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Daily Archives: October 27, 2022

RCT | Selective decontamination of the GI tract did not significantly reduce mortality in ICU patients on mechanical ventilation.

27 Oct, 2022 | 12:40h | UTC

Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

Related study: Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

 


M-A | Selective decontamination of the GI tract may reduce in-hospital mortality in ICU patients receiving mechanical ventilation.

27 Oct, 2022 | 12:39h | UTC

Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Related Study: Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

 


RCT | A lower oxygen saturation target did not improve outcomes after out-of-hospital cardiac arrest.

27 Oct, 2022 | 12:38h | UTC

Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest: The EXACT Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Early Oxygen Supplementation After Resuscitation From Cardiac Arrest – JAMA (free for a limited period)

Related:

RCT | In critically ill patients receiving MV, there was no difference in outcomes between different O2 saturation targets.

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Higher versus lower oxygenation strategies in the general intensive care unit population: A systematic review, meta-analysis and meta-regression of randomized controlled trials – Journal of Critical Care

 


Retrospective Cohort Study | Association of ECMO with new mental health diagnoses in adult survivors of critical illness.

27 Oct, 2022 | 12:37h | UTC

Association of Extracorporeal Membrane Oxygenation With New Mental Health Diagnoses in Adult Survivors of Critical Illness – JAMA (free for a limited period)

Editorial: Mental Health Outcomes Following Extracorporeal Membrane Oxygenation in Survivors of Critical Illness – JAMA (free for a limited period)

News Release: ECMO survivors have higher rate of new mental health diagnoses than other ICU survivors – Ottawa Hospital

 

Commentary from the author on Twitter (thread – click for more)

 


Review | Monkeypox.

27 Oct, 2022 | 12:36h | UTC

Monkeypox – New England Journal of Medicine

Related:

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine

Monkeypox: disease epidemiology, host immunity and clinical interventions.

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 

Commentary on Twitter

 


Cohort Study | Racial and ethnic differences in bystander CPR for witnessed cardiac arrest.

27 Oct, 2022 | 12:35h | UTC

Racial and Ethnic Differences in Bystander CPR for Witnessed Cardiac Arrest – New England Journal of Medicine

Commentary: Blacks, Hispanics Less Likely Than Whites to Receive Bystander CPR – HealthDay

 


2022 ETA Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma.

27 Oct, 2022 | 12:33h | UTC

2022 ETA Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma – European Thyroid Journal

Commentary: New EU Guidelines: Individualize Care for Thyroid Cancer in Kids – Medscape (free registration required)

 


AHA Scientific Statement | Physician wellness in academic cardiovascular medicine.

27 Oct, 2022 | 12:34h | UTC

Physician Wellness in Academic Cardiovascular Medicine: A Scientific Statement From the American Heart Association – Circulation

Top Things to Know: Physician Wellness in Academic CV Medicine – American Heart Association

Commentaries:

Fostering a Culture of Wellness: How To Care For Ourselves So We Can Care For Our Patients – American Heart Association

Physician Wellness in Academic Cardiovascular Medicine: Key Points – American College of Cardiology

 


[News Release] RCT | Shortened course of radiation therapy safe and effective for men with high-risk prostate cancer.

27 Oct, 2022 | 12:32h | UTC

News Release: Shortened course of radiation therapy safe and effective for men with high-risk prostate cancer – ASTRO Annual Meeting

Abstract: Conventional vs. Hypofractionated, Radiotherapy for High-Risk Prostate Cancer: 7-Year Outcomes of the Randomized, Non-Inferiority, Phase 3 PCS5 Trial – ASTRO Annual Meeting

 


Cohort Study | Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood.

27 Oct, 2022 | 12:31h | UTC

Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood: national population based cohort study – The BMJ

News Release: Blood pressure disorder in pregnancy linked to heightened risk of death in offspring – BMJ Newsroom

 

Commentary on Twitter

 


Review | Iron deficiency and cardiovascular disease.

27 Oct, 2022 | 12:31h | UTC

Iron deficiency and cardiovascular disease – European Heart Journal

 

Commentary on Twitter

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


Cohort Study | Cannabis, cocaine, methamphetamine, and opiates linked to increased risk of incident atrial fibrillation.

27 Oct, 2022 | 12:29h | UTC

Cannabis, cocaine, methamphetamine, and opiates increase the risk of incident atrial fibrillation – European Heart Journal

Editorial: Drug abuse and risk of atrial fibrillation: a neglected association – European Heart Journal

Commentaries:

Illicit drugs associated with increased likelihood of developing atrial fibrillation – European Society of Cardiology/News Medical

Marijuana, Meth, Cocaine Use Can Help Trigger Dangerous A-Fib – HealthDay

 

Commentary on Twitter

 


Case-control study | Alcohol intake as a risk factor for acute stroke.

27 Oct, 2022 | 12:26h | UTC

Alcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study – Neurology (PDF)

 

Commentary on Twitter

 


Study commentary | From the management of altitude sickness to congestion in acute HF: a new season for acetazolamide?

27 Oct, 2022 | 12:27h | UTC

From the management of altitude sickness to treatment of congestion in acute heart failure: a new season for acetazolamide? – European Heart Journal (free for a limited period)

Original study: RCT | Acetazolamide resulted in faster decongestion in patients with acute decompensated heart failure with volume overload.

 


Cohort study | MRI visible perivascular spaces and risk of incident dementia.

27 Oct, 2022 | 12:25h | UTC

MRI Visible Perivascular Spaces and Risk of Incident Dementia: The Framingham Heart Study – Neurology (PDF)

 

Commentary on Twitter

 


Review | Management of NAFLD in primary care settings.

27 Oct, 2022 | 12:24h | UTC

Management of NAFLD in primary care settings – Liver International

Related:

Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie

AGA Clinical Practice Update | Diagnosis and management of nonalcoholic fatty liver disease in lean individuals.

Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group – The Lancet Gastroenterology & Hepatology (free registration required)

Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease – Gastroenterology

Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports

 

Commentary on Twitter

 


RCT | Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel.

27 Oct, 2022 | 12:23h | UTC

Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: PRESIDE Trial Meets Primary End Point With Continuous Enzalutamide After Progression of mCRPC – Cancer Network

 


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