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New Consensus Definitions for Sepsis and Septic Shock

23 Feb, 2016 | 11:03h | UTC

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) – JAMA (free full text)

Editorial: New Definitions for Sepsis and Septic Shock: Continuing Evolution but With Much Still to Be Done – JAMA (free full text)

Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) – JAMA (free full text)

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) – JAMA (free full text)


Review article: cost effective strategies to reduce cardiovascular disease and related mortality

26 Feb, 2016 | 01:00h | UTC

Resource Effective Strategies to Prevent and Treat Cardiovascular Disease – Circulation (free full text)


Cochrane review: mild therapeutic hypothermia improves neurological outcome after cardiac arrest

22 Feb, 2016 | 12:57h | UTC

Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation – Cochrane Library (link to abstract – subscription required for full text)


IDSA and AASLD new guidelines for the treatment of Hepatitis C

26 Feb, 2016 | 00:22h | UTC

HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C – Infectious Diseases Society of America and American Association (IDSA) for The Study of Liver Diseases (AASLD)


ESC position paper on acute heart failure: which patients can be safely discharged from the emergency department and which require hospitalization?

22 Feb, 2016 | 13:34h | UTC

European Society of Cardiology – Acute Cardiovascular Care Association position paper on safe discharge of acute heart failure patients from the emergency department – European Heart Journal: Acute Cardiovascular Care (free full text)


Cochrane review: dopamine increases the risk of arrhythmia compared with norepinephrine and might increase mortality

23 Feb, 2016 | 11:25h | UTC

Vasopressors for hypotensive shock – Cochrane Library (link to abstract – subscription required for full text)


Canadian guidelines on screening for colorectal cancer recommend against colonoscopy

24 Feb, 2016 | 11:26h | UTC

Colorectal Cancer (2016): summary of recommendations for clinicians and policy makers – Canadian Task Force on Preventive Health Care (free full text)

Recommendations on screening for colorectal cancer in primary care [PDF] – Canadian Task Force on Preventive Health Care (free full text)

Canadian Guidelines Recommend Against Colonoscopy for Cancer Screening in Average-Risk Patients – NEJM Physician’s First Watch Commentary (Free)


Meta-analysis: treating anemia with erythropoietin-stimulating agents does not seem to improve health-related quality of life for patients with chronic Kidney Disease

19 Feb, 2016 | 19:04h | UTC

The Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – subscription required for full text)


Higher nurse to patient ratio linked to lower inpatient mortality

16 Feb, 2016 | 21:36h | UTC

Registered nurse, healthcare support worker, medical staffing levels and mortality in English hospital trusts: a cross-sectional study – BMJ Open (free full text)

Higher nurse to patient ratio linked to reduced risk of inpatient death – BMJ Blogs (free full text)


Meta-analysis: renin angiotensin system blockers are not superior to other antihypertensive drugs in people with diabetes

17 Feb, 2016 | 15:43h | UTC

Diabetes mellitus as a compelling indication for use of renin angiotensin system blockers: systematic review and meta-analysis of randomized trials – BMJ (free full text)


High-dose Vitamin D supplementation may increase risk of falls in elderly individuals

18 Feb, 2016 | 10:04h | UTC

Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial – JAMA (link to abstract – subscription required for full text)

High-Dose Vitamin D Supplementation Ups Elderly Fall Risk – Medscape Commentary (free registration required)


Meta-analysis: prevention strategies for contrast-induced nephropathy

21 Feb, 2016 | 14:18h | UTC

Effectiveness of Prevention Strategies for Contrast-Induced NephropathyA Systematic Review and Meta-analysis – Annals of Internal Medicine (free full text)


Warning symptoms frequently precede sudden cardiac arrest

14 Feb, 2016 | 18:05h | UTC

Warning Symptoms Are Associated With Survival From Sudden Cardiac Arrest – Annals of Internal Medicine (link to abstract – subscription required for full text)

Warning Symptoms Can Often Precede Sudden Cardiac Arrest: Cohort Study – Medscape Commentary (free registration required)


Videos explaining systematic reviews by Cochrane and NCCMT

12 Feb, 2016 | 12:50h | UTC

What are systematic reviews? – Cochrane

Types of Reviews: What kind of review do we need? – NCCMT (National Collaborating Centre for Methods and Tools)

Cochrane website

NCCMT website


Point of view: antibiotics may do more harm than good at the end of life

19 Feb, 2016 | 18:54h | UTC

Antibiotics may carry more cost than benefit for patients at end of life – ACP Hospitalist (free full text)


#HTA Free online course begins today

15 Feb, 2016 | 10:48h | UTC

Health Technology Assessment (HTA): Choosing Which Treatments Get Funded – Before new drugs or treatments are adopted, their effectiveness and cost must be assessed. Find out how in this online course


Proton pump inhibitors might increase dementia risk

16 Feb, 2016 | 16:22h | UTC

Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis – Jama Neurology (link to abstract – subscription required for full text)

Proton Pump Inhibitors Linked to Dementia – Medscape Commentary (free registration required)


Major trauma guidelines have just been released by NICE

17 Feb, 2016 | 15:33h | UTC

Major trauma: assessment and initial management – National Institute for Health and Care Excellence (NICE) (free full text)

Ensuring trauma care is delivered effectively and consistently – NICE news release (free full text)


New ISDA Guidelines for the Management of Candidiasis

10 Feb, 2016 | 15:21h | UTC

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America (free full text)

New Guideline Calls for Aggressive Treatment of Candidiasis – Medscape Commentary (free registration required)


New guidelines for antibiotic use in acute respiratory tract infections

9 Feb, 2016 | 13:04h | UTC

Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention (free full text)

CDC, ACP Issue Guideline on Antibiotic Use for RTIs – Medscape Commentary (free registration required)


Medscape slideshow – summary of new guidelines and recommendations from several different organizations

8 Feb, 2016 | 15:25h | UTC

New Guidelines and Recommendations – Medscape (free registration required)


NICE has published new guidance to improve and standardize the care for multiple myeloma

11 Feb, 2016 | 14:40h | UTC

Myeloma: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free full text)

Improving and standardizing care for people with incurable blood cancer – NICE news and features (free full text)


Early administration of antibiotics associated with lower mortality in hospitalized patients with community acquired pneumonia

12 Feb, 2016 | 12:35h | UTC

Antibiotic Therapy for Adults Hospitalized With Community-Acquired Pneumonia: A Systematic Review – JAMA (link to abstract – subscription required for full text)


New Guideline on perioperative care of the geriatric patient

10 Feb, 2016 | 07:32h | UTC

Optimal Perioperative Management of the Geriatric Patient: Best Practices Guideline from The American College of Surgeons and American Geriatrics Society (free full text)

Joint Guideline Addresses Geriatric Perioperative Care – Medscape Commentary (free registration required)


New guidelines for treating status epilepticus from the American Epilepsy Society

11 Feb, 2016 | 15:00h | UTC

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society (free full text)

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society [PDF] (free full text)

New Guideline for Treatment of Prolonged Seizures in Children and Adults – News Release from The American Epilepsy Society (free full text)


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