Archives
[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.
3 Oct, 2021 | 23:02h | UTCCommentaries:
Expert reaction to interim analysis of oral antiviral molnupiravir – Science Media Centre
Covid antiviral pill can halve risk of hospitalization – BBC
Why Merck’s Covid-19 pill molnupiravir could be so important – Vox
Commentaries on Twitter
.@DrEricDing convinced many that stopping the #molnupiravir trial early for benefit was a good idea
But it was NOT
Large body of evidence suggests that stopping early for benefit biases the results: overestimates the benefits of the treatment #EBM https://t.co/b3tHEtliO0 https://t.co/LwuCgqcY0C pic.twitter.com/vyPWc0nd37
— Kari Tikkinen (@KariTikkinen) October 2, 2021
(thread – click for more)
💡BREAKING—New oral anti-viral drug *molnupiravir* cuts risk of #COVID19 hospitalization and death **in HALF** in a randomized trial. Results so astounding that the trial is being stopped early, and Merck plans to apply for emergency authorization ASAP. 🧵 https://t.co/g8JGNzvuRg pic.twitter.com/K1SwC3QFXS
— Eric Feigl-Ding (@DrEricDing) October 1, 2021
Evaluating agreement between bodies of evidence from randomized controlled trials and cohort studies in nutrition research: meta-epidemiological study.
5 Oct, 2021 | 08:48h | UTC
Commentary on Twitter
The difference in results between RCTs and cohort studies in nutrition research was small, finds study.
However, with some substantial statistical heterogeneity in cohort studies, differences or potential bias cannot be excluded, say @LSchwingshackl et alhttps://t.co/dyUqhn87V0
— The BMJ (@bmj_latest) September 17, 2021
Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.
3 Oct, 2021 | 22:59h | UTCVaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance – The BMJ
Original Guidance: NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Related:
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
RCT: Effects of 30 days of ketogenic diet on body composition, muscle strength, muscle area, metabolism, and performance in semi-professional soccer players.
5 Oct, 2021 | 08:47h | UTC
[Preprint] Assessing the Burden of COVID-19 in Developing Countries: Systematic Review, Meta-Analysis, and Public Policy Implications.
3 Oct, 2021 | 22:56h | UTC
Commentary on Twitter
https://twitter.com/GidMK/status/1444125087553114113
Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues.
3 Oct, 2021 | 22:58h | UTC
New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks.
3 Oct, 2021 | 22:52h | UTCOriginal report: Vaccinating adolescents against SARS-CoV-2 in England: a risk-benefit analysis
Related: Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.
Editorial | Clinical ethics: consent for vaccination in children.
3 Oct, 2021 | 22:53h | UTCClinical ethics: consent for vaccination in children – Archives of Disease in Childhood
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
3 Oct, 2021 | 22:41h | UTC
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
3 Oct, 2021 | 22:49h | UTCCovid-19 vaccination: evidence of waning immunity is overstated – The BMJ
Related:
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists.
3 Oct, 2021 | 22:46h | UTCNews Release: WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists – World Health Organization
Report: WHO model list of essential medicines – 22nd list, 2021 – World Health Organization
Commentary: For the first time, WHO committee recommends action on high-priced essential medicines – STAT
Commentary on Twitter (thread – click for more)
🆕 WHO 2021 Essential Medicines Lists have 20 new medicines for adults & 17 for children, incl. insulin analogues, new oral medicines for diabetes & medicines for cancer treatment https://t.co/LfWwHEZtuM pic.twitter.com/HMFOP8ioBf
— World Health Organization (WHO) (@WHO) October 1, 2021
Systematic Review: Is exercise an effective therapy to treat long-lasting low back pain?
3 Oct, 2021 | 22:32h | UTCSummary: Is exercise an effective therapy to treat long-lasting low back pain? – Cochrane Library
Original Study: Exercise therapy for chronic low back pain – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1444221879502483456
Intensive care triage under exceptional resource scarcity.
3 Oct, 2021 | 22:48h | UTCIntensive care triage under exceptional resource scarcity – Swiss Medical Weekly
ADA Consensus Report: The Management of Type 1 Diabetes in Adults.
3 Oct, 2021 | 22:38h | UTCRelated: Guideline: ADA 2021 Standards of Medical Care in Diabetes
Commentary on Twitter
What a fantastic symposium on the management of #T1D at #EASD2021! Read the full ADA–EASD consensus report here https://t.co/8cEm8N0Enr pic.twitter.com/uMj2R64CkK
— Diabetologia (@DiabetologiaJnl) October 1, 2021
Physician Well-being 2.0: Where Are We and Where Are We Going?
3 Oct, 2021 | 22:36h | UTCPhysician Well-being 2.0: Where Are We and Where Are We Going? – Mayo Clinic Proceedings
Related:
[Abstract Only] Assessment of Risk Factors for Suicide Among US Health Care Professionals
Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care
Perspective: Hospital Administration Response to Physician Stress and Burnout
Opinion: It’s Time to Talk About Physician Burnout and Moral Injury
Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout
Perspective: The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution)
Physician Burnout: A Global Crisis (several resources on the subject)
Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?
3 Oct, 2021 | 22:33h | UTCOriginal article: Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with unprovoked VTE – Cochrane Library
RCT: Early computed tomography coronary angiography in patients with suspected acute coronary syndrome did not improve one year clinical outcomes.
3 Oct, 2021 | 22:35h | UTC
Commentary on Twitter
In this RCT, early CT coronary angiography in the emergency department for patients with suspected / provisional diagnosis of acute coronary syndrome had no effect on rate of death or subsequent non-fatal #heartattack at 1 year.@bmj_latest #Wondrmedicalhttps://t.co/usNKEGPDa4
— Prof Chris P Gale (@cpgale3) October 1, 2021
Coronary microvascular dysfunction: Considerations for diagnosis and treatment.
3 Oct, 2021 | 22:29h | UTCRelated:
Cohort study: Clinical characteristics and prognosis of patients with microvascular angina.
Position Paper on ‘Coronary Microvascular Dysfunction in Cardiovascular Disease’
Guide to Statistics and Methods: Interim Analyses During Group Sequential Clinical Trials.
3 Oct, 2021 | 22:30h | UTCInterim Analyses During Group Sequential Clinical Trials – JAMA (free for a limited period)
A new surgical robot is smaller, nimbler, and cheaper, its maker claims. But will it be better for patients?
3 Oct, 2021 | 22:26h | UTC
Oral health care for the critically ill: a narrative review.
3 Oct, 2021 | 22:25h | UTCOral health care for the critically ill: a narrative review – Critical Care
Ketogenic diets in the management of type 1 diabetes: Safe or safety concern?
3 Oct, 2021 | 22:28h | UTC
Review | Chronic hypertension and superimposed preeclampsia: screening and diagnosis.
3 Oct, 2021 | 22:23h | UTC
Impact of COVID-19 on Pediatric Immunocompromised Patients.
1 Oct, 2021 | 10:36h | UTCImpact of COVID-19 on Pediatric Immunocompromised Patients – Pediatric Clinics of North America
International registry shows mortality after ECMO for patients with COVID-19 worsened during 2020.
1 Oct, 2021 | 10:43h | UTCCommentaries:
ECMO in COVID-19: do not blame the tool – The Lancet
Commentary on Twitter (thread – click for more)
New study indicates mortality after ECMO for patients with #COVID19 worsened during 2020, and duration of ECMO support increased.
Continued surveillance of ECMO outcomes in #COVID19 is needed, authors suggest: https://t.co/9Yq7lYkVIC
(1/2) @ELSOOrg pic.twitter.com/Rcz1TZ7eGG
— The Lancet (@TheLancet) September 30, 2021