Archives
Review: Treating Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
4 Feb, 2018 | 16:56h | UTC
Review: Frontotemporal Dementia
4 Feb, 2018 | 16:58h | UTC
Review: Cardiovascular Event Reduction with GLP-1 and SGLT2 Agents
4 Feb, 2018 | 16:54h | UTC
Review: Management of Functional Dyspepsia
4 Feb, 2018 | 16:53h | UTC
Review: Developments in Rare Bone Diseases and Mineral Disorders
4 Feb, 2018 | 16:55h | UTCDevelopments in rare bone diseases and mineral disorders – Therapeutic Advances in Chronic Diseases (free)
Review: Acne Scarring-Pathogenesis, Evaluation, and Treatment Options
4 Feb, 2018 | 16:52h | UTC
Review: Managing Hyponatremia in Lung Cancer
4 Feb, 2018 | 16:52h | UTC
Review: Management of Cystitis and Pelvic Pain
4 Feb, 2018 | 16:49h | UTC
Fri, February 2 – 10 Stories of The Day!
2 Feb, 2018 | 00:01h | UTC
Editorial: Migraine and risk of cardiovascular disease (free)
Commentaries: Migraine Associated With Broad Range of CVD Diagnoses in Nationwide Study – TCTMD (free) AND Migraine Linked To Increased Risk of Stroke, AFib, PE and Cardiovascular Disease – MedicalResearch.com (free)
2 – High performance plasma amyloid-β biomarkers for Alzheimer’s disease – Nature (link to abstract – $ for full-text)
Commentaries: Expert reaction to biomarkers for amyloid-beta in Alzheimer’s disease – Science Media Centre (free) AND A Big Step toward a Blood Test for Alzheimer’s – Scientific American (free) AND Simple blood test spots dementia protein – Nature News (free) AND Alzheimer’s hope as scientists unveil blood test for early signs – The Guardian (free)
Commentaries: Breast cancer treatments may increase the risk of heart disease – AHA / ASA Newsroom (free) AND Heart group warns of cardiovascular risks after treatment for breast cancer – STAT (free)
4 – Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis – NIHR Signal (free)
Original article: Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials – The Lancet Infectious Diseases (link to abstract – $ for full-text)
5 – Early use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free)
Original article: Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free) AND Invited Commentary: Tranexamic acid: is it about time? (free)
“It is now clearer that every 15-minute delay after the first hour can reduce survival by about 10%”.
6 – Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4 – Diabetes Care (link to abstract – $ for full-text)
Commentaries: How I learned to stop worrying and love metformin – NephJC (free) AND Adjusted-Dose Metformin Appears Safe in Patients With Type 2 Diabetes and Chronic Kidney Disease Stage 3 or 4 – PracticeUpdate (free registration required)
7 – Unnecessary Medical Care: More Common Than You Might Imagine – NPR Shots (free)
Original report: First, Do No Harm Calculating Health Care Waste in Washington State (free PDF)
Related commentary: When Evidence Says No, but Doctors Say Yes – The Atlantic (free)
8 – Technology: Amazon Wants to Disrupt Health Care in America. In China, Tech Giants Already Have – The New York Times (10 articles per month are free)
9 – Medical Education: Bringing medicine back to the bedside – ACP Internist (free)
10 – History of Childhood Kidney Disease and Risk of Adult End-Stage Renal Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Childhood Kidney Disease and Adult ESRD (free)
Commentaries: History of Childhood Kidney Disease Linked to Risk of ESRD – Physician’s Weekly (free) AND Childhood Kidney Disease Predicts Adult ESRD – MedPage Today (free registration required)
Review: Hospitalisation in Patients With Heart Failure With Preserved Ejection Fraction
4 Feb, 2018 | 16:48h | UTC
Thu, February 1 – 10 Stories of The Day!
1 Feb, 2018 | 00:01h | UTC
1 – Catheter Ablation for Atrial Fibrillation with Heart Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Catheter ablation better than pharmacological atrial fibrillation therapies – University of Utah Health, via EurekAlert (free)
“In patients w/heart failure & atrial fibrillation, catheter ablation lowers rate of death and hospitalization for worsening HF vs. medical therapy”. (via @NEJM see Tweet)
2 – Guideline: Diagnosis and management of gastrointestinal complications in adult cancer patients – German Society of Hematology and Medical Oncology (free)
Commentary: Omega-3 Supplements Don’t Protect Against Heart Disease – The New York Times (10 articles per month are free)
Omega-3 fatty acids did not prevent fatal or nonfatal coronary heart disease or any major vascular events.
4 – New Series on malaria in pregnancy – The Lancet Infectious Diseases (via @Onisillos)
Comment: Putting malaria in pregnancy back in the spotlight (free registration required)
Article 1: Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem (free registration required)
Article 2: Prevention of malaria in pregnancy (free registration required)
Article 3: Treatment of uncomplicated and severe malaria during pregnancy (free registration required)
5 – Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study – PLOS One (free)
Commentaries: TBI is associated with increased dementia risk for decades after injury – PLOS, via ScienceDaily (free) AND More evidence traumatic brain injuries raise later dementia risk – Reuters (free)
“Using longitudinal, case-control, and sibling-matched analyses of nationwide data from Sweden, Peter Nordström & Anna Nordström describe the association between TBI and dementia, its time course, and the influence of familial factors”. (via @PLOSMedicine see Tweet)
6 – Pro/Con Debate – two doctors with opposite views on physician-assisted death:
Pro: I’m a doctor with end-stage cancer. I support medical aid in dying – STAT (free)
Con: Physician-assisted suicide won’t atone for medicine’s ‘original sin’ – STAT (free)
Commentary: CAR T-Cell Immunotherapy Named Advance of the Year in ASCO’s Clinical Cancer Advances 2018 – The ASCO Post (free)
8 – CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free)
Related reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Commentaries: ASCO Guideline Offers Recommendations for Management of Mesothelioma – Cancer Network (free) AND ASCO Releases First Mesothelioma Guideline – MedPage Today (free registration required)
Related Guideline: SIDS and Other Sleep-Related Infant Deaths: Updated 2016 Recommendations for a Safe Infant Sleeping Environment – Task Force on Sudden Infant Death Syndrome, American Academy of Pediatrics (free)
Review: The Incidental Thyroid Nodule
30 Jan, 2018 | 20:00h | UTCReview: The incidental thyroid nodule – CA: A Cancer Journal for Clinicians (free)
Wed, January 31 – 10 Stories of The Day!
31 Jan, 2018 | 00:33h | UTC
1 – Screening for Lung Cancer: CHEST Guideline and Expert Panel Report (free PDF)
Summary and commentary: New guideline released on lung cancer screening – ACP Internist (free)
2 – HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing – Diabetologia (free)
Commentaries: The Startling Link Between Sugar and Alzheimer’s – The Atlantic (free) And Study Shows Long-Term Effects Of Diabetes And Prediabetes On The Brain – Forbes (free) AND New research shows diabetes and worse blood sugar control are associated with long-term cognitive decline – MedicalXpress (free) AND HbA1c Levels in Diabetes Linked to Cognitive Decline – Medscape (free registration required)
3 – Viewpoint: Does Medicine Overemphasize IQ? – JAMA (free)
4 – Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries – The Lancet (link to abstract – $ for full-text)
Commentaries: What’s the 5-Year-Survival Rate For Cancer Patients Around The World? – NPR (free) AND Global improvement in cancer survival but international differences are still very wide – eCancer News (free)
Commentaries: More evidence of link between severe gum disease and cancer risk – eCancer News (free) AND Evidence mounts of link between severe gum disease and various cancers – eCancer News (free) AND Severe Gum Disease Increases Both Cancer Risk and Mortality – Medscape (free registration required)
6 – Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Analysis looks at long-term risks of living kidney donation – American College of Physicians, via EurekAlert (free) AND What Are The Health Risks To Living Kidney Donors? – MedicalResearch.com (free) AND Living kidney donors have low but elevated risk of renal failure – Reuters (free)
7 – Opinion: Pay for performance: a dangerous health policy fad that won’t die – STAT (free)
See related articles and commentaries on recent studies with disappointing results of P4P Programs
8 – Ministry of Health Clinical Practice Guidelines: Hypertension – Singapore Medical Journal (free PDF)
10 – Safety of hydroxyanthracene derivatives for use in food – EFSA Journal (free)
Press release: EFSA confirms health concerns for hydroxyanthracene derivatives in food – European Food Safety Agency (free)
Commentary: Europe’s safety watchdog says laxatives may increase cancer risk – Reuters (free)
“This group of substances naturally occurs in plants such as aloe or senna species. Extracts containing them are used in food supplements for their laxative effect”. (from Press Release)
New Series Published to Support the use of Qualitative Research in Decision-Making
30 Jan, 2018 | 19:58h | UTCNew series published to support the use of qualitative research in decision-making – World Health Organization (free) (via @olibiermann and @trishgreenhalgh)
The Series: Applying GRADE-CERQual to Qualitative Evidence Synthesis Findings – Implementation Science (free)
WHO Media Centre: Why is this new qualitative research tool (GRADE-CERQual) important? (free)
Research: Parental Supply and Alcohol-Related Harm in Adolescence
30 Jan, 2018 | 19:59h | UTCCommentaries: Parental supply and alcohol-related harm in adolescence: emerging but incomplete evidence – The Lancet Public Health (free) AND Expert reaction to study looking at parents giving alcohol to their teenage children, and alcohol-related risks – Science Media Centre (free) AND Parental provision of alcohol to teenagers does not reduce risks, compared to no supply, Australian study finds – ScienceDaily (free)
Key Concepts for Informed Health Choices
30 Jan, 2018 | 19:58h | UTCKey Concepts for Informed Health Choices: a framework for helping people learn how to assess treatment claims and make informed choices – BMJ Evidence-Based Medicine (free) (via @Students4BE)
Related free resources: Testing Treatments Interactive AND Students 4 Best Evidence – Key Concepts
Review: Current Approaches to Epistaxis Treatment in Primary and Secondary Care
30 Jan, 2018 | 19:56h | UTC
Meta-Analysis: Fluid Balance and Outcomes in Critically Ill Children
30 Jan, 2018 | 19:57h | UTCAssociation Between Fluid Balance and Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a period)
Commentaries: Fluid Overload Boosts Mortality in Critically Ill Children – Medscape (free registration required)
In the Land of the Skinny, People are Getting Fat
30 Jan, 2018 | 19:55h | UTCIn the Land of the Skinny, People are Getting Fat – The New York Times (10 articles per month are free)
Related report: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free) AND Editorial: Global Health Effects of Overweight and Obesity (free)
Related commentaries: Obesity now kills more people worldwide than car crashes, terror attacks, and Alzheimer’s combined – VOX (free) AND Global cost of obesity-related illness to hit $1.2tn a year from 2025 – The Guardian (free)
Guidelines for the Investigation and Management of Generalized pruritus
30 Jan, 2018 | 19:50h | UTC
A Surgical Procedure for Shoulder Pain is Less Effective than Previously Thought
30 Jan, 2018 | 19:54h | UTCA surgical procedure for shoulder pain is less effective than previously thought – NIHR Signal (free)
Original article: Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial – The Lancet (free) AND Editorial: No benefit of arthroscopy in subacromial shoulder pain (free)
Guidelines for the Management of Iatrogenic Colonoscopy Perforation
30 Jan, 2018 | 19:46h | UTC
Guideline: Acute Sore throat
30 Jan, 2018 | 19:48h | UTCGuideline: Sore throat (acute): antimicrobial prescribing – National Institute for Health and Care Excellence (NICE) (free)
News release: Use paracetamol to relieve a sore throat rather than antibiotics (free)
Commentaries: GPs should cut back on antibiotic prescriptions for sore throats, NICE says – GP (free) AND ‘Painkillers best option for sore throats’ say new NHS guidelines – NHS Choices (free)
Related guideline: Corticosteroids for sore throat – The BMJ (free)
Guideline: Imaging in Large Vessel Vasculitis in Clinical Practice
30 Jan, 2018 | 19:47h | UTC
Research: Gestational Diabetes and Risk of Future Ischemic Heart Disease, hypertension, and Type 2 Diabetes
30 Jan, 2018 | 19:45h | UTCCommentaries: Women who have gestational diabetes in pregnancy are at higher risk of future health issues – University of Birmingham, via ScienceDaily (free) AND Target Patients With Gestational Diabetes After Birth to Reduce Risks – Medscape (free registration required)
Related article and commentaries: Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk


