Daily Archives: August 1, 2022
RCT | Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden.
1 Aug, 2022 | 12:32h | UTCIntervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial – The Lancet (link to abstract – $ for full-text)
News Release: Treatment before patients develop rheumatism provides lasting relief – Leiden University Medical Centre
Commentaries on Twitter:
NEW in @TheLancet—The TREAT EARLIER trial shows that #methotrexate initiated in patients with arthralgia at risk of #rheumatoidarthritis did not prevent the development of clinical arthritis, but did modify the disease course https://t.co/5zh7lqb4NJ pic.twitter.com/lJflW9Prwm
— The Lancet Rheumatology (@TheLancetRheum) July 22, 2022
??Methotrexate,??study
MTX in pre-arthritis stage➡️ did not prevent the development of clinical arthritis
but ➡️sustained improvement in
♦️MRI-detected inflammation,
♦️Symptoms (Pain & EMS)
♦️Related impairments (HAQ n Presentism)
Vs placebohttps://t.co/I0IdKydPME pic.twitter.com/cNi6AhO151— EnvisionRheumat (@ERheumat) July 29, 2022
RCT | Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity.
1 Aug, 2022 | 12:35h | UTCEndoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity (MERIT): a prospective, multicentre, randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
MERIT trial suggests endoscopic sleeve gastroplasty should be considered as a synergistic weight loss intervention for patients with class 1 or class 2 obesity.
Find out more: https://t.co/FWeXeWbBF0 pic.twitter.com/W6qUKW92hR
— The Lancet (@TheLancet) July 30, 2022
Brief Review | Monitoring pain in the intensive care unit.
1 Aug, 2022 | 12:30h | UTCMonitoring pain in the intensive care unit (ICU) – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Monitoring pain in #ICU
➡️ self‐assessment tools in pts able to self‐report
➡️ observational behavioural scales in pts unable to self‐report
➡️ physiologic parameters in pts unable to self‐report nor express behaviours (deep sedaution, NMBAs)#FOAMcc
? https://t.co/SaD1BBxSNw pic.twitter.com/81tNNvnTDe— Intensive Care Medicine (@yourICM) July 30, 2022
Cohort Study | Long-term leisure-time physical activity intensity and all-cause and cause-specific mortality.
1 Aug, 2022 | 12:26h | UTCLong-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults – Circulation (free for a limited period)
News Release: New study finds lowest risk of death was among adults who exercised 150-600 minutes/week – American Heart Association
M-A | Probiotics in critical illness.
1 Aug, 2022 | 12:28h | UTCProbiotics in Critical Illness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Critical Care Medicine (free for a limited period)
Commentary on Twitter
#OpenAccess #VisualAbstract @SameerSharifMD et al: Sys Review & MA of #Probiotics in #CritCareMed
67 RCTs 8483 pts
⬇️VAP HAP #ICULOS, #mechvent
No effect on mortality
Low certainty evidenceLink: https://t.co/kN7FliTpbr@SCCM #CritCareMed @Bram_Rochwerg @leashgreer pic.twitter.com/pROjhq9T2J
— Critical Care Medicine (@CritCareMed) July 22, 2022
WHO chief advises men who have sex with men to reduce partners to limit exposure to monkeypox.
1 Aug, 2022 | 12:24h | UTCWHO chief advises men who have sex with men to reduce partners to limit exposure to monkeypox – CNN
See also: WHO recommends gay and bisexual men limit sexual partners to reduce the spread of monkeypox – CNBC
Related:
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Commentary on Twitter
The #monkeypox outbreak can be stopped if countries, communities and individuals inform themselves, take the risks seriously, and take the steps needed to stop transmission and protect vulnerable groups.pic.twitter.com/7CumPFyPhc
— Tedros Adhanom Ghebreyesus (@DrTedros) July 27, 2022
Perspective | Aspirin for the primary prevention of atherosclerotic cardiovascular disease in women.
1 Aug, 2022 | 12:25h | UTCAspirin for the Primary Prevention of Atherosclerotic Cardiovascular Disease in Women – JAMA (free for a limited period)
Monkeypox | A contemporary review for healthcare professionals.
1 Aug, 2022 | 12:20h | UTCMonkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Related:
WHO chief advises men who have sex with men to reduce partners to limit exposure to monkeypox – CNN
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Clinical features and novel presentations of human monkeypox in a central London center during the 2022 outbreak: descriptive case series.
1 Aug, 2022 | 12:22h | UTCRelated:
WHO chief advises men who have sex with men to reduce partners to limit exposure to monkeypox – CNN
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Commentary on Twitter
NEW research published by The BMJ today identifies important differences in monkeypox symptoms between the current outbreak and previous outbreaks in endemic regions https://t.co/uYnhbZoBhd pic.twitter.com/NZNoNVi6Lm
— The BMJ (@bmj_latest) July 29, 2022
M-A | Respiratory support strategy in adults with acute hypoxemic respiratory failure.
1 Aug, 2022 | 12:18h | UTC
Guidelines | Peri-operative management of people with cardiac implantable electronic devices.
1 Aug, 2022 | 12:39h | UTC
Guideline | Treatment of centered developmental dysplasia of the hip under the age of 1 year.
1 Aug, 2022 | 12:16h | UTC
Review | Advances in percutaneous patent foramen ovale closure: from the procedure to the echocardiographic guidance.
1 Aug, 2022 | 12:14h | UTC
When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy.
1 Aug, 2022 | 12:12h | UTCWhen underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy – Nature Reviews Rheumatology (if the link is paywalled, try this one in PMC)
Commentary on Twitter
New content online! When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy https://t.co/4vBcfXXNju pic.twitter.com/BuYwypWU15
— NatRevRheumatol (@NatRevRheumatol) July 25, 2022
Systematic Review | Stem cell transplantation for systemic sclerosis.
1 Aug, 2022 | 12:10h | UTCStem cell transplantation for systemic sclerosis – Cochrane Library
Summary: Stem cell transplantation for the treatment of systemic sclerosis – Cochrane Library
Global trends and age-specific incidence and mortality of cervical cancer from 1990 to 2019: an international comparative study based on the Global Burden of Disease.
1 Aug, 2022 | 12:09h | UTC
Global burden of rheumatic heart disease: trends from 1990 to 2019.
1 Aug, 2022 | 12:07h | UTCGlobal burden of rheumatic heart disease: trends from 1990 to 2019 – Arthritis Research & Therapy
Commentary: Death, disability from rheumatic heart disease decreased globally from 1990 to 2019 – Healio (free registration required)
Cohort Study | Association between excision margins and local recurrence in 1407 patients with primary in situ melanomas.
1 Aug, 2022 | 12:03h | UTCCommentary: Margin Size Associated With Risk of Local Recurrence From Melanoma In Situ – AJMC
Burden of pressure injuries: findings from the Global Burden of Disease study.
1 Aug, 2022 | 12:06h | UTCBurden of Pressure Injuries: Findings From the Global Burden of Disease Study – Eplasty
Review | Management of heart failure in patients with chronic kidney disease.
1 Aug, 2022 | 11:59h | UTCManagement of Heart Failure in Patients with Chronic Kidney Disease – European Cardiology Review
Cohort Study | Clinical outcomes and risk stratification of early-stage melanoma micrometastases.
1 Aug, 2022 | 12:04h | UTCClinical Outcomes and Risk Stratification of Early-Stage Melanoma Micrometastases From an International Multicenter Study: Implications for the Management of American Joint Committee on Cancer IIIA Disease – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary on Twitter
‼️ Patients with low-risk (pT1b-pT2a) #melanoma may still develop high-risk sentinel node metastases ➡️ https://t.co/cBVdpR6xrG #JCO #melsm @marc_moncrieff pic.twitter.com/TW0WHp5brA
— Journal of Clinical Oncology (@JCO_ASCO) July 27, 2022
M-A | Prevalence of suicidal ideation and self-harm behaviors in children aged 12 years and younger.
1 Aug, 2022 | 12:01h | UTCPrevalence of suicidal ideation and self-harm behaviours in children aged 12 years and younger: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
*New* systematic review & meta-analysis estimates a prevalence of 7·5% for suicidal ideation, 2·2% for suicide planning, 1·4% for self-harm, 1·3% for suicide attempts, & 21·9% for non-suicidal self-injury in children aged ≤12 years
In @TheLancetPsych #childhoodsuicide https://t.co/wFbv6eKpNs
— The Lancet Child & Adolescent Health (@LancetChildAdol) July 28, 2022
RCT | Efficacy and safety of viloxazine extended-release capsules in adults with attention-deficit/hyperactivity disorder.
1 Aug, 2022 | 11:57h | UTC
Cohort Study | Association of assisted reproductive technology with offspring growth and adiposity from infancy to early adulthood.
1 Aug, 2022 | 11:54h | UTC
Commentary on Twitter
This cohort study found that differences in early growth and adiposity for people conceived via assisted reproductive technology (vs. naturally) were small and reduced with older age. @aelhak19 @DeborahLawlor2 https://t.co/hwdldN6yDf
— JAMA Network Open (@JAMANetworkOpen) July 26, 2022
M-A | Cardiovascular and venous thromboembolic risk with Janus Kinase inhibitors in immune-mediated inflammatory diseases.
1 Aug, 2022 | 11:52h | UTC