Daily Archives: April 11, 2022
Clinical update on COVID-19 for the emergency and critical care clinician: Medical management.
11 Apr, 2022 | 02:00h | UTC
Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends.
11 Apr, 2022 | 02:01h | UTCCommentaries:
Keep your waist to less than half your height, guidance says – BBC
Draft Guideline: Obesity: identification and classification of overweight and obesity – National Institute for Health and Care Excellence
RCT: For adults with HIV, a 4-days-on and 3-days-off treatment strategy is noninferior to standard treatment for maintaining viral suppression.
11 Apr, 2022 | 01:56h | UTCA 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial – The Lancet HIV (link to abstract – $ for full-text)
Commentary: Intermittent Treatment Strategy Is Effective for HIV – Consultant360
Commentaries on Twitter
New: A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial by Roland Landman and colleagues https://t.co/Tc2Rbo1ISt pic.twitter.com/YTV3XwfELo
— The Lancet HIV (@TheLancetHIV) February 3, 2022
In virologically suppressed people with HIV, randomization to intermittent ART (4 days on, 3 off) was non-inf. to daily dosing. Challenges what I thought about level of adherence needed. Is good adherence only needed during the viremic phase? https://t.co/lM8QZW0C9h
— David Serota (@serotavirus) March 16, 2022
Review: Atrial fibrillation.
11 Apr, 2022 | 01:57h | UTCAtrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Atrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Commentary on Twitter
Get Primed on Atrial fibrillation with our NEW PrimeView! FREE to download this week! #AtrialFibrillation #AFibhttps://t.co/sI8Gx3yHmk pic.twitter.com/r6heFStAz5
— Nature Reviews Disease Primers (@DiseasePrimers) April 7, 2022
Twitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study.
11 Apr, 2022 | 01:48h | UTCTwitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study – European Society of Cardiology (link to abstract – $ for full-text)
Related:
Randomized Trial: Twitter Promotion Increases Citation Rates of Cardiovascular Articles
Does Tweeting Improve Citations? One-Year Results from the TSSMN Prospective Randomized Trial
A critical review on altmetrics: can we measure the social impact factor?
As scientists take to Twitter, study shows power of ‘visual abstract’ graphics
Perspective: How Twitter is Changing Medical Research
Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD
Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets
Rise of the Tweetorial – Precious Bodily Fluids
Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine
University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC
What’s your doctor reading? How social media is disrupting medical education – National Post
Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis.
11 Apr, 2022 | 01:58h | UTCInvited Commentary: How to interpret the total number of SARS-CoV-2 infections – The Lancet
Commentary on Twitter (thread – click for more)
Estimating #SARSCoV2 infections across the world is fraught with difficulties, hence the novel approach in the above study.@KayokoShioda & @B_Lopman discuss findings, interpretations, & implications. https://t.co/ua9arLXDOq
— The Lancet (@TheLancet) April 10, 2022
Review: Gastrointestinal post-acute COVID-19 syndrome.
11 Apr, 2022 | 01:49h | UTCGastrointestinal post-acute COVID-19 syndrome – Nature Reviews Gastroenterology & Hepatology
Commentary on Twitter
NEW! COMMENT
Gastrointestinal post-acute COVID-19 syndromehttps://t.co/SDAOnQSEp4#COVID19 #LongCovid pic.twitter.com/CUSoUt0azy
— Nature Reviews Gastroenterology & Hepatology (@NatRevGastroHep) April 9, 2022
RCT: Effect of Gram Stain–Guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia.
11 Apr, 2022 | 01:36h | UTCCommentary: Can Gram Stains Guide Antibiotics for Pneumonia in Critical Care? – Medscape (free registration required)
Commentary on Twitter
RCT found gram stain-guided antibiotic therapy for critically ill patients with VAP was noninferior to guideline-based antibiotics, with a reduction in antipseudomonal & antiMRSA use. https://t.co/1yoHO2pnER
— JAMA Network Open (@JAMANetworkOpen) April 8, 2022
CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: a test-negative case-control study.
11 Apr, 2022 | 01:40h | UTC
Clinical care of severe acute respiratory infections – Tool kit (COVID-19 adaptation, update 2022).
11 Apr, 2022 | 01:45h | UTCClinical care of severe acute respiratory infections – Tool kit – World Health Organization
Commentary on Twitter (thread – click for more)
Updated toolkit for the clinical care of severe acute respiratory infections including:
? severe #pneumonia
? acute respiratory distress syndrome
? sepsis & septic shock? https://t.co/ROvKZz12LT pic.twitter.com/LdcNJiJcxA
— World Health Organization (WHO) (@WHO) April 8, 2022
UK clinical guideline for the prevention and treatment of osteoporosis.
11 Apr, 2022 | 01:33h | UTCUK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis
Guideline Synopsis: Management of chronic multisymptom illness.
11 Apr, 2022 | 01:29h | UTC
NCCN Guidelines: CAR T-cell–related toxicities in patients with cancer.
11 Apr, 2022 | 01:32h | UTCRelated:
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
AHA Scientific Statement: addressing social determinants of health and mitigating health disparities across the lifespan in congenital heart disease.
11 Apr, 2022 | 01:31h | UTC
Predicting avoidable health care utilization: practical considerations for artificial intelligence/machine learning models in population health.
11 Apr, 2022 | 01:27h | UTC
RCT: Effects of abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer.
11 Apr, 2022 | 01:23h | UTCAbiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design – The Lancet (link to abstract – $ for full-text)
RCT: Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough.
11 Apr, 2022 | 01:22h | UTCEfficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
For refractory chronic cough or unexplained chronic cough, gefapixant 45 mg twice per day is the first treatment to show efficacy with an acceptable safety profile in phase 3 clinical trials.
New study by Lorcan P McGarvey & colleagues: https://t.co/XnWM75s6lN pic.twitter.com/VyYyRgWTod
— The Lancet (@TheLancet) March 7, 2022
Large database with 10 registries or clinical trials finds valve-in-valve transcatheter aortic valve implantation (TAVI) resulted in similar mortality and stroke rates compared to native valve TAVI.
11 Apr, 2022 | 01:02h | UTCOutcomes in Valve-in-Valve Transcatheter Aortic Valve Implantation – American Journal of Cardiology
M-A: Oxygen targets during mechanical ventilation in the ICU.
11 Apr, 2022 | 01:26h | UTC
M-A: Association of olfactory impairment with all-cause mortality.
11 Apr, 2022 | 01:01h | UTCAssociation of Olfactory Impairment With All-Cause Mortality: A Systematic Review and Meta-analysis – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)
Invited Commentary: Olfactory Impairment and Mortality—Is Smell Loss Deadly? – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)
Commentary on Twitter
Metaanalysis found that #olfactory impairment was associated with 52% higher all-cause #mortality, after adjustment for demographics & comorbidities. The ability to smell is an important marker of general health and biological aging. https://t.co/XEhSpjO2hZ @BenjaminKJTan @mysgh
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) April 7, 2022
Perspective: Supervised consumption sites—a tool for reducing risk of overdose deaths and infectious diseases in people who use illicit drugs.
11 Apr, 2022 | 00:59h | UTCSupervised Consumption Sites—A Tool for Reducing Risk of Overdose Deaths and Infectious Diseases in People Who Use Illicit Drugs – JAMA (free for a limited period)
Commentary on Twitter
NYC last fall opened the first 2 US supervised consumption sites, where people can use illicit drugs under the watchful eye of staff trained to reverse overdoses, but such centers have operated elsewhere—sometimes under the radar—for decades. https://t.co/mS7wLZd164
— JAMA (@JAMA_current) April 6, 2022
M-A: Prophylactic therapies for morbidity and mortality after aneurysmal subarachnoid hemorrhage.
11 Apr, 2022 | 00:52h | UTCProphylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials – Stroke (link to abstract – $ for full-text)
Commentary on Twitter
Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials #stroke #AHAJournals https://t.co/GkM5GlFBd7 pic.twitter.com/6ipIaUK5KX
— Stroke AHA/ASA (@StrokeAHA_ASA) April 8, 2022
You must be joking: funny paper titles might lead to more citations.
11 Apr, 2022 | 00:51h | UTCYou must be joking: funny paper titles might lead to more citations – Nature
Original Study (preprint): If this title is funny, will you cite me? Citation impacts of humor and other features of article titles in ecology and evolution – bioRxiv
M-A: Sentinel lymph node biopsy in patients with ductal carcinoma in situ.
11 Apr, 2022 | 00:46h | UTC
Commentary on Twitter
What is the role of #slnb in #dcis?
This #systematicreview included 16 studies/4388 patients.#DCIS associated with v. low rates of axillary + disease.
Palpable disease, tumour necrosis, g3 DCIS may predict +ve SLNB.#some4surgery #breastcancer https://t.co/oNR25Nu9KN pic.twitter.com/orlMF73300— BJS Open (@BjsOpen) April 8, 2022
Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial.
11 Apr, 2022 | 00:50h | UTCOriginal Study: Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
Commentary on Twitter (images under a https://creativecommons.org/licenses/by/4.0/ license)
Does aspirin have an effect on dementia and cognitive function? Discover it in the EHJ!https://t.co/u5X1fxrULk#aspirin #dementia #CVD #ASCEND #trial #diabetes #cardiotwitter @escardio @ESC_Journals pic.twitter.com/TyrnUnf0MN
— EHJ Editor-in-Chief (@ehj_ed) April 8, 2022