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Unvaccinated, unmasked teacher infected more than half of students in class with Covid-19, CDC reports.

29 Aug, 2021 | 18:52h | UTC

Unvaccinated, unmasked teacher infected more than half of students in class with Covid-19, CDC reports – CNN

Original study: Outbreak Associated with SARS-CoV-2 B.1.617.2 (Delta) Variant in an Elementary School — Marin County, California, May–June 2021 – CDC Morbidity and Mortality Weekly Report

 

#ESCCongress – 2021 ESC/EACTS Guidelines for the management of valvular heart disease – in the new guidelines, more patients are eligible for surgical and transcatheter interventions, based not only on symptoms but also on imaging criteria.

29 Aug, 2021 | 18:23h | UTC

2021 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) – European Heart Journal

News release: European valvular heart disease Guidelines published today – European Society of Cardiology

Summary: 2021 ESC/EACTS Valvular Heart Disease Guidelines: Key Points – American College of Cardiology

Commentary: Revamped Valve Disease Guideline: Europe Sees Nearly Eye to Eye With U.S. – MedPage Today (free registration required)

“In line with recent U.S. recommendations, the newest European guidelines favor a wider pool of patients eligible for surgical and transcatheter interventions for valvular heart disease.” (from MedPage Today)

 

Commentaries on Twitter

(thread – click for more)

 

M-A: Factors associated with household transmission of SARS-CoV-2 – recent studies showed higher household secondary attack rates than earliest reports (13.4% vs. 31.1%); more transmissible variants and vaccines may lead to further changes.

29 Aug, 2021 | 18:48h | UTC

Factors Associated With Household Transmission of SARS-CoV-2: An Updated Systematic Review and Meta-analysis – JAMA Network Open

Commentary: 1 in 5 people with COVID-19 pass it to others in household, study finds – UPI

 

Commentary on Twitter

 

New CDC Guidance says influenza and Covid vaccines can be given together – “COVID-19 vaccines and other vaccines may now be administered without regard to timing”

29 Aug, 2021 | 18:51h | UTC

Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021–22 Influenza Season – Centers for Disease Control and Prevention

Related: Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Authorized in the United States – Centers for Disease Control and Prevention

Commentary: Flu shot and a COVID jab? New 2021-2022 flu vaccine guidance points to both – McKnight’s

 

#ESCCongress – 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.

29 Aug, 2021 | 18:20h | UTC

2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA) – European Heart Journal

News release: ESC Guidelines on cardiac pacing and cardiac resynchronisation therapy launched today – European Society of Cardiology

See also: European Society of Cardiology Quality Indicators for the care and outcomes of cardiac pacing – EP Europace

 

Commentary on Twitter

 

#ESCCongress – 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure – SGLT2 inhibitors are now recommended for patients with heart failure with reduced ejection fraction regardless of the presence of diabetes.

29 Aug, 2021 | 18:25h | UTC

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC – European Heart Journal

News release: ESC Guidelines on heart failure management launched today – European Society of Cardiology

 

Commentary on Twitter

 

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

29 Aug, 2021 | 19:21h | UTC

Effect of Salt Substitution on Cardiovascular Events and Death – New England Journal of Medicine (link to abstract – $ for full-text)

News release: Low-sodium salt prevents stroke – European Society of Cardiology

Commentary: Massive SSaSS Study Shows Switch to Salt Substitute Cuts Stroke, CVD – TCTMD

 

Commentary on Twitter

 

#ESCCongress – RCT: SGLT2 inhibition reduced the combined risk of cardiovascular death or hospitalization in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.

29 Aug, 2021 | 18:19h | UTC

Empagliflozin in Heart Failure with a Preserved Ejection Fraction – New England Journal of Medicine

News release: Trial reports first successful results for heart failure with preserved ejection fraction – European Society of Cardiology

Commentary: Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction – EMPEROR-Preserved – American College of Cardiology

 

Commentary on Twitter

 

#ESCCongress – RCT: In patients with A. Fibrillation who underwent TAVR, Edoxaban was noninferior to Vit. K Antagonist regarding the composite primary outcome of adverse clinical events, but resulted in a higher incidence of major bleeding.

29 Aug, 2021 | 18:17h | UTC

Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR – New England Journal of Medicine

Commentaries:

ENVISAGE-TAVI AF: Edoxaban Disappoints in TAVI Setting – TCTMD

ENVISAGE-TAVI AF: Edoxaban vs. Warfarin Following Heart Valve Replacement – American College of Cardiology

Edoxaban vs. Standard of Care and Their Effects on Clinical Outcomes in Patients Having Undergone Transcatheter Aortic Valve Implantation–Atrial Fibrillation – ENVISAGE-TAVI AF – American College of Cardiology

 

#ESCCongress – RCT: In patients who underwent PCI at high bleeding risk, 1 month of dual antiplatelet therapy was noninferior to the continuation of dual therapy for at least 2 additional months and resulted in a lower incidence of bleeding events.

29 Aug, 2021 | 18:16h | UTC

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk – New England Journal of Medicine

Commentaries:

Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated vs. Standard DAPT Regimen – MASTER DAPT – American College of Cardiology

MASTER-DAPT: Abbreviated DAPT vs. Standard DAPT in High-Risk Patients Post-PCI – American College of Cardiology

 

#ESCCongress – RCT: Immediate coronary angiography after out-of-hospital cardiac arrest without ST-segment elevation did not improve outcomes compared to delayed/selective angiography.

29 Aug, 2021 | 18:12h | UTC

Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation – New England Journal of Medicine

News release: Trial does not support early coronary angiography in cardiac arrest without ST elevation – European Society of Cardiology

Commentaries:

Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation – TOMAHAWK – American College of Cardiology

TOMAHAWK: Immediate Coronary Angiography vs. Delayed Angiography in OHCA Patients Without ST-Segment Elevation – American College of Cardiology

 

Commentary on Twitter

 

#ESCCongress – RCT: Finerenone reduced CV events in patients with kidney disease and type 2 diabetes (12.4% vs. 14.2% during a median follow-up of 3.4 years), but the risk of hyperkalemia was increased (10.8% vs. 5.3%).

29 Aug, 2021 | 18:14h | UTC

Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes – New England Journal of Medicine

News release: Finerenone benefits patients with diabetes across spectrum of kidney disease – European Society of Cardiology

Commentaries:

Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease – FIGARO-DKD – American College of Cardiology

FIGARO-DKD and FIDELITY Findings Show Benefits of Finerenone to Improve Outcomes in Patients With Kidney Disease, Diabetes – American College of Cardiology

Related:

[Abstract Only] Randomized trial: Effect of Finerenone on chronic kidney disease outcomes in Type 2 diabetes

 

Commentary on Twitter

 

#ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).

29 Aug, 2021 | 18:11h | UTC

Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Quadruple UltrA-low-dose tReaTment for hypErTension – QUARTET – American College of Cardiology

 

#ESCCongress – RCT: Among asymptomatic patients with severe carotid stenosis, carotid surgery and stenting carry similar risks, and the long-term risk of stroke was comparable. There was no medically treated arm in this study.

29 Aug, 2021 | 18:06h | UTC

Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy – The Lancet

 

Commentary on Twitter

 

#ESCCongress – RCT: Small benefit from systematic screening for atrial fibrillation in older adults – After a median follow-up of 6.9 y there were fewer events (stroke, embolism, bleeding, and death) in the intervention group (31·9%) vs. control group (33·0%).

29 Aug, 2021 | 18:08h | UTC

Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

News release: Screening for atrial fibrillation could reduce risk of stroke – Karolinska Institutet

 

#ESCCongress – RCT: In patients with heart failure, hemodynamic-guided management was not associated with improved outcomes.

29 Aug, 2021 | 18:03h | UTC

Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial – The Lancet (free registration required)

Commentary:

GUIDE-HF: Does Hemodynamic-Guided Management of HF Improve Outcomes? – American College of Cardiology

Haemodynamic-GUIDEed management of Heart Failure – GUIDE-HF – American College of Cardiology

 

Commentary on Twitter

 

#ESCCongress – Pilot study in Sweden showed drones delivered defibrillators faster than ambulances to patients with suspected cardiac arrest.

29 Aug, 2021 | 18:02h | UTC

Automated external defibrillators delivered by drones to patients with suspected out-of-hospital cardiac arrest – European Heart Journal

Editorial: Automated external defibrillator delivery by drones: are we ready for prime time?

News releases:

Drones delivered defibrillators to patients with suspected cardiac arrests – Karolinska Institutet

Drones could deliver defibrillators to cardiac arrest victims faster than ambulances – European Society of Cardiology

 

Commentary on Twitter

 

It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols.

27 Aug, 2021 | 10:18h | UTC

It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols – University of California – San Diego

Original article: Airborne transmission of respiratory viruses – Science

 

Commentary on Twitter (thread – click for more)

 

#ESCCongress [not published yet] – Systematic FFR has no additional benefit at diagnostic angiography in patients with chest pain.

29 Aug, 2021 | 18:00h | UTC

Press release: Systematic pressure wire assessment has no additional benefit at diagnostic angiography – European Society of Cardiology

Commentaries:

FFR During Angiogram Not Beneficial in Chest Pain Patients: RIPCORD 2 – TCTMD

RIPCORD 2: No Benefit of Systematic FFR vs. Angiography During Diagnostic Angiography – American College of Cardiology

Related:

#ACC21 – RCT: In patients with STEMI undergoing complete revascularization, an FFR-guided strategy did not improve outcomes compared to an angiography-guided strategy.

Randomized Trial: Five-Year Outcomes with PCI Guided by FFR

 

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

27 Aug, 2021 | 10:11h | UTC

Press release: Is COVID vaccine protection fading? – ZOE Covid Study

Commentaries:

Covid infection protection waning in double jabbed – BBC

Expert reaction to press release from the ZOE app on vaccine effectiveness over time – Science Media Centre

 

Cohort study: Most COVID-19 hospital survivors had a good physical and functional recovery after 1 year of follow-up, but around half of the patients had at least one sequelae symptom.

27 Aug, 2021 | 10:13h | UTC

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study – The Lancet

Editorial: Understanding long COVID: a modern medical challenge – The Lancet

Related:

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

New guidelines to help doctors manage long COVID patients published.

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

 

[Preprint] Observational data suggests natural immunity after a SARS-CoV-2 infection confers longer lasting and stronger protection compared to vaccine-induced immunity.

27 Aug, 2021 | 10:16h | UTC

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections – medRxiv

Commentary: Having SARS-CoV-2 once confers much greater immunity than a vaccine—but no infection parties, please – Science

 

Commentary on Twitter (thread – click for more)

https://twitter.com/andrew_croxford/status/1430799815693250562

 

Editorial: The Guardian view on global vaccine inequality: unwise as well as unethical.

27 Aug, 2021 | 10:09h | UTC

The Guardian view on global vaccine inequality: unwise as well as unethical

 

Covid-19 vaccines flirted with perfection at first. Reality is more complicated.

27 Aug, 2021 | 10:05h | UTC

Covid-19 vaccines flirted with perfection at first. Reality is more complicated – STAT

 

Commentary on Twitter

 

mRNA vaccines for infectious diseases: principles, delivery and clinical translation.

27 Aug, 2021 | 10:03h | UTC

mRNA vaccines for infectious diseases: principles, delivery and clinical translation – Nature Reviews Drug Discovery

 

Commentary on Twitter

 

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