Archives
Cohort study: Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.
13 Aug, 2021 | 08:56h | UTC
Commentary on Twitter
Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.#EHJ #AF https://t.co/fd13eaDfmO pic.twitter.com/e1XmcTYcK5
— EHJ Editor-in-Chief (@ehj_ed) August 12, 2021
European guideline and expert statements on the management of narcolepsy in adults and children.
13 Aug, 2021 | 09:02h | UTC
M-A of randomized trials: proton pump inhibitors for gastro-esophageal reflux disease does not improve outcomes in patients with asthma.
13 Aug, 2021 | 08:53h | UTC
Randomized phase III trial of prophylactic cranial irradiation with or without hippocampal avoidance for small-cell lung cancer – “This trial provides the first clinical evidence that sparing the hippocampus during PCI in patients with SCLC better preserves cognitive function”.
13 Aug, 2021 | 08:54h | UTC
RCT: Effect of sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral ligament suspension on treatment failure in women with uterovaginal prolapse.
13 Aug, 2021 | 08:52h | UTCEffect of sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral ligament suspension on treatment failure in women with uterovaginal prolapse: 5-year results of a randomized clinical trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter (video summary)
https://t.co/DvGgwjug34#SUPeRTrial#PFDNresearch @AJOG_thegray pic.twitter.com/PDDr6NvGNV
— Pelvic Floor Disorders Network (PFDN) (@PFDNresearch) April 9, 2021
Review: Oxygenation strategies after extubation of critically ill and postoperative patients.
13 Aug, 2021 | 08:49h | UTC
Review: Preoperative laboratory testing in elderly patients.
13 Aug, 2021 | 08:50h | UTCPreoperative laboratory testing in elderly patients – Current Opinion in Anesthesiology
Global Incidence and Mortality of Gastric Cancer, 1980-2018
13 Aug, 2021 | 08:45h | UTCGlobal Incidence and Mortality of Gastric Cancer, 1980-2018 – JAMA Network Open
Opinion | Doctors pledge to do no harm. The entire health care sector should do the same by battling climate change
13 Aug, 2021 | 08:47h | UTC
RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.
12 Aug, 2021 | 09:56h | UTCEditorial: Third Time’s a Charm — Covid-19 Vaccine Hope for Solid-Organ Transplant Recipients
Related:
[Preprint] 3rd AstraZeneca shot gives strong immunity.
Commentaries on Twitter
https://twitter.com/hildabast/status/1425576801850433537
The authors conclude that a third-dose booster of mRNA-1273 vaccine should be considered for transplant recipients. https://t.co/Q3gakSaNjd pic.twitter.com/CMN8f7cq29
— NEJM (@NEJM) August 11, 2021
RCT: Evaluation of Moderna mRNA vaccine in adolescents.
12 Aug, 2021 | 09:58h | UTCEvaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents – New England Journal of Medicine
Related:
Commentaries on Twitter
The mRNA-1273 vaccine was effective in preventing #COVID19 in 12-to-17-year-olds. Immune response was similar to young adults. https://t.co/aC3Dmjqe2T pic.twitter.com/9RxgHApW29
— NEJM (@NEJM) August 11, 2021
The @moderna_tx covid vaccine trial in 3,732 teens, placebo-controlled, published today @NEJM with both excellent safety profile and efficacy vs covid, and immune response as least as good as young adults https://t.co/PVmhjwgwsU pic.twitter.com/3uCmteaWNx
— Eric Topol (@EricTopol) August 11, 2021
Moderna may be superior to Pfizer against Delta variant — breakthrough odds rise with time.
12 Aug, 2021 | 09:54h | UTCModerna may be superior to Pfizer against delta variant — breakthrough odds rise with time – CNBC
Original Study 1 (preprint): Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence – medRxiv
Original Study 2 (preprint): Neutralizing antibody responses to SARS-CoV-2 variants in vaccinated Ontario long-term care home residents and workers – medRxiv
Related:
[Preprint] Pfizer vs. Moderna COVID-19 vaccine effectiveness against the Delta variant in Qatar – Effectiveness against symptomatic disease due to Delta was 53.5% for Pfizer and 84.8% for Moderna; effectiveness against severe disease due to Delta was 89.7% for Pfizer and 100.0% for Moderna.
12 Aug, 2021 | 09:53h | UTCRelated:
Commentary on Twitter
New and important data on Delta breakthrough infections, large Qatar experience and follow-up of > 1.2 million vaccinees https://t.co/2ye1Kz9OPV
2-doses vaccine effectiveness vs infections
Pfizer 53.5%
Moderna 84.8%
Either 57.2%
(replicates gap of recent Mayo Clinic study) pic.twitter.com/ghWuWbYPLH— Eric Topol (@EricTopol) August 11, 2021
WHO’s Solidarity clinical trial enters a new phase with three new candidate drugs.
12 Aug, 2021 | 09:02h | UTCCommentary:
WHO-led Trial Will Test Malaria and Cancer Medicines Against COVID-19 – Health Policy Watch
Related:
WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
Commentary on Twitter (thread – click for more)
WHO’s #COVID19 Solidarity clinical trial enters a new phase – Solidarity PLUS – with three new candidate drugs:
-artesunate
-imatinib
-infliximab— World Health Organization (WHO) (@WHO) August 11, 2021
Video: Frequently Asked COVID-19 Vaccine Questions – August 2021 Update.
12 Aug, 2021 | 08:59h | UTCFrequently Asked COVID-19 Vaccine Questions – August 2021 Update – JAMA
Vaccination: Effectiveness versus Efficacy.
12 Aug, 2021 | 09:01h | UTCVaccination: Effectiveness versus Efficacy – by Luis Correa, MD
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
12 Aug, 2021 | 09:05h | UTCCommentary: Largest Study of VITT After COVID-19 Vaccination Digs Into Lab, Clinical Features – TCTMD
Related:
NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Commentary on Twitter
The phenotypes of VITT were defined in 220 patients presenting a 14-day median after the first ChAdOx1 nCoV-19 dose. Mortality was 22%. https://t.co/ir0yG5X0BP #COVID19 #IDTwitter pic.twitter.com/iAfxs0I1Ce
— NEJM (@NEJM) August 11, 2021
Guideline: Diagnosis and management of cutaneous lupus erythematosus – Therapy, risk factors and other special topics.
12 Aug, 2021 | 08:55h | UTC
Peripartum cardiomyopathy: from genetics to management.
12 Aug, 2021 | 08:47h | UTCPeripartum cardiomyopathy: from genetics to management – European Heart Journal
Related:
Review: Cardiomyopathy and Pregnancy (guidelines and reviews)
Commentary on Twitter
Must read review: peripartum cardiomyopathy, from genetics to management https://t.co/viVa7AbWsn@escardio #EHJ #ESCYoung #cardiotwitter #heartfailure #pregnancy @ehj_ed @rladeiraslopes pic.twitter.com/dfUi1jYxHB
— European Society of Cardiology Journals (@ESC_Journals) August 11, 2021
ASCO Guideline Update: Chemotherapy and Targeted Therapy for Patients with Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer That is Either Endocrine-Pretreated or Hormone Receptor–Negative.
12 Aug, 2021 | 08:52h | UTC
2021 guidelines for management of venous thromboembolism in Latin America.
12 Aug, 2021 | 08:56h | UTC
ESMO Guideline: Cancer cachexia in adult patients.
12 Aug, 2021 | 08:53h | UTC
Review: Diagnosis of uncomplicated and complicated appendicitis in adults.
12 Aug, 2021 | 08:45h | UTCDiagnosis of Uncomplicated and Complicated Appendicitis in Adults – Scandinavian Journal of Surgery
Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement.
12 Aug, 2021 | 08:49h | UTCCommentary: TAVR still comparable to surgery after 8 years – Cardiovascular Business
Commentary on Twitter
Long term results from NOTION, out to 8 years. #TAVR #SAVR #EHJhttps://t.co/V75hG0cGNQ pic.twitter.com/0CFNPmixNW
— EHJ Editor-in-Chief (@ehj_ed) August 11, 2021
RCT: Injectable long-acting Cabotegravir for HIV prevention in cisgender men and transgender women.
12 Aug, 2021 | 08:51h | UTC