Archives
RCT | Zanubrutinib vs. bendamustine and rituximab in untreated chronic lymphocytic leukemia and small lymphocytic lymphoma.
11 Jul, 2022 | 11:49h | UTCZanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Single-arm Study | Extended focal ablation of localized prostate cancer with high-frequency irreversible electroporation.
11 Jul, 2022 | 11:56h | UTCExtended Focal Ablation of Localized Prostate Cancer With High-Frequency Irreversible Electroporation: A Nonrandomized Controlled Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentary: Novel Focal Therapy Yields Low Rate of Serious Prostate Cancers — Trial’s 6-month rate of 6% was superior to historical control – MedPage Today (free registration required)
Commentary on Twitter
This single-arm objective performance criteria trial indicated excellent efficacy and safety profile of the second-generation high-frequency irreversible electroporation as primary treatment for localized prostate cancer. https://t.co/FheqcxJeA5
— JAMA Surgery (@JAMASurgery) July 7, 2022
Cohort Study | Association of high tumor mutation burden in non–small cell lung cancers with increased immune infiltration and improved clinical outcomes of PD-L1 blockade across PD-L1 expression levels.
11 Jul, 2022 | 11:53h | UTCAuthor Interview: High TMB in NSCLC and Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade – JAMA
Commentaries:
Tumor mutational burden ‘valuable biomarker’ for ICI response in NSCLC – medwire News
Commentary on Twitter
Very high levels of tumor mutational burden (TMB) are associated with benefit from #immunotherapy in NSCLC across PD-L1 expression levels and increased CD8+ T cells infiltration. https://t.co/qbq00ZzjFO #LCSM
— JAMA Oncology (@JAMAOnc) June 22, 2022
Brief Review | Monitoring cerebral oxygenation in acute brain-injured patients.
11 Jul, 2022 | 11:51h | UTCMonitoring cerebral oxygenation in acute brain-injured patients – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Monitoring cerebral oxygenation to understand brain dysfunction after #ABI & individualize management
🧠 pathophysiology of cerebral oxygenation
⚙️ technology of cerebral oxygen measurement
📖 evidence/clinical applications#FOAMcc @yourICM @chiara_robba
📎https://t.co/QpXQjznu8z pic.twitter.com/TrR62tWIyC— Intensive Care Medicine (@yourICM) July 9, 2022
AHA Scientific Statement | Escalating and de-escalating temporary mechanical circulatory support in cardiogenic shock.
8 Jul, 2022 | 12:05h | UTCTop Things to Know: Escalating and De-escalating Temporary Mechanical Circulatory Support in Cardiogenic Shock– American Heart Association
Commentary: Guiding Cardiogenic Shock Management: Filling in the (Wide) Data Gaps – American Heart Association
Long-term analysis of a Phase 2 RCT | Fulvestrant plus capivasertib vs. placebo after relapse or progression on an aromatase inhibitor in metastatic, estrogen receptor-positive, HER2-negative breast cancer.
11 Jul, 2022 | 11:48h | UTCNews Release: New phase of breast cancer drug trial provides fresh hope for patients with incurable disease – Cardiff University
RCT | Neutralizing COVID-19 convalescent plasma does not benefit adults hospitalized with COVID-19.
8 Jul, 2022 | 11:59h | UTC
BSG guidelines on the management of functional dyspepsia.
8 Jul, 2022 | 12:03h | UTCBritish Society of Gastroenterology guidelines on the management of functional dyspepsia – Gut
Related:
Perspective | How to find, read and organize papers.
8 Jul, 2022 | 11:57h | UTCHow to find, read and organize papers – Nature
Interim Analysis | Oral Sabizabulin for high-risk, hospitalized adults with Covid-19.
8 Jul, 2022 | 12:02h | UTCOral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim Analysis – NEJM Evidence
Clinical recommendations to diagnose and monitor patients with transthyretin amyloid cardiomyopathy.
8 Jul, 2022 | 11:53h | UTCRelated:
AHA Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis.
M-A | Associations of thiazide use with skin cancers.
8 Jul, 2022 | 11:55h | UTCAssociations of thiazide use with skin cancers: a systematic review and meta-analysis – BMC Medicine
Related:
Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma – JAMA Internal Medicine
Consensus statements on the diagnosis and management of obstructive sleep apnea in patients with cardiovascular disease.
8 Jul, 2022 | 11:51h | UTC
Cohort Study | Serious adverse event rates and reoperation after arthroscopic shoulder surgery.
8 Jul, 2022 | 11:49h | UTCNews Release: Overall risks of shoulder surgery low, but study finds significant risk of reoperation – BMJ Newsroom
RCT | Sacral neuromodulation for neurogenic lower urinary tract dysfunction.
8 Jul, 2022 | 11:47h | UTCSacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction – NEJM Evidence
Commentary on Twitter
Pts with neurogenic lower urinary tract dysfunction had sacral neuromodulators implanted and optimized. They were then randomized to have the device either remain ON or switched OFF for 2 months. The success rate was 76% in the ON group vs 42% in the OFF. https://t.co/dhteW70jXp pic.twitter.com/1c0w8HOMJm
— NEJM Evidence (@NEJMEvidence) July 7, 2022
RCT | Effect of electroacupuncture on insomnia in patients with depression.
8 Jul, 2022 | 11:45h | UTCInvited Commentary: Effects of Electroacupuncture for Depression-Related Insomnia – JAMA Network Open
Commentary on Twitter
This randomized clinical trial found that an 8-weeek electroacupuncture with standard care improved sleep quality for patients with insomnia and depression, compared with sham acupuncture and/or standard care. https://t.co/nacnxEI4Ik
— JAMA Network Open (@JAMANetworkOpen) July 7, 2022
Cross-Sectional Study | Comparison of radiation exposure among interventional echocardiographers, interventional cardiologists, and sonographers during percutaneous structural heart interventions.
8 Jul, 2022 | 11:43h | UTC
RCT | Cabozantinib plus atezolizumab vs. sorafenib for advanced hepatocellular carcinoma.
8 Jul, 2022 | 11:41h | UTCInvited Commentary: Cabozantinib plus atezolizumab in advanced hepatocellular carcinoma and the role of adjuvant antiviral therapy – The Lancet Oncology (free registration required)
Commentary on Twitter
In the phase III COSMIC-312 trial in 837 pts with advanced-stage HCC, mPFS was 6.8 vs 4.2 months (HR 0.63; P=.0012) & mOS was 15.4 vs 15.5 months (HR 0.90; P=.44) with cabozantinib+atezolizumab vs sorafenib; mPFS with cabozantinib alone was 5.8 months: https://t.co/eiZEqSxLAr
— NatureRevClinOncol (@NatRevClinOncol) July 6, 2022
RCT | Ustekinumab does not improve outcomes in patients with systemic lupus erythematosus.
8 Jul, 2022 | 11:39h | UTC
RCT | Balovaptan no better than placebo for social communication in childhood autism spectrum disorder.
8 Jul, 2022 | 11:38h | UTC
Commentary on Twitter
In this RCT, balovaptan did not demonstrate efficacy in improvement of socialization and communication in pediatric autism spectrum disorder (ASD), highlighting challenges faced in #ASD trial design, such as outcome measure sensitivity & placebo response. https://t.co/FFAJeu5xv0
— JAMA Psychiatry (@JAMAPsych) July 6, 2022
Podcast | BRUE’s Clues: understanding brief resolved unexplained events.
8 Jul, 2022 | 11:34h | UTC#54: BRUE’s Clues: Understanding Brief Resolved Unexplained Events with Dr. Tieder – The Cribsiders
M-A | Antithyroid drug therapy in pregnancy and risk of congenital anomalies.
8 Jul, 2022 | 11:36h | UTC
M-A | The efficacy and tolerability of antibiotics in scrub typhus.
8 Jul, 2022 | 11:32h | UTC
M-A | Transitional care interventions for older residents of long-term care facilities.
8 Jul, 2022 | 11:29h | UTCCommentaries:
Commentary on Twitter
This systematic review found transitional care interventions were associated with reduced readmissions for long-term care home residents. Such interventions are currently sparse and warrant investment from health service practitioners. @Kelly_B5 https://t.co/plPsEffMHM
— JAMA Network Open (@JAMANetworkOpen) May 4, 2022
M-A | Prenatal antibiotic exposure, asthma, and the atopic march.
8 Jul, 2022 | 11:31h | UTC