Daily Archives: June 29, 2023

AHA Scientific Statement | Considerations on the management of acute postoperative ischemia after cardiac surgery

29 Jun, 2023 | 14:07h | UTC

Considerations on the Management of Acute Postoperative Ischemia After Cardiac Surgery: A Scientific Statement From the American Heart Association – Circulation

Post hoc analysis | Low-dose aspirin linked to increased risk of anemia in older adults

29 Jun, 2023 | 14:06h | UTC

Summary: In a post hoc analysis of the ASPREE randomized controlled trial, the impact of daily low-dose aspirin on anemia, hemoglobin, and serum ferritin concentrations in elderly individuals was investigated. The study included 19,114 community-dwelling individuals aged 70 years and older (or ≥65 years for Black and Hispanic individuals) from Australia and the United States.

Findings reveal an increased incidence of anemia in the aspirin group compared to the placebo group (51.2 events versus 42.9 events per 1000 person-years, respectively). This correlates to a 20% increase in risk (hazard ratio, 1.20 [95% CI, 1.12 to 1.29]). Hemoglobin concentrations displayed a more pronounced decline in the aspirin group by 0.6 g/L per 5 years. Additionally, among participants with ferritin measures, the aspirin group exhibited a greater prevalence of ferritin levels less than 45 µg/L at year 3 and overall decline in ferritin by 11.5%. The study found similar results even in the absence of major bleeding.

This research underscores the risk of anemia and decline in ferritin in otherwise healthy older adults taking low-dose aspirin, highlighting the need for periodic monitoring of hemoglobin levels. However, the study lacked data on the causes of anemia, indicating the need for further research.

Article: Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly: A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Low-dose aspirin may increase anaemia risk in healthy older adults: study – Monash University

Commentaries:

Aspirin Use Ups Risk of Anemia in Elderly Patients: ASPREE – TCTMD

Low-dose aspirin associated with 20% increase in risk of anemia among older adults – ACP Internist

Original Study: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly – New England Journal of Medicine

Review | Breathing difficulties after covid-19: a guide for primary care

29 Jun, 2023 | 14:04h | UTC

Breathing difficulties after covid-19: a guide for primary care – The BMJ

M-A | Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery

29 Jun, 2023 | 14:03h | UTC

Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery: a systematic review, meta-analysis and trial sequential analysis – Anaesthesia

Clinical Trial Update | Equal long-term health and survival from restrictive vs. standard IV fluid therapy in septic shock patients

29 Jun, 2023 | 14:01h | UTC

Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock – Intensive Care Medicine

Original Study: RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.

Guidance on fecal immunochemical testing to help diagnose colorectal cancer among symptomatic patients in primary care

29 Jun, 2023 | 13:59h | UTC

Guidance on faecal immunochemical testing (FIT) to help diagnose colorectal cancer among symptomatic patients in primary care – British Journal of General Practice

RCT | Intravitreal therapy for uveitic macular edema—ranibizumab versus methotrexate versus the dexamethasone implant

29 Jun, 2023 | 13:57h | UTC

Intravitreal Therapy for Uveitic Macular Edema—Ranibizumab versus Methotrexate versus the Dexamethasone Implant – Ophthalmology (link to abstract – $ for full-text)

News Release: Intraocular corticosteroids best for treating complications of chronic inflammatory eye condition – National Institutes of Health

RCT | Acupuncture, doxylamine–pyridoxine, and their combination in nausea treatment during pregnancy

29 Jun, 2023 | 13:56h | UTC

Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy: A Randomized, Controlled, 2 × 2 Factorial Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Acupuncture and doxylamine-pyridoxine beneficial for moderate to severe nausea and vomiting during pregnancy: Study – American College of Physicians

Commentary: Combo treatment eases nausea and vomiting of pregnancy – MDedge

Commentary on Twitter

What's the risk of silent cerebral lesions following catheter ablation for #AF?? https://t.co/GJsUziHLeu @EuropaceEiC @GiulioConte9 @AAuricchioMD @Dominik_Linz @FraSantoroMD @AndyZhangMD @marcovitoloMD @DhirajGuptaBHRS #AF #ablation #europace pic.twitter.com/ZYQP7oS9sS

— European Society of Cardiology Journals (@ESC_Journals) June 21, 2023

Liver Transplantation 2023 | Status report, current and future challenges

29 Jun, 2023 | 13:50h | UTC

Liver Transplantation 2023: Status Report, Current and Future Challenges – Clinical Gastroenterology and Hepatology

SR | Anti‐vascular endothelial growth factors in combination with vitrectomy for complications of proliferative diabetic retinopathy

29 Jun, 2023 | 13:49h | UTC

Anti‐vascular endothelial growth factors in combination with vitrectomy for complications of proliferative diabetic retinopathy – Cochrane Library

RCT | Arthroscopic capsular shift surgery shows no significant pain or functional improvement in atraumatic shoulder instability

29 Jun, 2023 | 13:45h | UTC

Arthroscopic capsular shift surgery in patients with atraumatic shoulder joint instability: a randomised, placebo-controlled trial – British Journal of Sports Medicine (link to abstract – $ for full-text)