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Daily Archives: April 4, 2022

#ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.

4 Apr, 2022 | 01:42h | UTC

ACC Guideline Hub: Heart Failure

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

Executive Summary: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure

News Release: ACC, AHA, HFSA Issue Heart Failure Guideline – American Heart Association

Key Perspectives: 2022 AHA/ACC/HFSA Heart Failure Guideline

Slide Set Download: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure

Flipbook

 

Commentary on Twitter

 

#ACC22 – RCT: Treatment for mild chronic hypertension during pregnancy is associated with better pregnancy outcomes than a strategy of reserving treatment only for severe hypertension.

4 Apr, 2022 | 01:34h | UTC

Treatment for Mild Chronic Hypertension during Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Treating chronic hypertension in early pregnancy benefits parents, babies – NIH News Releases

CHAP: Treating Mild Chronic HTN is Associated With Better Pregnancy Outcomes – American College of Cardiology

CHAP: Better Blood Pressure Control, Better Pregnancy Outcomes – TCTMD

 

Commentary on Twitter

 

#ACC22 – RCT: Tranexamic acid reduces the risk of bleeding in patients undergoing noncardiac surgery.

4 Apr, 2022 | 01:37h | UTC

Tranexamic Acid in Patients Undergoing Noncardiac Surgery – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

POISE-3: Tranexamic Acid Reduces Severe Bleeding Risk in Patients Undergoing Noncardiac Surgery – American College of Cardiology

POISE-3: Tranexamic Acid Stems Bleeding During Noncardiac Surgery – TCTMD

 

Commentaries on Twitter

 

WHO Strategic preparedness, readiness and response plan to end the global Covid-19 emergency in 2022.

4 Apr, 2022 | 01:44h | UTC

Strategic Preparedness, Readiness and Response Plan to End the Global COVID-19 Emergency in 2022 – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge (deliberately infecting individuals in a controlled environment) in young adults.

4 Apr, 2022 | 01:27h | UTC

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults – Nature Medicine

Commentaries:

Understanding COVID-19 through human challenge models – Nature Medicine

First human challenge study of Covid-19 yields valuable insights about how we get sick – CNN

First Human Challenge Trial Shows How COVID-19 Strikes – HealthDay

Related:

Scientists deliberately gave people COVID — here’s what they learnt.

[Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).

Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.

World’s first coronavirus “Human Challenge” study receives ethics approval in the UK  (several texts on the subject)

Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

 

Commentary on Twitter

 

Researchers generate the first complete, gapless sequence of a human genome.

4 Apr, 2022 | 01:30h | UTC

News Release: Researchers generate the first complete, gapless sequence of a human genome – NIH News Releases

Original Study: The complete sequence of a human genome – Science

Commentaries:

Scientists sequence the complete human genome for the first time – CNN

First complete gap-free human genome sequence published – The Guardian

Scientists finally finish decoding entire human genome – Associated Press

 

#ACC22 – RCT: Among ambulatory patients with heart failure, a dietary intervention to reduce sodium intake did not reduce clinical events.

4 Apr, 2022 | 01:32h | UTC

Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial – The Lancet (free registration required)

Commentaries:

SODIUM-HF: No Impact of Dietary Salt Restriction on Death or Hospitalization – TCTMD

SODIUM-HF: Does Strictly Limiting Sodium Intake Reduce Cardiac Events, Improve QOL in HF Patients? – American College of Cardiology

Hold the salt: Study reveals how reducing sodium intake can help patients with heart failure – University of Alberta

 

Commentary on Twitter

 

Randomized, comparative effectiveness study: 3 at-home visual acuity tests validated through comparison with in-office visual acuity measurements, supporting their potential use in teleophthalmology care.

4 Apr, 2022 | 01:17h | UTC

Validation of Home Visual Acuity Tests for Telehealth in the COVID-19 Era – JAMA Ophthalmology (free for a limited period)

Commentaries:

Valid but Undervalued – JAMA Ophthalmology (free for a limited period)

At-Home Visual Acuity Tests Valid Versus In-Office Testing – HealthDay

 

RCT: Higher dose primaquine more effective for preventing relapse of Plasmodium vivax Malaria compared to standard dose.

4 Apr, 2022 | 01:25h | UTC

Higher-Dose Primaquine to Prevent Relapse of Plasmodium vivax Malaria – New England Journal of Medicine

 

Commentaries on Twitter

 

Two new studies show vaccination provides additional protection after Covid-19 infection.

4 Apr, 2022 | 01:16h | UTC

Study 1: Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden – The Lancet Infectious Diseases

Study 2: Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26.COV2.S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative, case-control study – The Lancet Infectious Diseases

Commentaries:

Interplay of infection and vaccination in long-term protection from COVID-19 – The Lancet Infectious Diseases

Effectiveness of SARS-CoV-2 vaccines in the post-natural infection world – The Lancet Infectious Diseases

Vaccines offer substantial extra protection after COVID-19 infection – CIDRAP

Had COVID? Getting Vaccine Boosts Resilience Even More, Studies Show – HealthDay

Related:

Retrospective cohort study: Pfizer vaccine reduces the risk of reinfection after recovery from Covid-19.

Cohort study: Protection against SARS-CoV-2 after Covid-19 vaccination lasts longer in patients with previous infection.

 

Commentary on Twitter (thread – click for more)

 

#ACC22 [Not published yet] – RCT: Mavacamten reduces the need for surgical intervention in patients with obstructive hypertrophic cardiomyopathy.

4 Apr, 2022 | 01:13h | UTC

VALOR-HCM: Mavacamten Significantly Reduces Need For Surgical Intervention in Patients With Obstructive HCM – American College of Cardiology

Commentaries:

Mavacamten Slashes Need for Septal Reduction in Obstructive HCM: VALOR-HCM – TCTMD

Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy – VALOR-HCM – American College of Cardiology

Trial shows drug effective in nearly 80% of patients with hypertrophic cardiomyopathy – Cleveland Clinic

Related: #ESCCongress – Randomized trial: Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy

 

Commentary on Twitter

 

Single-arm cohort study: percutaneous intramyocardial septal radiofrequency ablation in patients with drug-refractory hypertrophic obstructive cardiomyopathy.

4 Apr, 2022 | 01:10h | UTC

Percutaneous Intramyocardial Septal Radiofrequency Ablation in Patients With Drug-Refractory Hypertrophic Obstructive Cardiomyopathy – JAMA Cardiology (free for a limited period)

Invited Commentary: Septal Reduction Strategies in Hypertrophic Cardiomyopathy—The Scalpel, Catheter, or Wire? – JAMA Cardiology (free for a limited period)

Video: Percutaneous Intramyocardial Septal Radiofrequency Ablation

 

Commentary on Twitter

 

#ACC22 – RCT: Diltiazem did not significantly improve coronary vasomotor dysfunction in angina and nonobstructive coronary arteries.

4 Apr, 2022 | 01:09h | UTC

Efficacy of Diltiazem to improve coronary vasomotor dysfunction in angina and nonobstructive coronary arteries (ANOCA): Results of the EDIT-CMD randomized clinical trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentaries:

In ANOCA, Diltiazem Fails to Improve Vasomotor Function: EDIT-CMD – TCTMD

EDIT-CMD: Diltiazem Not Effective in Reducing Coronary Vasomotor Dysfunction, Improving Angina or QOL in ANOCA Patients – American College of Cardiology

 

Commentary on Twitter

 

ACG Guideline: Diagnosis and management of Barrett’s esophagus.

4 Apr, 2022 | 01:07h | UTC

Diagnosis and Management of Barrett’s Esophagus: An Updated ACG Guideline – American Journal of Gastroenterology

 

ESPEN micronutrient guideline.

4 Apr, 2022 | 01:00h | UTC

ESPEN micronutrient guideline – Clinical Nutrition

 

BSR guideline on management of pediatric, adolescent and adult patients with idiopathic inflammatory myopathy.

4 Apr, 2022 | 01:05h | UTC

British Society for Rheumatology guideline on management of paediatric, adolescent and adult patients with idiopathic inflammatory myopathy – Rheumatology

 

WHO launches global initiative to tackle deadly insect-borne ‘arboviruses’.

4 Apr, 2022 | 00:57h | UTC

WHO launches Global Initiative to Tackle Deadly Insect-Borne ‘Arboviruses’ – Health Policy Watch

 

WHO’s training for caregivers of children with autism goes online.

4 Apr, 2022 | 00:59h | UTC

News Release: WHO’s training for caregivers of children with autism goes online – World Health Organization

Online Course: WHO eLearning Caregiver Skills Training for Families of Children with Developmental Delays or Disabilities – OpenWHO

 

RCT: Pembrolizumab vs. placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma.

4 Apr, 2022 | 00:56h | UTC

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Building an evidence standards framework for artificial intelligence-enabled digital health technologies.

4 Apr, 2022 | 00:52h | UTC

Building an evidence standards framework for artificial intelligence-enabled digital health technologies – The Lancet Digital Health

 

Registry-based cohort study | recurrent mitral regurgitation after MitraClip: predictive factors, morphology, and clinical implication.

4 Apr, 2022 | 00:55h | UTC

Recurrent Mitral Regurgitation After MitraClip: Predictive Factors, Morphology, and Clinical Implication – Circulation: Cardiovascular Interventions

 

Commentary on Twitter

 

Before-and-after study: Antimicrobial stewardship in high-risk febrile neutropenia patients reduced carbapenem and glycopeptide use and was associated with improved clinical outcomes.

4 Apr, 2022 | 00:49h | UTC

Antimicrobial stewardship in high-risk febrile neutropenia patients – Antimicrobial Resistance & Infection Control

Related:

Safety and efficacy of antibiotic de-escalation and discontinuation in high-risk hematological patients with febrile neutropenia: a single-center experience.

Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology

 

Commentary from the author on Twitter (thread – click for more)

 

Guidelines for diagnosing incidental solitary bone lesions on CT and MRI in adults: bone reporting and data system (Bone-RADS).

4 Apr, 2022 | 00:45h | UTC

Society of Skeletal Radiology– white paper. Guidelines for the diagnostic management of incidental solitary bone lesions on CT and MRI in adults: bone reporting and data system (Bone-RADS) – Skeletal Radiology

 

Commentary on Twitter (article and images under a http://creativecommons.org/licenses/by-nc/4.0/)

 

Systematic review: there is insufficient evidence that therapeutic drug monitoring improves outcomes during treatment with penicillins.

4 Apr, 2022 | 00:47h | UTC

A systematic review of the effect of therapeutic drug monitoring on patient health outcomes during treatment with penicillins – Journal of Antimicrobial Chemotherapy

 

M-A: Global estimates of diabetic retinopathy prevalence and progression in pregnant women with preexisting diabetes.

4 Apr, 2022 | 00:42h | UTC

Global Estimates of Diabetic Retinopathy Prevalence and Progression in Pregnant Women With Preexisting Diabetes: A Systematic Review and Meta-analysis – JAMA Ophthalmology (free for a limited period)

Invited Commentary: Diabetic Retinopathy in Pregnancy – JAMA Ophthalmology (free for a limited period)

 

Commentary on Twitter

 

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