Archives
Randomized Trial: Dual Antiplatelet Therapy in Acute Ischemic Stroke and High-Risk TIA
18 May, 2018 | 02:36h | UTCClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (free)
Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA (free)
Commentary: Dual Antiplatelet Therapy or Aspirin Alone After TIA or Minor Stroke? – NEJM Physician’s First Watch (free)
Consensus: Adverse Effects of Statin Therapy
18 May, 2018 | 02:34h | UTCCommentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)
Clinical Guideline: Pharmacotherapy for Neuropathic Pain
18 May, 2018 | 02:33h | UTC
Guideline Summary: Cardio-Onco-Hematology in Clinical Practice
18 May, 2018 | 02:35h | UTCOriginal Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Opinion: The Ten Pitfalls of Lactate Clearance in Sepsis
18 May, 2018 | 02:33h | UTCThe ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)
Source: Critical Care Reviews Newsletter
Systematic Review: Psychological Therapies for Treatment-resistant Depression in Adults
18 May, 2018 | 02:31h | UTCPsychological therapies for treatment-resistant depression in adults – Cochrane Library (free)
Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)
Cohort Study: Chemotherapy-Induced Neuropathy in Survivors of Childhood Cancer
18 May, 2018 | 02:32h | UTCChemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)
Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)
Meta-Analysis: Cancer Immunotherapy Efficacy Influenced by Patient’s Sex
18 May, 2018 | 02:29h | UTCCancer immunotherapy efficacy and patients’ sex: a systematic review and meta-analysis – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries: Patient’s sex might affect immunotherapy outcomes – OnMedica (free) AND Men Do Better than Women on Cancer Immunotherapies – MedPage Today (free registration required) AND Patients’ sex may impact efficacy of immunotherapy in cancer treatment – eCancer News (free)
Disease Outbreak: Ebola Case Confirmed in Urban Area of DRC
18 May, 2018 | 02:30h | UTCCommentary: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City The New York Times (10 articles per month are free)
Cross-Sectional Study: Association of Disrupted Circadian Rhythmicity with Mood Disorders
18 May, 2018 | 02:31h | UTCAssociation of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)
Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)
Fri, May 18 – 10 Stories of The Day!
18 May, 2018 | 02:10h | UTC
1 – Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)
Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)
Commentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)
Commentaries: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City The New York Times (10 articles per month are free)
4 – Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)
Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)
5 – Psychological therapies for treatment-resistant depression in adults – Cochrane Library (free)
Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)
6 – Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)
Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)
7 – Opinion: The ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)
Source: Critical Care Reviews Newsletter
Commentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)
10 – Summary: The Practice of Cardio-Oncology in Spain: Position Statement From Scientific Societies Involved in Cancer and Heart Disease – American College of Cardiology (free)
Original Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Randomized Controlled Trial: Exercise Training Does Not Slow Dementia Progression
18 May, 2018 | 02:29h | UTCCommentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)
Randomized Controlled Trials: Treatments for Mild Asthma Compared
18 May, 2018 | 02:28h | UTCInhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)
Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)
Thu, May 17 – 10 Stories of The Day!
17 May, 2018 | 01:41h | UTC
#ESOC2018 – Highlights from the 4th European Stroke Organization Conference
Editorial: Haemostatic treatment for intracerebral haemorrhage (free)
Commentaries: Study: Drug to treat bleeding may reduce stroke deaths – UPI (free) AND Drug to treat bleeding may benefit some stroke patients, study finds – University of Nottingham, via EurekAlert (free)
Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA (free)
Commentary: Dual Antiplatelet Therapy or Aspirin Alone After TIA or Minor Stroke? – NEJM Physician’s First Watch (free)
Editorial: MRI-Guided Intravenous Alteplase for Stroke — Still Stuck in Time (free)
Commentary: New treatment option for ‘wake-up’ stroke patients – University of Glasgow, via MedicalXpress (free)
Commentaries: NAVIGATE ESUS: Rivaroxaban Fails to Prevent More Recurrent Cryptogenic Strokes Than Aspirin – TCTMD (free) AND Rivaroxaban Not Superior to Aspirin for Patients with Embolic Stroke of Unknown Source – NEJM Physician’s First Watch (free)
Commentaries: Elevated Stroke Risk Continues for 5 Years After TIA – NEJM Physician’s First Watch (free) AND Five Years after TIA or Minor Stroke, Second-Event Risk Persists – MedPage Today (free)
6 – Manual: Managing epidemics: Key facts about major deadly diseases – World Health Organization (free)
“Managing epidemics. This @WHO manual provides concise, up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them”. (via @Onisillos and @claireekt see Tweet)
7 – Report: Saving lives, spending less: a strategic response to noncommunicable diseases – World Health Organization (free PDF)
News Release: Investing in noncommunicable disease control generates major financial and health gains – World Health Organization (free)
“For every US$1 invested in each policy area, the following returns have been documented:
US$12.82 from promoting healthy diets
US$9.13 from reducing the harmful use of alcohol
US$7.43 from lower tobacco use
US$3.29 from providing drug therapy for cardiovascular disease
US$2.80 from increasing physical activity
US$2.74 from managing cancer”
8 – ASCO 2018: Shortening Adjuvant Trastuzumab to 6 Months in Patients With HER2-Positive Early Breast Cancer Is Effective and Reduces Cardiac Toxicities – The ASCO Post (free)
Commentaries: Test of Herceptin Finds Briefer Treatment Can Work, With Fewer Side Effects – NPR (free) AND Shorter drug treatment OK for many breast cancer patients – Associated Press (free) AND For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter – The New York Times (10 articles per month are free)
““For women with early-stage breast cancer who needed the drug Herceptin, 6 months of treatment were as good as 12, a major study found. Less risk of side effects, less cost, less time “being a patient.”” (via @NYTHealth see Tweet)
“Global incident cases of multiple myeloma more than doubled from 1990-2016 w/incident cases increasing by 126%. The largest increase was in middle-SDI countries, particularly E. Asia with a 262% increase in incidence cases”. (via @IHME_UW see Tweet)
Commentary: Ibuprofen alone not an option for simple UTIs, study finds – CIDRAP (free) AND Randomized trial finds ibuprofen not a safe alternative to antibiotics for UTIs – PLOS, via ScienceDaily (free)
Related Research: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)
Report: The Characteristics of Pandemic Pathogens
16 May, 2018 | 01:23h | UTCNews release: Study by center for health security identifies characteristics of microorganisms most likely to cause a global pandemic (free)
Commentaries: Is this the face of Disease X? The deadly pathogens which could cause the next global pandemic – The Telegraph (free) AND The Next Deadly Pandemic Could Be Unlike Any Threats We Know, Say Experts – Science Alert (free) AND The Next Pandemic: Forget Zika Or Ebola, Airborne Viruses Like The Flu And The Common Cold Are The Real Threat – Inquisitr (free) AND Report: Next Pandemic Will Likely Be Respiratory-Based Virus – MedPage Today (free)
Related: Are we prepared for the looming epidemic threat? (free commentaries and video)
Report: First-ever WHO List of Essential Diagnostic Tests
16 May, 2018 | 01:23h | UTCNews Release: First-ever WHO list of essential diagnostic tests to improve diagnosis and treatment outcomes (free) (via @Onisillos)
Executive summary: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free PDF)
Review: Management of Acute Right Ventricle Failure
16 May, 2018 | 01:22h | UTCDiagnostic workup, etiologies and management of acute right ventricle failure – Intensive Care Medicine (free for a limited period)
Source: Critical Care Reviews Newsletter
Position Paper: Some Calories More Harmful Than Others
16 May, 2018 | 01:20h | UTCCommentary: Some calories more harmful than others – University of California, via EurekAlert (free)
Review: Intensive Care for Patients with Aneurysmal Subarachnoid Hemorrhage
16 May, 2018 | 01:21h | UTCSource: Critical Care Reviews Newsletter
Research: Amyloid PET Scan for Predicting Alzheimer’s Disease in Mild Cognitive Impairment
16 May, 2018 | 01:19h | UTCCommentaries: Biomarkers, PET imaging may predict cognitive decline en route to Alzheimer’s – Health Imaging (free) AND Amyloid PET Scan Can Predict Progression to Alzheimer’s in Patients With Mild Cognitive Impairment – MedicalResearch.com (free)
Related Studies: Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons (link to abstract and free commentaries) AND Identifying incipient dementia individuals using machine learning and amyloid imaging (free full-text and commentaries) AND High performance plasma amyloid-β biomarkers for Alzheimer’s disease (link to abstract and free commentaries)
Randomized Trial: Drug-Eluting Stents vs. Bare-Metal Stents in Saphenous Vein Grafts
16 May, 2018 | 01:16h | UTCDrug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary: Outcomes similar with DES vs. BMS in saphenous vein graft lesions – Healio (free registration required)
Study: Visual Screening Tool Improves Prediction of Developing Dementia
16 May, 2018 | 01:18h | UTCImproving Prediction of Dementia in Primary Care – Annals of Family Medicine (free)
Commentaries: Screening Tool Improves Dementia Prediction – Medscape (free registration required) AND Visual Test Could Help Predict Dementia Risk in Elders – NEJM Physician’s First Watch (free)
Randomized Trial: Intravesical Gemcitabine Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer
16 May, 2018 | 01:16h | UTCEffect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Intravesical Gemcitabine Therapy Cuts Bladder Cancer Recurrence – MPR (free) AND Simple post-surgery step reduces bladder cancer recurrence – SWOG, via EurekAlert (free)
Perspective by Dr. Eugene Braunwald: Aortic Stenosis
16 May, 2018 | 01:14h | UTCPerspective by Dr. Eugene Braunwald: Aortic Stenosis: Then and Now – Circulation (free for a limited period)
Cohort Study: Colonoscopy Adenoma Findings and Long-term Colorectal Cancer Incidence
16 May, 2018 | 01:13h | UTCAssociation of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA (free for a limited period)
Related Review: Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist – Digestive Endoscopy (free) AND Optimal Colonoscopy Surveillance Interval after Polypectomy – Clinical Endoscopy (free)
Related Guidelines: Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer (free) AND Korean Guidelines for Postpolypectomy Colonoscopy Surveillance – Digestive Endoscopy (free) AND Colorectal cancer surveillance after index colonoscopy: Guidance from the Canadian Association of Gastroenterology (free) AND Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline (free)
Advanced adenomas seem to be associated with subsequent increased risk for colorectal cancer, but nonadvanced adenomas may not be associated with increased risk.