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M-A: Efficacy and safety of Selumetinib in pediatric patients with Neurofibromatosis Type 1.

5 May, 2022 | 09:41h | UTC

Efficacy and Safety of Selumetinib in Pediatric Patients With Neurofibromatosis Type 1: A Systematic Review and Meta-analysis – Neurology (link to abstract – $ for full-text)

Commentary: Selumetinib Significantly Decreased Tumor Burden in Children with Symptomatic Inoperable Plexiform Neurofibromas – Neurology Today

Commentary on Twitter

A study via @GreenJournal reported that #selumetinib is a safe and effective treatment for pediatric patients with symptomatic, inoperable plexiform neurofibromas, but further studies are needed to confirm long-term outcomes. https://t.co/sRVaNFPKwV #NeuroTwitter pic.twitter.com/hYJNpN1EoU

— Neurology Today (@NeurologyToday) March 11, 2022

M-A: Interventions to prevent bronchopulmonary dysplasia in preterm neonates.

5 May, 2022 | 09:44h | UTC

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates: An Umbrella Review of Systematic Reviews and Meta-analyses – JAMA Pediatrics (link to abstract – $ for full-text)

RCT: In preterm infants with respiratory distress syndrome, surfactant administration via a thin catheter did not improve outcomes.

Systematic Review: Late (after 6 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.

Systematic Review: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants.

State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.

Systematic Review: Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome is associated with reduced risk of death or bronchopulmonary dysplasia, less intubation in the first 72 hours, and reduced incidence of major complications and in‐hospital mortality.

ERS Guideline on Long-term Management of Children with Bronchopulmonary Dysplasia

Randomized Trial: Sustained Inflations vs Intermittent Positive Pressure Ventilation in Extremely Preterm Infants

Randomized Trial: Effect of Hydrocortisone on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation

Research: Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia

Commentary on Twitter

A meta-analysis in @JAMAPeds evaluates interventions that may prevent BPD https://t.co/871W5OaNAC #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/UXfYhQU3wd

— Evidence-Based Neo (@EBNEO) March 9, 2022

WHO calls for shorter drug course for resistant TB.

4 May, 2022 | 11:08h | UTC

WHO calls for shorter drug course for resistant TB – CIDRAP

Rapid communication: Key changes to the treatment of drug-resistant tuberculosis – World Health Organization

Retrospective cohort study: Treatment outcome with penicillin G or cloxacillin in penicillin susceptible Staphylococcus aureus bacteremia.

5 May, 2022 | 09:39h | UTC

Treatment outcome with penicillin G or cloxacillin in penicillin susceptible Staphylococcus aureus bacteraemia – A retrospective cohort study – International Journal of Antimicrobial Agents

Commentary on Twitter

In recent years, several publications from different parts of the world have reported an increasing incidence of penicillin susceptible Staphylococcus aureus (PSSA)
🆕💥Retro study Treatment outcome with penicillin G or cloxacillin in PSSA bacteremia
SNAP?https://t.co/01TTVN4MU7

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 11, 2022

Heart failure with preserved ejection fraction: recent concepts in diagnosis, mechanisms and management.

4 May, 2022 | 11:02h | UTC

Heart failure with preserved ejection fraction: recent concepts in diagnosis, mechanisms and management – Heart

Podcast: A comprehensive review on heart failure with preserved ejection fraction (HFpEF)

Randomized Trials: Neither detection nor control of high blood pressure improved by self-monitoring during pregnancy.

4 May, 2022 | 11:06h | UTC

News Release: Neither detection nor control of high blood pressure improved by self-monitoring during pregnancy – University of Oxford

Study 1: Effect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy: The BUMP 1 Randomized Clinical Trial – JAMA (free for a limited period)

Study 2: Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension: The BUMP 2 Randomized Clinical Trial – JAMA (free for a limited period)

Author Interview: Effect of Self-monitoring of Blood Pressure on Detection and Assessment of Hypertension During Higher-Risk Pregnancy: The BUMP 1 and BUMP 2 Trials

Editorial: Self-monitoring of Blood Pressure During Pregnancy – JAMA (free for a limited period)

Commentary on Twitter

In this randomized clinical trial, among pregnant individuals at higher risk of preeclampsia, self-monitoring of #bloodpressure with telemonitoring did not lead to earlier clinic-based detection of #hypertension. https://t.co/YKEQxpASA9 @RichardJMcManus pic.twitter.com/33Bf0gk59g

— JAMA (@JAMA_current) May 3, 2022

Cohort Study: Spectrum of nonkeratinocyte skin cancer risk among solid organ transplant recipients.

5 May, 2022 | 09:37h | UTC

Spectrum of Nonkeratinocyte Skin Cancer Risk Among Solid Organ Transplant Recipients in the US – JAMA Dermatology (link to abstract – $ for full-text)

Author Interview: Nonkeratinocyte Skin Cancer Risk Among Solid Organ Transplant Recipients

Commentary on Twitter

This cohort study found elevated incidence for common and rare skin #cancer in solid organ #transplant recipients. Long-term immunosuppression and UV radiation are important risk factors. Treatment with mTOR inhibitors may reduce #melanoma risk. https://t.co/V6Wbbhtyeq

— JAMA Dermatology (@JAMADerm) March 9, 2022

Paxlovid’s failure as a preventative measure raises questions, but doctors still back it as a therapeutic.

4 May, 2022 | 10:57h | UTC

Paxlovid’s failure as a preventative measure raises questions, but doctors still back it as a therapeutic – STAT

Brief Review: Management of chronic hypertension during pregnancy.

4 May, 2022 | 11:03h | UTC

Management of Chronic Hypertension During Pregnancy – JAMA (free for a limited period)

Cluster RCT: A village doctor-led multifaceted intervention for blood pressure control in rural China.

4 May, 2022 | 10:53h | UTC

A village doctor-led multifaceted intervention for blood pressure control in rural China: an open, cluster randomised trial – The Lancet (link to abstract – $ for full-text)

Preventing asthma deaths in school children: 3 things to know.

4 May, 2022 | 10:59h | UTC

Preventing asthma deaths in school children: 3 things to know – Evidently Cochrane

Cluster RCT: Algorithm-based care vs. usual care for the early recognition and management of complications after pancreatic resection.

4 May, 2022 | 10:55h | UTC

Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary on Twitter

New research @TheLancet – Smits et al – Algorithm-based care vs usual care for early recognition and management of complications after pancreatic resection in the Netherlands: a stepped-wedge, cluster-randomised trialhttps://t.co/8BeKhtk0mV #SoMe4Surgery #pancsm @DPCG_official pic.twitter.com/atPcJk4O8r

— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) April 29, 2022

Obesity causes cancer and is major determinant of disability and death, warns new WHO report.

4 May, 2022 | 10:49h | UTC

News Release: Obesity causes cancer and is major determinant of disability and death, warns new WHO report – WHO Europe

Report: WHO European Regional Obesity Report 2022 – World Health Organization

Commentary: ‘Epidemic’ of Obesity in Europe – Health Policy Watch

Commentary on Twitter

#Obesity is considered to be the cause of at least 13 types of #cancer. “To achieve our targets on beating cancer, we cannot delay taking action to address obesity,” says WHO/Europe’s @hans_kluge.

Find out more about the #ObesityReport 👉 https://t.co/gjrfUOu6gK pic.twitter.com/moNvObtevN

— WHO/Europe (@WHO_Europe) May 3, 2022

Systematic Review: Most common reasons for primary care visits in low- and middle-income countries.

4 May, 2022 | 10:46h | UTC

Most common reasons for primary care visits in low- and middle-income countries: A systematic review – PLOS Global Public Health

Review: Diagnosis and management of lumbar spinal stenosis.

4 May, 2022 | 10:45h | UTC

Diagnosis and Management of Lumbar Spinal Stenosis: A Review – JAMA (free for a limited period)

Audio Clinical Review: Lumbar Spinal Stenosis: A Review – JAMA

RCT: Effects of prophylactic oral dextrose gel on neurosensory impairment at 2-year follow-up in late preterm and term infants born at risk of neonatal hypoglycemia.

4 May, 2022 | 10:43h | UTC

Prophylactic Oral Dextrose Gel and Neurosensory Impairment at 2-Year Follow-up of Participants in the hPOD Randomized Trial – JAMA (link to abstract – $ for full-text)

Commentary: New insight into protecting newborns with low blood sugars – University of Auckland

Cohort Study: No association of neonatal hypoglycemia with academic performance in mid-childhood.

Oral dextrose gel for the treatment of hypoglycemia in newborn infants.

Commentary on Twitter

@EdwardsTaygen et al present 2-year Neurosensory Follow-Up results from their multicenter, double-blinded, placebo controlled hPOD randomized trial @JAMA_current https://t.co/ik6AKIjahS #EBNEOalerts, #neotwitter, #neoEBM pic.twitter.com/dQH8qti5Fv

— Evidence-Based Neo (@EBNEO) March 25, 2022

We Have Your Back: ED presentations, evaluation, and management of spinal cord injuries.

4 May, 2022 | 10:39h | UTC

We Have Your Back: ED Presentations, Evaluation, and Management of Spinal Cord Injuries – emDocs

M-A: Association of music interventions with health-related quality of life.

4 May, 2022 | 10:41h | UTC

Association of Music Interventions With Health-Related Quality of Life: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary on Twitter

This systematic review and meta-analysis demonstrated associations between music interventions and improvements in mental health-related quality of life, with substantial individual variation in intervention outcomes. https://t.co/6x6fb97JJl

— JAMA Network Open (@JAMANetworkOpen) March 22, 2022