Archives
Fauci says natural origins theory of coronavirus is still the most likely.
18 Jul, 2021 | 23:40h | UTCFauci says natural origins theory of coronavirus is still the most likely – CNN
Related article (preprint): The Origins of SARS-CoV-2: A Critical Review – Zenodo
See also: A Group of Scientists Presses a Case Against the Lab Leak Theory of Covid – The New York Times (a few articles per month are free) AND Leading scientists push back against Wuhan lab leak theory – The Age
Related: Opinion | The Covid-19 lab leak theory is a tale of weaponized uncertainty.
WHO publishes new Consolidated HIV guidelines for prevention, treatment, service delivery & monitoring.
18 Jul, 2021 | 23:22h | UTC
Review: Acute kidney injury.
18 Jul, 2021 | 23:18h | UTCAcute kidney injury – Nature Reviews Disease Primers (free for a limited period)
Commentary on Twitter
Get Primed on #AcuteKidneyInjury with our NEW PrimeView, FREE to download this week https://t.co/4RAOOaB8ep pic.twitter.com/d5iHCcqJwY
— Nature Reviews Disease Primers (@DiseasePrimers) July 15, 2021
Review: Parkinson disease-associated cognitive impairment.
18 Jul, 2021 | 23:17h | UTCParkinson disease-associated cognitive impairment – Nature Reviews Disease Primers (free for a limited period)
Infographic: Parkinson disease-associated cognitive impairment
Review: Glucocorticoid induced adrenal insufficiency.
18 Jul, 2021 | 23:15h | UTCGlucocorticoid induced adrenal insufficiency – The BMJ
Commentary on Twitter
◾ What factors affect the risk of Glucocorticoid induced adrenal insufficiency?
◾ What regimen can be used for glucocorticoid taper?
◾ How can adrenal function recovery be best assessed?Read our latest clinical review to find out: https://t.co/m814c1rgIs
— The BMJ (@bmj_latest) July 13, 2021
Study: Pooled saliva analysis is a low-cost and effective strategy for surveillance of Covid-19 in schools and universities and allows to rapidly assess transmission and adjust prevention protocols.
18 Jul, 2021 | 23:37h | UTCRelated: Pooling of Samples for Testing for SARS-CoV-2 in Asymptomatic People AND Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus — Duke University, Durham, North Carolina, August 2–October 11, 2020 – CDC Morbidity and Mortality Weekly Report
AHA/ASA Scientific Statement: Primary Care of Adult Patients After Stroke.
18 Jul, 2021 | 23:20h | UTCNews release: Comprehensive primary care is vital to holistic care and optimal recovery after a stroke – American Heart Association
Commentary on Twitter
Primary Care of Adult Patients After Stroke: A Scientific Statement From the American Heart Association/American Stroke Association https://t.co/moIZ1W2cXL @American_Heart @American_Stroke pic.twitter.com/jWOK8Fz0vM
— Stroke AHA/ASA (@StrokeAHA_ASA) July 15, 2021
M-A: benefit-to-harm balance of statins in primary prevention of cardiovascular disease generally favorable.
18 Jul, 2021 | 23:16h | UTCNews release: New study suggests benefit-to-harm balance of statins for healthy adults ‘generally favorable’ – BMJ
Commentary on Twitter
Statins are associated with a small increased risk of side effects in patients without a history of heart disease, but these effects are mild compared with the potential benefits of treatment in preventing major cardiovascular events, say researchers https://t.co/Yvn7Ojtx2F
— The BMJ (@bmj_latest) July 17, 2021
RCT: No benefit from platelet-rich plasma injection for patients with debilitating Achilles tendinopathy.
18 Jul, 2021 | 23:13h | UTCEffect of Platelet-Rich Plasma Injection vs Sham Injection on Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: No benefit from PRP treatment for patients with debilitating Achilles tendon pain – University of Warwick
Commentary on Twitter
A single injection of platelet-rich plasma compared with a sham injection did not significantly reduce #Achillestendon dysfunction https://t.co/K4YKHSbxZY
— JAMA (@JAMA_current) July 13, 2021
Body-mass index and diabetes risk in 57 low-income and middle-income countries – “Optimal BMI thresholds for diabetes screening ranged from 23·8 kg/m2 among men in east, south, and southeast Asia to 28·3 kg/m2 among women in the Middle East and north Africa and in Latin America and the Caribbean”.
18 Jul, 2021 | 23:10h | UTCBody-mass index and diabetes risk in 57 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 685 616 adults – The Lancet (link to abstract – $ for full-text)
Related: Study shows BMI cut-offs for obesity and diabetes risk do not work for non-white populations. AND Study: Certain Racial/Ethnic Groups More Likely to Have Diabetes and Prediabetes at Lower Weights
Perspective | Averting Future Vaccine Injustice.
16 Jul, 2021 | 11:04h | UTCAverting Future Vaccine Injustice – New England Journal of Medicine
Commentary on Twitter
As high-income countries have secured much of the #Covid19vaccine supply, many low-income countries have barely begun the immunization process. We need political courage to end vaccine injustice now and political vision to negotiate rules for averting future inequities.
— NEJM (@NEJM) July 15, 2021
Why was a major study on ivermectin for covid-19 just retracted?
16 Jul, 2021 | 11:11h | UTCWhy Was a Major Study on Ivermectin for COVID-19 Just Retracted? – Grifter Analysis and Review
See also: Huge study supporting ivermectin as Covid treatment withdrawn over ethical concerns – The Guardian AND Some problems in the dataset of a large study of Ivermectin for the treatment of Covid-19 – Nick Brown’s Blog AND Is Ivermectin for Covid-19 Based on Fraudulent Research? – Gideon M-K; Health Nerd
Commentary on Twitter (thread – click for more)
So, one of the biggest studies to date on ivermectin for COVID-19 has issues significant enough that, if not fraud, are so serious that it invalidates the study without further explanation
I promised a thread
Here we go 1/n https://t.co/L9QOChmGtA
— Health Nerd (@GidMK) July 16, 2021
Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.
16 Jul, 2021 | 11:06h | UTCLong-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – JAMA
Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.
16 Jul, 2021 | 11:02h | UTCHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Related: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
Health care workers who had received a dose of ChAdOx1 nCoV-19 were offered either ChAdOx1 nCoV-19 or mRNA-1273 9 to 12 weeks later. Levels of S-specific and RBD-specific IgG increased by a factor of 5 after ChAdOx1 nCoV-19 and by a factor of 115 to 125 after mRNA-1273.
— NEJM (@NEJM) July 14, 2021
Short review: The gut in COVID-19.
16 Jul, 2021 | 10:54h | UTCThe gut in COVID-19 – Intensive Care Medicine
Commentary on Twitter
Gut & #COVID19, main findings
➡️clinical GI features
➡️pathophysiology: cytotoxic enterocyte injury, microvascular injury/thromboinfammation, non‑specifc critical illness‑related dysfunction
➡️GI dysfunction in severe #SARSCoV2 vs other critical illnesseshttps://t.co/wzzTNldInN pic.twitter.com/DnHLMsSu6v— Intensive Care Medicine (@yourICM) July 9, 2021
Donuts, drugs, booze, and guns: what governments are offering people to take covid-19 vaccines – “Incentive programs do not target the trust relationship between the public and the providers”.
16 Jul, 2021 | 10:56h | UTC
Deaths from COVID ‘incredibly rare’ among children.
16 Jul, 2021 | 10:58h | UTCDeaths from COVID ‘incredibly rare’ among children – Nature
Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.
16 Jul, 2021 | 11:00h | UTCHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Related: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
https://twitter.com/EricTopol/status/1415297187718696964
AAFP Guideline: Pharmacologic Management of COPD Exacerbations.
16 Jul, 2021 | 10:51h | UTC
AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia.
16 Jul, 2021 | 10:46h | UTC
Commentary on Twitter
Out now in @AGA_CGH: AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia. Had great time working on this with @AasmaShaukatMD & @seth_crockett. Hope it's a useful reference! @AmerGastroAssn
https://t.co/UB5hFMq6hc pic.twitter.com/KwHeKjU2dk— Peter Liang, MD MPH (@petersliang) February 19, 2021
Pathophysiology of COVID-19-associated acute kidney injury.
16 Jul, 2021 | 10:52h | UTCPathophysiology of COVID-19-associated acute kidney injury – Nature Reviews Nephrology
Joint Opinion from ACC/AHA/ESC/WHF | Clinician Well-Being: Addressing Global Needs for Improvements in the Health Care Field.
16 Jul, 2021 | 10:48h | UTC
Commentary on Twitter
ICYMI: Leading CV orgs #AgainstClinicianBurnout recognize that #ClinicianWellBeing is paramount to providing high-quality patient care and are committed to improving the well-being of the CV workforce. ➡️ https://t.co/ufwAWWakPp @JACCJournals @AHAScience @escardio @worldheartfed pic.twitter.com/iyr3BxNRpr
— American College of Cardiology (@ACCinTouch) July 15, 2021
M-A of randomized trials: In patients with acute respiratory distress syndrome, there was no difference in mortality between higher vs. lower positive end-expiratory pressure strategies.
16 Jul, 2021 | 10:43h | UTC
Assessment and management of peripheral arterial disease: what every cardiologist should know.
16 Jul, 2021 | 10:33h | UTC
Commentary on Twitter
https://twitter.com/Heart_BMJ/status/1400364145980100609
RCT: Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease.
16 Jul, 2021 | 10:37h | UTC