adult Cigarette Smoking Cessation: A Meta-Analysis – American Journal of Public Health

Invited Commentaries: E-Cigarettes: A Public Health Threat, Not a Population Health Intervention – American Journal of Public Health AND Reporting Certainty of Evidence on E-Cigarette Use for Adult Smoking Cessation – American Journal of Public Health AND Is Good Enough Good Enough? E-Cigarettes, Evidence, and Policy – American Journal of Public Health AND Should E-Cigarette Regulation Be Based on Randomized Trials or Observational Studies? – American Journal of Public Health AND

Commentary: E-cigarettes, as consumer products, do not help people quit smoking, study finds – University of California – San Francisco

RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

Cohort study: The use of macrolide antibiotics in pregnancy is not associated with an increased risk of major congenital malformations

12 Feb, 2021 | 02:04h | UTC

Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study – The BMJ

RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19

12 Feb, 2021 | 02:25h | UTC

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial – medRxiv

News release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP

Commentary on Twitter

👇RECOVERY pre-print:

Tocilizumab
– reduces mortality
– shortens hospital stay
– reduces progression to invasive mechanical ventilation

Clear benefits on top of corticosteroids

Good news!https://t.co/dal17tQG5b

— Martin Landray (@MartinLandray) February 11, 2021

Study: New B.1.1.7 variant does not result in more severe disease in children compared to the original strain

12 Feb, 2021 | 02:23h | UTC

Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people – The Lancet Child & Adolescent Health

Commentary on Twitter

There were recent concerns and media reports that B.1.1.7 has more effects in children and young adults than the ancestral strain. Here are new data to provide reassurance that's not the case @LancetChildAdol https://t.co/85Dj4tl2qq pic.twitter.com/YmNOeOhpTB

— Eric Topol (@EricTopol) February 11, 2021

Podcast: Does vaccination mean the end of masking and social distancing?

12 Feb, 2021 | 02:22h | UTC

Does Vaccination Mean the End of Masking and Social Distancing? – New England Journal of Medicine

Fully vaccinated people can skip Covid quarantines, CDC says

12 Feb, 2021 | 02:21h | UTC

Fully vaccinated people can skip Covid quarantines, CDC says – CNN

Video (6 min): A visual guide to the new coronavirus variants

12 Feb, 2021 | 02:20h | UTC

A Visual Guide to the New Coronavirus Variants – Scientific American

Opinion: It’s time to consider vaccine mandates in high-risk settings

12 Feb, 2021 | 02:19h | UTC

It’s Time to Consider Vaccine Mandates in High-Risk Settings – Scientific American

Commentary on Twitter

It's Time to Consider #Vaccine Mandates in High-Risk Settings

"Leaving vaccination to individual choice is unacceptably high in places like #NursingHomes, #LongTermCare facilities and #Prisons"

Professors @doritmi @ArthurCaplan in @sciam https://t.co/km2PZPM5bK

— Paul Belcher *ON BLUESKY – DORMANT ON X* (@PaulJBelcher) January 28, 2021

Editorial: Covid-19 has amplified moral distress in medicine

12 Feb, 2021 | 02:16h | UTC

Covid-19 has amplified moral distress in medicine – The BMJ

[Preprint] Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19

12 Feb, 2021 | 02:14h | UTC

Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19 – medRxiv

Commentary: Covid linked to risk of mental illness and brain disorder, study suggests – The Guardian

Perspective: Mandating COVID-19 Vaccines—Ethical and Legal Considerations

12 Feb, 2021 | 02:18h | UTC

Mandating COVID-19 Vaccines – JAMA

Commentary on Twitter

Mandatory #COVID #vaccines are of intense interest. Now, in @JAMA_current, Dan Salmon @JohnsHopkinsSPH, @ProfHeidiLarson & I examine whether it's lawful & ethical. We cover mandates ordered by states, employers, schools, unis & as a condition of service. https://t.co/n9MQN3p1Wi pic.twitter.com/GmacRB5KKZ

— Lawrence Gostin (@LawrenceGostin) December 29, 2020