Archives
Research: Antipsychotics and Mortality in Patients With Schizophrenia
23 Jan, 2018 | 13:33h | UTCAntipsychotics and mortality in a nationwide cohort of 29,823 patients with schizophrenia – Schizophrenia Research (free) (via @psychopharmacol see Tweet)
Systematic Review: Clopidogrel plus Aspirin vs Aspirin Alone for Preventing Cardiovascular Events
23 Jan, 2018 | 13:27h | UTCClopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events – Cochrane Library (free)
Summary: Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events (free)
Mon, January 22 – 10 Stories of The Day!
22 Jan, 2018 | 00:11h | UTC
Commentaries: The Definitive Word on Steroids in Septic Shock – Emergency Medicine Literature of Note (free) AND Adrenal – The Bottom Line (free)
“For the primary outcome, there was no statistically significance difference in mortality at 90 days – 27.9% in the hydrocortisone cohort, and 28.8% with placebo. Looking at secondary outcomes, the results here tended to favor hydrocortisone – a slightly faster resolution of shock, shorter ICU stays, and, oddly, decreased transfusion requirements”. (from Emergency Medicine Literature of Note Blog)
2 – Critical Care Reviews Book 2018 (free PDF)
“The Critical Care Reviews Book summarizes, critiques and puts in context the biggest trials of the year”.
Commentary: Evidence Supports ‘Weekend Effect’ for Mortality after Surgery – Wolters Kluwer, via NewsWise (free)
“The odds of postoperative mortality were 27 percent higher for patients admitted to the hospital on Saturday or Sunday, compared to those hospitalized on a weekday” (from NewsWise).
4 – Women’s reproductive factors and incident cardiovascular disease in the UK Biobank – Heart (link to abstract – $ for full-text)
Commentaries: Starting periods before age of 12 linked to heightened risk of heart disease and stroke – The BMJ, via EurekAlert (free) AND Early periods linked to heightened cardiovascular risk – OnMedica (free) AND Starting periods early linked to health risks later in life – Medical News Today (free) AND Early menarche and menopause linked to cardiovascular disease risk – The Guardian (free)
5 – To improve global health, tax the things that are killing us – Financial Times (free)
Related: The Case for the Health Taxes – The New York Times (10 articles per month are free) AND Mexico and Hungary tried junk food taxes — and they seem to be working – VOX (free) AND Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian (free)
Related Policies, Guidelines and Commentaries (all free): Beverage consumption taxes on sugar-sweetened beverages AND The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities AND Fiscal policies for the prevention of diseases AND Reducing cardiovascular disease burden through targeted dietary policies
“The duration of treatment rather than dose is more strongly associated with opioid misuse after surgery, concludes this study” (via @bmj_latest see Tweet)
Commentaries: Study confirms flu spreads by aerosols, not just coughs, sneezes – CIDRAP (free) AND Flu may be spread just by breathing, new UMD-led study shows – University of Maryland, via EurekAlert (free)
10 – Staying on antidepressants may prevent a relapse of anxiety – NIHR Signals (free)
Original article: Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)
Clinical Guideline on the Management of Uncomplicated Urinary Tract Infections
21 Jan, 2018 | 17:05h | UTCThe 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients: Part 1 – Karger, Urologia Internationalis (free) (via @CIDRAP_ASP see Tweet)
Tue, January 23 – 10 Stories of The Day!
23 Jan, 2018 | 01:20h | UTC
1 – Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Hyperthermic intraperitoneal chemotherapy with surgery increases survival for epithelial ovarian cancer patients – 2 Minute Medicine (free) AND Add-On Hyperthermic Intraperitoneal Chemotherapy Assessed in Ovarian CA – MPR (free)
Patients treated with hyperthermic intraperitoneal chemotherapy associated with surgery had increased median overall survival compared to patients treated with surgery alone (45,7 months vs 33,9 months).
Related: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free) AND AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)
4 – Review: Treatment of anxiety disorders – Dialogues in Clinical Neuroscience (free)
5 – Review: Update on the management of venous thromboembolism – Cleveland Clinic Journal of Medicine (free)
6 – Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials – Critical Care (free) (via @fpereirapa)
7 – Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy? – Journal of General Internal Medicine (free for a period)
Related: Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free) AND Users’ guide to the surgical literature: how to assess a noninferiority trial – Canadian Journal of Surgery (free)
8 – Richard Lehman’s journal review, 22 January 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Commentary: Let’s Talk About End-of-Life Care – National Comprehensive Cancer Network, via NewsWise (free)
“…majority of people with cancer would like their physicians to ask them where they would prefer to receive end-of-life care” (from NewsWise).
Commentaries in the same issue: Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Significant Step Forward and a Model for Other High-Risk Industries (free) AND What an Evidence-based Guideline for Fatigue Risk Management Means for Us: Statements From Stakeholders (free) AND Proposed Performance Measures and Strategies for Implementation of the Fatigue Risk Management Guidelines for Emergency Medical Services (free) AND Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Step in the Right Direction Toward Better Sleep Health (free)
Video: Pandemics – a Worrying Global Public Health Threat
21 Jan, 2018 | 17:00h | UTCPandemics – a worrying global public health threat (free) (via @RSTMH see Tweet)
Related: The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) AND Is It Possible to Predict the Next Pandemic? – The Atlantic (free) AND Stopping Pandemics Before They Start – The New York Times (10 articles per month are free)
Research: Single Dose Moxidectin vs Ivermectin for Onchocerca Volvulus Infection
21 Jan, 2018 | 16:59h | UTCEditorial: A new powerful drug to combat river blindness (free)
Research: Detection of Surgically Resectable Cancers with a Multi-analyte Blood Test
21 Jan, 2018 | 17:03h | UTCDetection and localization of surgically resectable cancers with a multi-analyte blood test – Science (link to abstract – $ for full-text)
Commentaries: Simple blood test detects eight different kinds of cancer – Nature News (free) A new blood test can detect eight different cancers in their early stages – The Conversation (free) AND CancerSEEK: Blood Test That Detects Eight Common Cancers – Medscape (free registration required) AND Scientists Edge Closer To A Blood Test To Detect Cancers – NPR (free) And Blood test could use DNA to spot early-stage cancers, study shows – The Guardian (free)
The Best Response to Medical Errors? Transparency
21 Jan, 2018 | 14:33h | UTCThe Best Response to Medical Errors? Transparency – AAMC News (free)
Related: The Michigan Model: Medical Malpractice and Patient Safety at UMHS (free)
Perspective: Assessing the New Blood-Pressure Guidelines
21 Jan, 2018 | 17:01h | UTCPerspective: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free)
Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)
Early Palliative Care: a Video for Health and Care Professionals
21 Jan, 2018 | 14:29h | UTCVideo: Early Palliative Care: a video for health and care professionals – University of Edinburgh (free) (via @OUPMedicine see Tweet)
Related: Early palliative care for adults with advanced cancer – Cochrane Library (free summary and original article) AND How Early Palliative Care May Benefit Patients With Incurable Cancer – ASCO Post (free)
Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)
Research: Association of Dietary Inflammatory Potential With Colorectal Cancer Risk
21 Jan, 2018 | 14:34h | UTCAuthor interview: Dietary Inflammatory Potential and Risk of Colorectal Cancer in Men and Women (free)
Commentary: Why certain diets may increase your cancer risk – VOX (free)
Systematic Review: Patient Reminder and Recall Interventions to Improve Immunization Rates
21 Jan, 2018 | 14:32h | UTCPatient reminder and recall interventions to improve immunization rates – Cochrane Library (link to abstract – $ for full-text)
Commentaries: Boosting vaccination rates with reminders: new Cochrane evidence – Evidently Cochrane (free) AND Sending out reminders/recalls can drive up immunisation rates – OnMedica (free) AND Patient Reminders Improve Vaccination Rates in Primary Care – Physician’s First Watch (free)
Research: Household-Contact Investigation for Detection of Tuberculosis in Vietnam
21 Jan, 2018 | 14:27h | UTCQuick Take Video Summary: Contact Investigation for Tuberculosis (free)
Opinion: The Corruption of Medical Language
21 Jan, 2018 | 14:23h | UTCRichard Smith: The corruption of medical language – The BMJ Opinion (free)
Related: It’s not just you: science papers are getting harder to read – Nature (free) ‘It’s time to make sure research is understandable to all’ – The Telegraph (free) AND Scientific language is becoming more informal – Nature (free)
“Too often, academic journals are filled with complex language and turgid prose, which is intended not to inform the reader but to ennoble the writer”. (via @bmj_latest see Tweet)
New Catalogue of Bias – CEBM, University of Oxford
21 Jan, 2018 | 14:25h | UTCCatalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)
“25 biases affecting evidence on health kick off the new @CebmOxford Catalog of Bias” (via @hildabast see Tweet)
Research: Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance
21 Jan, 2018 | 14:26h | UTCLong-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Monoclonal Gammopathy of Undetermined Significance: Risk for Progression to Cancer, Other Disorders Examined – Physician’s First Watch (free) AND Patients with blood cancer precursor at risk of developing cancer even after 30 years – Mayo Clinic, via EurekAlert (free)
Research: Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass
21 Jan, 2018 | 14:21h | UTCEffect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Related article: Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid ObesityThe SM-BOSS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Laparoscopic Gastric Sleeve Compared to Bypass Bariatric Surgery – RheumNow (free) AND No Clinical Significance in Weight Loss Among Sleeve Gastrectomy and Gastric Bypass Patients – AJMC (free) AND Weight-Loss Surgery Approaches Offer Similar Results – MedPage Today (free registration required) AND Rise of Sleeve Gastrectomy Is No Therapeutic Misadventure – Medscape (free registration required) AND Newer weight-reduction surgery effective, but may worsen acid reflux – Reuters (free)
Meta-analysis: Identifying Older Adults at Risk of Harm Following Elective Surgery
21 Jan, 2018 | 14:24h | UTCCommentary : Age itself is not a risk factor for complications after surgery among older patients – OnMedica (free)
“Q: What predicts poor outcome after elective surgery in older people?
A: Frailty, cognitive impairment, depression, smoking but NOT age per se”. (via @trishgreenhalgh see Tweet)
Research: Association of Bariatric Surgery vs Usual Care Obesity Management With All-Cause Mortality
21 Jan, 2018 | 14:22h | UTCAssociation of Bariatric Surgery Using Laparoscopic Banding, Roux-en-Y Gastric Bypass, or Laparoscopic Sleeve Gastrectomy vs Usual Care Obesity Management With All-Cause Mortality – JAMA (link to abstract – $ for full-text)
Commentaries: Bariatric Surgery Prolongs Lifespan in Obese – Northwestern University, via NewsWise (free) AND Obesity surgery ‘halves risk of death’ compared with lifestyle changes – The Guardian (free) AND Bariatric Tx Bests Usual Care for Long-Term Health – MedPage Today (free registration required)
Research: Adverse Effects of Caffeinated Energy Drinks Among Youth and Young Adults in Canada
21 Jan, 2018 | 14:12h | UTCCommentaries: Over half of 12-24 year olds have side effects from energy drinks, survey reports – NHS Choices (free) AND Energy drinks can negatively impact health of youth – University of Waterloo, via ScienceDaily (free)
Related Position Statement: Energy and sports drinks in children and adolescents – Canadian Pediatric Society (free)
USPSTF Says Evidence is Insufficient to Recommend Ankle-Brachial Index, CRP, or Coronary Calcium
21 Jan, 2018 | 14:15h | UTCUSPSTF Not Backing Ankle-Brachial Index, CRP, or Coronary Calcium – MedPage Today (free registration required) AND No Change in USPSTF’s Stance on Using Nontraditional Risk Factors to Assess CV Risk – Physician’s First Watch (free)
Draft Recommendation Statement 1: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors – USPSTF (free)
Draft Recommendation Statement 2: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index (free)
“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), or coronary artery calcification (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.
Research: Bariatric Surgery vs Medical Obesity Treatment in Long-term Outcomes
21 Jan, 2018 | 14:18h | UTCAssociation of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities – JAMA (link to abstract – $ for full-text)
Commentaries: Bariatric Surgery for Obesity Reduces Some Risks, Raises Others – Medscape (free registration required)
Case Report – Snap, Crackle and Pop: When Sneezing Leads to Crackling in the Neck
21 Jan, 2018 | 14:08h | UTCSnap, crackle and pop: when sneezing leads to crackling in the neck – BMJ Case Reports (free)
Commentaries: Man Ruptures His Throat By Stifling A Big Sneeze, Prompting Doctors’ Warning – NPR (free) AND Here Is What Can Happen If You Hold In A Sneeze – Forbes (free)
Interest in the Ketogenic Diet Grows for Weight Loss and Type 2 Diabetes
21 Jan, 2018 | 14:11h | UTCMedical News & Perspectives: Interest in the Ketogenic Diet Grows for Weight Loss and Type 2 Diabetes – JAMA (free for a period)