Daily Archives: August 18, 2022
RCT | A lower glycemic criteria in not better than higher glycemic criteria for the diagnosis of gestational diabetes.
18 Aug, 2022 | 13:04h | UTCLower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Pros and cons with lower vs higher threshold for gestational diabetes diagnosis – medwire News
Commentary on Twitter (thread – click for more)
1/ Overdiagnosis of Gestational Diabetes (GDM): New large randomized trial compared broader/narrower criteria -> NO improvement in mother/baby outcomes BUT x2 increase in % pregnant women labelled as GDM. Time to reconsider GDM testing – https://t.co/xrr0XrdhaZ
— Paul Glasziou (@PaulGlasziou) August 18, 2022
RCT | Metformin, Ivermectin, and Fluvoxamine are not beneficial for obese outpatients with Covid-19.
18 Aug, 2022 | 13:00h | UTCEditorial: Time to Stop Using Ineffective Covid-19 Drugs – New England Journal of Medicine
Commentary on Twitter
In this trial involving overweight or obese outpatients with Covid-19, investigators found that none of three repurposed drugs (metformin, ivermectin, and fluvoxamine) reduced the risk of serious disease. https://t.co/8sd6R7CDK6 pic.twitter.com/bPZ6zeuZSA
— NEJM (@NEJM) August 17, 2022
Executive Summary | Guidelines for adrenalectomy.
18 Aug, 2022 | 12:58h | UTCAmerican Association of Endocrine Surgeons Guidelines for Adrenalectomy: Executive Summary – JAMA Surgery (free for a limited period)
Author interview: American Association of Endocrine Surgeons Guidelines for Adrenalectomy – JAMA
Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.
18 Aug, 2022 | 12:56h | UTCCommentaries:
Anal and oral sex spread monkeypox. Let’s talk about it. – Vox
Related:
CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.
Update on the Monkeypox Outbreak – JAMA
Author Interview: Diagnosis, Prevention, and Treatment of Monkeypox – JAMA
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Commentary on Twitter
New Spanish study investigates clinical and virological characteristics of confirmed human #monkeypox among 181 patients: https://t.co/3twjOaAVT5 pic.twitter.com/bfRxhjhEFn
— The Lancet (@TheLancet) August 10, 2022
Retrospective cohort study | Risk of preterm birth, small for gestational age at birth, and stillbirth after covid-19 vaccination during pregnancy.
18 Aug, 2022 | 12:51h | UTCNews Release: No link between COVID-19 vaccination in pregnancy and higher risk of preterm birth or stillbirth – British Medical Journal
Related:
SARS-CoV-2 infection and COVID-19 vaccination in pregnancy – Nature Reviews Immunology
WHO Questions and Answers: COVID-19 vaccines and pregnancy.
COVID vaccines safely protect pregnant people: the data are in.
COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter
No link between covid-19 vaccination in pregnancy and higher risk of preterm birth or stillbirth, finds study in @bmj_latesthttps://t.co/XLgFeoWVsp
Findings can help guide decision making about #covid-19 #vaccination during #pregnancy pic.twitter.com/9Pxm0Yv2Mf
— BMJ (@bmj_company) August 18, 2022
M-A | Performance of confirmatory tests for diagnosing primary aldosteronism.
18 Aug, 2022 | 12:54h | UTC
Commentary on Twitter
Less than 1% of patients suffering from PA are treated. Current strategies for diagnosing PA don't work well. Simplify testing for better diagnosis and treatment #hypertension #PrimaryAldosteronism @dr_alexleung @JanicePasieka @IAESurgeonshttps://t.co/AKkyUfSLoG pic.twitter.com/HcLQTdB2ao
— Hypertension (@HyperAHA) August 16, 2022
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients.
18 Aug, 2022 | 12:49h | UTC
Commentary on Twitter
NEW—People with #COVID19 continue to face increased risks of some neurological and psychiatric conditions up to 2 years after infection, according to a study published in @TheLancetPsych: https://t.co/9fD5zMU3hE pic.twitter.com/8YhTKJ9v72
— The Lancet (@TheLancet) August 17, 2022
Pooled analysis of drug-related interstitial lung disease and/or pneumonitis in nine trastuzumab deruxtecan monotherapy studies.
18 Aug, 2022 | 12:47h | UTCCommentaries:
Trastuzumab deruxtecan-related ILD/pneumonitis characterized – medwire News
M-A | Interventions for the prevention or treatment of epidural-related maternal fever.
18 Aug, 2022 | 12:45h | UTC
Modeling Study | Reducing daily salt intake in China by 1 g could prevent almost 9 million cardiovascular events by 2030.
18 Aug, 2022 | 12:42h | UTCNews Release: 1 g cut in daily salt intake could ward off nearly 9 million cases of stroke/heart disease in China – BMJ Newsroom
RCT | Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation.
18 Aug, 2022 | 12:43h | UTC
Commentary on Twitter
Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation: A multi-center randomized controlled trialhttps://t.co/8u1nizaDNq pic.twitter.com/QwqzN1dDHK
— Physio Meets Science (@PhysioMeScience) August 17, 2022
Under a Creative Commons license
RCT | Ceftolozane/Tazobactam plus Metronidazole vs. Meropenem in patients with complicated intra-abdominal infections.
18 Aug, 2022 | 12:37h | UTC
Single-arm phase 2 study | Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent alpha-thalassaemia or beta-thalassaemia.
18 Aug, 2022 | 12:40h | UTCSafety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study – The Lancet (link to abstract – $ for full-text)
Commentary: PK Modulator Shows Promise in Thalassemia — In small study, mitapivat increased hemoglobin in 80% of non-transfusion-dependent patients – MedPage Today (free registration required)
Preventing stillbirth: a review of screening and prevention strategies.
18 Aug, 2022 | 12:36h | UTCPreventing Stillbirth: A Review of Screening and Prevention Strategies – Maternal-Fetal Medicine
Review | Autoimmune/autoinflammatory syndrome induced by adjuvants: a focus on silicone.
18 Aug, 2022 | 12:34h | UTC
Commentary on Twitter
?Check out a NEW review on #autoimmune/autoinflammatory syndrome induced by #adjuvants (ASIA): a focus on #silicone
?https://t.co/ctLoUi79KN pic.twitter.com/BZCpp7iM8t— ClinRheumatol (@ClinRheumatol) August 17, 2022
Trends in active treatment of live-born neonates between 22 weeks 0 days and 25 weeks 6 days by gestational age and maternal race and ethnicity in the US, 2014 to 2020.
18 Aug, 2022 | 12:32h | UTCTrends in Active Treatment of Live-born Neonates Between 22 Weeks 0 Days and 25 Weeks 6 Days by Gestational Age and Maternal Race and Ethnicity in the US, 2014 to 2020 – JAMA (link to abstract – $ for full-text)
Commentaries:
Active Treatment for Extremely Preterm Babies on the Rise — Yet researchers find racial and ethnic disparities in treatment initiation – MedPage Today (free registration required)
Commentary on Twitter
From 2014 to 2020 in the US, the frequency of active treatment among neonates born alive between 22 weeks 0 days and 25 weeks 6 days significantly increased, and there were differences in rates of active treatment by race and ethnicity. https://t.co/Xflqhxklul #Research
— JAMA (@JAMA_current) August 17, 2022