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Drowning in the literature? These smart software tools can help.

3 Sep, 2021 | 10:09h | UTC

Drowning in the literature? These smart software tools can help – Nature

 

RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.

2 Sep, 2021 | 10:17h | UTC

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Commentaries:

Baricitinib: the first immunomodulatory treatment to reduce COVID-19 mortality in a placebo-controlled trial – The Lancet Respiratory Medicine

Rheumatoid Arthritis Drug Combined with Standard of Care May Help Reduce Mortality for Hospitalized COVID-19 Patients – Vanderbilt University Medical Center

 

Commentaries on Twitter

(thread – click for more)

 

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children.

3 Sep, 2021 | 09:55h | UTC

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children – Anesthesia & Analgesia

Related: ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

 

Review | COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.

2 Sep, 2021 | 10:06h | UTC

COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses – The Lancet Rheumatology

 

Commentary on Twitter

 

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

2 Sep, 2021 | 10:10h | UTC

Long COVID – the physical and mental health of children and non-hospitalised young people 3 months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) Study.

Commentaries:

Long Covid in children ‘nowhere near scale feared’ – BBC

Long covid: One in seven children may still have symptoms 15 weeks after infection, data show – The BMJ

Related:

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter (thread – click for more)

 

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

2 Sep, 2021 | 10:05h | UTC

Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv

Related:

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

 

Commentary on Twitter (thread – click for more)

 

Scientific Statement: Coronavirus Disease-2019 and Heart Failure.

2 Sep, 2021 | 10:08h | UTC

Coronavirus Disease-2019 and Heart Failure: A Scientific Statement From the Heart Failure Society of America – Journal of Cardiac Failure

 

Commentary on Twitter

 

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.

2 Sep, 2021 | 10:02h | UTC

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission – Journal of the Formosan Medical Association

Related:

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.

Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers.

WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19

CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk

Guidance: Using Ventilation and filtration to reduce aerosol transmission of COVID-19 in long-term care homes

 

RCT: Among critically ill patients, targeting oxygenation to a low-normal range vs. high-normal range did not result in a reduction in organ dysfunction.

2 Sep, 2021 | 08:23h | UTC

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Related:

M-A of randomized trials: Conservative oxygen therapy for critically ill patients.

Oxygen administration for patients with ARDS – Journal of Intensive Care

Randomized trial: Similar outcomes with lower vs. higher oxygenation targets for acute hypoxemic respiratory failure

Systematic Review: Higher vs. Lower Fraction of Inspired Oxygen or Targets of Arterial Oxygenation for Adults Admitted to the Intensive Care Unit

 

Commentary on Twitter

 

EBM Learning | How to create PICO questions about diagnostic test. In this paper, the author presents an example of a PICO for a question about test accuracy and an example of a PICO for a question about the effects of care with a test.

2 Sep, 2021 | 08:18h | UTC

How to create PICO questions about diagnostic test – BMJ Evidence-Based Medicine

 

RCT: In patients with acute hypoxemic respiratory failure, a strategy of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal was not associated with improved outcomes.

2 Sep, 2021 | 08:21h | UTC

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial – JAMA (free for a limited period)

Related: Randomized Trial: Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS

 

Commentary on Twitter

 

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review - short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

2 Sep, 2021 | 08:19h | UTC

Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics

 

Expired cardiac devices may do global good, but safety unknown – A discussion of the ethics of using expired technology in parts of the world with no other options is long past due, some say.

2 Sep, 2021 | 08:16h | UTC

Expired Cardiac Devices May Do Global Good, but Safety Unknown – TCTMD

 

Systematic review: In individuals with hemophilia A or B, there is evidence from RCTs that prophylaxis with clotting factor concentrates, as compared to on‐demand treatment, may reduce bleeding frequency.

2 Sep, 2021 | 08:17h | UTC

Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated individuals with haemophilia A or B – Cochrane Library

 

World leaders and experts call for significant reduction in the use of antimicrobial drugs in global food systems.

2 Sep, 2021 | 08:13h | UTC

World leaders and experts call for significant reduction in the use of antimicrobial drugs in global food systems – World Health Organization

Commentary: Global group urges limits on antimicrobials in food production – CIDRAP

 

[Preprint] Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a meta-epidemiological analysis – “Worldwide, 41 randomized trials assessing NPIs have been initiated with published results available to inform policy decisions for only 7 of them”.

1 Sep, 2021 | 10:01h | UTC

Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a meta-epidemiological analysis – medRxiv

 

Commentary on Twitter

 

M-A: non-invasive tests for advanced fibrosis can reduce the need for biopsy in patients with non-alcoholic fatty liver disease.

2 Sep, 2021 | 08:14h | UTC

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis – Gut

 

Commentary on Twitter

 

RCT: Ketamine administration in patients with acute painful sickle cell crisis was effective for pain control and reduced the cumulative morphine dose in the emergency department.

2 Sep, 2021 | 08:11h | UTC

Ketamine Administration for Acute Painful Sickle Cell Crisis: A Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)

 

[Preprint] Pfizer vaccine booster dose protection: A nationwide study from Israel – “Twelve days or more after the booster dose we found an 11.4-fold decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness”.

1 Sep, 2021 | 09:59h | UTC

BNT162b2 vaccine booster dose protection: A nationwide study from Israel – medRxiv

 

Perspective | COVID-19 boosters in rich nations will delay vaccines for all.

1 Sep, 2021 | 09:56h | UTC

COVID-19 boosters in rich nations will delay vaccines for all – Nature

 

Commentaries on Twitter

 

M-A mostly of observational studies found that in patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infection Daptomycin was associated with a lower risk of clinical failure than Vancomycin, without differences in mortality.

2 Sep, 2021 | 08:10h | UTC

Daptomycin versus Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection with or without Endocarditis: A Systematic Review and Meta-Analysis – Antibiotics

 

Why is a third COVID-19 vaccine dose important for people who are immunocompromised?

1 Sep, 2021 | 09:57h | UTC

Why is a third COVID-19 vaccine dose important for people who are immunocompromised? – The Conversation

Related:

FDA authorizes additional Covid-19 vaccine dose for certain immunocompromised individuals – Other fully vaccinated individuals do not need an additional vaccine dose right now.

RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.

Study: Among kidney transplant recipients who did not respond after 2 doses, a third dose of an mRNA-1273 vaccine induced a serologic response in 49% of patients.

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

 

COVID-19 patients at higher risk of blood clots after surgery, study shows.

1 Sep, 2021 | 09:54h | UTC

COVID-19 patients at higher risk of blood clots after surgery, study shows – CIDRAP

Original study: SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study – Anaesthesia

Related:

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

WSES Position Paper: The management of surgical patients in the emergency setting during COVID-19 pandemic

Preparing previously COVID-19-positive patients for elective surgery: A framework for preoperative evaluation

 

COVID may be most infectious 2 or 3 days around symptom onset.

1 Sep, 2021 | 09:51h | UTC

COVID may be most infectious 2 or 3 days around symptom onset – CIDRAP

Original article: COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19: A Population-Based Cohort Study in Zhejiang Province, China – JAMA Internal Medicine

 

AGA clinical practice update on the diagnosis and management of atrophic gastritis.

1 Sep, 2021 | 09:45h | UTC

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review – Gastroenterology

 

Commentary on Twitter

 

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