Daily Archives: June 5, 2023
Global burden, risk factors analysis, and prediction study of ischemic stroke, 1990–2030
5 Jun, 2023 | 13:53h | UTCGlobal Burden, Risk Factors Analysis, and Prediction Study of Ischemic Stroke, 1990–2030 – Neurology
News Release: Worldwide Stroke Deaths Expected to Increase to Nearly 5 Million by 2030 – American Academy of Neurology
Commentary on Twitter
Published online: Global Burden, Risk Factors Analysis, and Prediction Study of Ischemic #Stroke, 1990–2030 https://t.co/nIH5mBQDtE#NeuroTwitter pic.twitter.com/WUfFQM5t7Z
— Neurology Journal (@GreenJournal) May 23, 2023
RCT | Noninferiority shown between DOACs and LMWH for recurrent VTE prevention in cancer patients
5 Jun, 2023 | 13:50h | UTCSummary: This unblinded, pragmatic, noninferiority randomized clinical trial aimed to assess the efficacy of direct oral anticoagulants (DOACs) against low-molecular-weight heparin (LMWH) in preventing recurrent venous thromboembolism (VTE) in patients with cancer. The study included 671 patients from 67 oncology centers, with a new clinical or radiological diagnosis of VTE.
Participants were randomly assigned to receive either a DOAC or LMWH for 6 months, and treating physicians selected and prescribed the drugs based on considerations like availability and drug-drug interactions. The primary outcome was the rate of recurrent VTE at 6 months. Findings revealed that the DOAC group had a recurrent VTE rate of 6.1% as compared to 8.8% in the LMWH group, showing noninferiority. Both groups had statistically similar rates of major bleeding and severe adverse events.
This pragmatic study included patients with advanced cancer and brain metastases, impaired performance status, and reduced liver or kidney function, making it more representative of routine oncology practice. Moreover, patient adherence to DOAC treatment was significantly higher than to LMWH. Nevertheless, the study had limitations, including the lack of blinding and underrepresentation of certain racial and ethnic groups.
In conclusion, this trial suggests that DOACs were noninferior to LMWH for preventing recurrent VTE in patients with cancer over a 6-month follow-up period, supporting the use of DOACs in this population for VTE prevention. Further research is needed to confirm these results and investigate long-term outcomes.
Article: Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual abstract
Commentary on Twitter
Among adults with cancer and VTE, direct oral anticoagulants were noninferior to low-molecular-weight heparin for preventing recurrent VTE over 6-month follow-up. #ASCO23 https://t.co/DP5RvlSYxe pic.twitter.com/rBJ99plopK
— JAMA (@JAMA_current) June 2, 2023
Review | Prevention of venous thromboembolism in patients with cancer
5 Jun, 2023 | 13:48h | UTCPrevention of venous thromboembolism in patients with cancer – The BMJ
RCT | Osimertinib improves overall survival in resected EGFR-mutated NSCLC, but validity of control group questioned on social media
5 Jun, 2023 | 13:46h | UTCOverall Survival with Osimertinib in Resected EGFR-Mutated NSCLC – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter by Dr. Vinay Prasad (recommended – click to see the video)
Here is the REAL @Plenary_Session on #ADAURA #ASCO23 #ASCO2023
38.5% of people who had recurrence got OSI (very low!)
That just isn't good enough
Brain staging is suboptimal= occult met disease
Would you let your mother be on the control arm and not get OSI on progression? pic.twitter.com/CU3jtrvFOj— Vinay Prasad MD MPH (@VPrasadMDMPH) June 5, 2023
#ASCO23 – RCT | Simple hysterectomy shown non-inferior to radical hysterectomy in low-risk early-stage cervical cancer
5 Jun, 2023 | 13:43h | UTCCommentaries:
ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation
5 Jun, 2023 | 13:37h | UTC
Review | Advances in systemic therapies for triple negative breast cancer
5 Jun, 2023 | 13:36h | UTCAdvances in systemic therapies for triple negative breast cancer – The BMJ
RCT | Sulbactam-durlobactam non-inferior to colistin for acinetobacter baumannii-calcoaceticus complex infections
5 Jun, 2023 | 13:31h | UTCEfficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) – The Lancet Infectious Diseases (link to abstract – $ for full-text)
News Release: Novel Antibiotic Succeeds in Trial Against Hospital-Acquired Pneumonia – Rutgers University
Cohort Study | Overweight or obesity in early and middle adulthood linked to higher gastrointestinal cancer risk
5 Jun, 2023 | 13:34h | UTCEditorial: Obesity and Gastrointestinal Cancer: A Life Course Perspective – JAMA Network Open
Commentary: Association Between Overweight/Obesity and Risk of Gastrointestinal Cancer – The ASCO Post
M-A | Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy
5 Jun, 2023 | 13:29h | UTCRole of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis – The Lancet Oncology (free for a limited period)
Commentary from the author on Twitter
Our latest meta-analysis on #chemoradiation in nasopharyngeal cancer out in @TheLancetOncol
Huge collaborative work.
✅ 28 trials, 8.000+ pts, 7.6y FU
✅ more chemo (ind+conc or conc+adj) ➡️superior (OS/PFS) to CRT alone but more toxFree 50day link: https://t.co/BtRJDZERRZ pic.twitter.com/v2v5MsinnV
— Pierre Blanchard, MD (@PBlanchardMD) June 1, 2023
Cohort Study | Cannabis use disorder linked to increased risk of depression and bipolar disorder
5 Jun, 2023 | 13:26h | UTCCannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)
Author Interview: Cannabis Use Disorder and Subsequent Risk of Unipolar Depression and Bipolar Disorder
Commentary: Expert reaction to study of cannabis use disorder, bipolar disorder, and depression – Science Media Centre
How could ChatGPT impact my practice as an intensivist? An overview of potential applications, risks and limitations
5 Jun, 2023 | 13:23h | UTCHow could ChatGPT impact my practice as an intensivist? An overview of potential applications, risks and limitations – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
How could ChatGPT impact #ICU practice?
? what is it & how does it work?
? potential applications in intensive care medicine
? limitations/risks of large language models
ChatGPT potential valuable tools: be aware of limitations/potential misuses.
?️ https://t.co/x89Itabi2p pic.twitter.com/zf59ES5QQw— Intensive Care Medicine (@yourICM) May 31, 2023
WSES consensus guidelines on sigmoid volvulus management
5 Jun, 2023 | 13:19h | UTCWSES consensus guidelines on sigmoid volvulus management – World Journal of Emergency Surgery
Review | Hypovolemia with peripheral edema: what is wrong?
5 Jun, 2023 | 13:18h | UTCHypovolemia with peripheral edema: What is wrong? – Critical Care
M-A | Efficacy and safety of duloxetine in chronic musculoskeletal pain
5 Jun, 2023 | 13:09h | UTC
Clinical Trial Update | Olaparib plus bevacizumab first-line maintenance in ovarian cancer
5 Jun, 2023 | 13:07h | UTCOriginal Study: Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer – New England Journal of Medicine
Review | The future of intensive care: the study of the microcirculation will help to guide our therapies
5 Jun, 2023 | 13:05h | UTC
M-A | Comparison of intercostal block and epidural analgesia for post-thoracotomy
5 Jun, 2023 | 13:04h | UTC
M-A | Hypoxia-inducible factor stabilizers’ effects on lab parameters and outcomes in CKD patients with renal anemia
5 Jun, 2023 | 13:00h | UTC
Cryptococcosis: 90% cases in HIV-negative patients, Australasian study identifies risk factors
5 Jun, 2023 | 12:52h | UTC