Daily Archives: September 19, 2022 | LinksMedicus Free Medical News & Perspectives

RCT | Cerebral embolic protection during transcatheter aortic-valve replacement did not significantly reduce the incidence of periprocedural stroke.

19 Sep, 2022 | 12:49h | UTC

Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

PROTECTED TAVR: No Less Stroke With Embolic Protection, but Some See Hope – TCTMD

Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement – PROTECTED TAVR – American College of Cardiology

Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven — Large trial comes up short in proving a definitive benefit to debris filters – MedPage Today (free registration required)

News Release: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement – Cedars-Sinai

Commentary on Twitter

In a randomized trial involving patients with aortic stenosis, the use of a cerebral protection device during TAVR did not decrease the risk of periprocedural stroke, but there were fewer disabling strokes. #TCT2022 https://t.co/wBgNlgmIty pic.twitter.com/EViLG19shX

— NEJM (@NEJM) September 17, 2022

RCT | Multiple doses of prophylactic intravenous antibiotics are no better than a single dose in implant-based breast reconstruction.

19 Sep, 2022 | 12:48h | UTC

Effectiveness of Single vs Multiple Doses of Prophylactic Intravenous Antibiotics in Implant-Based Breast Reconstruction: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

Multiple-dose antibiotic prophylaxis was not superior to a single-dose regimen in preventing surgical site infection and implant removal after implant-based breast reconstruction in this RCT. https://t.co/p7GbNRMPfW #OAResarch

— JAMA Network Open (@JAMANetworkOpen) September 16, 2022

Cohort Study | Seven healthy lifestyle habits linked to reduced risk of dementia in people with diabetes.

19 Sep, 2022 | 12:45h | UTC

Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes – Neurology (link to abstract – $ for full-text)

News Release: Seven healthy lifestyle habits may reduce dementia risk for people with diabetes – American Academy of Neurology

Commentary: Lifestyle Factors May Cut Dementia Risk in Patients With Diabetes – HealthDay

Cluster RCT | Effects of real-time prescription benefit recommendations on patient out-of-pocket costs.

19 Sep, 2022 | 12:47h | UTC

Effects of Real-time Prescription Benefit Recommendations on Patient Out-of-Pocket Costs: A Cluster Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Real-time Prescription Benefit Tools—The Promise and Peril – JAMA Internal Medicine (free for a limited period)

Commentary on Twitter

Real-time Prescription Benefits (RTPB) uses patient out-of-pocket (OOP) cost to recommend lower-cost med alternatives to prescribers. In a RCT, RTPB reduced med OOP costs by 11%, though recommendations were only made for a small proportion of orders. https://t.co/xXviGvnbKw pic.twitter.com/naeciB3CDg

— JAMA Internal Medicine (@JAMAInternalMed) September 12, 2022

M-A | Nonpharmacological interventions to lengthen sleep duration in healthy children.

19 Sep, 2022 | 12:44h | UTC

Nonpharmacological Interventions to Lengthen Sleep Duration in Healthy Children: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)

Editorial: Children’s Sleep and Our Power to Improve It – JAMA Pediatrics (free for a limited period)

Commentary: Data Demonstrates the Best Intervention for Pediatric Sleep Health is Earlier Bedtime – HCP Live

Commentary on Twitter

Supporting children to go to bed earlier can increase sleep duration in healthy children, and interventions to encourage earlier bedtimes should be included. https://t.co/i8BzSKwlQX #Research

— JAMA Pediatrics (@JAMAPediatrics) September 14, 2022

Guideline | Procedural sedation in the emergency department.

19 Sep, 2022 | 12:43h | UTC

Procedural Sedation in the Emergency Department – Royal College of Emergency Medicine (PDF)

Diet and irritable bowel syndrome: an update from a UK consensus meeting.

19 Sep, 2022 | 12:42h | UTC

Diet and irritable bowel syndrome: an update from a UK consensus meeting – BMC Medicine

M-A | Efficacy of a restrictive diet in irritable bowel syndrome.

Diet or medication in primary care patients with IBS: the DOMINO study – a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute – Gut

AGA Clinical Practice Update on the Role of Diet in Irritable Bowel Syndrome: Expert Review – Gastroenterology

RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

AAP Policy Statement | Helmet use in preventing head injuries in bicycling, snow sports, and other recreational activities and sports.

19 Sep, 2022 | 12:43h | UTC

Helmet Use in Preventing Head Injuries in Bicycling, Snow Sports, and Other Recreational Activities and Sports – Pediatrics

Technical Report: Helmet Use in Preventing Head Injuries in Bicycling, Snow Sports, and Other Recreational Activities and Sports – Pediatrics

Commentary: Multifaceted Approach Urged for Promoting Helmet Use for Children – HealthDay

RCT | Open-source automated insulin delivery in Type 1 Diabetes.

19 Sep, 2022 | 12:41h | UTC

Open-Source Automated Insulin Delivery in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Video summary: Open-Source Automated Insulin Delivery in Type 1 Diabetes – NEJM

Commentaries:

Open-Source AID Systems Can Improve Glycemic Control in Both Children and Adults with Type 1 Diabetes – Endocrinology Network

Automated Insulin Delivery Ups Time in Target Glucose Range in T1D – HealthDay

RCT | Methotrexate may increase response rates in patients with uncontrolled gout receiving Pegloticase.

19 Sep, 2022 | 12:38h | UTC

A Randomized Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled GOut Receiving Pegloticase (MIRROR RCT): Primary Efficacy and Safety Findings – Arthritis & Rheumatology

Commentary: Data Now Out for Pegloticase-MTX Combo Gout Treatment – MedPage Today (free registration required)

Systematic Review | Debulking hysterectomy followed by chemoradiotherapy vs. chemoradiotherapy alone for women with locally advanced cancer of the cervix – not enough evidence to guide recommendations.

19 Sep, 2022 | 12:39h | UTC

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer – Cochrane Library

Summary: Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO (2019) stage IB3/II cervical cancer – Cochrane Library

M-A of randomized trials | Transanal tube vs. defunctioning stoma after low anterior resection for rectal cancer.

19 Sep, 2022 | 12:37h | UTC

Transanal tube versus defunctioning stoma after low anterior resection for rectal cancer: network meta-analysis of randomized controlled trials – British Journal of Surgery

M-A | Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide.

19 Sep, 2022 | 12:36h | UTC

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data – BMC Medicine

RCT | Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumor necrosis factor inhibitor therapy.

19 Sep, 2022 | 12:35h | UTC

Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study – Annals of Rheumatic Diseases

M-A of randomized trials | Ondansetron vs. Metoclopramide for managing hyperemesis gravidarum.

19 Sep, 2022 | 12:34h | UTC

Ondansetron versus metoclopramide for managing hyperemesis gravidarum: A systematic review and meta-analysis of randomized controlled trials – Turkish Journal of Obstetrics and Gynecology

Commentary: Ondansetron or metoclopramide, which is better for managing hyperemesis gravidarum? – Medical Dialogues

The risk of subsequent surgery following bowel resection for Crohn’s disease in a national cohort of 19,207 patients.

19 Sep, 2022 | 12:33h | UTC

The risk of subsequent surgery following bowel resection for Crohn’s disease in a national cohort of 19,207 patients – Colorectal Disease (link to abstract – $ for full-text)

Commentary: Investigators Assess Risk of Further Surgery for Crohn’s Disease Patients – HCPLive

RCT | Intensity-modulated radiotherapy vs. stereotactic body radiotherapy for prostate cancer.

19 Sep, 2022 | 12:31h | UTC

Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary from the author on Twitter (thread – click for more)

My first Tweetorial ? 2 year toxicity results of PACE B published here. Big thanks to the ???? and??collaborators and the 874 men with prostate cancer who made this trial possible https://t.co/mERz2ox8TM

— Alison Tree ??? (@alison_tree) September 14, 2022