Daily Archives: March 10, 2023
New WHO guidelines to boost the use of life-saving safety restraints in vehicles
10 Mar, 2023 | 14:40h | UTCNews Release: New global guidelines to boost the use of life-saving safety restraints in vehicles – World Health Organization
WHO urges countries to implement comprehensive sodium reduction policies to combat cardiovascular disease
10 Mar, 2023 | 14:43h | UTCSummary:
A new report from the World Health Organization (WHO) has shown that the world needs to catch up to achieve its global target of reducing sodium intake by 30% by 2025. The report highlights that only 5% of WHO member states have mandatory and comprehensive sodium reduction policies.
Sodium, found in table salt and other condiments, increases the risk of heart disease, stroke, and premature death when eaten in excess. Implementing highly cost-effective sodium reduction policies could save an estimated seven million lives globally by 2030.
WHO suggests a number of policies, such as reducing the amount of sodium in food products, introducing front-of-pack labeling, launching mass media campaigns, and enforcing public policies related to food service and sales.
The report urges member states to implement sodium intake reduction policies without delay, and calls on food manufacturers to set ambitious targets for sodium reduction in their products.
Article: WHO global report on sodium intake reduction – World Health Organization
News Release: Massive efforts needed to reduce salt intake and protect lives – World Health Organization
Related:
Adding salt to foods and hazard of premature mortality – European Heart Journal
New WHO benchmarks help countries reduce salt intake and save lives – World Health Organization
WHO global sodium benchmarks for different food categories – World Health Organization
Commentary on Twitter
Eating too much salt is one of the top risk factors for heart disease, stroke, and death.
WHO’s first global report on sodium intake reduction shows only 5% of WHO Member States are protected by mandatory and comprehensive sodium reduction policies?https://t.co/hiocdiXUiy pic.twitter.com/NXSv0oe7fn
— World Health Organization (WHO) (@WHO) March 9, 2023
RCT | Treat-to-target strategy is noninferior to high-intensity statin therapy in patients with coronary artery disease
10 Mar, 2023 | 14:44h | UTCSummary: This randomized, multicenter, noninferiority trial in South Korea enrolled 4,400 patients with known coronary artery disease. Patients were randomly assigned to one of two groups: a treat-to-target group and a high-intensity statin group.
The treat-to-target group received moderate or high-intensity statins and titrated their medication to achieve an LDL-C goal of 50-70 mg/dL, while the high-intensity statin group received rosuvastatin 20 mg or atorvastatin 40 mg. The primary endpoint was a 3-year composite of death, myocardial infarction, stroke, or coronary revascularization.
The study found that the primary endpoint occurred in 8.1% of the treat-to-target group and 8.7% of the high-intensity statin group, indicating that the treat-to-target strategy was noninferior to the high-intensity statin strategy.
Overall, the results of this study indicate that a treat-to-target strategy could be an appropriate substitute for high-intensity statin therapy in patients with coronary artery disease. This approach enables a personalized treatment plan that accounts for variations in individual drug response to statin therapy.
Article: Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries:
Not all patients with coronary artery disease require high intensity statins – MedicalResearch.com
Commentary on Twitter
Among patients with coronary artery disease, a treat-to-target LDL-C strategy was noninferior to a high-intensity statin strategy for major clinical outcomes. https://t.co/Orv8IeF4Gv #ACC23 #WCCardio pic.twitter.com/NVEEJfQYfJ
— JAMA (@JAMA_current) March 6, 2023
Current recommendations for management of pediatric diabetic ketoacidosis
10 Mar, 2023 | 14:38h | UTC
AASLD guidance on the clinical assessment and management of nonalcoholic fatty liver disease
10 Mar, 2023 | 14:36h | UTCRelated:
Management of NAFLD in primary care settings – Liver International
Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports
Recommendations for cardiac point-of-care ultrasound in children
10 Mar, 2023 | 14:35h | UTC
RCT | Cannabidiol oil not effective for post-ureteroscopy pain control
10 Mar, 2023 | 14:34h | UTCSummary: The study evaluated the effect of cannabidiol oil on pain control and opioid usage in patients undergoing ureteroscopy with stent placement for urinary stone disease. Ninety patients were randomized 1:1 to receive either placebo or 20mg of cannabidiol oil daily for 3 days postoperatively.
Results showed no difference between CBD oil and placebo in reducing pain scores, opioid usage, or stent-related symptoms. The study suggests that despite the availability of numerous analgesic agents, stent symptoms continue to be bothersome for most patients, and further research is needed to find effective non-opioid alternatives for pain management in this setting.
Article: Effect of Cannabidiol Oil on Post-ureteroscopy Pain for Urinary Calculi: A Randomized, Double-blind, Placebo-controlled Trial – The Journal of Urology (free for a limited period)
Cohort Study | Effect of prosthesis-patient mismatch on long-term clinical outcomes after bioprosthetic aortic valve replacement
10 Mar, 2023 | 14:32h | UTCSummary: The study examined the impact of prosthesis-patient mismatch (PPM) on long-term clinical outcomes following bioprosthetic surgical aortic valve replacement (SAVR). The observational cohort study analyzed data from 16,423 patients who underwent bioprosthetic SAVR in Sweden from 2003 to 2018.
Results showed that increasing grades of PPM were associated with higher long-term mortality and heart failure hospitalization. Severe PPM was linked to an increased risk of heart failure, but moderate PPM did not have significant clinical significance. The study also found that PPM was not associated with aortic valve reintervention. The incidence of moderate and severe PPM has decreased in Sweden since 2013 but remained common.
Review | How to use nebulized antibiotics in severe respiratory infections
10 Mar, 2023 | 14:31h | UTCHow to Use Nebulized Antibiotics in Severe Respiratory Infections – Antibiotics
M-A | The influence of seated exercises on disability after a stroke
10 Mar, 2023 | 14:25h | UTC
RCT | Vaginal cleansing before unscheduled cesarean delivery did not reduce postoperative infections
10 Mar, 2023 | 14:23h | UTCVaginal cleansing before unscheduled cesarean delivery to reduce infection: a randomized clinical trial – American Journal of Gynecology & Obstetrics (link to abstract – $ for full-text)
Related studies with conflicting results:
Vaginal Cleansing Before Cesarean Delivery: A Systematic Review and Meta-analysis – Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter
Vaginal Cleansing Before Unscheduled Cesarean Delivery to Reduce Infection: A Randomized Clinical Trial https://t.co/QuNWfCxl3D @acog pic.twitter.com/sauvsRq5C1
— AJOG (@AJOG_thegray) November 30, 2022
SR | Surgical treatments for epilepsies in children aged 1–36 months
10 Mar, 2023 | 14:21h | UTCSurgical Treatments for Epilepsies in Children Aged 1–36 Months: A Systematic Review – Neurology
Commentary on Twitter
Tsou and colleagues summarize findings of a systematic review commissioned by the @AmEpilepsySoc to assess evidence and identify evidence gaps for surgical treatments for #epilepsy in children aged 1–36 months without infantile spasms. Read the article: https://t.co/Q1WW8Yy0Jf pic.twitter.com/Ko1c27x6cw
— Neurology Journal (@GreenJournal) January 9, 2023
RCT | The effect of skin traction on pain relief in patients with isolated intertrochanteric fractures
10 Mar, 2023 | 14:24h | UTC
Cohort Study | Depression and poor mental health linked to premature CVD and suboptimal CVH in young adults
10 Mar, 2023 | 14:14h | UTC
Commentary on Twitter
A new analysis of #BRFSS data from >600K young adults finds double the odds of #CVD in people with depression. #AHAJournals @GarimaVSharmaMD https://t.co/ZFzTTnUs95 pic.twitter.com/gvIAqbg47H
— JAHA (@JAHA_AHA) January 31, 2023
Cohort Study | Analysis of mortality among transgender and gender diverse adults in England
10 Mar, 2023 | 14:19h | UTCAnalysis of Mortality Among Transgender and Gender Diverse Adults in England – JAMA Network Open
Commentary on Twitter
Transgender and gender diverse adults in England have higher mortality compared to cisgender people, particularly due to suicide, homicide, accidental poisoning. https://t.co/gNzxBiRGac
— JAMA Network Open (@JAMANetworkOpen) January 30, 2023
Cohort Study | A simple classification of pancreatic duct size and texture predicts the risk of postoperative pancreatic fistula
10 Mar, 2023 | 14:10h | UTCRelated:
M-A | Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy.
Commentary on Twitter
NEW classification from @ISGPS_news for reporting of pancreatoduodenectomy trials:
A – not-soft (hard) texture and duct >3 mm ?
B – not-soft (hard) texture and duct ≤3 mm ?
C – soft texture and duct >3 mm ?
D – soft texture and duct ≤3 mm ?https://t.co/sZeL3MAva2— Pascal Probst (@ProbstPascal) May 1, 2021
Cohort Study | Clinical associations and classification of immune checkpoint inhibitor‐induced cutaneous toxicities
10 Mar, 2023 | 14:09h | UTC
M-A | Supplemental breast cancer screening in women with dense breasts and negative mammography
10 Mar, 2023 | 14:12h | UTCSupplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis – Radiology (link to abstract – $ for full-text)
News Release: Breast MRI effective at detecting cancer in dense breasts – Radiological Society of North America
Commentary on Twitter
Compared with other supplemental modalities, MRI was superior in detecting breast cancer in a systematic review and meta-analysis. @JDMIRadiologist @UHN @UHN_Research https://t.co/NiZIFO5z9K pic.twitter.com/f9xzVXN9LJ
— Radiology (@radiology_rsna) February 1, 2023
RCT | Tranexamic acid did not significantly reduce blood loss in pancreaticoduodenectomy
10 Mar, 2023 | 14:05h | UTCTranexamic acid and blood loss in pancreaticoduodenectomy: TAC-PD randomized clinical trial – British Journal of Surgery (link to abstract – $ for full-text)
RCT | Transanal vs. laparoscopic total mesorectal excision for mid and low rectal cancer
10 Mar, 2023 | 14:03h | UTCTransanal versus laparoscopic total mesorectal excision for mid and low rectal cancer (Ta-LaTME study): multicentre, randomized, open-label trial – British Journal of Surgery (link to abstract – $ for full-text)
Pregnancy complications linked to long-term mortality in a racially diverse cohort
10 Mar, 2023 | 14:01h | UTCPregnancy Complications and Long-Term Mortality in a Diverse Cohort – Circulation
Related:
Severity of obstructive coronary artery stenosis after pre-eclampsia – Heart