Daily Archives: November 7, 2022
CDC Clinical Practice Guideline for prescribing opioids for pain.
7 Nov, 2022 | 13:00h | UTCCommentaries:
CDC issues new opioid prescribing guidance, giving doctors more leeway to treat pain – NPR
NICE Guideline | Self-harm: assessment, management and preventing recurrence.
7 Nov, 2022 | 12:58h | UTC
RCT | In patients with CKD (eGFR 20-45 mL/min per 1.73 m2), Empagliflozin reduced the risk of progression of kidney disease.
7 Nov, 2022 | 12:56h | UTCEmpagliflozin in Patients with Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: EMPA-KIDNEY supports SGLT2 inhibition for chronic kidney disease – medwire News
Video Summary: EMPA-KIDNEY results: Empagliflozin reduces kidney disease progression and cardiovascular deaths
Commentary on Twitter
In this trial involving patients with chronic kidney disease, empagliflozin resulted in a lower risk of disease progression or death from cardiovascular causes than placebo. #KidneyWk https://t.co/HFgzPgrRFx pic.twitter.com/EPU6Rl14F1
— NEJM (@NEJM) November 4, 2022
RCT | Triglyceride lowering with Pemafibrate fails to reduce CVD risk in patients with Type 2 DM and hypertriglyceridemia.
7 Nov, 2022 | 12:54h | UTCTriglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk – New England Journal of Medicine (link to abstract – $ for full-text)
News Releases:
Commentaries:
Pemafibrate Fails to Lower CVD Risk in Patients With High Triglycerides: PROMINENT – TCTMD
Commentary on Twitter
In a randomized trial, the incidence of cardiovascular events was not lower in patients with diabetes, HTG, and low HDL cholesterol levels who received pemafibrate, although TG, VLDL cholesterol, remnant cholesterol, and Apo C-III levels decreased. #AHA22 https://t.co/bNtIAwWTX0 pic.twitter.com/yWaTWarlsv
— NEJM (@NEJM) November 5, 2022
RCT | Early amino acids in extremely preterm infants did improve neurodisability at 2 Years.
7 Nov, 2022 | 12:52h | UTCEarly Amino Acids in Extremely Preterm Infants and Neurodisability at 2 Years – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Extra Parenteral Amino Acids No Benefit for Extremely Preterm Infants – HealthDay
Commentary on Twitter
ProVIDE trial @NEJM: In ELBW infants, extra parenteral amino acids at a dose of 1 g/day for 5 days after birth did not improve survival free from neurodisability at 2 yrs.
Higher rates of mod-sev disability noted in intervention group.https://t.co/8hT3Ol3qOi#EBNEOalerts #neoEBM pic.twitter.com/2Z9qgkQF54— Evidence-Based Neo (@EBNEO) November 5, 2022
RCT | Chlortalidone and Hydrochlorothiazide resulted in similar reductions of CVD in older patients with hypertension.
7 Nov, 2022 | 12:50h | UTCNews Release (not published yet): No difference in heart outcomes found in use of two diuretics to treat blood pressure – American Heart Association
Commentaries:
In High BP, Chlorthalidone and Hydrochlorothiazide Have Similar Impact on MACE – TCTMD
Diuretic Comparison Project – DCP – American College of Cardiology
RCT | Intravenous iron did not significantly reduce hospital admissions in patients with heart failure and iron deficiency.
7 Nov, 2022 | 12:48h | UTCCommentaries:
IRONMAN Misses but Lends Support to IV Iron Repletion in HF – TCTMD
Cohort Study | Preoperative hemodialysis timing and postoperative mortality in patients with end-stage kidney disease.
7 Nov, 2022 | 12:46h | UTCAssociation Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease – JAMA (free for a limited period)
Editorial: Optimal Timing of Hemodialysis Before Surgery – JAMA (free for a limited period)
Commentary from the author on Twitter (thread – click for more)
1/
In @JAMA_current, we asked: Is the timing of hemodialysis before surgery associated with postoperative mortality?The answer: YES
Here’s what we found:https://t.co/ZQl0SHZpAn
— Vikram Fielding-Singh, MD, JD (@vikramfs) November 3, 2022
Expert consensus | Use of sponge-assisted endoluminal vacuum therapy for the treatment of colorectal anastomotic leaks.
7 Nov, 2022 | 12:42h | UTC
Commentary on Twitter
https://twitter.com/BjsOpen/status/1585594658863939586
Consensus Paper | State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease.
7 Nov, 2022 | 12:44h | UTC
Guidelines for empirical antibacterial therapy of sepsis in adults.
7 Nov, 2022 | 12:40h | UTC
Updated systematic review on cannabis and other plant-based treatments for chronic pain.
7 Nov, 2022 | 12:39h | UTCRelated:
Systematic Review: Cannabis-based products for chronic pain.
Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders
M-A: Birth outcomes of neonates exposed to marijuana in utero.
Cannabis-related allergies: an international overview and consensus recommendations.
Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
Review: Considerations for cannabinoids in perioperative care by anesthesiologists.
Review: Cannabis-based Medicines and the Perioperative Physician
Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know
RCT | Effectiveness of tonsillectomy vs. modified uvulopalatopharyngoplasty in patients with tonsillar hypertrophy and sleep apnea.
7 Nov, 2022 | 12:36h | UTCEffectiveness of Tonsillectomy vs Modified Uvulopalatopharyngoplasty in Patients With Tonsillar Hypertrophy and Obstructive Sleep Apnea: The TEAMUP Randomized Clinical Trial – JAMA Otolaryngology—Head & Neck Surgery (free for a limited period)
RCT | Efficacy of a digital behavioral therapeutic application to improve glycemic control in adults with Type 2 DM.
7 Nov, 2022 | 12:33h | UTCCommentary: Smartphone-delivered CBT improves glycemic control in people with type 2 diabetes – medwire News
M-A | Association of intraventricular fibrinolysis with clinical outcomes in intracerebral hemorrhage.
7 Nov, 2022 | 12:31h | UTCAssociation of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis – Stroke (free for a limited period)
Commentary on Twitter
#STROKE #IntraventricularFibrinolysis is associated with better functional outcomes and reduced mortality in #ICH patients with #IVH, with treatment effect linked to an early time window <48h #MetaAnalysis https://t.co/hRQJ9w5ppv @WendyZiai @GuidoFalconeMD @sheth_kevin pic.twitter.com/INeDIIHCBw
— Stroke AHA/ASA (@StrokeAHA_ASA) September 30, 2022
RCT | Efficacy of prune juice containing sorbitol, pectin, and polyphenol in chronic constipation.
7 Nov, 2022 | 12:34h | UTCPrune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial – American Journal of Gastroenterology (free for a limited period)
Commentary on Twitter
In the 📕#RedJournal — Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial
Koyama, et al.👉 https://t.co/IFnZTfnw8I@AmCollegeGastro pic.twitter.com/C244dAWNIa
— AJG – The American Journal of Gastroenterology (@AmJGastro) October 19, 2022
RCT | Naltrexone-bupropion and behavior therapy, alone and combined, for binge-eating disorder.
7 Nov, 2022 | 12:27h | UTCNews Release: People With Binge-eating Disorder Benefit From Specific Behavioral Therapy and Medication – Yale School of Medicine
Commentary: Behavioral Therapy Plus Naltrexone-Bupropion Combination May Reduce Binge Eating – Psychiatric News Alert
RCT | Efficacy of drug-eluting stent vs. bare metal stent for symptomatic femoropopliteal peripheral artery disease.
7 Nov, 2022 | 12:29h | UTCEfficacy of a Drug-Eluting Stent Versus Bare Metal Stents for Symptomatic Femoropopliteal Peripheral Artery Disease: Primary Results of the EMINENT Randomized Trial – Circulation (free for a limited period)
Commentary on Twitter
https://twitter.com/CircAHA/status/1585005809955651584
RCT | Low-dose immunotherapy (nivolumab) may improve outcomes when added to chemotherapy for head and neck cancer.
7 Nov, 2022 | 12:26h | UTCLow-Dose Immunotherapy in Head and Neck Cancer: A Randomized Study – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary from the author on Twitter
Low-Dose Immunotherapy has made immunotherapy more accessible, and has brought down the cost of therapy from 60-80 lakhs to below 5.0 lakhs per year. Hugh cost saving. A step towards atmanirbhar Bharat. @PMOIndia @TOIIndiaNews @ndtv @ZeeNews @the_hindu https://t.co/c0WuC9Wlfk
— Dr (Prof). Vijay Patil (@DrVijayPatil11) October 21, 2022
Post-trial follow-up | Long-term outcomes with stereotactic radiosurgery vs. whole-brain RT for resected brain metastasis.
7 Nov, 2022 | 12:22h | UTCAssociation of Long-term Outcomes With Stereotactic Radiosurgery vs Whole-Brain Radiotherapy for Resected Brain Metastasis: A Secondary Analysis of The N107C/CEC.3 (Alliance for Clinical Trials in Oncology/Canadian Cancer Trials Group) Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentary: Survivors face less late cognitive deterioration after stereotactic radiosurgery than WBRT – medwire News
Original Study: Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
In pts w limited brain mets after surgical resection, secondary analysis of rand phase 3 trial shows more patients declined significantly in 1 or more cognitive tests with whole brain radiation therapy (WBRT) vs stereotactic radiosurgery (SRS) https://t.co/6nSCO5kSpW #BTSM
— JAMA Oncology (@JAMAOnc) October 22, 2022
Crossover RCT | Efficacy of low-dose Empagliflozin as an adjunct to hybrid closed-loop insulin therapy in adults with Type 1 DM.
7 Nov, 2022 | 12:24h | UTCLow-Dose Empagliflozin as Adjunct to Hybrid Closed-Loop Insulin Therapy in Adults With Suboptimally Controlled Type 1 Diabetes: A Randomized Crossover Controlled Trial – Diabetes Care (link to abstract – $ for full-text)
Review | Early appropriate diagnostics and treatment of MDR Gram-negative infections.
7 Nov, 2022 | 12:19h | UTCRelated:
Commentary on Twitter
This is a ⚡fantastic article⚡
by super 🌟s Dr. Bassetti & @davidvanduin @jac_amr
We really need more adoption to RDTs coupled with stewardship programs
Early appropriate diagnostics and treatment of MDR Gram-negative infections #IDTwitter #MedEd https://t.co/h6eOvK2iH8 pic.twitter.com/WBjogJ6IYu— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) September 14, 2022
Under a https://creativecommons.org/licenses/by/4.0/ license
Review | The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections.
7 Nov, 2022 | 12:17h | UTCRelated:
Review | How and when to manage respiratory infections out of hospital.
7 Nov, 2022 | 12:15h | UTCHow and when to manage respiratory infections out of hospital – European Respiratory Review
M-A | Prevalence, risk factors and treatments for post-COVID-19 breathlessness.
7 Nov, 2022 | 12:14h | UTC