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“Broadly, overdiagnosis means making people patients unnecessarily, by identifying problems that were never going to cause harm or by medicalising ordinary life experiences through expanded definitions of diseases”.

3 – Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline – Canadian Medical Association Journal (free)

4 – Shorter Versus Longer Courses of Antibiotics for Infection in Hospitalized Patients: A Systematic Review and Meta-Analysis – Journal of Hospital Medicine (free PDF)

Source: Hospital Medicine Virtual Journal Club

5 – Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States – JAMA (free for a period)

Commentaries: Birth defects climb in US areas with local Zika – CIDRAP (free) AND More birth defects in U.S. areas with Zika: U.S. health officials – Reuters (free)

6 – Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study – PLOS One (free)

Commentaries: Women who have gestational diabetes in pregnancy are at higher risk of future health issues – University of Birmingham, via ScienceDaily (free) AND Target Patients With Gestational Diabetes After Birth to Reduce Risks – Medscape (free registration required)

7 – Association of Exposure to Communities With Higher Ratios of Obesity with Increased Body Mass Index and Risk of Overweight and Obesity Among Parents and Children – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Your Neighbors, Your Waistline – New York Times (10 articles per month are free) AND Is ‘Social Contagion’ at Play When It Comes to Obesity Risk? – MedPage Today (free registration required) AND Location of military assignment tied to obesity risk for families – Cardiovascular Business (free)

8 – Richard Lehman’s journal review, 29 January 2018 – The BMJ Opinion (free)

9 – WSES guidelines for the management of iatrogenic colonoscopy perforation – World Journal of Emergency Surgery (free)

10 – EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice – Annals of Rheumatic Diseases (free)

To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis

26 Jan, 2018 | 01:42h | UTC

Perspectives: To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free)

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke

26 Jan, 2018 | 01:44h | UTC

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)

Commentaries: More stroke patients eligible for crucial treatments under new guidelines – American Heart Association News (free) AND More stroke patients may receive crucial treatments under new guideline – AHA/ASA Newsroom (free)

“A new guideline for treating acute ischemic stroke recommends an increased treatment window for mechanical clot removal from six hours to up to 24 hours in certain patients with clots in large vessels”. (from AHA/ASA Newsroom)

Research: Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus

26 Jan, 2018 | 01:39h | UTC

Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus – JAMA Neurology (free for a period)

Editorial: Time May Be of the Essence in the Treatment of Pediatric Patients With Refractory Convulsive Status Epilepticus (free)

Commentary: Delays Raise Death Risk in Kids with Status Epilepticus – MedPage Today (free registration required)

“These findings may change the perception of acute seizure and status epilepticus treatment, tentatively converting it into an extremely time-sensitive emergency that is similar to stroke or other cardiovascular events”.

Research: Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

26 Jan, 2018 | 01:43h | UTC

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging – New England Journal of Medicine (free)

Commentaries: Brain-scan guided emergency stroke treatment can save more lives – NIH News Releases (free) AND Study confirms late clot extraction can save brain cells of stroke victims – Reuters (free) AND New Findings Could Save Lives of More Stroke Patients – The New York Times (10 articles per month are free)

Related article: Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (link to abstract – $ for full-text)

Guideline: Deprescribing Antipsychotics for Behavioural and Psychological Symptoms of Dementia and Insomnia

26 Jan, 2018 | 01:37h | UTC

Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Guideline: Oesophago-Gastric Cancer

26 Jan, 2018 | 01:32h | UTC

Guideline: Oesophago-gastric cancer: assessment and management in adults – National Institute for Health and Care Excellence (NICE) (free)

Guideline: Age-related macular degeneration

26 Jan, 2018 | 01:31h | UTC

Guideline on the Pharmacological Treatment of People with Multiple Sclerosis

26 Jan, 2018 | 01:33h | UTC

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis – European Journal of Neurology (free)

Research: Trends in Survival After In-Hospital Cardiac Arrest During Nights and Weekends

26 Jan, 2018 | 01:26h | UTC

Trends in Survival After In-Hospital Cardiac Arrest During Nights and Weekends – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Survival From In-Hospital Cardiac Arrest Improves But Still Worse on Nights and Weekends – MedicalResearch.com (free)

AND Hospital patients less likely to survive ‘off-hours’ cardiac arrest – Reuters (free) AND You are still more likely to die in a hospital on the weekend – CNN (free)

Research: Left Atrial Appendage Occlusion and Readmission for Thromboembolism Among Patients With Atrial Fibrillation Undergoing Concomitant Cardiac Surgery

26 Jan, 2018 | 01:29h | UTC

Association Between Left Atrial Appendage Occlusion and Readmission for Thromboembolism Among Patients With Atrial Fibrillation Undergoing Concomitant Cardiac Surgery – JAMA (free)

Commentaries: Largest Study to Date Supports Surgical LAA Closure in A-fib Patients – TCTMD (free) AND Thromboembolism Less Likely With LAA Closure Added to Cardiac Surgery – MedPage Today (free registration required)

Randomized trials are needed to confirm these interesting findings.

Guideline: Advocacy for Improving Nutrition in the First 1000 Days To Support Childhood Development and Adult Health

26 Jan, 2018 | 01:20h | UTC

Advocacy for Improving Nutrition in the First 1000 Days To Support Childhood Development and Adult Health – Pediatrics (free)

Commentary: AAP Issues Recommendations for Improving Early-Childhood Nutrition – Physician’s First Watch (free) AND These Are the Best Foods for a Baby’s Brain – TIME (free)

Report: Public Health Consequences of E-Cigarettes

26 Jan, 2018 | 01:24h | UTC

Report: Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free PDF)

Press release: New Report One of the Most Comprehensive Studies on Health Effects of E-Cigarettes; Finds That Using E-Cigarettes May Lead Youth to Start Smoking, Adults to Stop Smoking (free)

Commentaries: E-Cigarettes Likely Encourage Kids To Try Tobacco But May Help Adults Quit – NPR (free) AND 4 big takeaways from the most comprehensive report on e-cigarettes yet – VOX (free) AND Vaping Can Be Addictive and May Lure Teenagers to Smoking, Science Panel Concludes – The New York Times (10 articles per month are free)

Research: Antithyroid Drugs and Congenital Malformations

26 Jan, 2018 | 01:23h | UTC

Antithyroid Drugs and Congenital Malformations: A Nationwide Korean Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: First trimester exposure to antithyroid drugs associated with increased risk of birth defects – 2 Minute Medicine (free) AND Use of Antithyroid Drugs Early in Pregnancy Tied to Birth Defect Risk – Physician’s First Watch (free) AND First trimester exposure to antithyroid drugs linked with birth defects – OnMedica (free)

Fri, January 26 – 10 Stories of The Day!

26 Jan, 2018 | 00:45h | UTC

1 – Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Myocardial Infarction after Influenza Infection (free)

Commentaries: Flu infection raises risk of heart attack in week after diagnosis – STAT (free) AND Flu Virus Can Trigger A Heart Attack – NPR (free) AND Flu increases the risk of heart attack – Reuters (free)

The researchers identified a six-fold increased risk of heart attack in the 7 days after a flu diagnosis.

2 – Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports – The BMJ (free)

Editorial: Just one cigarette a day seriously elevates cardiovascular risk (free)

Commentaries: CHD and stroke risk seriously elevated with just one daily cigarette – OnMedica (free) AND Smoking Even One Cigarette a Day Raises Cardiovascular Risk – Medscape (free registration required) AND Smoking Just One Cigarette a Day Carries Substantial Risks – Physician’s First Watch (free)

3 – Guideline: Duration of Contact Precautions for Acute-Care Settings – Society for Healthcare Epidemiology of America (SHEA) (free)

Summary and commentary: New guidelines issued on contact precautions for C. diff, resistant infections – ACP Hospitalist (free)

4 – Guideline: International technical guidance on sexuality education: An evidence-informed approach – UNESCO (free PDF)

News release: UN urges Comprehensive Approach to Sexuality Education – UNESCO (free)

Commentary: UN issues more progressive guidelines on sex education – Devex (free)

5 – Association of Resting Heart Rate and Temporal Changes in Heart Rate With Outcomes in Participants of the Atherosclerosis Risk in Communities Study – JAMA Cardiology (free)

Commentaries: Heart Rate Changes Over Time Hint at Higher Cardiovascular Risk – TCTMD (free) AND Increasing Heart Rate Over Time May Predict CV Events – MedPage Today (free registration required)

6 – Existing and potential infection risk zones of yellow fever worldwide: a modelling analysis – The Lancet Global Health (free)

7 – Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis – PLOS Medicine (free)

Commentaries: Caesarean section versus natural birth – an obstetrician examines a new review – The Conversation (free) AND Expert reaction to review paper looking at long-term risks and benefits of caesarean sections – Science Media Centre (free) AND C-sections linked to long-term risks and benefits – PLOS, via EurekAlert (free) AND Long-term risks and benefits of C-section revealed – Medical News Today (free)

“As a scientist, I can appreciate the effort made in conducting a systematic review on the topic, but as an obstetrician I worry that the results can be over-interpreted by patients – not to mention obstetricians and midwives – and caesarean section “marketed” as a safe way to avoid pelvic floor problems”. (from The Conversation)

8 – Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial – The BMJ (free)

Commentaries: Pre-surgery breathing physio halves risk of complications – OnMedica (free) AND Respiratory Training Before Surgery Significantly Reduces Risk of Postoperative Lung Complications – Medindia (free) AND Breath Training Before Surgery Halves Postoperative Pneumonia Risk – Medscape (free registration required)

9 – Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer – Cell (free)

Commentaries: These monkey twins are the first primate clones made by the method that developed Dolly – Science (free) AND First monkeys cloned with technique that made Dolly the sheep – Nature (free) AND How afraid of human cloning should we be? – The Guardian (free)

10 – Projections of multi-morbidity in the older population in England to 2035: estimates from the Population Ageing and Care Simulation (PACSim) model – Age and Ageing (free)

Commentaries: Number of older people with four or more diseases will double by 2035 – OnMedica (free) AND Number of older people with four or more diseases will double by 2035 – Newcastle University (free) AND We’ll live longer but suffer more ill-health by 2035, says study – The Guardian (free)

See related articles and commentaries on Designing Health Care Systems for Patients with Complex Needs (free)