Archives

Meta-Analysis: Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease

2 Mar, 2018 | 01:23h | UTC

Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Meta-analysis – Journal of the American Geriatrics Society (free)

Source: Medscape (free registration required)

“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.

Research: Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Artery Disease

2 Mar, 2018 | 01:20h | UTC

Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Artery Disease – JAMA (link to abstract – $ for full-text)

Commentaries: Patients with varicose veins at greater risk for thrombosis, other vascular diseases – Cardiovascular Business (free) AND Varicose Veins Linked to Greater Risk for VTE, PAD – NEJM Physician’s First Watch (free) AND Varicose Veins May Increase Likelihood of Blood Clots – Physician’s Weekly (free)

Guidelines for the Pharmacological Treatment of Social Anxiety Disorder

2 Mar, 2018 | 01:17h | UTC

Korean Guidelines for the Pharmacological Treatment of Social Anxiety Disorder: Initial Treatment Strategies – Psychiatric Investigation (free)

Research: Impact of frailty on outcomes after discharge in older surgical patients

2 Mar, 2018 | 01:18h | UTC

Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study – Canadian Medical Association Journal (free)

Commentary: Frailty associated with readmission risk and postdischarge mortality in older surgical patients – ACP Hospitalist (free)

Related Systematic Review: Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis – BMC Medicine (free) AND Commentary: Age itself is not a risk factor for complications after surgery among older patients – OnMedica (free)

Research: Patterns and Predictors of Short-Term PICCs Use

2 Mar, 2018 | 01:15h | UTC

Patterns and Predictors of Short-Term Peripherally Inserted Central Catheter Use: A Multicenter Prospective Cohort Study – Journal of Hospital Medicine (free PDF)

Commentary: Short-term use of IV devices is common — and risky — study shows – University of Michigan, via ScienceDaily (free)

“Intravenous devices known as PICCs should be reserved for long-term use, but a new study shows 1 in 4 are used for 5 days or less” (from ScienceDaily)

Research: TV viewing and incident venous thromboembolism

2 Mar, 2018 | 01:16h | UTC

TV viewing and incident venous thromboembolism: The Atherosclerotic Risk in Communities Study – Journal of Thrombosis and Thrombolysis (free)

Commentaries: Turn it off: Binge watching TV can cause venous thromboembolism—even if you’re fit – Cardiovascular Business (free)

How too much TV could kill you – MedicalNewsToday (free)

Research: Real-World Effectiveness of Pharmacologic Treatments for Bipolar Disorders

2 Mar, 2018 | 01:14h | UTC

Real-World Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)

Editorial: Enthusiasm and Skepticism About Using National Registers to Analyze Psychotropic Drug Outcomes (free for a limited period)

Commentaries: Lithium treatment for bipolar disorder linked to lowest risk of rehospitalization – Karolinska Institutet, via EurekAlert (free) AND Lithium Top Choice for Preventing Bipolar Rehospitalization – MedPage Today (free registration required)

These observational studies suggest Lithium may be a better choice for treating these patients, but randomized controlled trials are needed to clarify this issue.

Position Statement: Hidden Curricula, Ethics, and Professionalism: Optimizing Clinical Learning Environments in Becoming and Being a Physician

2 Mar, 2018 | 01:12h | UTC

Medical Education: Hidden Curricula, Ethics, and Professionalism: Optimizing Clinical Learning Environments in Becoming and Being a Physician: A Position Paper of the American College of Physicians – Annals of Internal Medicine (free)

News Release: ACP calls on medicine to optimize learning environments by aligning positive ’hidden’ curriculum with formal curriculum of medical education (free)

Systematic Review: Interventions for paracetamol (acetaminophen) overdose

2 Mar, 2018 | 01:01h | UTC

Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (free)

Original article: Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (link to abstract – $ for full-text)

Richard Lehman’s journal review – 26 February 2018

2 Mar, 2018 | 01:00h | UTC

Richard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

Impact of Bystander Automated External Defibrillator Use on Outcomes

2 Mar, 2018 | 01:11h | UTC

Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests – Circulation (free PDF for a limited period)

Commentary: Bystander defibrillator use tied to better cardiac arrest outcomes – Reuters (free)

Research: Bariatric Surgery Associated With Reduced Need For Diabetes Medications 6 Years Later

2 Mar, 2018 | 01:10h | UTC

Association Between Bariatric Surgery and Rates of Continuation, Discontinuation, or Initiation of Antidiabetes Treatment 6 Years Later – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery Associated With Reduced Need For Diabetes Medications at Six Years – MedicalResearch (free) AND Roughly Half of Obese Patients Who Have Bariatric Surgery Are Off Type 2 Diabetes Meds at 6 Years – TCTMD (free)

Idiopathic pulmonary fibrosis: pathogenesis and management

2 Mar, 2018 | 00:58h | UTC

Idiopathic pulmonary fibrosis: pathogenesis and management – Respiratory Research (free)

Research: Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients

2 Mar, 2018 | 00:57h | UTC

Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Pulmonary Embolism Rule-out Criteria non-inferior to usual care for patients at low-risk for pulmonary embolism – 2 Minute Medicine (free) AND EM Nerd-The Case of the Diagnostic Absurdity (free) AND Using PERC & Sending Home Pulmonary Emboli For Fun and Profit – Emergency Literature of Note (free)

FDA Safety Alert: Clarithromycin Associated with Increased Risk of Heart Problems or Death in Patients With Heart Disease

2 Mar, 2018 | 00:59h | UTC

FDA Safety Alert: Clarithromycin (Biaxin): Drug Safety Communication – Potential Increased Risk of Heart Problems or Death in Patients With Heart Disease (free)

Commentaries: FDA: Antibiotic Linked to Increased Risk of Death in Heart Disease Patients – MPR (free) AND FDA: Clarithromycin Risks Persist in Patients With CAD – TCTMD (free) FDA Alert: Clarithromycin Risky in Patients With Heart Disease – Medscape (free registration required)

Research: Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning

2 Mar, 2018 | 00:56h | UTC

Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning – Nature Biomedical Engineering (link to abstract – $ for full-text) (via @EricTopol see Very interesting Tweet)

Commentaries: Assessing Cardiovascular Risk Factors with Computer Vision – Google Research Blog (free) AND Google’s new AI algorithm predicts heart disease by looking at your eyes – TheVerge (free) AND Combination of AI, eye images could predict cardiovascular disease – Cardiovascular Business (free) AND It’s All in the Eyes: Google AI Calculates Cardiovascular Risk From Retinal Images – Medium (free)

The global crackdown on parents who refuse vaccines for their kids has begun

2 Mar, 2018 | 00:55h | UTC

The global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)

“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.

Research: Spironolactone Vs Clonidine for Resistant Hypertension

2 Mar, 2018 | 00:54h | UTC

Spironolactone Versus Clonidine as a Fourth-Drug Therapy for Resistant Hypertension: The ReHOT Randomized Study (Resistant Hypertension Optimal Treatment) – Hypertension

Commentary: Spironolactone bests clonidine as fourth drug for resistant hypertension – Univadis (free registration required)

An Evidence-Based Approach to Pressors in Shock

1 Mar, 2018 | 22:12h | UTC

An Evidence-Based Approach to Pressors in Shock: Part I – emDocs (free)

An Evidence-Based Approach to Pressors in Shock: Part II – emDocs (free)