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Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.

27 Jun, 2022 | 11:17h | UTC

Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet Gastroenterology & Hepatology

Commentary: Chronic Hepatitis B Infections Decreasing in Recent Years – HCP Live

 

Commentary on Twitter

 

RCT: Efficacy of Ipilimumab vs. FOLFOX in combination with Nivolumab and Trastuzumab in patients with previously untreated ERBB2-positive esophagogastric adenocarcinoma.

27 Jun, 2022 | 11:11h | UTC

Efficacy of Ipilimumab vs FOLFOX in Combination With Nivolumab and Trastuzumab in Patients With Previously Untreated ERBB2-Positive Esophagogastric Adenocarcinoma: The AIO INTEGA Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Commentary: AIO INTEGA Provides Further Support for Immunotherapy in Patients With Advanced ERBB2-Positive Gastroesophageal Adenocarcinoma – JAMA Oncology (free for a limited period)

 

Systematic Review: Short‐acting inhaled bronchodilators for cystic fibrosis.

27 Jun, 2022 | 11:15h | UTC

Short‐acting inhaled bronchodilators for cystic fibrosis – Cochrane Library

Summary: Short-acting inhaled bronchodilators for cystic fibrosis – Cochrane Library

 

Cohort Study: Prognostic and biologic significance of ERBB2-low expression in early-stage breast cancer.

27 Jun, 2022 | 11:09h | UTC

Prognostic and Biologic Significance of ERBB2-Low Expression in Early-Stage Breast Cancer – JAMA Oncology (link to abstract – $ for full-text)

News Release: Study finds breast cancers with low levels of HER2 protein are not a distinct subtype of the disease – Dana-Farber Cancer Institute

 

Commentary on Twitter

 

Systematic Review: Locally recurrent rectal cancer according to a standardized MRI classification system.

27 Jun, 2022 | 11:07h | UTC

Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature – Journal of Clinical Medicine

 

Cluster RCT: Effect of automated telephone infectious disease consultations to nonacademic hospitals on 30-day mortality among patients with Staphylococcus aureus bacteremia.

27 Jun, 2022 | 11:03h | UTC

Effect of Automated Telephone Infectious Disease Consultations to Nonacademic Hospitals on 30-Day Mortality Among Patients With Staphylococcus aureus Bacteremia: The SUPPORT Cluster Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 

M-A: Prevalence of perinatal depression and anxiety in both parents.

27 Jun, 2022 | 11:05h | UTC

Prevalence of Perinatal Depression and Anxiety in Both Parents: A Systematic Review and Meta-analysis – JAMA Network Open

 

Does the “July effect” of new trainees at teaching hospitals impact outcomes for patients hospitalized with heart failure? Real-world analyses of more than half a million US admissions.

27 Jun, 2022 | 10:57h | UTC

Does the “July effect” of new trainees at teaching hospitals impact outcomes for patients hospitalized with heart failure? Real-world analyses of more than half a million US admissions – American Heart Journal Plus: Cardiology Research and Practice

 

M-A: Relationship between serum lipid level and colorectal cancer.

27 Jun, 2022 | 11:01h | UTC

Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis – BMJ Open

 

M-A: Safety and efficacy of SSRIs in improving poststroke recovery.

27 Jun, 2022 | 10:58h | UTC

Safety and Efficacy of SSRIs in Improving Poststroke Recovery: A Systematic Review and Meta‐Analysis – Journal of the American Heart Association

 

M-A: Hypothermic vs. normothermic temperature control after cardiac arrest.

24 Jun, 2022 | 11:51h | UTC

Hypothermic versus Normothermic Temperature Control after Cardiac Arrest – NEJM Evidence

Related:

ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (if the link is paywalled, try this one)

Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis – Critical Care

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine

Targeted Temperature Management for Cardiac Arrest Due to Non-shockable Rhythm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Frontiers in Medicine

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine

 

Analysis of 7 RCTs: Dupilumab treatment reduces hospitalizations in adults with moderate-to-severe atopic dermatitis.

27 Jun, 2022 | 10:56h | UTC

Dupilumab Treatment Reduces Hospitalizations in Adults With Moderate-to-Severe Atopic Dermatitis – The Journal of Allergy and Clinical Immunology: In Practice

Commentary: Treatment Reduces, Exterminates Hospitalizations in Adults With Moderate to Severe AD – Consultant360

 

Commentary on Twitter

 

Systematic Review: Parenteral Vitamin C in patients with severe infection.

24 Jun, 2022 | 11:49h | UTC

Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence

Related:

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 

New COVID drugs face delays as trials grow more difficult.

24 Jun, 2022 | 11:47h | UTC

New COVID drugs face delays as trials grow more difficult – Nature

 

An update on refractory hypertension.

24 Jun, 2022 | 11:44h | UTC

An Update on Refractory Hypertension – Current Hypertension Reports

 

Research must do no harm: new guidance addresses all studies relating to people.

24 Jun, 2022 | 11:46h | UTC

Research must do no harm: new guidance addresses all studies relating to people – Nature

See Guidance: Research Ethics – Nature Portfolio

 

Perspective | Four areas of health innovation boosted by the pandemic.

24 Jun, 2022 | 11:36h | UTC

Four areas of health innovation boosted by the pandemic – Nature Medicine

 

Commentary on Twitter

 

Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics.

24 Jun, 2022 | 11:38h | UTC

Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics – JAC-Antimicrobial Resistance

 

EULAR/PRES recommendations for vaccination of pediatric patients with autoimmune inflammatory rheumatic diseases.

24 Jun, 2022 | 11:17h | UTC

EULAR/PRES recommendations for vaccination of paediatric patients with autoimmune inflammatory rheumatic diseases: update 2021 – Annals of Rheumatic Diseases

 

EULAR/ACR points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases.

24 Jun, 2022 | 11:23h | UTC

The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist – Annals of Rheumatic Diseases

 

Cohort Study: COVID-19 trajectories among 57 million adults in England.

24 Jun, 2022 | 11:34h | UTC

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records – The Lancet Digital Health

News Release: Most comprehensive analysis of COVID-19 data reveals previously unattributed deaths – Health Data Research UK

 

Commentary from one of the authors on Twitter (thread – click for more)

 

Consensus Paper: Diagnosis and treat-to-target management of macrophage activation syndrome in children.

24 Jun, 2022 | 11:13h | UTC

Egyptian evidence-based consensus on clinical practice guidelines for the diagnosis and treat-to-target management of macrophage activation syndrome in children – Egyptian Rheumatology and Rehabilitation

 

ESPGHAN Position Paper: use of low-FODMAP diet in pediatric gastroenterology.

24 Jun, 2022 | 11:15h | UTC

An ESPGHAN Position Paper on the Use of Low-FODMAP Diet in Pediatric Gastroenterology – Pediatric Gastroenterology and Nutrition

 

RCT: Effect of banded Roux-en-Y gastric bypass versus sleeve gastrectomy on diabetes remission at 5 years among patients with obesity and type 2 diabetes.

24 Jun, 2022 | 11:10h | UTC

Effect of Banded Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy on Diabetes Remission at 5 Years Among Patients With Obesity and Type 2 Diabetes: A Blinded Randomized Clinical Trial – Diabetes Care (link to abstract – $ for full-text)

 

Position Paper: Teleconsultation in respiratory medicine.

24 Jun, 2022 | 11:11h | UTC

Teleconsultation in respiratory medicine – A position paper of the Portuguese Pulmonology Society – Pulmonology

 

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