Daily Archives: June 15, 2023
RCT | Prehospital use of tranexamic acid in severe trauma cases shows no superiority over placebo
15 Jun, 2023 | 15:16h | UTCPrehospital Tranexamic Acid for Severe Trauma – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Shining a new light on tranexamic acid for trauma care – Monash University
Commentary on Twitter
Late breaking at #CCR23: In the PATCH-Trauma trial involving adults with major trauma, treatment with tranexamic acid did not result in a greater number of patients surviving with a favorable functional outcome at 6 months than placebo. https://t.co/i8fu34ReCB pic.twitter.com/GEOtRphOBb
— NEJM (@NEJM) June 14, 2023
Consensus Statement | Concussion in sport
15 Jun, 2023 | 15:14h | UTC
Perspective | Observational studies must be reformed before the next pandemic
15 Jun, 2023 | 15:12h | UTCObservational studies must be reformed before the next pandemic – Nature Medicine
Evidence-based clinical practice guideline for deprescribing opioid analgesics
15 Jun, 2023 | 15:08h | UTC
RCT | Cannabis-based medicines show no significant relief for moderate-to-severe cancer pain
15 Jun, 2023 | 15:10h | UTCCannabis‐based medicines and medical cannabis for adults with cancer pain – Cochrane Library
Summary: Cannabis-based medicines for cancer pain – Cochrane Library
Cohort Study | Identification of an optimal threshold to define oliguria in critically ill patients
15 Jun, 2023 | 15:05h | UTC
Commentary on Twitter
Identification of an optimal threshold to define oliguria in critically ill patients
Read the full article: https://t.co/4msRdcWZYY@jlvincen @ISICEM #FOAMed #FOAMcc pic.twitter.com/5PfiXkE5FO
— Critical Care (@Crit_Care) June 9, 2023
RCT | No significant kidney outcome differences observed across glucose-lowering medications in T2D patients
15 Jun, 2023 | 15:02h | UTCComparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
See also: Visual Abstract
Commentaries:
No differences found in effects of secondary diabetes drugs on kidney outcomes – ACP Diabetes
Do glucose-lowering medications have different effects on kidney outcomes? – News Medical
RCT | Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer
15 Jun, 2023 | 15:04h | UTC
M-A | Similar death rates in left main disease patients treated with PCI or CABG, both in patients with and without ACS
15 Jun, 2023 | 14:59h | UTCPercutaneous Coronary Intervention vs Coronary Artery Bypass Graft Surgery for Left Main Disease in Patients With and Without Acute Coronary Syndromes: A Pooled Analysis of 4 Randomized Clinical Trials – JAMA Cardiology (link to abstract – $ for full-text)
Commentary: CABG and PCI Comparable in ACS Patients With Left Main CAD – TCTMD
RCT | Sublingual microcirculatory assessment fails to reduce 30-day mortality in shock patients
15 Jun, 2023 | 15:00h | UTC
Commentary on Twitter
Direct assessment of microcirculation in shock, prospective multicenter RCT
🩸knowledge of sublingual microcirculatory perfusion variables resulted in significantly more therapy adjustments
🩸these changes did not improve 30d survival
#FOAMcc @yourICM
🖇️ https://t.co/Mn5bAqjDtS pic.twitter.com/i3zPwomb0V— Intensive Care Medicine (@yourICM) June 6, 2023
SR | Quality improvement strategies for diabetes care: Effects on outcomes for adults living with diabetes
15 Jun, 2023 | 14:57h | UTC
M-A | Influencing factors of medication adherence in schizophrenic patients
15 Jun, 2023 | 14:56h | UTC
RCT | Nalbuphine reduces cough in idiopathic pulmonary fibrosis, despite adverse effects
15 Jun, 2023 | 14:55h | UTCNalbuphine Tablets for Cough in Patients with Idiopathic Pulmonary Fibrosis – NEJM Evidence
Cohort Study | Weight change and risk of obesity-related complications
15 Jun, 2023 | 14:53h | UTC
Commentary from the author on Twitter
Our paper showing association of weight loss on risk of developing 13 obesity-related complications
Weight loss benefit dependent on weight loss magnitude & initial BMI-weight gain associated with a similar risk ⬆️
4 patterns of association identifiedhttps://t.co/7iQCCsIJ3x pic.twitter.com/xVVLruS6Jg
— Prof Kamlesh Khunti (@kamleshkhunti) June 8, 2023
M-A | Comparing non-invasive tests, histology for predicting non-alcoholic fatty liver outcomes
15 Jun, 2023 | 14:50h | UTC
Review | Candidate biomarkers in psychiatric disorders
15 Jun, 2023 | 14:52h | UTCCandidate biomarkers in psychiatric disorders: state of the field – World Psychiatry
Review | Contribution of wastewater to antimicrobial resistance
15 Jun, 2023 | 14:49h | UTCRelated studies on surveillance of wastewater:
Use of Wastewater for Mpox Outbreak Surveillance in California – New England Journal of Medicine
Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.
CDC unveils its latest weapon in Covid-19 detection: wastewater.
[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.
Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT
The myriad ways sewage surveillance is helping fight COVID around the world – Nature
It’s time to begin a national wastewater testing program for Covid-19 – STAT
Coronavirus: Testing sewage an ‘easy win’ – BBC
M-A | Biosimilar and reference biologics in rheumatoid arthritis show equivalent results
15 Jun, 2023 | 14:47h | UTCCommentary: Adalimumab, Etanercept, Infliximab Biosimilars Show Clinically Equivalence to Biologics in RA – HCP Live
Cohort Study | 63.1% of uncomplicated appendicitis in children successfully treated non-operatively at 1 year
15 Jun, 2023 | 14:45h | UTC
Commentary on Twitter
1y outcomes of CASCADE examining💊treatment for uncomp🪱itis in kids ➡️overall success: 63.1%, 21.5% req🔪during hospitalisation, 10.4% recurrence @1y. Overall comp: 7.3%🔪vs. 1.3% in success Non🔪treatment. Thoughts?https://t.co/AuIgSKkU6w#SoMe4Surgery #some4peds #emgensurg pic.twitter.com/9mM5NFOEh1
— BJS Open (@BjsOpen) June 7, 2023
Imaging features of the postoperative spine: a guide to basic understanding of spine surgical procedures
15 Jun, 2023 | 14:43h | UTC