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Time-restricted eating (TRE) and high-intensity interval training (HIIT) both improve glucose control and reduce fat mass in people w/ obesity.

Combining TRE (<10 hour eating window) with 3 x weekly HIIT enhances these benefits.

🔗:https://t.co/m051O3AUPW pic.twitter.com/6q6mtzDwVB

— Brady Holmer (@B_Holmer) October 4, 2022

Under a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) license

Opinion | Is it time to reconsider the indications for surgery in patients with tennis elbow?

7 Feb, 2023 | 13:51h | UTC

Is it time to reconsider the indications for surgery in patients with tennis elbow? – The Bone & Joint Journal

Podcast | Hemochromatosis pearls

7 Feb, 2023 | 13:53h | UTC

#380 Hemochromatosis with Elliot Tapper – The Curbsiders

RCT | Higher complication rate after nail compared with plate fixation of ankle fractures in patients aged 60 years or older

7 Feb, 2023 | 13:50h | UTC

Higher complication rate after nail compared with plate fixation of ankle fractures in patients aged 60 years or older: a prospective, randomized controlled trial – The Bone & Joint Journal (link to abstract – $ for full-text)

M-A | Above elbow vs. below elbow immobilization for conservative treatment of distal end radius fracture in adults

7 Feb, 2023 | 13:49h | UTC

Comparison of above elbow and below elbow immobilisation for conservative treatment of distal end radius fracture in adults: A systematic review and meta-analysis of randomized clinical trials – Chinese Journal of Traumatology

An analysis of national action plans for antimicrobial resistance—gaps and opportunities in strategies optimizing antibiotic use

7 Feb, 2023 | 13:48h | UTC

An analysis of existing national action plans for antimicrobial resistance—gaps and opportunities in strategies optimising antibiotic use in human populations – The Lancet Global Health

Commentary on Twitter

Online First: An analysis of existing national action plans for antimicrobial resistance—gaps and opportunities in strategies optimising antibiotic use in human populations https://t.co/Ox0sEwFWgQ pic.twitter.com/cjOVpIblnJ

— The Lancet Global Health (@LancetGH) February 6, 2023

Complications of diagnostic upper gastrointestinal endoscopy: recognition, assessment and management

7 Feb, 2023 | 13:41h | UTC

Complications of diagnostic upper Gastrointestinal endoscopy: common and rare – recognition, assessment and management – BMJ Open Gastroenterology

M-A | Effectiveness of therapeutic exercise models on cancer-related fatigue

7 Feb, 2023 | 13:46h | UTC

Effectiveness of Therapeutic Exercise Models on Cancer-Related Fatigue in Patients with Cancer Undergoing Chemotherapy: A Systematic Review and Network Meta-Analysis – Archives of Physical Medicine and Rehabilitation

Commentary: What is the effectiveness of different exercise modalities in reducing cancer-related fatigue in cancer patients undergoing chemotherapy? – News Medical

ASCO Guideline: Exercise, diet, and weight management during cancer treatment.

A systematic review of rehabilitation and exercise recommendations in oncology guidelines

Five reasons physical activity is important for cancer patients – The Conversation

RCT | Effects of a physical exercise intervention during vs. after chemotherapy to improve cardiorespiratory fitness.

Review | Prevention and management of minor complications in percutaneous endoscopic gastrostomy

7 Feb, 2023 | 13:39h | UTC

Prevention and management of minor complications in percutaneous endoscopic gastrostomy – BMJ Open Gastroenterology

Cohort Study | Neurodevelopmental outcomes after late-onset meningitis in children born extremely preterm

7 Feb, 2023 | 13:38h | UTC

Incidence of and Neurodevelopmental Outcomes After Late-Onset Meningitis Among Children Born Extremely Preterm – JAMA Network Open

Commentary: Late-Onset Meningitis ID’d in 1 Percent of Extreme Preemies – HealthDay

Commentary on Twitter

A cohort study in @JAMANetworkOpen examines neurodevelopmental outcomes in infants born < 26 weeks with late onset meningitis https://t.co/AmnRiKaeYt #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/USlLDbG2UY

— Evidence-Based Neo (@EBNEO) December 28, 2022

Review | Valvular heart disease: shifting the focus to the myocardium

7 Feb, 2023 | 13:37h | UTC

Valvular heart disease: shifting the focus to the myocardium – European Heart Journal

Commentary on Twitter

Valvular heart disease: shifting the focus to the myocardium https://t.co/u1Nu7nnQvq @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/QFM8BJItRl

— European Society of Cardiology Journals (@ESC_Journals) October 10, 2022

Review | Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury

7 Feb, 2023 | 13:32h | UTC

Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury: A narrative review – Frontiers in Physiology

Cohort Study | The use of 5-alfa-reductase inhibitors may increase the risk of depression, but not dementia

7 Feb, 2023 | 13:35h | UTC

Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide – JAMA Network Open

Commentary: 5α-Reductase Inhibitors Linked to Depression, but Not Dementia – HealthDay

Can the future of ID escape the inertial dogma of its past? The exemplars of shorter is better and oral is the new IV

7 Feb, 2023 | 13:34h | UTC

Can the Future of ID Escape the Inertial Dogma of Its Past? The Exemplars of Shorter Is Better and Oral Is the New IV – Open Forum Infectious Diseases

Updating international consensus on best practice in care of the dying: a Delphi study

6 Feb, 2023 | 13:41h | UTC

Updating international consensus on best practice in care of the dying: A Delphi study – Palliative Medicine

ACG Guideline | Management of patients with acute lower gastrointestinal bleeding

6 Feb, 2023 | 13:43h | UTC

Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline

Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Endoscopy

Randomized Trial: Efficacy and Safety of Early vs. Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding

[Abstract Only] Systematic Review: Early Colonoscopy Does Not Improve Outcomes of Patients with Lower Gastrointestinal Bleeding

Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology – Gut

Update guidelines for women with HIV who are virally suppressed incorporate breastfeeding their infants as a viable option

6 Feb, 2023 | 13:40h | UTC

Update to Clinical Guidelines for Infant Feeding Supports Shared Decision Making: Clarifying Breastfeeding Guidance for People with HIV – HIV.gov

Commentary on Twitter

Updated guidelines now incorporate breastfeeding options for PWH with suppressed VL on ART. https://t.co/JPR1K8zzv6

— Carlos del Rio (@CarlosdelRio7) February 3, 2023

Phase 2 RCT | Baxdrostat for treatment-resistant hypertension

6 Feb, 2023 | 13:38h | UTC

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: A Study of CIN-107 in Adults With Treatment-Resistant Hypertension – BrigHTN – American College of Cardiology

Commentary on Twitter (thread – click for more)

Aldosterone has long been a pharmacologic target for the treatment of hypertension. However, a new small-molecule drug called baxdrostat inhibits aldosterone synthase in patients with treatment-resistant hypertension. 1/14 pic.twitter.com/F27WE4Wa1d

— NEJM (@NEJM) February 3, 2023

Opinion | Hospital masking should be optional

6 Feb, 2023 | 13:37h | UTC

Hospital masking should be optional – Sensible Medicine

RCT | Personalized accelerated pacing may improve QOL in patients with heart failure with preserved EF

6 Feb, 2023 | 13:35h | UTC

Effect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrillation in Patients With Preclinical and Overt Heart Failure With Preserved Ejection Fraction: The myPACE Randomized Clinical Trial – JAMA Cardiology (free for a limited period)

News Release: Speeding up heart rate helps heart failure patients with stiff hearts – University of Minnesota Medical School

Commentary on Twitter

In study of patients with HFpEF and pacemakers, moderately accelerated pacing (median pacing rate 75bpm) improved health-related QOL, natriuretic peptide levels, activity levels, and Afib compared w/ standard 60 bpm setting. https://t.co/Ow3W3qD6DM @maggieinfeld @markusmeyermd

— JAMA Cardiology (@JAMACardio) February 1, 2023

Case-control study | Estimation of vaccine effectiveness of CoronaVac and BNT162b2 in patients with SARS-CoV-2 Omicron

6 Feb, 2023 | 13:32h | UTC

Estimation of Vaccine Effectiveness of CoronaVac and BNT162b2 Against Severe Outcomes Over Time Among Patients With SARS-CoV-2 Omicron – JAMA Network Open

Commentary on Twitter

The CoronaVac and BNT162b2 (Pfizer) vaccines were effective against severe outcomes due to Omicron (74-77%), but protection among older individuals in Hong Kong was more likely to wane 6 months after the second dose; boosters can bring effectiveness >90%. https://t.co/kqgwryJ1kT

— JAMA Network Open (@JAMANetworkOpen) February 3, 2023