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Opinion | The Antiscience Movement Is Escalating, Going Global and Killing Thousands

5 Apr, 2021 | 01:34h | UTC

The Antiscience Movement Is Escalating, Going Global and Killing Thousands – Scientific American

Opinion | How to lose friends and alienate people? On the problems of vaccine passports

5 Apr, 2021 | 01:42h | UTC

How to lose friends and alienate people? On the problems of vaccine passports – The BMJ Opinion

Commentary on Twitter

"All in all, there are reasons to conclude that vaccine passports for basic activities may actually undermine vaccine rollout by disincentivising the very populations who most need incentivising" @ReicherStephen @ProfJohnDrury https://t.co/UL9qfFiOcA

— The BMJ (@bmj_latest) April 2, 2021

Many hospitalized Covid-19 patients are given antibiotics. That’s a problem

5 Apr, 2021 | 01:33h | UTC

Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

What we know so far about the effort to vaccinate children

5 Apr, 2021 | 01:31h | UTC

What we know so far about the effort to vaccinate children – National Geographic

RCT: Upadacitinib vs. Adalimumab for Psoriatic Arthritis

5 Apr, 2021 | 00:57h | UTC

Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)

RCT: Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1

5 Apr, 2021 | 01:01h | UTC

Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1 – New England Journal of Medicine (link to abstract – $ for full-text)

RCT: Efficacy and safety of a dexamethasone intracanalicular insert in patients with allergic conjunctivitis

5 Apr, 2021 | 00:54h | UTC

Phase 3 Randomized Study of Efficacy and Safety of a Dexamethasone Intracanalicular Insert in Patients With Allergic Conjunctivitis – American Journal of Ophthalmology (link to abstract – $ for full-text)

M-A: Similar oncological outcomes with laparoscopic vs. open rectal cancer resections

5 Apr, 2021 | 00:43h | UTC

Oncological outcomes of laparoscopic versus open rectal cancer resections: meta-analysis of randomized clinical trials – British Journal of Surgery

Guideline for elective cesarean section: updated systematic review and procedure‐specific postoperative pain management recommendations

2 Apr, 2021 | 09:09h | UTC

PROSPECT guideline for elective caesarean section: updated systematic review and procedure‐specific postoperative pain management recommendations – Anaesthesia

RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious

2 Apr, 2021 | 09:17h | UTC

Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)

Preliminary study finds a low-calorie diet and mild exercise may improve survival for young people with leukemia

2 Apr, 2021 | 09:12h | UTC

Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial – Blood Advances

Commentary: Low-calorie diet and mild exercise improve survival for young people with leukemia – University of California, Los Angeles (UCLA)

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

2 Apr, 2021 | 09:15h | UTC

Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: ART in pregnant women living with HIV – The Lancet

Short review | A practical approach to the patient with chronic diarrhea

2 Apr, 2021 | 09:03h | UTC

A practical approach to the patient with chronic diarrhoea – Clinical Medicine Journal

Systematic review: Lens extraction for chronic angle-closure glaucoma

2 Apr, 2021 | 09:01h | UTC

Lens extraction for chronic angle-closure glaucoma – Cochrane Library

Systematic review: Laser peripheral iridoplasty for chronic angle closure

2 Apr, 2021 | 09:02h | UTC

Laser peripheral iridoplasty for chronic angle closure – Cochrane Library

Summary: What are the benefits and risks of laser peripheral iridoplasty (a surgical procedure) for chronic primary angle closure (an eye condition)? – Cochrane Library

M-A: Non-drug therapies as good as or better than drugs for treating depression in people with dementia

2 Apr, 2021 | 09:05h | UTC

Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis – The BMJ

Commentaries: Non-drug therapies as good as or better than drugs for treating depression in people with dementia – The BMJ AND Social prescribing may help reduce symptoms of depression in people with dementia – The BMJ Opinion AND Nondrug Interventions Can Help Alleviate Depression in Dementia Patients – HealthDay

Video: Why you can’t compare Covid-19 vaccines

2 Apr, 2021 | 09:33h | UTC

Why you can’t compare Covid-19 vaccines – Vox

Long Covid in the UK – More than a million affected in February, survey suggests

2 Apr, 2021 | 09:31h | UTC

Long Covid: More than a million affected in February, survey suggests – BBC

Report: Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 1 April 2021 – Office for National Statistics

Commentary on Twitter

YOUNG ADULTS MOST AFFECTED—Long-Covid symptoms are affecting about 1.1 million people in the U.K., with about half that number saying the disease is harming their day-to-day lives, government statistics show. Top #LongCovid age group? 25-34! Thread 🧵 https://t.co/Fwo8Opeqr6

— Eric Feigl-Ding (@DrEricDing) April 1, 2021

After the WHO report: what’s next in the search for COVID’s origins

2 Apr, 2021 | 09:26h | UTC

After the WHO report: what’s next in the search for COVID’s origins – Nature

Why is it so hard to investigate the rare side effects of COVID vaccines?

2 Apr, 2021 | 09:28h | UTC

Why is it so hard to investigate the rare side effects of COVID vaccines? – Nature

[Press release – not published yet] Pfizer/BioNTech vaccine is 91% effective for at least 6 months

2 Apr, 2021 | 09:29h | UTC

Pfizer and BioNTech Confirm High Efficacy and No Serious Safety Concerns Through Up to Six Months Following Second Dose in Updated Topline Analysis of Landmark COVID-19 Vaccine Study

Commentaries: Ongoing trial shows Pfizer Covid-19 vaccine remains highly effective after six months – CNN AND Coronavirus: Pfizer jab ‘stopping 91% of cases in first six months’ – BBC AND Expert reaction to press release from Pfizer and BioNTech on efficacy and safety up to six months after second vaccine dose, including data from South Africa – Science Media Centre AND Pfizer’s COVID-19 vaccine effective after 6 months and works against problem variant – LiveScience

Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis

2 Apr, 2021 | 09:23h | UTC

Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis – The Lancet Global Health

Commentaries: Covid-19 led to a global increase in stillbirths, maternal mortality, and depression, review finds – CNN AND COVID-19 pandemic and health-care disruptions: count the most vulnerable – The Lancet Global Health

Commentary on Twitter

NEW—Pregnancy outcomes worsened during the #COVID19 pandemic worldwide, with an increase in maternal deaths, stillbirth, ruptured ectopic pregnancies, and maternal depression.

New review of 40 studies from 17 countries in @LancetGH: https://t.co/GWBohu6b6k pic.twitter.com/4RzgtShYeH

— The Lancet (@TheLancet) April 1, 2021