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Systematic Review: Marijuana Use and Cardiovascular Risk Factors and Outcomes

25 Jan, 2018 | 23:47h | UTC

Associations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Insufficient evidence to determine if marijuana use can affect cardiovascular risk – 2 Minute Medicine (free) AND Scant Evidence for Heart Benefits, Risks with Cannabis – MedPage Today (free registration required)

 


Systematic Review: Interventions to Reduce Adverse Gastrointestinal Effects of Pelvic Radiotherapy for Primary Pelvic Cancers

25 Jan, 2018 | 23:50h | UTC

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers – Cochrane Library (free)

Summary: Interventions to reduce digestive side effects of pelvic x-ray treatment – Cochrane Library (free)

 


Concerns About Composite Reference Standards in Diagnostic Research

25 Jan, 2018 | 23:43h | UTC

Research Methods & Reporting: Concerns about composite reference standards in diagnostic research – The BMJ (free)

 


Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors

25 Jan, 2018 | 23:44h | UTC

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology (free PDF)

Commentary: Leading medical organizations update lung cancer guideline – International Association for the Study of Lung Cancer, via EurekAlert (free)

 


Busting 10 Common Myths about the “Greatest Pandemic in History”

25 Jan, 2018 | 21:03h | UTC

Busting 10 Common Myths about the “Greatest Pandemic in History” – Scientific American (free)

 


Guideline: Laboratory Tests to Monitor Drug Therapy in Pain Management Patients

25 Jan, 2018 | 21:04h | UTC

Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients – American Association for Clinical Chemistry (AACC) (free PDF)

Commentary: AACC Releases Practice Guidelines for Using Laboratory Drug Tests to Combat Opioid Addiction, Overdoses – American Association for Clinical Chemistry (AACC) (free)

 


Guideline: Nutrition in Critically Ill Patients

25 Jan, 2018 | 21:02h | UTC

An Iranian Consensus Document for Nutrition in Critically Ill Patients, Recommendations and Initial Steps toward Regional Guidelines – Tanaffos (free)

Source: Critical Care Reviews Newsletter

 


Review: Cardiorenal Syndrome in Sepsis

25 Jan, 2018 | 21:00h | UTC

Cardiorenal syndrome in sepsis: A narrative review – Journal of Critical Care (free)

Source: Critical Care Reviews Newsletter

 


Do You Work More Than 39 Hours a Week? Your Job Could be Killing You

25 Jan, 2018 | 21:01h | UTC

Do you work more than 39 hours a week? Your job could be killing you – The Guardian (free)

 


Guideline: Neuroendovascular Management of Emergent Large Vessel Occlusion

25 Jan, 2018 | 20:58h | UTC

Neuroendovascular management of emergent large vessel occlusion: update on the technical aspects and standards of practice by the Standards and Guidelines Committee of the Society of NeuroInterventional Surgery (free)

 


Position Statement: Cross-infection Risk in Patients with Bronchiectasis

25 Jan, 2018 | 20:57h | UTC

Cross-infection risk in patients with bronchiectasis: a position statement from the European Bronchiectasis Network (EMBARC), EMBARC/ELF patient advisory group and European Reference Network (ERN-Lung) Bronchiectasis Network (free)

 


Systematic Review: Routine Antibiotic Prophylaxis After Normal Vaginal Birth

25 Jan, 2018 | 20:56h | UTC

Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity – Cochrane Library (link to abstract – $ for full-text)

Related Guideline: Antibiotic Prophylaxis in Obstetric Procedures – Society of Obstetricians and Gynaecologists of Canada (free)

 


Guideline: Leptospirosis

25 Jan, 2018 | 20:59h | UTC

Leptospirosis: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine – Journal of Critical Care (free)

Source: Critical Care Reviews Newsletter

 


Research: Incidence of STI Before and After Pre-Exposure Prophylaxis for HIV

25 Jan, 2018 | 20:51h | UTC

Incidence of sexually transmitted infections before and after Pre-Exposure Prophylaxis for HIV: a cohort study – AIDS (link to abstract – $ for full-text)

Commentary: Preexposure Prophylaxis for HIV Tied to Increased STI Rates – Medscape (free registration required)

 


Gene Editing – And What it Really Means to Rewrite the Code of Life

25 Jan, 2018 | 20:53h | UTC

Gene editing – and what it really means to rewrite the code of life – The Guardian (free)

Related: Correction of a pathogenic gene mutation in human embryos (free articles and commentaries) AND Simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free)

 


Research: Socioeconomic Outcomes of Women Who Receive and Women Who Are Denied Wanted Abortions

25 Jan, 2018 | 20:52h | UTC

Socioeconomic Outcomes of Women Who Receive and Women Who Are Denied Wanted Abortions in the United States – American Journal of Public Health (free PDF)

Commentary: Opinion: Restricting access to abortion makes poor women poorer – LA Times (free)

 


Review: Biology and Therapy of Medullary Thyroid Carcinoma

25 Jan, 2018 | 20:46h | UTC

Recent advances in the biology and therapy of medullary thyroid carcinoma – F1000 Research (free)

 


Research: Association of Depression With Mortality in Older Adults Undergoing TAVR and SAVR

25 Jan, 2018 | 20:50h | UTC

Association of Depression With Mortality in Older Adults Undergoing Transcatheter or Surgical Aortic Valve Replacement – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: Depression May Increase Risk of Death Following Heart Procedure, Study Suggests – Psychiatric News Alert (free) AND One-Third of TAVR and SAVR Patients Are Depressed, Upping Mortality Risk – TCTMD (free) AND Association of Depression With Mortality After SAVR and TAVR – American College of Cardiology, Latest in Cardiology (free)

 


Review: Sleep Apnea and its Role in Transportation Safety

25 Jan, 2018 | 20:45h | UTC

Sleep apnea and its role in transportation safety – F1000 Research (free)

 


Review: Vancomycin-resistant Enterococcus Infection in the Hematopoietic Stem Cell Transplant Recipient

25 Jan, 2018 | 20:48h | UTC

Vancomycin-resistant enterococcus infection in the hematopoietic stem cell transplant recipient: an overview of epidemiology, management, and prevention – F1000 Research (free)

 


Wed, January 24 – 10 Stories of The Day!

24 Jan, 2018 | 01:18h | UTC

 

1 – Report: Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free PDF)

Press release: New Report One of the Most Comprehensive Studies on Health Effects of E-Cigarettes; Finds That Using E-Cigarettes May Lead Youth to Start Smoking, Adults to Stop Smoking (free)

Commentaries: E-Cigarettes Likely Encourage Kids To Try Tobacco But May Help Adults Quit – NPR (free) AND 4 big takeaways from the most comprehensive report on e-cigarettes yet – VOX (free) AND Vaping Can Be Addictive and May Lure Teenagers to Smoking, Science Panel Concludes – The New York Times (10 articles per month are free)

  

2 – Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study – The BMJ (free)

See prognostic calculator: Prediction models for 3 month outcome after aSAH

 

3 – Antithyroid Drugs and Congenital Malformations: A Nationwide Korean Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: First trimester exposure to antithyroid drugs associated with increased risk of birth defects – 2 Minute Medicine (free) AND Use of Antithyroid Drugs Early in Pregnancy Tied to Birth Defect Risk – Physician’s First Watch (free) AND First trimester exposure to antithyroid drugs linked with birth defects – OnMedica (free)

 

4 – Advocacy for Improving Nutrition in the First 1000 Days To Support Childhood Development and Adult Health – Pediatrics (free)

Commentary: AAP Issues Recommendations for Improving Early-Childhood Nutrition – Physician’s First Watch (free) AND These Are the Best Foods for a Baby’s Brain – TIME (free)

 

5 – Robust research needs many lines of evidence – Nature (free)

 

6 – Parkinson’s disease in the ED: a potpourri of hyperpyrexia, dyskinesias, psychosis, and autonomic dysfunction – emDocs (free)

 

7 – Management of severe community acquired pneumonia in the emergency department – Journal of Emergency Medicine and Critical Care (free)

Source: Critical Care Reviews Newsletter

 

8 – Choosing Wisely Campaign: American Society of Breast Surgeons – Benign Breast Disease: Five Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: 5 Procedures to Avoid in Benign Breast Disease – Physician’s First Watch (free)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

9 – Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Propranolol May Help Patients With PTSD – Psychiatric News Alert (free) AND Propranolol May Fill ‘Dire’ Treatment Need for PTSD – Medscape (free registration required)

 

10 – Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)

Original article: Implications for a policy of initiating antiretroviral therapy in people diagnosed with human immunodeficiency virus: the CAPRA research programme – Programme Grants for Applied Research (free)

 


Review: Predictors of Outcome in Phaeochromocytomas and Paragangliomas

25 Jan, 2018 | 20:42h | UTC

Predictors of outcome in phaeochromocytomas and paragangliomas – F1000 Research (free)

 


Thu, January 25 – 10 Stories of The Day!

25 Jan, 2018 | 00:56h | UTC

 

1 – 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)

Commentaries: More stroke patients eligible for crucial treatments under new guidelines – American Heart Association News (free) AND More stroke patients may receive crucial treatments under new guideline – AHA/ASA Newsroom (free)

A new guideline for treating acute ischemic stroke recommends an increased treatment window for mechanical clot removal from six hours to up to 24 hours in certain patients with clots in large vessels”. (from AHA/ASA Newsroom)

 

2 – Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging – New England Journal of Medicine (free)

Commentaries: Brain-scan guided emergency stroke treatment can save more lives – NIH News Releases (free) AND Study confirms late clot extraction can save brain cells of stroke victims – Reuters (free) AND New Findings Could Save Lives of More Stroke Patients – The New York Times (10 articles per month are free)

Related article: Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (link to abstract – $ for full-text)

 

3 – Perspectives: To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free)

 

4 – Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus – JAMA Neurology (free for a period)

Editorial: Time May Be of the Essence in the Treatment of Pediatric Patients With Refractory Convulsive Status Epilepticus (free)

Commentary: Delays Raise Death Risk in Kids with Status Epilepticus – MedPage Today (free registration required)

“These findings may change the perception of acute seizure and status epilepticus treatment, tentatively converting it into an extremely time-sensitive emergency that is similar to stroke or other cardiovascular events”.

 

5 – Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Related: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

6 – ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis – European Journal of Neurology (free)

 

7 – Guideline: Oesophago-gastric cancer: assessment and management in adults – National Institute for Health and Care Excellence (NICE) (free)

 

8 – Guideline: Age-related macular degeneration – National Institute for Health and Care Excellence (NICE) (free)

 

9 – Association Between Left Atrial Appendage Occlusion and Readmission for Thromboembolism Among Patients With Atrial Fibrillation Undergoing Concomitant Cardiac Surgery – JAMA (free)

Commentaries: Largest Study to Date Supports Surgical LAA Closure in A-fib Patients – TCTMD (free) AND Thromboembolism Less Likely With LAA Closure Added to Cardiac Surgery – MedPage Today (free registration required)

Randomized trials are needed to confirm these interesting findings. 

 

10 – Trends in Survival After In-Hospital Cardiac Arrest During Nights and Weekends – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Survival From In-Hospital Cardiac Arrest Improves But Still Worse on Nights and Weekends – MedicalResearch.com (free)

AND Hospital patients less likely to survive ‘off-hours’ cardiac arrest – Reuters (free) AND You are still more likely to die in a hospital on the weekend – CNN (free)

See also a recent meta-analysis showing the “weekend effect” in surgical patients

 


Review: Electroanalgesia and Laser Therapies for Pain Management

25 Jan, 2018 | 20:44h | UTC

Use of electroanalgesia and laser therapies as alternatives to opioids for acute and chronic pain management – F1000 Research (free)

 


Guideline Synopsis: Management of High Blood Pressure in Adults

23 Jan, 2018 | 16:57h | UTC

Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline – Annals of Internal Medicine (free)

Related: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free) AND AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)

 


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