Archives
10-year results of a phase 3 RCT: High-dose radiotherapy and risk-adapted androgen deprivation in localized prostate cancer.
19 Apr, 2022 | 01:22h | UTCHigh-dose radiotherapy and risk-adapted androgen deprivation in localised prostate cancer (DART 01/05): 10-year results of a phase 3 randomised, controlled trial – The Lancet Oncology (link to abstract – $ for full-text)
M-A of randomized trials: Intraoperative recurrent laryngeal nerve monitoring vs. visualization alone.
19 Apr, 2022 | 01:17h | UTC
ASCO Guideline Update: Use of immune checkpoint inhibitor Pembrolizumab in the treatment of high-risk, early-stage triple-negative breast cancer.
19 Apr, 2022 | 01:18h | UTC
Network M-A: Comparative efficacy and safety of oral P2Y12 inhibitors after non-ST-elevation acute coronary syndromes.
19 Apr, 2022 | 01:16h | UTC
Endocrine therapies for breast and prostate cancers: Essentials for primary care.
19 Apr, 2022 | 01:14h | UTC
RCT: Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder.
19 Apr, 2022 | 01:20h | UTCSafety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)
Public health doctors and scientists are investigating 74 cases of hepatitis in children living in the UK that were not caused by hepatitis A to E virus.
18 Apr, 2022 | 10:56h | UTCCommentaries:
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
An update on hepatitis cases in children:
We are continuing to investigate 74 cases of hepatitis (liver inflammation) in children in the UK since January 2022. 1/2
— UK Health Security Agency (@UKHSA) April 12, 2022
RCT: In patients with acute Achilles’ tendon rupture, a nonoperative strategy resulted in similar outcomes compared with routine surgical treatment.
18 Apr, 2022 | 10:53h | UTCNonoperative or Surgical Treatment of Acute Achilles’ Tendon Rupture – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Heal Thyself: Most who tear Achilles tendon can skip surgery – Associated Press
Review: Covid-19: virology, variants, and vaccines.
18 Apr, 2022 | 10:50h | UTCCovid-19: virology, variants, and vaccines – BMJ Medicine
Commentary on Twitter
🆕 New review on #COVID: virology, variants and vaccines by Megan Young, Harry Crook, Janet Scott and Paul Edison from @ImperialMed
➡️ Read it now! https://t.co/hYrCQYVvNr#BMJMedicine #MedTwitter pic.twitter.com/aGA0DsX38K— BMJMedicine (@BMJMedicine) April 14, 2022
Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study.
18 Apr, 2022 | 10:52h | UTCCommentary: COVID-19 household transmission is high, with children being a significant source of spread: study – CHEO
Commentary on Twitter (thread – click for more)
This new study on household transmission of #COVID19 from Canada is pretty interesting
-Children made up less than half index cases
-Adults odds of transmitting more than double vs children
-Mask use in household didn't reduce transmission— Alasdair Munro (@apsmunro) April 14, 2022
Analysis: Changing the assortment of available food and drink for leaner, greener diets.
18 Apr, 2022 | 10:39h | UTCChanging the assortment of available food and drink for leaner, greener diets – The BMJ
News Release: Changing products on offer in shops and restaurants can lead to leaner, greener diets – BMJ
EBM Analysis: Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomized studies.
18 Apr, 2022 | 10:48h | UTC
Commentary on Twitter
Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomised studies – by John P A Ioannidis#OpenAccess
▶️ https://t.co/ddc2xF4hdg pic.twitter.com/okUAdQwb85— BMJ Evidence-Based Medicine (@BMJ_EBM) April 15, 2022
RCT: A 12-months oral itraconazole regimen is superior to 6-months of treatment to prevent relapses of chronic pulmonary aspergillosis.
18 Apr, 2022 | 10:36h | UTCEfficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Cohort Study: Changes in the incidence of retinal vascular occlusions after COVID-19 diagnosis.
18 Apr, 2022 | 10:34h | UTCCommentaries:
COVID-19 Diagnosis and Incidence of Retinal Thromboembolism – JAMA Ophthalmology
Threatening Eye Condition Rare After COVID Infection – HealthDay
M-A: Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination.
18 Apr, 2022 | 10:32h | UTCCommentaries:
Myopericarditis following COVID-19 vaccination is rare, finds international study – The Lancet
Study explores myopericarditis incidence and COVID-19 vaccination – News Medical
Commentary on Twitter
NEW—Myopericarditis following #COVID19 vaccination is rare, finds international study published in @LancetRespirMed: https://t.co/d3ZRvTWrGB pic.twitter.com/6sHiRyEbTk
— The Lancet (@TheLancet) April 11, 2022
AHA Scientific Statement: Nonalcoholic fatty liver disease and cardiovascular risk.
18 Apr, 2022 | 10:37h | UTCNews Releases:
Fatty liver disease not caused by alcohol is common – and often missed – American Heart Association
Diarrhea during critical illness: a multicenter cohort study.
18 Apr, 2022 | 10:20h | UTCDiarrhea during critical illness: a multicenter cohort study – Intensive Care Medicine
Commentary on Twitter
Diarrhea in #ICU
➡️common but variable incidence (definition applied)
➡️rarely caused by Clostridioides difficile
➡️modifiable predictors include EN/duration of ABs exposure
➡️associated with longer time to discharge but not increased mortality#FOAMcc
📖 https://t.co/Wx0T7RWukV pic.twitter.com/CvhWgTEwJb— Intensive Care Medicine (@yourICM) April 14, 2022
Commentary: Loneliness and health.
18 Apr, 2022 | 10:16h | UTCLoneliness and health – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Related:
The prevalence of loneliness across 113 countries: systematic review and meta-analysis – The BMJ
Social Isolation and Loneliness – World Health Organization
Psychological Distress and Loneliness Reported by US Adults in 2018 and April 2020 – JAMA
Commentary on Twitter
In this Comment, Louise Hawkley discusses associations of #Loneliness with increased mortality and disease risk, and that a multi-level approach including individuals, community organizations and society is needed to reduce loneliness.@NORCNewshttps://t.co/CzP5fR6G0n pic.twitter.com/X3use2Aybe
— Nature Reviews Disease Primers (@DiseasePrimers) April 14, 2022
Guidelines for therapeutic drug monitoring of vancomycin in the framework of model-informed precision dosing.
18 Apr, 2022 | 10:26h | UTCRelated Guideline:
Commentary on Twitter
https://twitter.com/IDPharmacometrx/status/1514219239732912131
RCT: Mitapivat vs. placebo for Pyruvate Kinase Deficiency.
18 Apr, 2022 | 10:13h | UTCMitapivat versus Placebo for Pyruvate Kinase Deficiency – New England Journal of Medicine
An observational study in patients with chronic kidney disease suggests the optimum range of water intake is around 1–2 L/day.
18 Apr, 2022 | 10:12h | UTC
A preliminary study showed prolonged viral suppression is feasible with anti-HIV-1 antibody therapy.
18 Apr, 2022 | 10:06h | UTCProlonged viral suppression with anti-HIV-1 antibody therapy – Nature
Commentary on Twitter
Still in disbelief but our paper is now out in @nature!
We show that immunotherapy with two broadly neutralizing anti-HIV-1 antibodies maintains virologic suppression for several months in people living with HIV in the absence of anti-retroviral therapy.https://t.co/eVem5yDE0C
— Christian Gaebler (@c_gaebler) April 14, 2022
A randomized controlled trial explored the safety and tolerability of Sulthiame in sleep apnea.
18 Apr, 2022 | 10:08h | UTCNews Release: Drug reduced frequency of breathing pauses in sleep apnea – University of Gothenburg
Commentary on Twitter
In a four-week trial of patients with OSA not tolerating PAP therapy, researchers found that the carbonic anhydrase inhibitor sulthiame reduced OSA by more than 20 events per hour, one of the strongest reductions reported in a drug trial in OSA. https://t.co/EizlbFbvFm pic.twitter.com/DxylRQR4Pa
— American Academy of Sleep Medicine (@AASMorg) February 28, 2022
The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates.
18 Apr, 2022 | 10:03h | UTCNews Release: Global estimates of headaches suggest disorder impacts over 50 percent of the population – BMC
Review: Management challenges and therapeutic advances in congenital adrenal hyperplasia.
18 Apr, 2022 | 10:10h | UTCManagement challenges and therapeutic advances in congenital adrenal hyperplasia – Nature Reviews Endocrinology (if the link is paywalled, try this one)
Commentary on Twitter
New content online: Management challenges and therapeutic advances in congenital adrenal hyperplasia https://t.co/RCH4mRmvYe pic.twitter.com/76Jm00ISV1
— Nature Reviews Endocrinology (@NatureRevEndo) April 11, 2022