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As Denmark scraps COVID restrictions, WHO urges caution.

2 Feb, 2022 | 08:47h | UTC

As Denmark Scraps COVID Restrictions, WHO Urges Caution – Health Policy Watch

Related: Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

 

M-A: Impact of Ketamine on analgosedative consumption in critically ill patients.

2 Feb, 2022 | 08:44h | UTC

Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis – Annals of Pharmacotherapy

Related:

RCT: Fentanyl vs. placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department.

RCT: In patients undergoing emergency endotracheal intubation, 7-day survival was significantly lower with etomidate vs. ketamine (77.3% versus 85.1%), but 28 survival rates were not significantly different (etomidate 64.1% vs. ketamine 66.8%, p = 0.294).

 

Perspective: Avoidance of β-blockers in patients who use stimulants is not supported by good evidence.

2 Feb, 2022 | 08:39h | UTC

Avoidance of β-blockers in patients who use stimulants is not supported by good evidence – Canadian Medical Association Journal

 

Perspective: The ongoing saga of normal saline vs. balanced fluids.

2 Feb, 2022 | 08:43h | UTC

The ongoing saga of normal saline versus balanced fluids – First10EM

Original studies:

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis – NEJM Evidence

Related:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

 

Using melatonin for sleep is on the rise, study says, despite potential health harms.

2 Feb, 2022 | 08:41h | UTC

Using melatonin for sleep is on the rise, study says, despite potential health harms – CNN

Original Study: Trends in Use of Melatonin Supplements Among US Adults, 1999-2018 – JAMA (free for a limited period)

 

Cohort Study: Association of posttraumatic epilepsy with 1-year outcomes after traumatic brain injury.

2 Feb, 2022 | 08:36h | UTC

Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury – JAMA Network Open

 

Commentary on Twitter

 

Cluster Randomized Trial: In older patients undergoing elective surgical procedures, a multimodal nonpharmacological prevention program reduced postoperative delirium occurrence and days with delirium.

2 Feb, 2022 | 08:38h | UTC

Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial – JAMA Surgery

Author Interview: Effective Delirium Prevention in Older Persons After Elective Surgery

 

Commentary on Twitter

 

RCT: Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling.

2 Feb, 2022 | 08:34h | UTC

Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling: a double-blind, randomised, controlled, phase 3 trial in nine countries – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

 

NCCN Guideline: Kidney Cancer.

2 Feb, 2022 | 08:30h | UTC

Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

 

Review: Primary and metastatic peritoneal surface malignancies.

2 Feb, 2022 | 08:33h | UTC

Primary and metastatic peritoneal surface malignancies – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Primary and metastatic peritoneal surface malignancies – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Takotsubo Syndrome: A review of presentation, diagnosis and management.

2 Feb, 2022 | 08:25h | UTC

Takotsubo Syndrome: A Review of Presentation, Diagnosis and Management – Clinical Medicine Insights: Cardiology

Related:

Middle-aged and older women are being diagnosed with Takotsubo Syndrome more frequently, up to 10 times more often, than younger women or men of any age.

International Expert Consensus Document on Takotsubo Syndrome

International Registry: 16.6% of Patients with Takotsubo Syndrome Have Underlying Malignancy

Systematic Review: Long-Term Prognosis and Outcome Predictors in Takotsubo Syndrome

Cohort Study: Hospital Readmission Following Takotsubo Syndrome

 

RCT: 2 L polyethylene glycol plus ascorbic acid may provide similar efficacy and better tolerability as 4 L polyethylene glycol for bowel cleansing in elderly patients aged 60–79.

2 Feb, 2022 | 08:29h | UTC

Comparison of 2 L Polyethylene Glycol Plus Ascorbic Acid and 4 L Polyethylene Glycol in Elderly Patients Aged 60–79: A Prospective Randomized Study – Digestive Diseases and Sciences (link to abstract – $ for full-text)

Related Guidelines:

Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2019 – Endoscopy

Bowel preparation before colonoscopy – Gastrointestinal Endoscopy

 

DIC in Pregnancy: Pathophysiology, clinical characteristics, diagnostic scores, and treatments.

2 Feb, 2022 | 08:27h | UTC

DIC in Pregnancy – Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments – Journal of Blood Medicine

 

RCT: Efficacy and safety of Risankizumab for active psoriatic arthritis.

2 Feb, 2022 | 08:23h | UTC

Efficacy and safety of risankizumab for active psoriatic arthritis: 24-week results from the randomised, double-blind, phase 3 KEEPsAKE 1 trial – Annals of Rheumatic Diseases

 

Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicenter pooled analysis of 5161 patients.

2 Feb, 2022 | 08:22h | UTC

Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients – The Lancet Oncology

Commentary: Long-Term Outcomes According to Residual Cancer Burden After Neoadjuvant Chemotherapy for Breast Cancer – The ASCO Post

 

Short Review | Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2.

2 Feb, 2022 | 08:13h | UTC

Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2 – Pediatric Allergy and Immunology

Commentary: Vaccine hypersensitivity in children – News Medical

 

M-A: Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis.

2 Feb, 2022 | 08:20h | UTC

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Review finds upadacitinib most effective for moderate to severe ulcerative colitis remission – ACP Gastroenterology

 

M-A: Birth outcomes of neonates exposed to marijuana in utero.

2 Feb, 2022 | 08:19h | UTC

Birth Outcomes of Neonates Exposed to Marijuana in Utero: A Systematic Review and Meta-analysis – JAMA Network Open

Invited commentary: Reexamining Risks of Prenatal Cannabis Use—Mounting Evidence and a Call to Action – JAMA Network Open

 

Commentary on Twitter

 

Review: Advance care planning and goals of care discussions in advanced liver disease.

2 Feb, 2022 | 08:17h | UTC

Advance Care Planning and Goals of Care Discussions in Advanced Liver Disease – Current Hepatology Reports

 

Review: Diagnosis and Management of Multiple Myeloma.

2 Feb, 2022 | 08:11h | UTC

Diagnosis and Management of Multiple Myeloma: A Review – JAMA (free for a limited period)

Audio Clinical Review: Diagnosis and Management of Multiple Myeloma – JAMA

 

Review: Eosinophils and eosinophilic immune dysfunction in health and disease.

2 Feb, 2022 | 08:15h | UTC

Eosinophils and eosinophilic immune dysfunction in health and disease – European Respiratory Review

 

Systematic Review: Non-operative treatment for lumbar spinal stenosis with neurogenic claudication.

2 Feb, 2022 | 08:08h | UTC

Non-operative treatment for lumbar spinal stenosis with neurogenic claudication: an updated systematic review – BMJ Open

 

Review: Prevention of atherosclerosis from childhood.

2 Feb, 2022 | 08:12h | UTC

Prevention of atherosclerosis from childhood – Nature Reviews Cardiology (if the link is paywalled, try this one)

 

Study Commentary | Diagnostic labels in mental illness: helpful or harmful?

2 Feb, 2022 | 08:10h | UTC

Diagnostic labels: helpful or harmful? – The Mental Elf

Original Study: How does diagnostic labelling affect social responses to people with mental illness? A systematic review of experimental studies using vignette-based designs – Journal of Mental Health

Related: Consequences of a diagnostic label: A systematic scoping review and thematic framework.

 

Observational study suggests Ceftaroline has comparable efficacy vs. Daptomycin for the treatment of Methicillin-Resistant Staphylococcus aureus bloodstream infection.

2 Feb, 2022 | 08:07h | UTC

Multicenter Cohort Study of Ceftaroline versus Daptomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection – Open Forum Infectious Diseases

 

Commentary on Twitter

 

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