Open access
Open access
Powered by Google Translator Translator

Archives

Novel gene therapy for hemophilia A leads to sustained expression of clotting factor and reduced bleeding events.

19 Nov, 2021 | 10:25h | UTC

News release: Novel gene therapy for hemophilia a leads to sustained expression of clotting factor and reduced bleeding events – Children’s Hospital of Philadelphia

Original Study: Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A – New England Journal of Medicine

 

Commentary on Twitter

 

M-A: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality.

18 Nov, 2021 | 08:59h | UTC

Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis – The BMJ

 

Commentary on Twitter

 

Long-term results of RCT: Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for patients with locally advanced rectal cancer.

19 Nov, 2021 | 10:15h | UTC

Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Author Interview: Chemoradiotherapy Plus Induction or Consolidation Chemotherapy for Locally Advanced Rectal Cancer – JAMA Oncology

 

Commentary on Twitter

 

Review: Should children under 12 years of age be vaccinated against COVID-19?

18 Nov, 2021 | 08:56h | UTC

Should children be vaccinated against COVID-19? – Archives of Disease in Childhood

 

Commentary from the author on Twitter (thread – click for more)

 

Review: Treatment selection in first-line metastatic renal cell carcinoma—the contemporary treatment paradigm in the age of combination therapy.

19 Nov, 2021 | 10:14h | UTC

Treatment Selection in First-line Metastatic Renal Cell Carcinoma—The Contemporary Treatment Paradigm in the Age of Combination Therapy: A Review – JAMA Oncology (free for a limited period)

 

Covid: Children in UK told to delay jab for 12 weeks after infection.

18 Nov, 2021 | 08:54h | UTC

Covid: Children told to delay jab for 12 weeks after infection – BBC

Original Report: Joint Committee on Vaccination and Immunisation (JCVI) advice on COVID-19 vaccination in people aged 16 to 17 years: 15 November 2021

 

Observational study finds mRNA vaccination is associated with an effectiveness of 85% against Covid-19 hospitalization.

18 Nov, 2021 | 08:49h | UTC

Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity – JAMA

Editorial: Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination – JAMA

Commentary: COVID-19 vaccines 85% effective against hospital cases but weaken over time – TCTMD

Related Study: Study compares the decline in effectiveness for Moderna, Pfizer, and Janssen vaccines and consequences for mortality.

 

[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.

18 Nov, 2021 | 08:48h | UTC

Inhaled Corticosteroids for Outpatients with Covid-19: A Meta-Analysis – medRxiv

Commentary: Favourable meta-analysis of inhaled corticosteroids in COVID-19 outpatients – News Medical

Related:

PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.

Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.

RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

 

Commentary on Twitter

 

Observational study finds the effectiveness of mRNA vaccination against Covid-19 hospitalization was lower (77%) among immunocompromised adults than among immunocompetent adults (90%).

18 Nov, 2021 | 08:52h | UTC

Effectiveness of 2-Dose Vaccination with mRNA COVID-19 Vaccines Against COVID-19–Associated Hospitalizations Among Immunocompromised Adults — Nine States, January–September 2021 – CDC Morbidity and Mortality Weekly Report

Related:

CDC Guidance: Immunocompromised may need a fourth Covid-19 shot.

 

Commentary on Twitter (thread – click for more)

 

8 lingering questions about the new Covid pills from Merck and Pfizer.

18 Nov, 2021 | 08:46h | UTC

8 lingering questions about the new Covid pills from Merck and Pfizer – STAT

Related:

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

Observational study in patients with stroke with large-vessel occlusion presenting in the extended window suggests non-contrast CT is as good as CT perfusion or MRI to select patients for thrombectomy.

18 Nov, 2021 | 08:41h | UTC

Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion – JAMA Neurology

Commentary: Noncontrast CT a cost-friendly alternative to select late-stroke patients for thrombectomy – Health Imaging

 

Commentary on Twitter

 

NICE Guideline | Heart valve disease presenting in adults: investigation and management.

18 Nov, 2021 | 08:44h | UTC

Heart valve disease presenting in adults: investigation and management – National Institute for Health and Care Excellence

Related Guidelines:

#ESCCongress – 2021 ESC/EACTS Guidelines for the management of valvular heart disease – in the new guidelines, more patients are eligible for surgical and transcatheter interventions, based not only on symptoms but also on imaging criteria.

2020 ACC/AHA Guideline for the management of patients with valvular heart disease

 

RCT: An exercise program reduced upper limb disability one year after non-reconstructive breast cancer surgery.

18 Nov, 2021 | 08:39h | UTC

Exercise versus usual care after non-reconstructive breast cancer surgery (UK PROSPER): multicentre randomised controlled trial and economic evaluation – The BMJ

Commentaries:

Exercise reduces upper limb disability after breast cancer surgery – BMJ / News Medical

Exercise Helps Ease Arm, Shoulder Pain After Breast Cancer Surgery- HealthDay

Structured Exercise Improves Upper Limb Function After Breast Ca Surgery – Physician’s Weekly

 

Commentary on Twitter

 

M-A: In patients with anterior circulation acute stroke and evidence of reversible cerebral ischemia across the 6–24 h time window, thrombectomy was associated with higher rates of independence in activities of daily living at 90 days than best medical therapy alone.

18 Nov, 2021 | 08:43h | UTC

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis – The Lancet (link to abstract – $ for full-text)

 

Editorial: Twenty recommendations to individualize interventions in the early resuscitation of patients with sepsis.

18 Nov, 2021 | 08:38h | UTC

Twenty recommendations to individualize interventions in the early resuscitation of patients with sepsis – Critical Care

Related: Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

 

Review: A fresh look at coronary microembolization.

18 Nov, 2021 | 08:35h | UTC

A fresh look at coronary microembolization – Nature Reviews Cardiology (if this link is paywalled, try this one)

 

Commentary on Twitter

 

Demystifying the EEG report for intensivists.

18 Nov, 2021 | 08:36h | UTC

Demystifying the EEG Report – NeuroEMCrit

 

Podcast | Liver emergencies: acute liver failure, hepatic encephalopathy, hepatorenal syndrome, liver test interpretation & drugs to avoid.

18 Nov, 2021 | 08:32h | UTC

Liver Emergencies: Acute Liver Failure, Hepatic Encephalopathy, Hepatorenal Syndrome, Liver Test Interpretation & Drugs to Avoid – Emergency Medicines Cases (text summary and podcast)

 

What Is the best maintenance therapy for ANCA vasculitis?

18 Nov, 2021 | 08:34h | UTC

What Is the Best Maintenance Therapy for ANCA Vasculitis? – Clinical Journal of the American Society of Nephrology

 

RCT: In Infants with infantile hemangioma, nadolol is noninferior to propranolol and may be an efficacious and safe alternative in cases of propranolol unresponsiveness or adverse events.

18 Nov, 2021 | 08:29h | UTC

Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma: A Randomized Clinical Trial – JAMA Pediatrics

Commentary: Oral Nadolol Feasible for the Treatment of Infantile Hemangiomas – HealthDay

 

Commentary on Twitter

 

New ACR radiation diagnostic reference levels for top 10 pediatric CT exams.

18 Nov, 2021 | 08:31h | UTC

News Release: New Radiation Diagnostic Reference Levels for Top 10 Pediatric CT Exams – American College of Radiology

Original Guideline: U.S. Diagnostic Reference Levels and Achievable Doses for 10 Pediatric CT Examinations – Radiology

Commentary: ACR releases new benchmarks to help radiology departments optimize radiation dose levels – Health Imaging

 

Case-control study: sleep disorders linked to more severe outcomes from COVID-19, study suggests.

17 Nov, 2021 | 08:50h | UTC

News Release: Sleep disorders linked with more severe outcomes from COVID-19, study suggests – Cleveland Clinic

Original Study: Association of Sleep-Related Hypoxia With Risk of COVID-19 Hospitalizations and Mortality in a Large Integrated Health System – JAMA Network Open

Commentary: Some sleep disorders may lead to worse COVID-19 outcomes – CIDRAP

 

Commentary on Twitter

 

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic.

17 Nov, 2021 | 08:56h | UTC

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic – European Heart Journal

Part 1—epidemiology, pathophysiology, and diagnosis

Part 2—care pathways, treatment, and follow-up

News release: European Society of Cardiology COVID-19 guidance launched – European Society of Cardiology

 

Commentaries on Twitter

 

Systematic Review: Multidisciplinary rehabilitation for older people with hip fractures.

18 Nov, 2021 | 08:28h | UTC

Summary: Are mixed-speciality (multidisciplinary) teams the best way to help older people recover from hip fracture? – Cochrane Library

Original Study: Multidisciplinary rehabilitation for older people with hip fractures – Cochrane Library

 

Commentary on Twitter

 

Observational study found monitoring outpatients with Covid-19 using text messages that allowed the report of worsening symptoms was associated with improved outcomes.

17 Nov, 2021 | 08:53h | UTC

Comparative Effectiveness of an Automated Text Messaging Service for Monitoring COVID-19 at Home – Annals of Internal Medicine

News Release: Automated Texting System Saved Lives Weekly During First COVID Surge – Penn Medicine

Commentaries:

Monitoring outpatients by text appeared to reduce mortality from COVID-19 – ACP Internist

Texting saved lives during Covid. What does that mean for health care’s future? – STAT

 

Commentary from the author on Twitter (thread – click for more)

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.