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Cohort Study: Being a ‘Night owl’ May Lead to Premature Death

16 Apr, 2018 | 16:42h | UTC

Associations between chronotype, morbidity and mortality in the UK Biobank cohort – Chronobiology International (free)

Commentaries: ‘Night owls’ slightly more likely to die sooner than ‘early birds’ – NHS Choices (free) AND Why being a night owl may lead to earlier death – VOX (free) AND Night Owls Could Face Higher Risk Of Premature Death, Study Suggests – Forbes (free)

Meta-Analysis of Observational Studies: Proton Pump Inhibitors are Associated with Increased Risk of Kidney Disease

16 Apr, 2018 | 16:54h | UTC

Acid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis – Journal of Gastroenterology and Hepatology (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

Proton pump inhibitors were associated with higher risks of acute interstitial nephritis (HR, 2.78; 95% CI, 1.25‐6.17), acute kidney injury (HR, 1.85; 95% CI, 1.33‐2.59), chronic kidney disease (HR, 1.47; 95% CI, 1.03‐2.09), and end‐stage renal disease (HR, 1.61; 95% CI, 1.26‐2.04) than non‐PPI therapy. Similar risks were not identified for H₂RA therapy.

Randomized Controlled Trial: Combination Therapy with Immunotherapy Increases Overall Survival in Patients with Lung Cancer

16 Apr, 2018 | 16:34h | UTC

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer – New England Journal of Medicine (free)

Commentaries: AACR 2018: Combination therapy doubles survival in metastatic lung cancer – eCancer News (free) AND Lung Cancer Patients Live Longer With Immune Therapy – New York Times (10 articles per month are free)

Mon, April 16 – 10 Stories of The Day!

16 Apr, 2018 | 00:03h | UTC

1 – Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies – The Lancet (free)

Editorial: Thresholds for safer alcohol use might need lowering (free)

Commentaries: Drinking a pint of beer may lower your life expectancy by the same amount as smoking a cigarette – new research – The Conversation (free) AND Expert reaction to study looking at drinking alcohol, life expectancy and alcohol limits – Science Media Centre (free) AND More than six weekly glasses of wine could curb life expectancy by up to five years – OnMedica (free) AND Consuming more than five drinks a week could shorten your life – University of Cambridge, via ScienceDaily (free) AND How much alcohol is too much? A new study says it’s found the number – PBS News Hour (free)

2 – Short-term Elevation of Fine Particulate Matter Air Pollution and Acute Lower Respiratory Infection – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentaries: Brief SExposure to Tiny Air Pollution Particles Triggers Childhood Lung Infections – Intermountain Medical Center, via NewsWise (free) AND Spikes in air pollution can heighten risk of chest infections, research suggests – The Guardian (free) AND Air Pollution May Pose Serious Risks to Young Children – The New York Times (10 articles per month are free) AND Short-Term Pollution Spikes Trigger Lung Infections in Young Kids – MedPage Today (free registration required)

3 – Primary care of adults with intellectual and developmental disabilities: 2018 Canadian consensus guidelines – Canadian Family Physician (free)

4 – New affordable hepatitis C combination treatment shows 97 percent cure rate – Drugs for Neglected Diseases Initiative, via EurekAlert (free)

5 – Association of Survival With Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors After Colon Cancer Diagnosis: The CALGB 89803/Alliance Trial – JAMA Oncology (free for a limited period)

Editorial: Helping Colorectal Cancer Survivors Benefit From Changing Lifestyle Behaviors: Implementation Science and Private Industry Collaboration to the Rescue (free for a limited period)

Commentaries: Colon Cancer Patients Who Follow a Healthy Lifestyle Have Longer Survival – NEJM Physician’s First Watch (free) AND Adherence to ACS Guidelines Linked to Survival in Colon Cancer – Physician’s Briefing (free)

6 – Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults – PLOS One (free)

Commentaries: Sitting Is Bad for Your Brain – Not Just Your Metabolism or Heart – University of California – Los Angeles, via NewsWise (free) AND Could Too Much Sitting Possibly Make Your Brain Thinner? – Forbes (free)

7 – n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease – New England Journal of Medicine (free for a limited period)

Commentaries: Omega-3s From Fish Oil Supplements No Better Than Placebo for Dry Eye – NIH, National Eye Institute (NEI), via NewsWise (free) AND Fish oil capsules don’t help dry eye symptoms, study finds – STAT (free) AND Fish oil supplements ineffective against dry eye – Reuters (free)

8 – The Clinical Trial Is Open. The Elderly Need Not Apply – The New York Times (10 articles per month are free)

Related: Cardiac Patients in Trials Don’t Reflect Real-World Populations (link to abstract and commentaries on the subject)

“There’s a shocking lack of data on effective treatments for older people. So what do doctors do? Make guesses”. (via @NYTHealth see Tweet)

9 – Gallstones: Watch and wait, or intervene? – Cleveland Clinic Journal of Medicine (free)

“Consider laparoscopic cholecystectomy for symptomatic cholelithiasis, expectant management for asymptomatic cases”.

10 – Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomised controlled, two-by-two factorial design trial – The Lancet (free)

Commentaries: Insecticide-resistant malaria vectors must be tackled – The Lancet (free) AND Advanced insecticidal nets protect against malaria, study shows – CIDRAP News Scan for Apr 12, 2018 (free) AND ‘Resistance breaking’ mosquito net provides children with greater protection against malaria – London School of Hygiene & Tropical Medicine (free)

“The novel net nearly halves malaria infection rate in Tanzanian children compared to standard long-lasting pyrethroid nets” (from London School of Hygiene & Tropical Medicine)

Perspective: We Can’t Spend All Our Money on Health Care

15 Apr, 2018 | 23:52h | UTC

We Can’t Spend All Our Money on Health Care – NEJM Catalyst (free)

Registry Analysis: Safety of Low-Dose Glucocorticoid Exposure Was Assessed

15 Apr, 2018 | 23:48h | UTC

Association Between Glucocorticoid Exposure and Healthcare Expenditures for Potential Glucocorticoid-related Adverse Events in Patients with Rheumatoid Arthritis – The Journal of Rheumatology (link to abstract – $ for full-text)

Commentary: How Safe Are Low-Dose Steroids in Patients with Rheumatoid Arthritis? – NEJM Journal Watch (free for a limited period)

Research: Hand Hygiene Notification Machine Learning System Improves Adherence to 100%

15 Apr, 2018 | 23:51h | UTC

Feasibility Of A Real-Time Hand Hygiene Notification Machine Learning System In Outpatient Clinics – Journal of Hospital Infection (link to abstract – $ for full-text)

Commentary: Machine learning hand hygiene notifications improve adherence to 100% – Clinical Innovation & Technology (free)

Perspective: Improving Patient Involvement in Care

15 Apr, 2018 | 23:41h | UTC

Improving Patient Involvement in Care – NEJM Catalyst (free)

ASGE Guideline: Infection Control During GI Endoscopy

15 Apr, 2018 | 23:38h | UTC

ASGE guideline for infection control during GI endoscopy – Gastrointestinal Endoscopy (free)

Systematic Review: Indicators of Intensive Care Unit Capacity Strain

15 Apr, 2018 | 23:42h | UTC

Indicators of intensive care unit capacity strain: a systematic review – Critical Care (free)

Guideline: Haemostatic Aspects of Peripartum Haemorrhage

15 Apr, 2018 | 23:37h | UTC

Peripartum Haemorrhage: Haemostatic Aspects of the New German PPH Guideline – Transfusion Medicine and Hemotherapy (free) (Source: Critical Care Reviews Newsletter)

Guideline: Endoscopic Eradication Therapy in Barrett’s Esophagus

15 Apr, 2018 | 23:39h | UTC

Endoscopic eradication therapy for patients with Barrett’s esophagus–associated dysplasia and intramucosal cancer – Gastrointestinal Endoscopy (free)

Commentary: New recommendations for endoscopic eradication therapy in Barrett’s esophagus – American Society for Gastrointestinal Endoscopy, via EurekAlert (free)

Checar link

Review: Emergency Management of Intracerebral Hemorrhage

15 Apr, 2018 | 23:36h | UTC

EM Cases: Emergency Management of Intracerebral Hemorrhage – The Golden Hour – emDocs (free)

Perspective: Unnecessary Exclusions Shut Patients Out of Clinical Trials

15 Apr, 2018 | 23:35h | UTC

Unnecessary exclusions shut patients out of clinical trials – STAT (free)

Randomized Controlled Trial: Novel Insecticidal Net Nearly Halves Malaria Infection Rate

15 Apr, 2018 | 23:32h | UTC

Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomised controlled, two-by-two factorial design trial – The Lancet (free)

Commentaries: Insecticide-resistant malaria vectors must be tackled – The Lancet (free) AND Advanced insecticidal nets protect against malaria, study shows – CIDRAP News Scan for Apr 12, 2018 (free) AND ‘Resistance breaking’ mosquito net provides children with greater protection against malaria – London School of Hygiene & Tropical Medicine (free)

“The novel net nearly halves malaria infection rate in Tanzanian children compared to standard long-lasting pyrethroid nets” (from London School of Hygiene & Tropical Medicine)