Archives
RCT: Lopinavir-ritonavir and hydroxychloroquine worsened outcomes in critically ill patients with COVID-19.
14 Jul, 2021 | 11:25h | UTC
Commentary on Twitter (thread – click for more)
Results of @remap_cap #Covid_19 #Antiviral Domain released Online First @yourICM: Among critically ill patients with COVID-19, #lopinavir-ritonavir, #HydroxyChloroquine, or combination therapy worsened outcomes compared to no antiviral therapy
— remap-cap (@remap_cap) July 13, 2021
Acute promyelocytic leukemia current treatment algorithms.
15 Jul, 2021 | 09:01h | UTCAcute promyelocytic leukemia current treatment algorithms – Blood Cancer Journal
Opinion | The case for mandating COVID-19 vaccines for health care workers.
14 Jul, 2021 | 11:22h | UTCThe Case for Mandating COVID-19 Vaccines for Health Care Workers – Annals of Internal Medicine
News release: Case is strong for mandating COVID-19 vaccination for health care workers – American College of Physicians
Commentary on Twitter
The Case for Mandating COVID-19 Vaccines for Health Care Workers https://t.co/pdaBRZdkfG via @AnnalsofIM "The case for mandating SARS-CoV-2 vaccines for health care workers is substantially stronger than the case was for mandating influenza vaccines." I fully agree.
— Kenny Lin, MD, MPH (@kennylinafp) July 12, 2021
RCT: Neither Remdesivir nor Hydroxychloroquine affect viral clearance in hospitalized patients with COVID-19.
14 Jul, 2021 | 11:23h | UTCNews release: Neither remdesivir nor HCQ affect viral clearance in hospitalized patients with COVID-19 – American College of Physicians
Original Study: Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 – Annals of Internal Medicine
Commentary on Twitter
Newly published research in Annals concludes neither remdesivir nor #hydroxychloroquine affected viral clearance in hospitalized patients with #COVID19 https://t.co/K3qWLUW8uY. pic.twitter.com/ugbjJJ3qI5
— Annals of Int Med (@AnnalsofIM) July 12, 2021
[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.
14 Jul, 2021 | 11:19h | UTCOriginal Study: Assessing multiplex tiling PCR sequencing approaches for detecting genomic variants of SARS-CoV-2 in municipal wastewater – medRxiv
Related: Perspective | Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start. (texts on the subject) AND Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
Commentary on Twitter (thread – click for more)
Excited to share our new preprint assessing different approaches for sequencing SARS-CoV-2 in wastewater! We compared different sample matrices and tiled PCR schemes, and then applied the best combo to track variants of concern in @MetroVancouver: https://t.co/cXFhr1qmAe
— Ryan Ziels (@RyanZiels) June 1, 2021
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
14 Jul, 2021 | 11:20h | UTCBetween BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women – JAMA
Commentary: Pfizer COVID vaccine shows 78% efficacy in pregnancy – CIDRAP
Real-World Evidence: The low validity of temperature screening for COVID-19 triage.
14 Jul, 2021 | 11:11h | UTC
Commentary on Twitter
Temperature screening with infrared thermometers has a sensitivity of 9.43% for PCR+ COVID. https://t.co/GjaKpkUqwU
— Carlos del Rio (@CarlosdelRio7) July 7, 2021
New Zealand children falling ill in high numbers due to Covid ‘immunity debt’.
14 Jul, 2021 | 11:16h | UTCNew Zealand children falling ill in high numbers due to Covid ‘immunity debt’ – The Guardian
Related: New Zealand, where Covid-19 is dormant, fights another respiratory virus – The New York Times
Next steps for wastewater testing to help end this pandemic — and prevent the next one.
14 Jul, 2021 | 11:18h | UTCNext steps for wastewater testing to help end this pandemic — and prevent the next one – STAT
Author interview: A biostatistician on the ‘gold mine’ in our sewers – STAT
Related: Perspective | Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start. (texts on the subject) AND Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
One COVID vaccine dose yields good protection in elderly, 2 studies find.
14 Jul, 2021 | 11:15h | UTCOne COVID vaccine dose yields good protection in elderly, 2 studies find – CIDRAP
Commentary on Twitter (thread – click for more)
2 research Articles on #COVID19 vaccine effectiveness in older people:
1) Effectiveness of BNT162b2 and ChAdOx1 nCoV-19 COVID-19 vaccination at preventing hospitalisations in people aged at least 80 years: a test-negative, case-control study https://t.co/ELvMCPwSHF— The Lancet Infectious Diseases (@TheLancetInfDis) June 24, 2021
AAP Technical Report | Prevention of Drowning.
14 Jul, 2021 | 11:09h | UTCPrevention of Drowning – Pediatrics
News releases: American Academy of Pediatrics Identifies Children Most at Risk of Drowning and Recommends Layers of Protection to Prevent Tragedy – American Academy of Pediatrics AND New information, research adds to understanding of drowning risks, precautions – AAP News
Related: The Burden of Unintentional Drowning: Global, Regional and National Estimates of Mortality from the Global Burden of Disease Study AND Preventing drowning: an implementation guide – World Health Organization AND Global report on drowning: preventing a leading killer – World Health Organization AND Report: Open Water Drowning and Risks for Children AND Wilderness Medical Society Clinical Practice Guidelines for the Treatment and Prevention of Drowning: 2019 Update – Wilderness and Environmental Medicine
Commentary on Twitter
Drowning is a leading cause of injury-related death in children. In 2018, almost 900 US children younger than 20 years died from drowning. As educators and advocates, pediatricians can play an important role in #DrowningPrevention: https://t.co/P3eLa1M28p #Pediatrics pic.twitter.com/h3YnqyiMDU
— AAP CME Journals (@AAPJournals) July 13, 2021
WHO: New study highlights unacceptably high global prevalence of syphilis among men who have sex with men.
14 Jul, 2021 | 11:04h | UTCOriginal Study: Prevalence of syphilis among men who have sex with men: a global systematic review and meta-analysis from 2000–20 – The Lancet Global Health
Commentary: Syphilis in men who have sex with men: advancing research and human rights – The Lancet Global Health
Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.
14 Jul, 2021 | 11:07h | UTCNews release: Alcohol consumption linked to more than 740,000 new cancer cases in 2020 – The Lancet
Commentaries: Alcohol caused 740,000 cancer cases globally last year – study – The Guardian AND Expert reaction to study of alcohol and cancer – Science Media Centre
Review: Diagnosis, evaluation, and treatment of adenomyosis.
14 Jul, 2021 | 11:01h | UTCDiagnosis, Evaluation, and Treatment of Adenomyosis – JAMA (free for a limited period)
Review: Diagnosis and treatment of alcohol-associated liver disease.
14 Jul, 2021 | 11:02h | UTCDiagnosis and Treatment of Alcohol-Associated Liver Disease: A Review – JAMA (free for a limited period)
Audio Clinical Review: Diagnosis and Treatment of Alcohol-Associated Liver Disease – JAMA
Summary: SGLT2 inhibitors and GLP-1 receptor agonists established and emerging indications.
14 Jul, 2021 | 10:56h | UTCSGLT2 Inhibitors and GLP-1 Receptor Agonists: Indications – American College of Cardiology
Original review: SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications – The Lancet (link to abstract – $ for full-text)
A UK expert consensus approach for managing symptomatic arteriovenous fistula (AVF) stenosis in hemodialysis patients.
14 Jul, 2021 | 10:55h | UTC
Summary | Universal definition and classification of heart failure: a step in the right direction from failure to function.
14 Jul, 2021 | 10:58h | UTC
FDA Safety Alert: hydroxyethyl starch products should not be used unless adequate alternative treatment is unavailable.
14 Jul, 2021 | 10:48h | UTCCommentary: FDA Piles on New Warnings for Blood Volume Expanders – MedPage Today (free registration required)
Related: Hydroxyethyl-starch Solutions (HES) Should no Longer be Used – European Medicines Agency AND Randomized Trial: Hydroxyethyl Starch vs. Saline for Volume Replacement Therapy in High-Risk Patients Undergoing Major Abdominal Surgery AND Systematic Review: Colloids vs Crystalloids for Fluid Resuscitation in Critically Ill People
SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe.
14 Jul, 2021 | 10:53h | UTCEditorial: Redefining cardiovascular risk prediction: is the crystal ball clearer now?
Commentary: New risk calculator to save many more lives from heart attack and stroke – University of Cambridge
Commentary on Twitter (thread – click for more)
1/2 SCORE2—a new algorithm derived, calibrated, & validated to predict 10-year risk of first-onset CVD in European populations—enhances the identification of individuals at higher risk of developing CVD across Europe https://t.co/VLYfZyXUek#EHJ #ESCYoung @ehj_ed @rladeiraslopes pic.twitter.com/0yZTJBdKDK
— European Society of Cardiology Journals (@ESC_Journals) June 17, 2021
German national treatment guidance for hospitalized COVID-19 patients.
13 Jul, 2021 | 10:02h | UTC
Long Covid: 39% of patients report persistent symptoms more than seven months after diagnosis of COVID-19 in an outpatient setting.
13 Jul, 2021 | 09:57h | UTCCommentaries: Long COVID symptoms in a third of people with COVID-19 – American College of Physicians AND Covid-19: 1-in-3 Patients Reported Long-Hauler Symptoms – Physician’s Weekly
Commentary on Twitter
A new prospective cohort study of >400 people with mild to moderate (outpatient) covid at 7-9 months: nearly 1 of 3 had persistent symptoms #LongCovid @AnnalsofIM
https://t.co/ix1Hhsm0iZ
by @mayssamnehme and colleagues pic.twitter.com/Uc4UEclDvA— Eric Topol (@EricTopol) July 5, 2021
WHO warns against mixing and matching COVID vaccines.
13 Jul, 2021 | 09:53h | UTCWHO warns against mixing and matching COVID vaccines – Reuters
Commentary: WHO cautions data still limited on mixing COVID-19 vaccines, but Canadian officials say it’s OK – CTV News
Related: Germany issues world’s strongest recommendation for mixing Covid-19 vaccines. AND [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Perspective | Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects. AND Should you mix and match COVID-19 vaccines? Scientists are seeking answers
Commentary on Twitter
The World Health Organization's chief scientist on Monday advised against people mixing and matching COVID-19 vaccines from different manufacturers, calling it a "dangerous trend" since there was little data available about the health impact. https://t.co/Oog6fWDSMz
— Reuters Health (@Reuters_Health) July 13, 2021
Large genomic analysis has identified 13 new genomic regions associated with susceptibility and severity to Covid-19.
13 Jul, 2021 | 09:59h | UTCMapping the human genetic architecture of COVID-19 – Nature
Commentaries: The quest to find genes that drive severe COVID – Nature AND Gene hunters turn up new clues to help explain why Covid-19 hits some people so hard – STAT AND Large genomic analysis highlights COVID-19 risk factors – Broad Institute of MIT and Harvard AND A new study finds genetic variations in Covid patients that could point to better drug treatments. – The New York Times AND How your DNA may affect whether you get COVID-19 or become gravely ill – ScienceNews
[Preprint] Long Covid: Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people.
13 Jul, 2021 | 09:55h | UTCCommentary: Study explores the prevalence of long COVID in England – News Medical