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M-A: Antibiotic duration for community acquired pneumonia in outpatient children in high-income countries – treatment duration of 3–5 days is equally effective and safe vs. 7–10 days.

20 May, 2022 | 11:10h | UTC

Antibiotic treatment duration for community acquired pneumonia in outpatient children in high-income countries – a systematic review and meta-analysis – Clinical Infectious Diseases

Related:

Antibiotics for Pediatric Pneumonia: Might Less Be Enough? – Annals of Emergency Medicine

Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial – JAMA

Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial – The Pediatric Infectious Disease Journal

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians – Annals of Internal Medicine

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics

Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy

 

Commentary on Twitter

 

Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality.

20 May, 2022 | 11:06h | UTC

Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality – Intensive Care Medicine

 

Commentary on Twitter

 

SCAI guidelines for the management of patent foramen Ovale.

20 May, 2022 | 11:01h | UTC

SCAI Guidelines for the Management of Patent Foramen Ovale – JSCAI

Editorial: New SCAI Guidelines: Trying to Close the Holes in the PFO Literature – JSCAI

Commentary: PFO Closure Guidelines Address Older Adults, Trial-Excluded Groups— Document acknowledges skimpy evidence – MedPage Today (free registration required)

Related:

Advances in the management of cardioembolic stroke associated with patent foramen ovale – The BMJ

Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology – Neurology

Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke – JAMA (link to abstract – $ for full-text)

Management of the Patient With Patent Foramen Ovale in 2021: A Spectrum of Cases – Mayo Clinic Proceedings

 

RCT: Apixaban is not superior to the standard of care (vitamin K antagonist or antiplatelet therapy if anticoagulation is indicated or not, respectively) after transcatheter aortic valve implantation.

20 May, 2022 | 10:59h | UTC

Apixaban vs. standard of care after transcatheter aortic valve implantation: the ATLANTIS trial – European Heart Journal (link to abstract – $ for full-text)

Editorial: Defining optimal antithrombotic therapy post-TAVI: the contribution of ATLANTIS – European Heart Journal

Related:

Edoxaban versus Dual Antiplatelet Therapy for Leaflet Thrombosis and Cerebral Thromboembolism after TAVR: The ADAPT-TAVR Randomized Clinical Trial – Circulation

Comparing Single- and Dual-Antiplatelet Therapies After Transcatheter Aortic Valve Implantation – The Annals of Thoracic Surgery

Aspirin Alone Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Implantation: A Systematic Review and Patient‐Level Meta‐Analysis – Journal of the American Heart Association

Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation – New England Journal of Medicine

Anti-Thrombotic Strategy to Lower All cardiovascular and Neurologic Ischemic and Hemorrhagic Events after Trans-Aortic Valve Implantation for Aortic Stenosis – ATLANTIS – American College of Cardiology

 

Variation in the estimated prevalence of multimorbidity: systematic review and meta-analysis of 193 international studies.

20 May, 2022 | 10:58h | UTC

Variation in the estimated prevalence of multimorbidity: systematic review and meta-analysis of 193 international studies – BMJ Open

 

Commentary on Twitter

 

RCT: Elacestrant (oral selective estrogen receptor degrader) vs. standard endocrine therapy for estrogen receptor–positive, human epidermal growth factor receptor 2–negative advanced breast cancer.

20 May, 2022 | 10:55h | UTC

Elacestrant (oral selective estrogen receptor degrader) Versus Standard Endocrine Therapy for Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: Results From the Randomized Phase III EMERALD Trial – Journal of Clinical Oncology

Commentary: EMERALD Trial: Oral Selective Estrogen Receptor Degrader as Second- or Third-Line Therapy for Advanced Breast Cancer – The ASCO Post

 

M-A: Comparison of Amitriptyline with other FDA–approved treatments for fibromyalgia.

20 May, 2022 | 10:49h | UTC

Comparison of Amitriptyline and US Food and Drug Administration–Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis – JAMA Network Open

 

M-A: Management of asymptomatic severe aortic stenosis.

20 May, 2022 | 10:54h | UTC

Management of asymptomatic severe aortic stenosis: a systematic review and meta-analysis – openheart

 

Commentaries on Twitter

 

Age distribution of all-cause mortality among children younger than 5 years in low- and middle-income countries.

20 May, 2022 | 10:46h | UTC

Age Distribution of All-Cause Mortality Among Children Younger Than 5 Years in Low- and Middle-Income Countries – JAMA Network Open

 

Association of extreme heat with all-cause mortality in the contiguous US, 2008-2017.

20 May, 2022 | 10:48h | UTC

Association of Extreme Heat With All-Cause Mortality in the Contiguous US, 2008-2017 – JAMA Network Open

 

Commentary on Twitter

 

Systematic Review: Landscaping the evidence of intimate partner violence and postpartum depression.

20 May, 2022 | 10:44h | UTC

Landscaping the evidence of intimate partner violence and postpartum depression: a systematic review – BMJ Open

 

RCT: Tenecteplase vs. alteplase for the management of acute ischemic stroke.

20 May, 2022 | 10:43h | UTC

Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway (NOR-TEST 2, part A): a phase 3, randomised, open-label, blinded endpoint, non-inferiority trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentary: Tenecteplase yields worse safety and functional outcomes compared to alteplase in ischaemic stroke: Lancet – Medical Dialogues

 

Hemoperfusion: technical aspects and state of the art.

20 May, 2022 | 10:41h | UTC

Hemoperfusion: technical aspects and state of the art – Critical Care

 

Routine use of indirect calorimetry in critically ill patients: pros and cons.

20 May, 2022 | 10:39h | UTC

Routine use of indirect calorimetry in critically ill patients: pros and cons – Critical Care

 

Overview of complications in cirrhosis.

20 May, 2022 | 10:37h | UTC

Overview of Complications in Cirrhosis – Journal of Clinical and Experimental Hepatology

 

Review: Management of refractory variceal bleed in cirrhosis.

20 May, 2022 | 10:36h | UTC

Management of Refractory Variceal Bleed in Cirrhosis – Journal of Clinical and Experimental Hepatology

 

Systematic Review | Post-stroke dysphagia: prognosis and treatment.

20 May, 2022 | 10:33h | UTC

Post-stroke Dysphagia: Prognosis and Treatment–A Systematic Review of RCT on Interventional Treatments for Dysphagia Following Subacute Stroke – Frontiers in Neurology

 

Systematic Review: Percutaneous transluminal angioplasty and stenting for vertebral artery stenosis.

20 May, 2022 | 10:28h | UTC

Percutaneous transluminal angioplasty and stenting for vertebral artery stenosis – Cochrane Library

Summary: Endovascular treatment for vertebral artery stenosis – Cochrane Library

 

Systematic Review: Antibiotics for the induction and maintenance of remission in ulcerative colitis.

20 May, 2022 | 10:29h | UTC

Antibiotics for the induction and maintenance of remission in ulcerative colitis – Cochrane Library

Summary: The use of antibiotics in the treatment of ulcerative colitis – Cochrane Library

 

Network meta-analysis of different intravenous glucocorticoid regimes for the treatment of Graves’ orbitopathy.

20 May, 2022 | 10:34h | UTC

Network Meta-Analysis of Different Intravenous Glucocorticoid Regimes for the Treatment of Graves’ Orbitopathy – Frontiers in Pharmacology

 

Systematic Review: Immediate versus delayed postabortion insertion of contraceptive implant.

20 May, 2022 | 10:26h | UTC

Immediate versus delayed postabortal insertion of contraceptive implant – Cochrane Library

Summary: Inserting a contraceptive implant at the same visit as an abortion or at a follow-up visit – Cochrane Library

 

Systematic Review: Pain management for medical abortion before 14 weeks’ gestation.

20 May, 2022 | 10:25h | UTC

Pain management for medical abortion before 14 weeks’ gestation – Cochrane Library

Summary: Pain management for medical abortion before 14 weeks’ gestation – Cochrane Library

 

UK, Spain, Portugal report more monkeypox cases.

19 May, 2022 | 11:15h | UTC

UK, Spain, Portugal report more monkeypox cases – CIDRAP

See also:

U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT

Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization

Monkeypox cases confirmed in England – latest updates – UK Health Security Agency

Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch

European outbreak of monkeypox: what you need to know – The Conversation

Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR

Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News

 

Commentary on Twitter

 

Pollution and health: a progress update.

19 May, 2022 | 11:12h | UTC

Pollution and health: a progress update – The Lancet Planetary Health

Commentaries:

One in six killed by pollution worldwide, study finds – CNN

Pollution responsible for one in six deaths across planet, scientists warn – The Guardian

 

Commentary on Twitter

 

The pandemic’s true health cost: how much of our lives has COVID stolen?

19 May, 2022 | 11:09h | UTC

The pandemic’s true health cost: how much of our lives has COVID stolen? – Nature

 

Commentary on Twitter

 

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