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Daily Archives: July 20, 2023

IDSA 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections

20 Jul, 2023 | 11:15h | UTC

Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections – Clinical Infectious Diseases

 

USPSTF Statement | Evidence lacking for lipid disorders screening in asymptomatic children and adolescents

20 Jul, 2023 | 11:13h | UTC

Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Screening for Lipid Disorders in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Editorial: Still “on the Fence” About Universal Childhood Lipid Screening: The USPSTF Reaffirms an I Statement – JAMA

Patient Page: Screening for Lipid Disorders in Children and Adolescents – JAMA

Commentary: USPSTF: Screening Kids for Lipid Disorders Still Needs More Data – TCTMD

 

Study | Large language models show potential for medical question answering capabilities

20 Jul, 2023 | 11:12h | UTC

Large language models encode clinical knowledge – Nature

News Release: Benchmarking AI’s ability to answer medical questions – Nature Publishing Group

Commentary: Expert reaction to study presenting Med-PaLM, a large language model (LLM) for answering medical questions, and a benchmark for assessing how well LLMs can answer medical questions – Science Media Centre

 

Review | Management of severe acute respiratory distress syndrome

20 Jul, 2023 | 11:10h | UTC

Management of severe acute respiratory distress syndrome: a primer – Critical Care

Related: ESICM guidelines on ARDS: definition, phenotyping and respiratory support strategies

 

RCT | Hearing intervention fails to impact 3-year cognitive decline in older adults

20 Jul, 2023 | 11:09h | UTC

Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Prospective Study | Intelligence likely remains intact after pediatric concussion

20 Jul, 2023 | 11:06h | UTC

IQ After Pediatric Concussion – Pediatrics (free for a limited period)

Commentaries:

IQ After Pediatric Concussion: Clinical Considerations – Pediatrics

No Evidence Seen for Differences in IQ After Pediatric Concussion – HealthDay

Concussions do not affect IQ in children, study finds – News Medical

 

Pooled Analysis | Post-CABG graft failure found in 33.7% of patients, strongly linked to cardiac events

20 Jul, 2023 | 11:03h | UTC

Graft Failure After Coronary Artery Bypass Grafting and Its Association With Patient Characteristics and Clinical Events: A Pooled Individual Patient Data Analysis of Clinical Trials With Imaging Follow-Up – Circulation (free for a limited period)

 

Commentary on Twitter

 

Phase 2 Trial | Nivolumab shows promise as adjuvant therapy in completely resected Merkel cell carcinoma

20 Jul, 2023 | 11:02h | UTC

Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Adjuvant Nivolumab vs Observation for Patients With Completely Resected Merkel Cell Carcinoma – The ASCO Post

 

RCT | Preterm infants show same feeding tolerance with NCPAP or HHHFNC

20 Jul, 2023 | 11:01h | UTC

Effect of Nasal Continuous Positive Airway Pressure vs Heated Humidified High-Flow Nasal Cannula on Feeding Intolerance in Preterm Infants With Respiratory Distress Syndrome: The ENTARES Randomized Clinical Trial – JAMA Network Open

Commentary: Changing oxygenation strategies not associated with differences in feeding intolerance in preterm infants – Physician’s Weekly

 

M-A | Hepatic, extra-hepatic outcomes and causes of mortality in NAFLD

20 Jul, 2023 | 10:59h | UTC

Hepatic, Extra-hepatic Outcomes and Causes of Mortality in NAFLD – An Umbrella Overview of Systematic Review of Meta-Analysis – Journal of Clinical and Experimental Hepatology

 

Phase 1–2 study | Liso-cel shows effectiveness against resistant CLL/SLL post BTK inhibitor, venetoclax treatment

20 Jul, 2023 | 10:58h | UTC

Lisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004): a multicentre, open-label, single-arm, phase 1–2 study – The Lancet (link to abstract – $ for full-text)

News Release: Immunotherapy Improves Remission for Relapsed, Refractory Leukemia – Northwestern Medicine

 

RCT | Ischemic stroke patients benefit from Panax notoginseng saponins therapy

20 Jul, 2023 | 10:57h | UTC

Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

Commentary: Do Panax notoginseng saponins (Xuesaitong soft capsules) improve function in patients with ischemic stroke? – News Medical

 

Systematic Review | Platinum doublet therapy outperforms non-platinum for advanced NSCLC, performance status 2 patients

20 Jul, 2023 | 10:56h | UTC

Best first‐line therapy for people with advanced non‐small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status – Cochrane Library

Summary: Best therapy for people with advanced non-small cell lung cancer who have not been treated without a targetable mutation and moderately impaired performance status – Cochrane Library

 

Systematic Review | Outcomes in deprescribing implementation trials and compliance with expert recommendations

20 Jul, 2023 | 10:55h | UTC

Outcomes in deprescribing implementation trials and compliance with expert recommendations: a systematic review – BMC Geriatrics

Related:

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 

Review | Painful diabetic peripheral neuropathy

20 Jul, 2023 | 10:53h | UTC

Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management – Diabetes, Metabolic Syndrome and Obesity

 

Systematic Review | Vedolizumab for induction and maintenance of remission in Crohn’s disease

20 Jul, 2023 | 10:51h | UTC

Vedolizumab for induction and maintenance of remission in Crohn’s disease – Cochrane Library

 

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