Archives
Systematic Review | Vagus nerve stimulation for focal seizures
15 Jul, 2022 | 12:45h | UTCVagus nerve stimulation for focal seizures – Cochrane Library
Summary: Vagus nerve stimulation for focal seizures – Cochrane Library
Guidelines on germline testing for urologic tumor syndromes.
15 Jul, 2022 | 12:49h | UTCGuidelines on Germline Testing for Urologic Tumor Syndromes – European Urology Focus
Brain volume abnormalities and clinical outcomes following pediatric traumatic brain injury.
15 Jul, 2022 | 12:41h | UTCBrain volume abnormalities and clinical outcomes following paediatric traumatic brain injury – Brain
News Release: Head injuries in children linked to reduced brain size and learning difficulties – Imperial College London
Commentary: Experts use MRI to pinpoint link between pediatric TBI and cognitive impairment – Health Imaging
Commentary on Twitter
Bourke et al. identify paediatric brain injury patients with low brain volume for their age and associated cognitive difficulties by generating age norms from over 1,200 healthy paediatric controls. https://t.co/N06ELchNPd pic.twitter.com/ouDU1kTYPT
— Brain (@Brain1878) July 8, 2022
RCT | Efficacy and safety of ciprofloxacin plus fluocinolone acetonide among patients with acute otitis externa.
15 Jul, 2022 | 12:43h | UTC
Commentary on Twitter
In this randomized clinical trial, ciprofloxacin 0.3% plus fluocinolone acetonide 0.025% otic solution was efficacious and safe in treating acute otitis externa. https://t.co/VRf1vEojY1
— JAMA Network Open (@JAMANetworkOpen) July 14, 2022
M-A (mostly of observational studies) | Catheter-directed thrombolysis vs. systemic anticoagulation alone for submassive pulmonary embolism.
15 Jul, 2022 | 12:39h | UTC
M-A of RCTs | Effectiveness of home-based cardiac rehabilitation, using wearable sensors, as a multicomponent, cutting-edge intervention.
15 Jul, 2022 | 12:35h | UTC
Review | Regional anesthesia and acute perioperative pain management in thoracic surgery.
15 Jul, 2022 | 12:33h | UTC
Registry-based cohort study | Modifiable and non-modifiable risk factors in hip fracture mortality in Norway, 2014 to 2018.
15 Jul, 2022 | 12:31h | UTC
RCT | Deucravacitinib vs. placebo vs. apremilast in moderate to severe plaque psoriasis.
15 Jul, 2022 | 12:26h | UTCDeucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial – Journal of the American Academy of Dermatology (link to abstract – $ for full-text)
Phase 2 RCT | Efficacy of preoperative mFOLFIRINOX vs. mFOLFIRINOX plus hypofractionated radiotherapy for borderline resectable adenocarcinoma of the pancreas.
15 Jul, 2022 | 12:29h | UTCEfficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the PancreasThe A021501 Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Editorial: The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer – JAMA (free for a limited period)
Commentary on Twitter
Ph 2 trial of 126 pts w/borderline resectable pancreatic ductal adenoCa shows 18 mo OS after neoadjuvant mFOLFIRINOX of 66.7%, favorable vs. historical data; 18m OS if mFOLFORINOX then hypofract RT is 47.3%, if chemo then pancreatectomy is 87.5%. https://t.co/wOMNrTOAzm
— JAMA Oncology (@JAMAOnc) July 14, 2022
One-year safety and efficacy of Tapinarof cream for the treatment of plaque psoriasis.
15 Jul, 2022 | 12:28h | UTCNews Release: Tapinarof Effective for Longer-Term Treatment of Plaque Psoriasis – HealthDay
Related Study: Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis – New England Journal of Medicine
Pediatric intestinal pseudo-obstruction: progress and challenges.
15 Jul, 2022 | 12:24h | UTCPediatric Intestinal Pseudo-Obstruction: Progress and Challenges – Frontiers in Pediatrics
Review | Strongyloides stercoralis.
15 Jul, 2022 | 12:23h | UTCStrongyloides stercoralis – Lung (if the link is paywalled, try this one)
Randomized trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review.
15 Jul, 2022 | 12:22h | UTC
Cohort Study | Comparison of diagnostic criteria for acute kidney injury in critically ill children.
15 Jul, 2022 | 12:17h | UTC
Pressure ulcers (pressure injuries) | Cochrane Library evidence and resources.
14 Jul, 2022 | 13:03h | UTCPressure ulcers (pressure injuries): evidence and resources – Evidently Cochrane
M-A | Vortioxetine for the treatment of major depressive disorder in adults.
15 Jul, 2022 | 12:15h | UTC
RCT | Pharmacogenomic testing for drug-gene interactions provides little benefit for the remission of symptoms in major depressive disorder.
14 Jul, 2022 | 13:05h | UTCEffect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (free for a limited period)
Commentary: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (free registration required)
Commentary on Twitter
In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN
— JAMA (@JAMA_current) July 12, 2022
FDA authorizes emergency use of Novavax COVID-19 vaccine.
14 Jul, 2022 | 13:01h | UTCCommentaries:
FDA authorizes Novavax Covid vaccine, in hopes the traditional shot will convince holdouts – STAT
US regulators OK new COVID-19 shot option from Novavax – Associated Press
How to bounce back from a PhD-project failure.
14 Jul, 2022 | 12:59h | UTCHow to bounce back from a PhD-project failure – Nature
WHO Updated Report | Severe acute hepatitis of unknown etiology in children.
14 Jul, 2022 | 12:54h | UTCSevere acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Related:
Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
A case series of children with acute hepatitis and human Adenovirus infection.
14 Jul, 2022 | 12:56h | UTCA Case Series of Children with Acute Hepatitis and Human Adenovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Unexplained Acute Hepatitis in Children: More Evidence for Adenovirus 41 — Two studies point to a suspiciously high prevalence – MedPage Today (free registration required)
Commentaries on Twitter
A majority of children admitted to a single hospital in late 2021–early 2022 with acute hepatitis of unknown cause tested positive for adenovirus. This report describes the children’s illnesses and outcomes. https://t.co/QYvi6U1jUN pic.twitter.com/auPRq1duQm
— NEJM (@NEJM) July 13, 2022
From January–April 2022, 44 children with acute hepatitis of unknown cause were referred to a liver-transplantation center in the U.K. Six underwent liver transplantation. https://t.co/CMI4KCqdxM pic.twitter.com/og72u58L5R
— NEJM (@NEJM) July 13, 2022
Nationwide cohort study | Safety of heterologous primary and booster schedules with ChAdOx1-S and BNT162b2 or mRNA-1273 vaccines.
14 Jul, 2022 | 12:52h | UTC
M-A of RCTs | Megestrol Acetate not beneficial for cancer-related anorexia/cachexia.
14 Jul, 2022 | 12:50h | UTC
Coronary Artery Disease Reporting and Data System (CAD-RADS 2.0) reporting system for patients undergoing coronary CT angiography.
14 Jul, 2022 | 12:49h | UTCCommentary: SCCT Releases New Expert Consensus Document on CAD Reporting – American College of Cardiology