Daily Archives: August 25, 2022
Randomized Crossover Trial | In patients with diabetic neuropathic pain, amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin were similarly effective.
25 Aug, 2022 | 12:14h | UTC
RCT | In patients with low-risk nasopharyngeal carcinoma, radiotherapy alone was noninferior to radiotherapy plus concurrent chemoradiotherapy on survival without disease relapse at 3 years.
25 Aug, 2022 | 12:13h | UTCEffect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial – JAMA (free for a limited period)
Video Editor’s Note: Radiotherapy With vs Without Chemoradiotherapy in Low-risk Nasopharyngeal Carcinoma – JAMA
Editorial | Keeping meta-analyses fresh.
25 Aug, 2022 | 12:09h | UTCKeeping Meta-analyses Fresh – JAMA Network Open
RCT | Enoxaparin (40 mg/d) is superior to aspirin (100 mg/d) for the prevention of thromboembolism in patients undergoing hip or knee arthroplasty.
25 Aug, 2022 | 12:12h | UTCEffect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial – JAMA (free for a limited period)
Editorial: Thromboprophylaxis After Hip or Knee Arthroplasty – JAMA
Commentary on Twitter
In patients undergoing hip or knee arthroplasty for osteoarthritis, aspirin compared with enoxaparin resulted in a significantly higher rate of symptomatic venous thromboembolism (VTE), including below-knee VTE. #Research https://t.co/CdlbAgBttJ
— JAMA (@JAMA_current) August 23, 2022
RCT | In patients with alcohol use disorder, the percentage of heavy drinking days was reduced with a psychedelic drug.
25 Aug, 2022 | 12:10h | UTCNews Release: Psychedelic drug therapy may help treat alcohol addiction – NYU Grossman School of Medicine
Commentary on Twitter:
In adults with alcohol-dependence, two doses of #psilocybin in combination with psychotherapy produced robust decreases in drinking relative to the outcomes observed with placebo and psychotherapy. https://t.co/M8PCbfwmWn #Research pic.twitter.com/duCJUL0jhx
— JAMA Psychiatry (@JAMAPsych) August 24, 2022
Retrospective Cohort Study | Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge.
25 Aug, 2022 | 12:08h | UTC
Commentary on Twitter
During the clinical rollout of nirmatrelvir in Israel in early 2022, most patients (78%) had previous SARS-CoV-2 immunity. Benefit was seen among patients at highest risk for Covid-19 progression, such as those 65+. https://t.co/O6CxzDdIfH pic.twitter.com/ccCaCCh15i
— NEJM (@NEJM) August 24, 2022
Hospitalizations for unintentional cannabis poisonings among Canadian children surged after legalization.
25 Aug, 2022 | 12:07h | UTCOriginal Study: Edible Cannabis Legalization and Unintentional Poisonings in Children – New England Journal of Medicine ($)
Consensus Document | Management of decompensated cirrhosis in the surgical ICU.
25 Aug, 2022 | 12:05h | UTC
Commentary on Twitter
#TSACOTuesday 🔥 !
Check out what the AAST Critical Care Committee has to say about the managing Decompensated Cirrhotics in the SICU! https://t.co/lKVn9Y50xO pic.twitter.com/A4MQzaDvTk— Trauma Surgery & Acute Care Open (TSACO) (@TSACO_AAST) August 2, 2022
RCTs | Ublituximab vs. Teriflunomide in relapsing multiple sclerosis.
25 Aug, 2022 | 12:04h | UTCUblituximab versus Teriflunomide in Relapsing Multiple Sclerosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In two parallel randomized trials in patients with MS, ublituximab resulted in lower relapse rates and fewer brain lesions on MRI than teriflunomide over a period of 96 weeks but did not affect disability. https://t.co/fpdtYhTNER pic.twitter.com/EPJEetSVdS
— NEJM (@NEJM) August 24, 2022
RCT | Olokizumab vs. Placebo or Adalimumab in rheumatoid arthritis.
25 Aug, 2022 | 12:04h | UTCOlokizumab versus Placebo or Adalimumab in Rheumatoid Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Novel IL-6 Blocker Matches Humira in Rheumatoid Arthritis – MedPage Today (free registration required)
Cohort Study | Characteristics of prescription opioid analgesics in pregnancy and risk of neonatal opioid withdrawal syndrome in newborns.
25 Aug, 2022 | 12:02h | UTC
Cohort Study | Association between changes in alcohol consumption and cancer risk.
25 Aug, 2022 | 12:03h | UTCAssociation Between Changes in Alcohol Consumption and Cancer Risk – JAMA Network Open
Invited Commentary: Reducing Alcohol Use for Cancer Prevention – JAMA Network Open
Network M-A | Efficacy of various adjuvant chemotherapy methods in preventing liver metastasis from potentially curative colorectal cancer.
25 Aug, 2022 | 12:01h | UTC
Expert Analysis | Clinical applications of cardiac magnetic resonance imaging in pericardial diseases.
25 Aug, 2022 | 11:59h | UTCRelated: Case Series: Cardiac magnetic resonance in the assessment of pericardial abnormalities.
Phase 2 RCT | Adjuvant intravesical chemohyperthermia not better than passive chemotherapy in patients with intermediate-risk non–muscle-invasive bladder cancer.
25 Aug, 2022 | 12:00h | UTC
Commentary on Twitter
No benefit of adjuvant intravesical hyperthermic chemo (CHT) for intermediate-risk non–muscle-invasive bladder cancer
🔸DFS @ 24 mo was 61% vs 60%
🔸Patients treated with CHT were less likely to complete their treatment @EUplatinum @OncoAlert @Uroweb https://t.co/q8lB2MxBFf pic.twitter.com/E8Ay5hirBb— Yüksel Ürün (@DrYukselUrun) August 22, 2022
Under a Creative Commons license
Supplement | The role of liver transplantation in acute-on-chronic liver failure.
25 Aug, 2022 | 11:57h | UTCHomepage: The Role of Liver Transplantation in Acute-on-Chronic Liver Failure – Clinical Liver Disease
Introduction: The Role of Liver Transplantation in Acute-on-Chronic Liver Failure
Identifying the patient with acute-on-chronic liver failure: navigating through multiple definitions
Pretransplant management of the patient with severe acute-on-chronic liver failure
Transplantation in Acute-on-Chronic Liver Failure: Feasibility and Futility
Palliative Care in the Patient With Acute-on-Chronic Liver Failure
Con: Patients With Acute-on-Chronic Liver Failure Should Not Receive Priority on the Waiting List
Observational study suggests Hydroxychloroquine is associated with increased risk of cardiovascular events compared to Methotrexate in patients with heart failure.
25 Aug, 2022 | 11:56h | UTCCardiovascular Risks of Hydroxychloroquine vs Methotrexate in Patients With Rheumatoid Arthritis – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Editorial: Hydroxychloroquine: Heart-Throb No More? – Journal of the American College of Cardiology
Commentary: Caution needed with hydroxychloroquine use in older RA patients with heart failure – medwire News
Brief Review | New drugs for acute kidney injury.
25 Aug, 2022 | 11:58h | UTCNew drugs for acute kidney injury – Intensive Care Medicine
Systematic Review | Therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal disease.
25 Aug, 2022 | 11:55h | UTC
Vasospastic angina: a contemporary review of its pathophysiology, diagnosis and management.
25 Aug, 2022 | 11:53h | UTC
Commentary on Twitter
Almost 50% of angina pts have non obstructive CAD on cath: 3 types of ANOCA & each has its’ own Rx:
🫀Coronary micro vascular dz B blockers
🫀Coronary endothelial dysfunction (? Rx)
🫀Coronary vasospasm (Ca channel blockers/nitrates) @minissianm https://t.co/zJjhEDAs0K pic.twitter.com/zxDjDoM6ru— Ritu Thamman MD (@iamritu) August 20, 2022
Review | Prevention of first decompensation in advanced chronic liver disease.
25 Aug, 2022 | 11:52h | UTCPrevention of First Decompensation in Advanced Chronic Liver Disease – Clinics in Liver Disease
Commentary on Twitter
Presentations and drivers of decompensated liver disease #LiverTwitter #MedEdhttps://t.co/3h5eJ0tWVM pic.twitter.com/k6A00EGM8L
— Keith Siau (@drkeithsiau) August 20, 2022
Cohort Study | Analysis of neonatal neurobehavior and developmental outcomes among preterm infants.
25 Aug, 2022 | 11:51h | UTCInvited commentary: Neurobehavior in the Neonatal Intensive Care Unit—Window to the Future? – JAMA Network Open
Commentary on Twitter
A new study in @JAMANetworkOpen examines the association between medical and neurobehavioral risk at discharge and neurodevelopmental outcomes at 2 years https://t.co/1hAJwIpLQp #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/a0F01LqUcd
— Evidence-Based Neo (@EBNEO) July 27, 2022
Study Commentary | Is the evidence strong for spinal cord stimulation for diabetic neuropathy? Not all experts agree.
25 Aug, 2022 | 11:52h | UTCOriginal Study: RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Study Commentary | Digital youth mental health interventions: will the evidence ever catch up?
25 Aug, 2022 | 11:54h | UTCDigital youth mental health interventions: will the evidence ever catch up? – The Mental Elf
Original Study: Evidence on Digital Mental Health Interventions for Adolescents and Young People: Systematic Overview – JMIR Mental Health
Review | Subphenotypes in acute kidney injury.
25 Aug, 2022 | 11:50h | UTCSubphenotypes in acute kidney injury: a narrative review – Critical Care