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Daily Archives: October 25, 2022

RCT | In critically ill patients receiving MV, there was no difference in outcomes between different O2 saturation targets.

25 Oct, 2022 | 13:23h | UTC

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study finds that the most common oxygen saturation targets for hospitalized patients appear equally safe and effective – Vanderbilt University Medical Center

Related:

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Higher versus lower oxygenation strategies in the general intensive care unit population: A systematic review, meta-analysis and meta-regression of randomized controlled trials – Journal of Critical Care

 

Commentary on Twitter

 

Recommendations for laboratory testing of patients with acute myeloid leukemia.

25 Oct, 2022 | 13:21h | UTC

A British Society for Haematology good practice paper: Recommendations for laboratory testing of UK patients with acute myeloid leukaemia – British Journal of Haematology

 

Diaphragmatic function in cardiovascular disease: JACC review topic of the week.

25 Oct, 2022 | 13:22h | UTC

Diaphragmatic Function in Cardiovascular Disease: JACC Review Topic of the Week – Journal of the American College of Cardiology

 

Guideline | Reporting of surgically removed lymph nodes for breast tumors.

25 Oct, 2022 | 13:20h | UTC

Reporting of Surgically Removed Lymph Nodes for Breast Tumors: Recommendations From the International Collaboration on Cancer Reporting – Archives of Pathology & Laboratory Medicine

 

ESGE Position Statement | Expected value of artificial intelligence in gastrointestinal endoscopy.

25 Oct, 2022 | 13:20h | UTC

Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement – Endoscopy

 

RCT | Recapture and retreatment rates with ixekizumab after withdrawal of therapy in patients with axial spondyloarthritis.

25 Oct, 2022 | 13:19h | UTC

Recapture and retreatment rates with ixekizumab after withdrawal of therapy in patients with axial spondyloarthritis: results at week 104 from a randomised placebo-controlled withdrawal study – Annals of Rheumatic Diseases

Commentary: Successful retreatment of axSpA flare feasible following ixekizumab withdrawal – medwire News

 

RCT | Effect of a novel brief motivational intervention for alcohol-intoxicated young adults in the emergency department.

25 Oct, 2022 | 13:18h | UTC

Effect of a Novel Brief Motivational Intervention for Alcohol-Intoxicated Young Adults in the Emergency Department: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

Post-trial follow-up | IV calcium does not improve long-term outcomes in patients with out-of-hospital cardiac arrest.

25 Oct, 2022 | 13:17h | UTC

Effect of calcium vs. placebo on long-term outcomes in patients with out-of-hospital cardiac arrest – Resuscitation

Original Study: RCT: Intravenous or intraosseous calcium does not improve the return of spontaneous circulation in adults with out-of-hospital cardiac arrest.

 

Commentary on Twitter

 

Post-hoc analysis | Two-year visual field outcomes of the Treatment for Advanced Glaucoma Study (TAGS).

25 Oct, 2022 | 13:15h | UTC

Two-year visual field outcomes of the Treatment for Advanced Glaucoma Study (TAGS) – American Journal of Ophthalmology

Original study and commentary: Study Commentary | Advanced glaucoma: surgery lowers pressure in the eye more effectively than eye drops.

 

Systematic Review | Point-of-care ultrasound in dyspnea, nontraumatic hypotension, and shock.

25 Oct, 2022 | 13:16h | UTC

POCUS in dyspnea, nontraumatic hypotension, and shock; a systematic review of existing evidence – European Journal of Internal Medicine

 

Post-trial follow-up | Long-term treatment with Ponesimod in relapsing-remitting multiple sclerosis.

25 Oct, 2022 | 13:14h | UTC

Long-term Treatment With Ponesimod in Relapsing-Remitting Multiple Sclerosis: Results From Randomized Phase 2b Core and Extension Studies – Neurology

Commentary: Optimal Dose of Ponesimod for Control of Relapsing-Remitting Multiple Sclerosis – Neurology Advisor

Original Study: Oral ponesimod in relapsing–remitting multiple sclerosis: a randomised phase II trial – Journal of Neurology, Neurosurgery & Psychiatry

 

RCT | Transcutaneous Electrical Acustimulation (TEA) vs. sham-TEA for irritable bowel syndrome with constipation.

25 Oct, 2022 | 13:12h | UTC

Transcutaneous Electrical Acustimulation Improves Irritable Bowel Syndrome With Constipation by Accelerating Colon Transit and Reducing Rectal Sensation Using Autonomic Mechanisms – American Journal of Gastroenterology

 

Systematic Review | Mu‐opioid antagonists for opioid‐induced bowel dysfunction in palliative care and people with cancer.

25 Oct, 2022 | 13:13h | UTC

Mu‐opioid antagonists for opioid‐induced bowel dysfunction in people with cancer and people receiving palliative care – Cochrane Library

Summary: Mu-opioid antagonists for bowel dysfunction due to opioids in people with cancer and people receiving palliative care – Cochrane Library

 

RCT | Empagliflozin in acute myocardial infarction accompanied by a large creatine kinase elevation.

25 Oct, 2022 | 13:11h | UTC

Empagliflozin in acute myocardial infarction: the EMMY trial – European Heart Journal

 

Commentary on Twitter

 

Systematic Review | Antipsychotic polypharmacy reduction vs. polypharmacy continuation for people with schizophrenia.

25 Oct, 2022 | 13:12h | UTC

Antipsychotic polypharmacy reduction versus polypharmacy continuation for people with schizophrenia – Cochrane Library

Summary: Reduction in the number of antipsychotics for people with schizophrenia – Cochrane Library

Related: Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations – Drugs

 

M-A of RCT | Analgesic efficacy and risk of low-to-medium dose intrathecal morphine in patients undergoing cardiac surgery.

25 Oct, 2022 | 13:10h | UTC

Analgesic efficacy and risk of low-to-medium dose intrathecal morphine in patients undergoing cardiac surgery: An updated meta-analysis – Frontiers in Medicine

 

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