Archives
RCT: Paclitaxel and Carboplatin noninferior to Paclitaxel and Ifosfamide in patients with carcinosarcoma of the uterus or ovary.
18 Jan, 2022 | 09:10h | UTCRandomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)
CDC urges Americans to wear most-protective mask or respirator that fits well and that they’ll wear consistently.
17 Jan, 2022 | 00:46h | UTCCDC Guidance: Types of Masks and Respirators – Centers for Disease Control and Prevention
See also: CDC encourages more Americans to consider N95 masks – STAT
Rise of the preprint: how rapid data sharing during COVID-19 has changed science forever.
17 Jan, 2022 | 00:45h | UTC
Viewpoint: COVID-19 therapeutics for nonhospitalized patients.
17 Jan, 2022 | 00:31h | UTCCOVID-19 Therapeutics for Nonhospitalized Patients – JAMA
Editorial: Realizing the Potential of Anti–SARS-CoV-2 Monoclonal Antibodies for COVID-19 Management – JAMA
Hospital admissions from childhood common infections were largely reduced in England during the pandemic due to control measures for Covid-19.
17 Jan, 2022 | 00:37h | UTCEditorial: Covid-19 control measures and common paediatric infections – The BMJ
News Release: Dramatic fall in hospital admissions for child infections during first year of covid-19 pandemic – BMJ
One in 10 people may still be infectious for COVID after 10 days, new research indicates.
17 Jan, 2022 | 00:34h | UTCNews Release: One in 10 people may still be infectious for COVID after 10 days, new research indicates – University of Exeter
The French health pass holds lessons for mandatory COVID-19 vaccination.
17 Jan, 2022 | 00:38h | UTCThe French health pass holds lessons for mandatory COVID-19 vaccination – Nature Medicine
2022 Guidelines on the management of chronic venous disease of the lower limbs.
16 Jan, 2022 | 23:22h | UTC
Is Covax finally going to vaccinate the world?
17 Jan, 2022 | 00:29h | UTCIs Covax finally going to vaccinate the world? – Vox
Related:
Perspective | A beautiful idea: how COVAX has fallen short.
WHO Launches Strategy to Achieve Global Covid-19 Vaccination by mid-2022.
WHO special envoys: To beat Covid, there’s a simple lesson – no one’s safe until everyone’s safe.
WHO COVAX Joint Statement: Call to action to equip COVAX to deliver 2 billion doses in 2021.
Covax: How will Covid vaccines be shared around the world?
N95 respirators can be safely decontaminated up to 25 times, research shows.
17 Jan, 2022 | 00:26h | UTCNews Release: N95 Respirators Can Be Safely Decontaminated Up to 25 Times, Research Shows – Beth Israel Deaconess Medical Center
Original Study: Assessing changes to N95 respirator filtration efficiency, qualitative and quantitative fit, and seal check with repeated vaporized hydrogen peroxide (VHP) decontamination – American Journal of Infection Control (link to abstract – $ for full-text)
Opinion: Omicron represents a new kind of epidemic – we must keep up.
17 Jan, 2022 | 00:28h | UTCOmicron represents a new kind of epidemic – we must keep up – The Guardian
RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.
16 Jan, 2022 | 23:13h | UTCThe D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Related:
Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention
Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases
Research: Circulating vitamin D concentration and risk of seven cancers
Research: Vitamin D and risk of total and site specific cancers
Guidelines for the provision of nutrition support therapy in the adult critically ill patient.
16 Jan, 2022 | 23:19h | UTC
ERAS Guidelines for perioperative care in bariatric surgery.
16 Jan, 2022 | 23:21h | UTCRelated: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
Commentary on Twitter
#VisualAbstract ➡️ Guidelines for Perioperative Care in Bariatric Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations: A 2021 Update@Jasosamd @iss_sic
🆓🔗https://t.co/HknWwLUjCZ pic.twitter.com/amhszadwup— World Journal of Surgery (@WorldJSurg) January 5, 2022
Multi-Disciplinary Guideline: Management of nephrolithiasis in pregnancy.
16 Jan, 2022 | 23:17h | UTC
Commentary from the author on Twitter
https://t.co/bFtOYFgBmr Started as an assigned resident presentation. Turned into a set of multi-d guidelines implemented at the university level. Now published for all to reference! Thank you all authors for input & guidance @peepeeDoctor @willrobe1 @amy_krambeck @sapanambani
— Matthew Lee (@MSLee_MD) December 23, 2021
RCT: Vitamin D supplementation is not beneficial for the prevention of cardiovascular disease and cancer.
16 Jan, 2022 | 23:11h | UTCNews Release: Five years of high-dose vitamin D did not affect incidence of cardiovascular disease or cancer – University of Eastern Finland
Related:
Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention
Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases
Research: Circulating vitamin D concentration and risk of seven cancers
Research: Vitamin D and risk of total and site specific cancers
RCT: In patients undergoing emergency endotracheal intubation, 7-day survival was significantly lower with etomidate vs. ketamine (77.3% versus 85.1%), but 28 survival rates were not significantly different (etomidate 64.1% vs. ketamine 66.8%, p = 0.294).
16 Jan, 2022 | 23:09h | UTC
Commentary on Twitter
Etomidate vs ketamine for emergency endotracheal intubation, RCT
💉801 critically ill pts assigned to receive etomidate (0.2–0.3 mg/kg) or ketamine (1–2 mg/kg)
💉day 7 survival significantly lower with etomidate
💉no significantly different day 28 survivalhttps://t.co/CkxufORC8A pic.twitter.com/xQ4AtCifc7— Intensive Care Medicine (@yourICM) December 17, 2021
Video: Is noninferior not inferior?
16 Jan, 2022 | 22:57h | UTCIs Noninferior Not Inferior? – NEJM Evidence
Commentary on Twitter
Stats, STAT! Watch this animated video that explores the basis for non-inferiority trials, the meaning of non-inferiority margins, and the interpretation of a non-inferiority trial’s results. #MedEd #ClinicalTrials https://t.co/wvDAHbQu8l pic.twitter.com/Z0LyJv1sN1
— NEJM Evidence (@NEJMEvidence) January 11, 2022
RCT: Ketamine induced remission in 46% of patients but was NOT non-inferior to electroconvulsive therapy for the treatment of hospitalized patients with unipolar depression.
16 Jan, 2022 | 23:01h | UTCNews Release: ECT more effective than ketamine in severe depression – Lund University
Commentary on Twitter
RCT-OL: 63% of inpatients with MDD receiving ECT remitted vs. 46% receiving ketamine infusions (p=0.026). Both ketamine and ECT required a median of 6 sessions to induce remission. Long-lasting AE include persisting amnesia with ECT https://t.co/tvJ0qwUu62 pic.twitter.com/NOQK8Xv8TW
— P𝘧OL (@psychopharmacol) December 12, 2021
Perspective: Primary care providers should prescribe aspirin to prevent cardiovascular disease based on benefit−risk ratio, not age.
16 Jan, 2022 | 22:53h | UTCCommentaries:
Researchers urge: ‘Prescribe aspirin based on benefit-to-risk not age’ – Florida Atlantic University
Preventive Aspirin Should Be Based on Benefit, Not Age – HealthDay
Cluster randomized trial: no added value of duloxetine for patients with chronic pain due to hip or knee osteoarthritis.
16 Jan, 2022 | 22:59h | UTC
Analysis: Sarcopenia: early prevention or overdiagnosis?
16 Jan, 2022 | 22:48h | UTCSarcopenia: early prevention or overdiagnosis? – The BMJ
Related: Overdiagnosis: it’s official – the term is now included in the medical subject headings (MeSH) vocabulary. (several articles on the subject)
Commentary from the author on Twitter
We have a new diagnosis! 2 billion people may turn into patients with sarcopenia. Despite no evidence to justify why we should diagnose elderly people. My latest article in @bmj_latest with @drjohnbrodersen and JBülow. #overdiagnosis #sarcopenia #EBM https://t.co/mNFxmuz4U1
— Christoffer Bjerre Haase (@BjerreHaase) January 13, 2022
Coming to consensus: the Delphi technique.
16 Jan, 2022 | 22:54h | UTCComing to consensus: the Delphi technique – European Journal of Cardiovascular Nursing
Viewpoint: Hierarchical payment models—a path for coordinating population- and episode-based payment models.
16 Jan, 2022 | 22:52h | UTCHierarchical Payment Models—A Path for Coordinating Population- and Episode-Based Payment Models – JAMA (free for a limited period)
Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.
16 Jan, 2022 | 22:42h | UTCAssessment and treatment of thyroid disorders in pregnancy and the postpartum period – Nature Reviews Endocrinology (if the link is paywalled, try this one)
Commentary on Twitter
New content online: Assessment and treatment of thyroid disorders in pregnancy and the postpartum period https://t.co/KrXeocu8sd pic.twitter.com/HeSCXNkelb
— Nature Reviews Endocrinology (@NatureRevEndo) January 4, 2022