Daily Archives: May 3, 2022
Remdesivir and three other drugs for hospitalized patients with COVID-19: final results of the WHO Solidarity randomized trial and updated meta-analyses.
3 May, 2022 | 11:18h | UTCInvited Commentary: When and which patients should receive remdesivir? – The Lancet
RCT: Effects of an online breathing and wellbeing program for people with persistent symptoms following COVID-19.
3 May, 2022 | 11:16h | UTCInvited Commentary: Treating COVID-19-related breathlessness with novel interventions – The Lancet Respiratory Medicine
News Release: Singing techniques can improve quality of life and breathlessness after COVID-19 – Imperial College London
Commentary on Twitter
NEW Research—Online breathing and wellbeing programme (ENO Breathe) can improve mental
component of HRQoL & elements of breathlessness in #LongCovidStudy from @keirphilip, @COPDdoc, & colleagues https://t.co/Sn0TO6gSev pic.twitter.com/asTiepHhyz
— The Lancet Respiratory Medicine (@LancetRespirMed) April 28, 2022
Atherosclerosis: Recent developments.
3 May, 2022 | 11:03h | UTCAtherosclerosis: Recent developments – Cell
Commentary on Twitter
We've learned a lot about atherosclerosis in recent years, including new genomic underpinnings, role of aging, clonal hematopoiesis, and the gut microbiome. A new, excellent review covers all of the progress and the many residual questionshttps://t.co/nF59sqiB6P @CellCellPress pic.twitter.com/oXVzf4J5XT
— Eric Topol (@EricTopol) May 2, 2022
Under a CC BY 4.0 license
Systematic Review: Telerehabilitation improves physical function and reduces dyspnea in people with COVID-19 and post-COVID-19 conditions.
3 May, 2022 | 11:05h | UTC
Point/Counterpoint: Should therapeutic heparin be administered to acutely ill hospitalized patients with COVID-19?
3 May, 2022 | 11:04h | UTCCOUNTERPOINT: Should Therapeutic Heparin Be Administered to Acutely Ill Hospitalized Patients With COVID-19? No – CHEST
See also: Rebuttal From Dr Tritschler et al – CHEST
Related:
Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library
M-A of randomized trials: association of influenza vaccination with cardiovascular risk.
3 May, 2022 | 10:58h | UTCAssociation of Influenza Vaccination With Cardiovascular Risk: A Meta-analysis – JAMA Network Open
Commentary on Twitter
In this meta-analysis, seasonal flu vaccine was associated with a 34% reduced risk of major adverse cardiovascular events in 1 year, with the biggest difference in patients with recent acute coronary syndrome. @WCHResearch @PMunkCardiacCtr https://t.co/SPrXNfMQJS
— JAMA Network Open (@JAMANetworkOpen) April 29, 2022
CDC reports the first case and issues recommendations for highly pathogenic avian Influenza A(H5N1) virus.
3 May, 2022 | 11:00h | UTCSee also: U.S. Case of Human Avian Influenza A(H5) Virus Reported – Centers for Disease Control and Prevention
Commentary: Alaska, Oklahoma report first avian flu outbreaks in poultry – CIDRAP
AAP Guidance for structuring a pediatric intermediate care unit.
3 May, 2022 | 10:55h | UTCGuidance for Structuring a Pediatric Intermediate Care Unit – Pediatrics
SUNBURN: a protocol for delivering bad news in trauma and acute care surgery.
3 May, 2022 | 10:53h | UTC
Commentary on Twitter
Delivery of bad news can be a challenging tasks for practicing surgeons
Protocol-based delivery can provide support to help guide these difficult conversations
S-U-N-B-U-R-N protocol by @DrMentorA provides a framework
Read more: https://t.co/3H5AyT6125 pic.twitter.com/imJ9HuUQJ3
— Trauma Surgery & Acute Care Open (TSACO) (@TSACO_AAST) February 15, 2022
Perspective: Less pharmacotherapy is more in delirium.
3 May, 2022 | 10:56h | UTCLess pharmacotherapy is more in delirium – Intensive Care Medicine (if the link is paywalled, try this one)
Related:
Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine
Commentary on Twitter
⬇️ ?Less medications (& ⬆️ awareness of behavioural interventions) is more in #delirium, common, challenging/costly (but often preventable) in #ICU. Despite lacking evidence, medications widely used.
Prevent/minimize addressing suspected contributors!
? https://t.co/fYWAsIcuiZ pic.twitter.com/DyC3agSP7w— Intensive Care Medicine (@yourICM) April 30, 2022
Guidelines for reporting cardiovascular magnetic resonance examinations.
3 May, 2022 | 10:52h | UTC
Review | Glycemic control in the critically ill: Less is more.
3 May, 2022 | 10:50h | UTCGlycemic control in the critically ill: Less is more – Cleveland Clinic Journal of Medicine
Editorial: Glycemic targets in the ICU: A look back, and ahead – Cleveland Clinic Journal of Medicine
RCT: Pulsed low-intensity ultrasonography does not provide symptom relief to patients with knee osteoarthritis.
3 May, 2022 | 10:47h | UTCCommentaries:
Pulsed low-intensity ultrasonography shows no benefit in knee OA – medwire News
Hopes Dashed for Novel Osteoarthritis Treatment — Noninvasive therapy looked like a sure winner until trial results came in – MedPage Today (free registration required)
Commentary on Twitter
Phase 2a RCT finds no benefit from pulsed low-intensity ultrasound in the treatment of knee osteoarthritis in veterans. https://t.co/dEqjkqCadj pic.twitter.com/0qwKQ3rfkD
— JAMA Network Open (@JAMANetworkOpen) March 8, 2022
Brief Review: Lung recruitment.
3 May, 2022 | 10:49h | UTCLung recruitment – Intensive Care Medicine
Commentary on Twitter
Lung recruitment
? what's it?
? how to explain variability in recruitability among pts?
? how can recruitment be measured? Directly &/or indirectly?
Knowing potential recruitability crucial to optimize MV: lot of questions, answers #FOAMcc on @yourICM
?https://t.co/y3LizTsWWZ pic.twitter.com/9CNS382O9H— Intensive Care Medicine (@yourICM) May 2, 2022
Review: Integrating palliative care into the modern cardiac intensive care unit.
3 May, 2022 | 10:45h | UTC
Review: Equianalgesia, opioid switch and opioid association in different clinical settings.
3 May, 2022 | 10:42h | UTC
Cohort Study: Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism.
3 May, 2022 | 10:41h | UTC
Commentary on Twitter
Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism: the FOCUS study https://t.co/IOvHAzKwa2 #EHJ #ESCYoung @ehj_ed @rladeiraslopes pic.twitter.com/ADFp09rooI
— European Society of Cardiology Journals (@ESC_Journals) May 2, 2022
Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts.
3 May, 2022 | 10:40h | UTC
Recommendation reversals in gastroenterology clinical practice guidelines.
3 May, 2022 | 10:39h | UTC
RCT: Improved survival with enzalutamide in patients with metastatic hormone-sensitive prostate cancer.
3 May, 2022 | 10:38h | UTC
Commentary on Twitter
? #JCO #ClinicalTrialUpdate: ARCHES trial – ? Enzalutamide + ADT improved OS in men with metastatic horomone-sensitive #ProstateCancer ? https://t.co/FQ1lViCTZz #PCSM @AarmstrongDuke pic.twitter.com/fLs6PdFYlr
— Journal of Clinical Oncology (@JCO_ASCO) April 27, 2022
M-A: Definition of oligometastatic esophagogastric cancer and impact of local oligometastasis-directed treatment.
3 May, 2022 | 10:33h | UTC
RCT: Topical imiquimod versus surgery for vulvar intraepithelial neoplasia.
3 May, 2022 | 10:30h | UTCTopical imiquimod versus surgery for vulvar intraepithelial neoplasia: a multicentre, randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
RCT: Tislelizumab vs. chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma.
3 May, 2022 | 10:36h | UTC
Commentary on Twitter
In the phase III RATIONALE-302 trial of tislelizumab vs chemotherapy as 2nd-line therapy for advanced-stage ESCC, mOS was 8.6 vs 6.3 months (HR 0.70; P=0.0001), rising to 10.3 vs 6.8 months for those with a PD-L1 tumour area positivity score >10%: https://t.co/CNxads2Kn2 #esocsm
— NatureRevClinOncol (@NatRevClinOncol) April 27, 2022
M-A: Risk factors for contracting invasive meningococcal disease and related mortality.
3 May, 2022 | 10:29h | UTC
M-A: Endoscopic spinal surgery vs. microscopic surgery in lumbar spinal stenosis.
3 May, 2022 | 10:28h | UTC