Archives

Meta-Analysis: Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention After Acute Coronary Syndromes

15 Feb, 2018 | 10:34h | UTC

Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention After Acute Coronary Syndromes: A Systematic Review and Meta-analysis – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: Could NOACs Have a Role for Secondary Prevention After STEMI? – TCTMD (free) AND Meta-Analysis: ACS Type Matters for DOAC Use in Secondary Prevention – MedPage Today (free registration required) AND Adding DOACs Beneficial for STEMI — Not Non-STEMI — But with Bleeding Risk – Physician’s First Watch (free)

“63 STEMI patients would need to receive a DOAC to prevent one cardiovascular event, while 96 would need to be treated to cause one major bleeding event”. (from Physician’s First Watch)

Wed, February 14 – 10 Stories of The Day!

14 Feb, 2018 | 00:01h | UTC

1 – Family Planning – A global handbook for providers: 2018 edition – World Health Organization (free)

News release: Updated and expanded guidance for family planning providers worldwide (free)

2 – Guideline: Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from EHRA, ESC, HRS, APHRS and ISCP (free)

Source: Antiarrhythmics: multinational consensus recommendations – Univadis (free registration required)

3 – Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Ovarian Cancer in Asymptomatic Women (free) AND The Yet Unrealized Promise of Ovarian Cancer Screening (free) AND Is There a Future for Ovarian Cancer Screening? (free)

Author interview: USPSTF Recommendation: Screening for Ovarian Cancer (free audio)

“The USPSTF recommends against screening for ovarian cancer in asymptomatic women. (D recommendation) This recommendation applies to asymptomatic women who are not known to have a high-risk hereditary cancer syndrome”.

4 – Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences – JAMA Psychiatry (free)

Commentaries: Risk of Psychotic Experiences Up With Teen Cannabis Use – Physician’s Briefing (free) AND Teen Pot Use Linked to Increased Risk for Psychotic Episodes – MedPage Today (free registration required)

5 – Randomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations – The Journal of Pediatrics (link to abstract – $ for full-text)

Commentary: Asthma Exacerbation in Kids: A Trial of Two Steroids – Medscape (free registration required)

6 – Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer – New England Journal of Medicine (free)

“Apalutamide improves castration resistant prostate CA survival compared with… placebo. Why wasn’t it compared w bicalutamide?” (via @RichardLehman1 see Tweet). See Richard Lehman’s point of view

7 – In Sweeping War on Obesity, Chile Slays Tony the Tiger – The New York Times (10 articles per month are free)

8 – One Health Approach is Critical to De-risk Human, Animal and Environmental Health – The World Bank (free)

See report: Operational Framework for Strengthening Human, Animal And Environmental Public Health Systems At Their Interface – The World Bank (free PDF)

9 – Comprehensive geriatric assessment for older people admitted to a surgical service – Cochrane Library (free)

Summary: Does special assessment of older people getting surgery improve their recovery after surgery? – Cochrane Library (free)

10 – Cancer risk associated with chronic diseases and disease markers: prospective cohort study – The BMJ (free)

Commentaries: Study reveals substantial impact of chronic diseases on cancer risk – eCancer News (free) AND Chronic Disease Linked To Increased Risk of Cancer and Cancer Death – MedicalResearch.com (free) AND Double Trouble: These Diseases Could Raise Your Risk for Cancer – Live Science (free) AND Higher cancer risk from chronic diseases – OnMedica (free)

Tue, February 13 – 10 Stories of The Day!

13 Feb, 2018 | 00:59h | UTC

1 – Delayed umbilical cord clamping reduces hospital mortality for preterm infants – NIHR Signal (free)

Original article: Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology (free)

2 – Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Early Integration of Palliative Care Improves Quality of Life in Advanced Cancer – Oncology Nurse Advisor (free)

3 – Infographic: ATLS Trauma Update 2018 (free) (via @CritCareReviews)

4 – The Hypertension Guideline War Is Not A Fake War – Cardiobrief (free)

Related: The Fake Hypertension War: Medical politics and mud fights – MedPage Today (free registration required)

5 – Overtesting and undertesting in primary care: a systematic review and meta-analysis – BMJ Open (free) (via @JackOSullivan3 and @KariTikkinen)

6 – Opinion: Heart Stents Are Useless for Most Stable Patients. They’re Still Widely Used – The New York Times (10 articles per month are free)

7 – State of The Art Review: The role of robotics in colorectal surgery – The BMJ (free for a limited period)

8 – Richard Lehman’s journal reviews, 12 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

9 – Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study – The BMJ (free)

“Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia compared with other antibiotics used to treat UTIs, but not a greater risk of death”

10 – FIGO consensus guidelines on placenta accreta spectrum disorders – International Journal of Gynecology & Obstetrics

– Introduction (free)

– Epidemiology (free)

– Prenatal Diagnosis and Screening (free)

– Nonconservative surgical management (free)

Thu, February 15 – 10 Stories of The Day!

15 Feb, 2018 | 01:35h | UTC

1 – Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)

A fractional dose containing one fifth of the standard dose was effective at inducing seroconversion, supporting the use of fractional-dose vaccination for outbreak control.

2 – Evidence-based clinical practice guidelines for inflammatory bowel disease – Journal of Gastroenterology (free)

3 – Medical News & Perspectives: Do All Patients Need β-Blockers After a Heart Attack? – JAMA (free for a limited period)

4 – The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles – PeerJ (free)

5 – Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free)

Commentary: New Guidelines for Treating Checkpoint Inhibitor Toxicities – Medscape (free registration required)

Relate guideline: Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

6 – Uterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology (free)

7 – New Dutch law to make all adults organ donors unless they opt out – CNN (free) AND Every Adult in This Country Is Now an Organ Donor Unless They Opt Out – TIME (free) AND Dutch law to make everyone organ donors unless they opt out – ABC News (free)

8 – Benefits and Harms of Cranial Electrical Stimulation for Chronic Painful Conditions, Depression, Anxiety, and Insomnia: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Mild shock therapy may ease anxiety and depression, but not chronic pain – Reuters (free) AND Jury Still Out on CES for Depression, Anxiety, Pain, Insomnia – Medscape (free registration required)

9 – Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Opioids may be associated with increased risk for serious invasive pneumococcal infections – ACP Internist (free) AND Opioids For Pain Can Exacerbate Pneumococcal Infections – MedicalResearch.com (free) AND Prescription Opioid Use Tied to Higher Pneumonia Risk – MedPage Today (free registration required)

10 – Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study – The Lancet Infectious Diseases (free)

Commentaries: Surgical site infection—the next frontier in global surgery – The Lancet Infectious Diseases (free) AND Poor nations have higher risk of surgical infections, including resistant ones – CIDRAP (free)

Guideline: Antibiotics After Incision and Drainage for Uncomplicated Skin Abscesses

9 Feb, 2018 | 12:48h | UTC

Rapid Recommendations: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free text and infographics)

Mon, February 12 – 10 Stories of The Day!

12 Feb, 2018 | 01:06h | UTC

1 – 10 threats to global health in 2018 – The World Health Organization (free)

2 – Environmental Noise and the Cardiovascular System – Journal of the American College of Cardiology (free for a limited period)

Commentaries: Everyday noises may cause increased risk of heart disease, experts say – ABC News (free) AND How Loud Noise Exposure Is Linked to Heart Disease – TIME (free) AND Traffic Noise Linked to Increased CVD Risk – Medscape (free registration required) AND Heart & hearing: Noise pollution tied to higher risk of stroke, MI – Cardiovascular Business (free)

3 – Energy Drinks: A Contemporary Issues Paper – American College of Sports Medicine (free)

Commentary: ACSM Announces New Recommendations and Warnings Regarding Safety of Energy Drinks – NewsWise (free)

4 – New Cochrane Systematic Reviews – Vaccines for Preventing Influenza and Its Complications

– In Healthy Children (free) / Summary (free)

– In The Elderly (free) / Summary (free)

– In Immunosuppressed Adults With Cancer (free) / Summary (free)

– In Healthy Adults (free) / Summary (free)

5 – Report: Weekly U.S. Influenza Surveillance – Centers for Disease Control and Prevention (free)

Commentaries: Flu-like illness in US reaches 2009 pandemic levels – CIDRAP (free) AND Flu Is Causing 1 in 10 American Deaths and Climbing – Bloomberg (free) AND This Flu Season Is the Worst in Nearly a Decade – The New York Times (10 articles per month are free)

6 – The Equity Impact Vaccines May Have On Averting Deaths And Medical Impoverishment In Developing Countries – Health Affairs (free)

Commentaries: Study: vaccines prevent not just disease, but also poverty – The Vaccine Alliance (free) AND For world’s poorest, vaccines prevent deaths, medical impoverishment – Harvard T.H. Chan School of Public Health (free)

7 – Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Commentary: New Guidelines Outline Management of Immunotherapy Side Effects – MedPage Today (free registration required) AND SITC Spearheads Initiative for Management of Immunotherapy-Related Side Effects – The ASCO Post (free)

8 – The open abdomen in trauma and non-trauma patients: WSES guidelines – World Journal of Emergency Surgery (free)

9 – Review compares effectiveness, cost, and safety of second-line drugs for diabetes – ACP Diabetes Monthly (free)

Original Report: New Drugs for Type 2 Diabetes: Second-Line Therapy – Canadian Agency for Drugs and Technologies in Health (free)

10 – Draft Recommendation Statement: Screening Syphilis Infection in Pregnant Women – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Recommends Screening Pregnant Women for Syphilis – American Academy of Family Physicians (free) AND USPSTF: Screening for Syphilis in Pregnant Women Beneficial – MPR (free) AND Syphilis Rising In Newborns, Pregnant Moms: USPSTF Reaffirms Mandatory Testing – American Council on Science and Health (free)

Recommended Childhood and Adolescent Immunization Schedules

9 Feb, 2018 | 12:46h | UTC

Policy Statement: Recommended Childhood and Adolescent Immunization Schedules: United States, 2018 – American Academy of Pediatrics (free)

The Immunization Schedules for 2018 are available in the Red Book Online (free) and in the Centers for Disease Control and Prevention Website (free)

Recommended Immunization Schedule for Adults Aged 19 Years or Older

9 Feb, 2018 | 12:47h | UTC

How Fake Surgery Exposes Useless Treatments

9 Feb, 2018 | 12:45h | UTC

How Fake Surgery Exposes Useless Treatments – Scientific American (free)

Opinion: This flu season, physicians need to scrap the ‘martyr culture’ of working while sick

9 Feb, 2018 | 12:43h | UTC

This flu season, physicians need to scrap the ‘martyr culture’ of working while sick – STAT (free) (via @CMichaelGibson)

Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout

9 Feb, 2018 | 12:44h | UTC

Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free)

Related Infographic: Date Night with the EHR – NEJM Catalyst (free)

Free Online Course – The Lancet Maternal Health Series: Global Research and Evidence

9 Feb, 2018 | 12:45h | UTC

Free online course. Starts 12 February 2018. The Lancet Maternal Health Series: Global Research and Evidence – London School of Hygiene & Tropical Medicine, via Future Learn

“Hear the latest expert evidence from The Lancet Maternal Health Series and learn what you can do to improve maternal healthcare”.

Research: Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy

9 Feb, 2018 | 12:39h | UTC

Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy: population based cohort study in Sweden – The BMJ (free)

Infographic: The vital first 10 minutes (free PDF)

Even slight changes within the normal Apgar score range (7-10) from five to 10 minutes have a major influence in the risks of cerebral palsy and epilepsy.

Overview of Systematic Reviews: Intraoperative Interventions for Preventing Surgical Site Infection

9 Feb, 2018 | 12:40h | UTC

Intraoperative interventions for preventing surgical site infection: an overview of Cochrane Reviews – Cochrane Library (free)

Summary: Overview of Cochrane Reviews of interventions used during surgery for preventing surgical site infection (free)

Meta-Analysis: Prognostic Accuracy of qSOFA and SIRS criteria for Mortality in Patients With Suspected Infection

9 Feb, 2018 | 12:42h | UTC

Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: For mortality prediction, qSOFA has poor sensitivity, moderate specificity, review finds – ACP Hospitalist (free) AND Systemic inflammatory response syndrome criteria may be more sensitive than quick sequential organ failure assessment for predicting mortality in patients with suspected infection – 2 Minute Medicine (free)

NICE Guideline: Pancreatic Cancer in Adults

9 Feb, 2018 | 12:38h | UTC

Pancreatic cancer in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

News release: Pancreatic cancer patients should be offered early scans to avoid unnecessary surgery, says NICE (free)

Research: Effectiveness of Family Integrated Care in neonatal intensive care units on infant and parent outcomes

9 Feb, 2018 | 12:37h | UTC

Effectiveness of Family Integrated Care in neonatal intensive care units on infant and parent outcomes: a multicentre, multinational, cluster-randomised controlled trial – The Lancet child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Premature babies healthier when parents help with hospital care, study shows – The Guardian (free) AND Preemies Fared Better When Parents Helped with NICU Care – MedPage Today (free registration required) AND Parents’ care can help premature babies in hospital, says study – BBC News (free)

– Impact of Conventional Stroke Risk Factors on Stroke in Women – Stroke (free PDF for a limited period)

– Stroke Risk Factors Unique to Women – Stroke (free PDF for a limited period)

Research: Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds

9 Feb, 2018 | 12:35h | UTC

Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds: cluster randomised controlled trial (WAVES study) – The BMJ (free)

Editorial: The failure of anti-obesity programmes in schools (free)

Commentary: Obesity crisis can’t be solved by schools – major new study – The Conversation (free) AND Schools are not the answer to childhood obesity epidemic, study shows – The Guardian (free)

““In the words of Winston Churchill, “However beautiful the strategy, you should occasionally look at the results.”” (from editorial)

Report: Top 10 Health Economics and Outcomes Research Trends

9 Feb, 2018 | 12:21h | UTC

ISPOR 2018 – Top 10 Health Economics and Outcomes Research Trends (free PDF)

Commentary: Top 10 Trends Driving Healthcare in 2018 – NewsWise (free)

New Cellphone and Health Studies Don’t Eliminate Uncertainty

9 Feb, 2018 | 12:22h | UTC

New cellphone and health studies don’t eliminate uncertainty – Science (free)

Other commentaries: Largest Animal Study of Cell Phone Radiation and Cancer Risk – Medscape (free registration required) AND High doses of cellphone radiation linked to some cancers in rats – STAT (free) AND Cell phone radiation: Could high exposure cause tumors? – Medical News Today (free)

2018 annual review of the Blueprint list of priority diseases

9 Feb, 2018 | 12:22h | UTC

2018 annual review of the Blueprint list of priority diseases – World Health Organization (free) (via @equitylist)

Key actions: Diseases for which R&D preparedness activities are already in development – World Health Organization (free)

Systematic review: Preoperative exercise halves the postoperative complication rate in patients with lung cancer

9 Feb, 2018 | 12:18h | UTC

Preoperative exercise halves the postoperative complication rate in patients with lung cancer: a systematic review of the effect of exercise on complications, length of stay and quality of life in patients with cancer – British Journal of Sports Medicine (link to abstract – $ for full-text)

Commentaries: Regular exercise halves complication rate after lung cancer surgery – eCancer News (free) AND Lung Cancer Postoperative Complications Reduced With Preoperative Exercise – Pulmonology Advisor (free)