Cohort Study | Heavy coffee intake is associated with kidney disfunction in genetically predisposed individuals

Summary: The study investigated whether a person’s genetic variation in the enzyme that metabolizes caffeine, called CYP1A2, modifies the association between coffee intake and kidney dysfunction. The study was conducted on 1180 participants with stage 1 hypertension. Data were collected from April 1, 1990, to June 30, 2006, with a follow-up of approximately 10 years. The study found that consuming more than three cups of coffee per day was associated with increased risks of albuminuria, hyperfiltration, and hypertension only among slow metabolizers of caffeine. The findings suggest that caffeine may play a role in the development of kidney disease in genetically susceptible individuals, but further studies are required to confirm these findings.

Article: CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction – JAMA Network Open

Commentaries:

Drinking 3 or more cups of coffee daily may increase kidney dysfunction risk – Medical News Today

Coffee may raise risk of kidney disease and hypertension in about half of population – MedicalResearch.com