Archives
Perspective | Covid-19: What should we do about B.1.617.2? A classic case of decision making under uncertainty.
19 May, 2021 | 08:48h | UTC
SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment.
19 May, 2021 | 08:49h | UTCSARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment – Cell Metabolism
Commentary on Twitter
A new report reinforces the capability for #SARSCoV2 to infect and kill pancreatic β-islet cells, affect insulin secretion https://t.co/4tpIVNpjTf @Cell_Metabolism #diabetes @StanfordMed @stanfordimmuno @UCSF and collaborators pic.twitter.com/dG027CXS5e
— Eric Topol (@EricTopol) May 18, 2021
WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
19 May, 2021 | 08:47h | UTCInternational COVID-19 trial to restart with focus on immune responses – Nature
Opinion | Vaccinating children before poor morally wrong, Oxford scientist says.
19 May, 2021 | 08:44h | UTCVaccinating children before poor morally wrong, Oxford scientist says – BBC
Related: WHO: Wealthy nations urged to delay youth Covid vaccines, donate to solidarity scheme AND Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”. AND Opinion | American Kids Can Wait – “The U.S. should delay shots for children until global vaccine-manufacturing capacity significantly expands and the crisis in India subsides”.
Former CDC director: Direct Covid-19 vaccines to where they’re needed most.
19 May, 2021 | 08:42h | UTCFormer CDC director: Direct Covid-19 vaccines to where they’re needed most – CNN
Commentary on Twitter
Vaccine inequity is a serious problem ethically and epidemiologically. Read my latest at @CNN on why we must direct Covid vaccines to where they’re needed the most. https://t.co/2CD5xzI00h
— Dr. Tom Frieden (@DrTomFrieden) May 17, 2021
USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.
19 May, 2021 | 08:40h | UTCScreening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement
Evidence Report: Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
Editorials: US Preventive Services Task Force Recommendations for Colorectal Cancer Screening: Forty-Five Is the New Fifty – JAMA AND Updated USPSTF Guidelines for Colorectal Cancer Screening: The Earlier the Better – JAMA Surgery AND Colorectal Cancer Screening Starting at Age 45 Years—Ensuring Benefits Are Realized by All – JAMA Network Open AND
Modeling study: Colorectal Cancer Screening: An Updated Modeling Study for the US Preventive Services Task Force – JAMA
Author interview: USPSTF Recommendation: Screening for Colorectal Cancer
JAMA Patient Page: Screening for Colorectal Cancer
Review: Testing at scale during the COVID-19 pandemic.
19 May, 2021 | 08:45h | UTCTesting at scale during the COVID-19 pandemic – Nature Reviews Immunology
Commentary on Twitter
🆕💥 @NatureRevGenet
Testing at scale during the COVID-19 pandemic
💥Changes in modes of testing across a generalized COVID-19 infectious course💥
✨Excellent Figure ✨ https://t.co/sUZjRr1gQR pic.twitter.com/ZiOXCw7en2— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 10, 2021
M-A: Encephalitis as Neurological Complication of COVID‐19.
19 May, 2021 | 08:41h | UTC
ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections.
19 May, 2021 | 08:37h | UTC
Commentary on Twitter
📢New ACG Clinical Guideline on Prevention, Diagnosis & Treatment of C. difficile Infections
Focus on clinical challenges – diagnostic issues in diarrhea, distinguishing C. diff colonization from active infection + eval/mgmt of CDI in IBD
Full guideline: https://t.co/QTCzeLB9Ri pic.twitter.com/mqZUN4r4jA
— AJG – The American Journal of Gastroenterology (@AmJGastro) May 18, 2021
Fluid-induced harm in the hospital: look beyond volume and start considering sodium. From physiology towards recommendations for daily practice in hospitalized adults.
19 May, 2021 | 08:32h | UTC
Guideline: Early intervention for children aged 0 to 2 years with or at high risk of cerebral palsy.
19 May, 2021 | 08:35h | UTCEarly Intervention for Children Aged 0 to 2 Years With or at High Risk of Cerebral Palsy: International Clinical Practice Guideline Based on Systematic Reviews – JAMA Pediatrics (free for a limited period)
Editorial: Early Intervention in Cerebral Palsy and Beyond (free for a limited period)
Series: Social determinants of health in people with kidney disease.
19 May, 2021 | 08:29h | UTCIntroduction: Social Determinants of Health in People with Kidney Disease
The Pathogenesis of Race and Ethnic Disparities
Social Determinants of Kidney Health
Reducing the Burden of CKD among Latinx
The Seen and the Unseen: Race and Social Inequities Affecting Kidney Care
Personal Experiences of Patients in the Interaction of Culture and Kidney Disease
Commentary on Twitter
A series of Perspective articles were written based on talks at the 2020 Alison Norris Symposium at the New York Academy of Medicine on Social Determinants of Kidney Health. Dr. Alan M. Weinstein & Paul L. Kimmel share an overview of the program and series https://t.co/TlG0mOzZs4
— CJASN (@CJASN) May 14, 2021
WHO and UNICEF launch new tools for the promotion of adolescent mental health.
19 May, 2021 | 08:33h | UTCNews release: WHO and UNICEF launch new tools for the promotion of adolescent mental health – World Health Organization
WHO/UNICEF Helping Adolescents Thrive programme
Helping Adolescents Thrive Toolkit
Magnificent Mei and Friends: Comic 1
The mental and brain health of children and adolescents
Commentary on Twitter (thread – click for more)
📢 NEW RELEASE : The Helping Adolescents Thrive Toolkit, developed by WHO & @UNICEF, provides guidance for people working in the health, social services, education & justice sectors on how to promote & protect adolescent mental health.
Download 👉https://t.co/gtAK7WeQC7 pic.twitter.com/x7lq6m51Ze
— World Health Organization (WHO) (@WHO) May 18, 2021
Perspective | Facebook calls links to depression inconclusive. These researchers disagree.
19 May, 2021 | 08:30h | UTCFacebook Calls Links To Depression Inconclusive. These Researchers Disagree – NPR
Related: Cohort study: Preschoolers’ extensive electronic media use linked to emotional/behavioral issues AND Analysis: Smartphones, Social Media Use and Youth Mental Health AND [Abstract Only] Study: Associations Between Time Spent Using Social Media and Mental Health Problems Among Youth AND Association of Screen Time and Depression in Adolescence AND The Adverse Effects of Social Media use on Young People’s Mental Health May be Caused by Exposure to Cyberbullying, Loss of Sleep, and Reduced Physical Activity AND Research: This Is Your Brain Off Facebook AND Cohort Study: Social Media Use and Adolescent Mental Health AND Supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn
Guide to enhanced recovery for cancer patients undergoing surgery: ERAS for Patients Undergoing Cytoreductive Surgery with or Without hyperthermic intraperitoneal chemotherapy.
19 May, 2021 | 08:23h | UTCRelated Guidelines:
See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines
The catastrophization effects of an MRI report on the patient and surgeon and the benefits of ‘clinical reporting’: results from an RCT and blinded trials.
19 May, 2021 | 08:25h | UTCRelated: You cannot unsee your MRI report AND Direct communication between radiologists and patients improves the quality of imaging reports – European Radiology
Commentary on Twitter
https://twitter.com/hjluks/status/1392151713700794374
Large cohort study confirms the renal toxicities of anti-inflammatories, suggesting Ibuprofen may be the safest option among them.
19 May, 2021 | 08:28h | UTCComparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary: Study: Ibuprofen Found Safest NSAID for the Kidney – MPR
Commentary on Twitter
Comparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD
Read this new @CJASN study and listen to the accompanying podcast:https://t.co/GL1ITzh4O4 pic.twitter.com/lZGeFqfrDZ
— American Society of Nephrology (@ASNKidney) April 29, 2021
Systematic review: Paying for performance to improve the delivery of health interventions in low‐ and middle‐income countries.
19 May, 2021 | 08:19h | UTCSummary: Paying for performance to improve the delivery of health interventions in LMICs
Systematic Review: Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome is associated with reduced risk of death or bronchopulmonary dysplasia, less intubation in the first 72 hours, and reduced incidence of major complications and in‐hospital mortality.
19 May, 2021 | 08:20h | UTC
Commentary on Twitter
https://twitter.com/CochraneUK/status/1393463418913443843
[Preprint] Practice Changing RCT: Therapeutic-dose anticoagulation with heparin (LMWH or unfractionated heparin) improves outcomes in non-critically ill patients with Covid-19 – the superiority of therapeutic-dose anticoagulation was seen in both high and low D-dimer groups.
18 May, 2021 | 08:04h | UTCTherapeutic Anticoagulation in Non-Critically Ill Patients with Covid-19 – medRxiv
Commentary on Twitter
Final results of the mpRCT now on preprint server. In non-critically ill patients with COVID-19 (n=2219), therapeutic-dose anticoagulation with heparins increases survival to hospital discharge with reduced use of organ support. https://t.co/TkhGs5qow5
— Ryan Zarychanski (@RZarychanski) May 17, 2021
#ACC21 – [Not published yet] RCT: Among hospitalized patients with Covid-19 and elevated D-Dimer, therapeutic anticoagulation with Rivaroxaban 20 mg was not associated with improved outcomes and resulted in increased major bleeding.
18 May, 2021 | 08:01h | UTCAntiCoagulaTIon cOroNavirus – ACTION – American College of Cardiology
Commentary: ACTION: Full-Dose Rivaroxaban Doesn’t Help in Hospitalized COVID-19 – TCTMD
More flexible storage conditions for BioNTech/Pfizer’s COVID-19 vaccine. – “This change extends the approved storage period of the unopened thawed vial at 2-8°C (i.e. in a normal fridge after taking out of deep-freeze conditions) from five days to one month”.
18 May, 2021 | 07:59h | UTCMore flexible storage conditions for BioNTech/Pfizer’s COVID-19 vaccine – European Medicines Agency
Commentary: EU Regulator Backs Month-Long Storage of Pfizer COVID-19 Vaccine in Fridges – U.S. News/Reuters
Commentary on Twitter
EMA has changed the recommended storage conditions for Pfizer vaccine. Instead of 5 days the thawed, unopened vials can now be stored in a normal fridge for a month. 👏 https://t.co/MVkDJRQn4b
— Kai Kupferschmidt (@kakape) May 17, 2021
COVID vaccines can block variant hitting Asia, lab study finds – “Assays using live SARS-CoV-2 offer hope that the vaccines made by Pfizer and Moderna will protect against a viral strain first seen in India”.
18 May, 2021 | 07:56h | UTCCOVID vaccines can block variant hitting Asia, lab study finds – Nature
See also: Pfizer, Moderna vaccines effective against Indian variants: study – MedicalXpress
Commentary on Twitter
Pfizer & Moderna mRNA vaccines are effective against multiple SARSCoV2 variants, including the B.1.617 & B.1.618, 2 variants underlying the surge in India. The research, while not yet peer-reviewed, was conducted at NYU School of Medicine in New York City https://t.co/3ziRhk8f4t pic.twitter.com/VzYQKWqyQF
— delthia ricks 🔬 (@DelthiaRicks) May 17, 2021
SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy.
18 May, 2021 | 07:52h | UTC
M-A: Incidence and mortality of COVID‐19‐associated pulmonary aspergillosis – The incidence and mortality in the ICU were estimated to be 10.2% and 54.9%, respectively.
18 May, 2021 | 07:50h | UTC