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“Largest ever prostate cancer trial – CAP – published in the JAMA. No effect from low intensity PSA screening on prostate cancer mortality at 10 years”. (via @KariTikkinen see Tweet)

3 – Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)

“‘The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)

4 – One-Month Tuberculosis Prophylaxis as Effective as Nine-Month Regimen for People Living with HIV – National Institute of Allergy and Infectious Diseases (free) (via @iasociety see Tweet)

5 – Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure – Anaesthesiologica Scandinavica (free)

Source: Critical Care Reviews Newsletter

6 – Why Apple, Amazon, and Google are making big health care moves – VOX (free)

7 – Opinion: Are Hospitals Becoming Obsolete? – The New York Times (10 articles per month are free)

8 – Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free)

9 – Frailty and the management of patients with acute cardiovascular disease: A position paper from the Acute Cardiovascular Care Association – European Heart Journal: Acute Cardiovascular Care (free)

10 – Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis – European Heart Journal (free)

Late-onset asthma: current perspectives

8 Mar, 2018 | 20:15h | UTC

Late-onset asthma: current perspectives – Journal of Asthma and Allergy (free)

Tue, March 6 – 10 Stories of The Day!

6 Mar, 2018 | 00:47h | UTC

1 – Hemoglobin A_1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

Commentary: Major Medical Associations Feud Over Diabetes Guidelines – NPR (free)

“Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes”

2 – Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party – Journal of Antimicrobial Chemotherapy (free) (via @ABsteward)

3 – Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0 (free)

See original EACS Guidelines in 7 languages (all free)

4 – Management of opioid use disorders: a national clinical practice guideline – Canadian Medical Association Journal (free) (via @DavidJuurlink see Tweet)

5 – Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

Editorial: Pharmacological strategies in heart failure with preserved ejection fraction: time for an individualised treatment strategy? (free)

Commentary: Heartbeat: Is there any effective therapy for heart failure with preserved ejection fraction? (free)

In this meta-analysis of RCT testing treatments for patients with heart failure with preserved ejection fraction, only beta-blockers demonstrated reductions in all-cause and cardiovascular mortality.

6 – Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors: The INTERMAP Study – Hypertension (link to abstract – $ for full-text)

Commentaries: Healthy diet may not offset high salt intake – Imperial College London (free) AND Dietary sodium’s impact may not be offset by other aspects of a diet – AHA / ASA Newsroom (free)

7 – Richard Lehman’s journal review, 5 March 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

8 – Too Late To Operate? Surgery Near End Of Life Is Common, Costly – NPR (free)

9 – Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)

Original guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)

10 – Outcomes, experiences and palliative care in major stroke: a multicentre, mixed-method, longitudinal study – Canadian Medical Association Journal (free)

““Palliative care” had connotations of treatment withdrawal and imminent death… practicing the principles of palliative care is needed, but the term “palliative care” should be avoided or reframed”.

Meta-Analysis: The effect of exercise on cancer-related fatigue in cancer survivors

8 Mar, 2018 | 20:15h | UTC

The effect of exercise on cancer-related fatigue in cancer survivors: a systematic review and meta-analysis – Neuropsychiatric Disease and Treatment (free)

Fri, March 2 – 10 Stories of The Day!

2 Mar, 2018 | 02:16h | UTC

1 – Hydrocortisone plus Fludrocortisone for Adults with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Hydrocortisone-fludrocortisone cuts deaths in septic shock – The Hospitalist (free)

2 – Policy Statement: Pediatric Medication Safety in the Emergency Department – American Academy of Pediatrics (free)

Commentaries: Recommendations Issued on Reducing Pediatric Medication Errors in the ED – NEJM Physician’s First Watch (free) AND Policy statement outlines ways to improve pediatric medication safety – 2 Minute Medicine (free)

3 – Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

This meta-analysis of randomized trials showed CABG had a mortality benefit over PCI in patients with multivessel disease, particularly those with diabetes and higher coronary complexity. There was no mortality benefit in patients with left main disease.

4 – Meta-analysis: Long-Term Outcomes of On- Versus Off-Pump Coronary Artery Bypass Grafting – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Long-Term Outcomes of On- vs. Off-Pump CABG – American College of Cardiology, Latest in Cardiology (free) AND Long-term survival benefit seen in on-pump vs off-pump CABG – Cardiovascular Business (free)

“Off pump CABG. probably best used in a limited set of patients…” (via @keaglemd see Tweet)

5 – Public Health: Tackling multiple unhealthy risk factors: Emerging lessons from practice – The King’s Fund (free PDF)

Commentary: Multiple unhealthy risk factors: why they matter and how practice is changing (free)

See also: Summary (free PDF) AND Overview (free)

6 – TV viewing and incident venous thromboembolism: the Atherosclerotic Risk in Communities Study – Journal of Thrombosis and Thrombolysis (free)

Commentaries: Turn it off: Binge watching TV can cause venous thromboembolism—even if you’re fit – Cardiovascular Business (free) AND How too much TV could kill you – MedicalNewsToday (free)

7 – Cancer diagnosis in patients with heart failure: epidemiology, clinical implications and gaps in knowledge – European Journal of Heart Failure (free)

8 – Robot-assisted laparoscopic surgery versus conventional laparoscopic surgery in randomized controlled trials: A systematic review and meta-analysis – PLOS One (free)

“Despite higher operative cost, robot-assisted laparoscopic surgery does not result in statistically better treatment outcomes, with the exception of lower estimated blood loss. Operative time and total complication rate are significantly more favorable with conventional laparoscopic surgery”.

9 – Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Meta-analysis – Journal of the American Geriatrics Society (free)

Source: Medscape (free registration required)

“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.

10 – A Time-Motion Study of Primary Care Physicians’ Work in the Electronic Health Record Era – Family Medicine (free)

Commentary: EHR Time Exceeds Patient Face Time in Family Practice Visits – Medscape (free registration required)

Mon, March 5 – 10 Stories of The Day!

5 Mar, 2018 | 01:08h | UTC

1 – Guidelines for the diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children – World Health Organization (free)

See also: Key Messages AND Policy Brief (free PDF)

2 – Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: 5 Classifications of Diabetes Proposed – Physician’s First Watch (free) AND Should diabetes be divided into 5 categories to improve treatment? – Cardiovascular Business (free) AND Diabetes Consists of Five Types, Not Two, Say Researchers – Medscape (free registration required)

3 – New Guide to Infection Control in The Hospital – International Society for Infectious Diseases (free)

A free, online resource on the principles and interventions needed to reduce healthcare associated infections, with suggested control measures across different resource levels.

4 – Clinical Practice Guideline: Hoarseness (Dysphonia) – American Academy of Otolaryngology—Head and Neck Surgery (free)

See also: Executive Summary

5 – Opioid Wisely – Choosing Wisely Canada (free)

See complete lists from Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

This campaign encourages thoughtful conversation between clinicians and patients to reduce harms associated with opioid prescribing, with recommendations relevant to different specialties.

6 – New campaign: Nursing Now campaign: empowering nurses to improve global health – World Health Organization (free)

Related: Global nursing movement launches – Devex (free) AND Nursing Now campaign: raising the status of nurses – The Lancet (free registration required)

See also: Nursing Now Website

Source: International Health Policies Newsletter

7 – Effectiveness of brief alcohol interventions in primary care populations – Cochrane Library (free)

In general practice or emergency care settings, brief alcohol interventions can reduce alcohol consumption and related harm.

8 – The Challenge of Doctor-Patient Relations in the Internet Age – The New York Times (10 articles per month are free)

9 – Editorial: Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations (free)

Trial 1: Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations – The New England Journal of Medicine (free)

Trial 2: Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations – The New England Journal of Medicine (free)

10 – Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance) – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries: Nut Consumption May Aid Colon Cancer Survival – Yale Cancer Center, via NewsWise (free) AND Nuts, Especially Tree Nuts, and Improved CRC Survival – Medscape (free registration required

A survival benefit was suggested by this observational trial.

Thu, March 8 – 10 Stories of The Day!

8 Mar, 2018 | 02:13h | UTC

1 – Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non–Vaccine-Targeted Infections From 24 Through 47 Months of Age – JAMA (link to abstract – $ for full-text)

Commentaries: Vaccines won’t overload your child’s immune system—or increase their risk of other infections – Science (free) AND Too Many Too Soon? No! – Science-Based Medicine (free) AND Study finds no immune overload for US kids’ vaccine schedule – CIDRAP (free)

2 – Frequency and level of evidence used in recommendations by the National Comprehensive Cancer Network guidelines beyond approvals of the US Food and Drug Administration: retrospective observational study – The BMJ (free)

Commentaries: Vinay Prasad on the NCCN’s cancer treatment guidelines: The US system needs an audit – The BMJ Opinion (free) AND US cancer network recommending expensive drugs based on weak evidence, study finds – The Guardian (free) AND New Study Questions Evidence for NCCN Recommendations – Medscape (free registration required)

3 – Digoxin and Mortality in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Digoxin and Mortality in Patients With Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free) AND Digoxin Associated with Higher Mortality in Patients with Atrial Fibrillation – NEJM Physician’s First Watch (free)

4 – Effect of β‐Blockers Beyond 3 Years After Acute Myocardial Infarction – Journal of the American Heart Association (free for a limited period)

5 – Cancer screening recommendations: an international comparison of high income countries – Public Health Reviews (free) (via @hildabast see Tweet)

6 – Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations – Intensive Care Medicine (free for a limited period) (via @luiscamacho02)

7 – Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation – Cochrane Library (free)

Summary: Comparing two types of blood-thinning drugs, factor Xa inhibitors and vitamin K antagonists, to prevent blood clots in people with atrial fibrillation – Cochrane Library (free)

When available, Factor Xa inhibitors seem to be a better choice for treating these patients.

8 – The Science of Obesity Management: An Endocrine Society Scientific Statement – Endocrine Reviews (free)

Commentary: Research Finds Little Difference Among Diet Plans’ Long-Term Effectiveness – Endocrine Society, via NewWise (free)

9 – Cough Due to TB and Other Chronic Infections – CHEST Guideline and Expert Panel Report (free)

10 – Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial – JAMA (free)

Editorial: The Global HIV Epidemic: What Will It Take to Get to the Finish Line? (free)

Commentary: HIV in sub-Sahara Africa: Testing and treatment start at home improves therapy – Swiss Tropical and Public Health Institute, via EurekAlert (free)

Related: Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)

Practical recommendations for managing in-flight medical emergencies

2 Mar, 2018 | 02:08h | UTC

“Is there a doctor on board?”: Practical recommendations for managing in-flight medical emergencies – Canadian Medical Association Journal (free)

News release: Responding to inflight medical emergencies can be stressful for doctors – CMAJ News (free)

Balanced Crystalloids vs Saline in Hospitalized Patients

2 Mar, 2018 | 02:10h | UTC

Balanced Crystalloids versus Saline in Critically Ill Adults – New England Journal of Medicine (free)

Commentary: Balanced Crystalloids May Be Better Than Saline for Critically Ill Patients – NEJM Physician’s First Watch (free)

“Balanced crystalloids may be superior to saline in critically ill patients — but not in patients hospitalized outside an ICU” (from Physician’s First Watch)

Hydrocortisone plus Fludrocortisone Reduces Deaths in Septic Shock

2 Mar, 2018 | 02:08h | UTC

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Hydrocortisone-fludrocortisone cuts deaths in septic shock – The Hospitalist (free)

ACG Clinical Guideline: Alcoholic Liver Disease

2 Mar, 2018 | 02:05h | UTC

ACG Clinical Guideline: Alcoholic Liver Disease – The American Journal of Gastroenterology (free)

Commentary and summary: New Guideline for Management of Alcoholic Liver Disease – NEJM Journal Watch (free for a limited period)

Clinical Practice Guidelines for the Management of Hemorrhoids

2 Mar, 2018 | 02:07h | UTC

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Hemorrhoids – Diseases of the Colon & Rectum (free)

Related guideline: ACG Clinical Guideline: Management of Benign Anorectal Disorders – The American Journal of Gastroenterology (free)

Research: Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI)

2 Mar, 2018 | 02:06h | UTC

Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial – European Heart Journal (free)

Commentaries: 3% rise in deaths for every 10 min delay in restoring blood flow after heart attack – OnMedica (free) AND Treatment Delay and Mortality in STEMI With Shock – American College of Cardiology, Latest in Cardiology (free)

Report: Tackling Multiple Unhealthy Risk Factors

2 Mar, 2018 | 02:02h | UTC

Public Health: Tackling multiple unhealthy risk factors: Emerging lessons from practice – The King’s Fund (free PDF)

Commentary: Multiple unhealthy risk factors: why they matter and how practice is changing (free)

See also: Summary (free PDF) AND Overview (free)

Guideline: Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy

2 Mar, 2018 | 02:04h | UTC

Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Opinion: Doctors, Revolt!

2 Mar, 2018 | 02:04h | UTC

Opinion: Doctors, Revolt! – The New York Times (free)

“Healing is replaced with treating, caring is supplanted by managing, and the art of listening is taken over by technological procedures. Bernard Lown” (via @lucadf see Tweet)

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