Thu, May 25 – 10 Medical Stories of The Day!

1 – Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study – BMJ (free)

Recommended: New QRISK-3 2017 Calculator (free)

QRISK-3 risk prediction model was developed with data from 7.89 million patients in the derivation cohort and 2.67 million patients in the validation cohort. QRISK-3 includes more factors than QRISK2 to help enable doctors to identify those at most risk of heart disease and stroke. New risk factors include: 1) Chronic kidney disease, which now includes stage 3 CKD; 2) Migraine; 3) Use of corticosteroids; 4) Systemic lupus erythematosus (SLE); 5) Use of atypical antipsychotics; 6) Severe mental illness; 7) Erectile dysfunction; 8) and Systolic blood pressure variability.

2 – Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (2017) – Royal College of Paediatrics and Child Health (free PDF) (RT @bmj_latest see Tweet)

News release: New guidelines launched to help healthcare professionals and parents spot the signs of stroke in children (free)

Other resources: Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (2017) (free)

3 – Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial – JAMA (Link to abstract – $ for full-text)

Commentaries: Adding Anti-MRSA to Cephalexin No Better for Simple Cellulitis – Medscape (free registration required) AND Adding TMP/SMX to Cephalexin May Not Boost Cure Rate in Uncomplicated Cellulitis – Physician’s First Watch (free)

4 – Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Study confirms ‘flushing’ blocked fallopian tubes can improve fertility and reduce need for IVF – The Conversation (free) AND Can poppyseed oil help infertile couples conceive? – STAT News (free)

5 – Effect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery: A Cluster Randomized Clinical Trial – JAMA Surgery (free) (RT @PreetiNMalani see Tweet)

Commentary: Anti-delirium strategy reduces after-surgery confusion in elderly – Reuters Health (free)

Multicomponent nonpharmacologic interventions, including orienting communications, oral and nutritional assistance, and early mobilization reduced postoperative delirium by 56% and length of stay by 2 days.

6 – Very strict blood sugar control in critically ill children provides no benefit – NIHR Signal (free)

Original article (link to abstract – $ for full-text): Tight Glycemic Control in Critically Ill Children – New England Journal of Medicine (free)

7 – Human papillomavirus vaccines: WHO position paper, May 2017 – World Health Organization Weekly epidemiological record (free PDF)

“WHO update on HPV vaccine. Short summary – it’s very safe, very effective, widespread implementation recommended” (RT @michaelghead see Tweet)

8 – Factors Associated with Pediatric Mortality from Motor Vehicle Crashes in the United States: A State-Based Analysis – The Journal of Pediatrics (free PDF)

Commentaries: 43 Percent Of Children Who Died From Car Crashes Were Improperly Restrained – NPR Health News (free)

9 – Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (link to abstract – $ for full-text) (RT @Gas_Craic see Tweet)

“Compared with culprit-only intervention, the complete revascularisation strategy may be superior due to lower proportions of long-term cardiovascular mortality, long-term revascularisation, and long-term non-fatal myocardial infarction, but these findings are based on evidence of very low quality”

10 – Angioedema in the emergency department: a practical guide to differential diagnosis and management – International Journal of Emergency Medicine (free) (RT @Gas_Craic see Tweet)