Daily Archives: March 25, 2022 | LinksMedicus Free Medical News & Perspectives

M-A: Comparative effectiveness of statins on non-HDL cholesterol in people with diabetes and at risk of cardiovascular disease.

25 Mar, 2022 | 10:01h | UTC

Comparative effectiveness of statins on non-high density lipoprotein cholesterol in people with diabetes and at risk of cardiovascular disease: systematic review and network meta-analysis – The BMJ

News Release: Best statins for reducing cardiovascular risk in people with diabetes found – University of Manchester

Commentary on Twitter

This network meta-analysis indicated that rosuvastatin, at moderate and high intensity doses, and simvastatin and atorvastatin, at high intensity doses, were most effective at moderately reducing levels of non-HDL-C in patients with diabeteshttps://t.co/NwUf4sX5KA

— The BMJ (@bmj_latest) March 24, 2022

Cochrane Special Collection: Diagnosing tuberculosis.

25 Mar, 2022 | 09:57h | UTC

Diagnosing tuberculosis – Cochrane Library

Studies show same-day discharge post–transcatheter aortic valve replacement is feasible.

25 Mar, 2022 | 09:58h | UTC

Study 1: Same-Day Discharge Post–Transcatheter Aortic Valve Replacement During the COVID-19 Pandemic: The Multicenter PROTECT TAVR Study – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Study 2: Feasibility and Safety of Same-Day Discharge Following Transfemoral Transcatheter Aortic Valve Replacement – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Editorial: Did the COVID-19 Pandemic Just Turn TAVR Into an Outpatient Procedure?

Commentary: ‘Right Time, Right Moment’: Same-Day Discharge After TAVI Safe, Feasible – TCTMD

3 orthopedic surgeries that might be doing patients (and their pockets) more harm than good.

25 Mar, 2022 | 09:54h | UTC

3 orthopaedic surgeries that might be doing patients (and their pockets) more harm than good – The Conversation

RCT: Among patients with heart failure and atrial fibrillation, an ablation-based rhythm-control strategy was not significantly better than a rate-control strategy for improving all-cause mortality and heart failure events (hazard ratio 0.71; 95% CI 0.49-1.03; p=0.066).

25 Mar, 2022 | 09:59h | UTC

Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients with Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial – Circulation

Update on management of atrial fibrillation in heart failure: a focus on ablation.

Review: Cryoballoon ablation as initial treatment for atrial fibrillation.

Subgroup analysis of RCT suggests early rhythm control therapy is beneficial for patients with atrial fibrillation and heart failure.

Meta-Analysis: Catheter Ablation Improves Outcomes in Patients with Atrial Fibrillation Complicated with Heart Failure

Catheter Ablation for Atrial Fibrillation Improves Outcomes in Heart Failure with Reduced Ejection Fraction

M-A: In patients with atrial fibrillation, catheter ablation was associated with a 38% reduction in recurrence and a 68% reduction in hospitalizations. The rate of serious complications was 4.2% with ablation vs. 2.8% in the antiarrhythmic group, a difference that was not statistically significant.

CABANATrial: Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation

Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.

25 Mar, 2022 | 09:56h | UTC

Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study – PLOS Medicine

Commentaries:

Sweeteners may be linked to increased cancer risk – new research – The Conversation

Expert reaction to observational study of sweeteners and cancer risk – Science Media Centre

[Preprint] Vaccine effectiveness of two and three doses of Pfizer and CoronaVac against COVID-19 in Hong Kong.

25 Mar, 2022 | 09:43h | UTC

Vaccine effectiveness of two and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong – medRxiv

Commentary on Twitter

New data from Hong Kong on Coronavac and Pfizer vaccines implicates lack of vaccination and boosters in people of advanced age, not type of vaccine, for extreme fatality rates.
2 doses: Coronavac less protective than Pfizer
3 doses: equivalent VEhttps://t.co/BSOGscPvmc pic.twitter.com/UZqYhN7zP5

— Eric Topol (@EricTopol) March 23, 2022

[Preprint] Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study.

25 Mar, 2022 | 09:47h | UTC

Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study – medRxiv

Commentary on Twitter

Pleased to share our study showing that there is no evidence of an increased risk of death in young people after COVID-19 vaccination in England

Great collaboration with @kamleshkhunti @amibanerjee1 and others not on twitter!https://t.co/EV4xmDWeyB pic.twitter.com/VQy2PtCxeC

— Vahé Nafilyan (@Vnafilyan) March 24, 2022

Review: Tobacco and nicotine use.

25 Mar, 2022 | 08:49h | UTC

Tobacco and nicotine use – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Tobacco and nicotine use (if the link is paywalled, try this one)

Commentary on Twitter

Get Primed on Tobacco and nicotine use with our NEW PrimeView! FREE to download this week! #smoking https://t.co/OYwqtYwWLb pic.twitter.com/11xDdLFTvC

— Nature Reviews Disease Primers (@DiseasePrimers) March 24, 2022

[Preprint] RCT: Vitamin D supplements did not prevent Covid-19 or other acute respiratory infections.

25 Mar, 2022 | 09:49h | UTC

Vitamin D Supplements for Prevention of Covid-19 or other Acute Respiratory Infections: a Phase 3 Randomized Controlled Trial (CORONAVIT) – medRxiv

M-A: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19.

In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.

RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

Commentary on Twitter (thread – click for more)

CORONAVIT trial (vitamin D supplements for Covid prevention) results are negative, but the implications are narrow and must not be misinterpreted.https://t.co/mnmDeOJFak
This was a well done trial in many ways. Here's what is reasonable to conclude from it & what isn't:

— Karl Pfleger, PhD (@KarlPfleger) March 24, 2022

Did the COVID lockdowns work? Here’s what we know two years on.

25 Mar, 2022 | 09:44h | UTC

Did the COVID lockdowns work? Here’s what we know two years on – The Conversation

M-A: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality.

Is the cure really worse than the disease? The health impacts of lockdowns during COVID-19 – “While there are certainly costs to be expected from intervening against COVID-19—every decision has a cost, after all—the counterfactual of an unmitigated epidemic makes these restrictions far less damaging than some have suggested”.

Review: Surgical risk assessment in patients with chronic liver diseases.

25 Mar, 2022 | 08:46h | UTC

Surgical Risk Assessment in Patients With Chronic Liver Diseases – Journal of Clinical and Experimental Hepatology

Commentary on Twitter

Surgical Risk Assessment in Patients With Chronic Liver Diseases https://t.co/us01T2XsxE

— Journal of Clinical and Experimental Hepatology (@JCEH_Hepatology) March 23, 2022

The Role of Cardioprotection in Cancer Therapy Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review.

25 Mar, 2022 | 08:51h | UTC

The Role of Cardioprotection in Cancer Therapy Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review – JACC: CardioOncology

Review: Surgical management of gastric cancer.

25 Mar, 2022 | 08:48h | UTC

Surgical Management of Gastric Cancer: A Review – JAMA Surgery (free for a limited period)

Review | Imaging findings of malignant skin tumors: radiological–pathological correlation.

25 Mar, 2022 | 08:40h | UTC

Imaging findings of malignant skin tumors: radiological–pathological correlation – Insights into Imaging

RCT: In patients with chronic migraine and overuse of symptomatic medications, migraine preventive therapy without switching or limiting the frequency of the overused medication was non-inferior to switching to a different symptomatic medication with a maximum limit of two treatment days/week.

25 Mar, 2022 | 08:44h | UTC

Patient-Centered Treatment of Chronic Migraine With Medication Overuse: A Prospective, Randomized, Pragmatic Clinical Trial – Neurology (link to abstract – $ for full-text)

Single-center RCT: Postoperative analgesic efficacy and safety of ropivacaine plus diprospan for preemptive scalp infiltration in patients undergoing craniotomy.

25 Mar, 2022 | 08:42h | UTC

Postoperative Analgesic Efficacy and Safety of Ropivacaine Plus Diprospan for Preemptive Scalp Infiltration in Patients Undergoing Craniotomy: A Prospective Randomized Controlled Trial – Anesthesia & Analgesia

Weight maintenance after dietary weight loss: systematic review and meta-analysis on the effectiveness of behavioral interventions.

25 Mar, 2022 | 08:41h | UTC

Weight Maintenance after Dietary Weight Loss: Systematic Review and Meta-Analysis on the Effectiveness of Behavioural Intensive Intervention – Nutrients

Review | Imaging findings of gastrointestinal tract tumors in children and adolescents.

25 Mar, 2022 | 08:38h | UTC

Imaging findings of gastrointestinal tract tumors in children and adolescents – Insights into Imaging

M-A: Staphylococcus aureus bacteremia mortality.

25 Mar, 2022 | 08:36h | UTC

Staphylococcus aureus bacteremia mortality: A systematic review and meta-analysis – Clinical Microbiology and Infection

Study Commentary: Widespread screening catches more cases of depression. But follow-up care still falls far short.

25 Mar, 2022 | 08:34h | UTC

Widespread screening catches more cases of depression. But follow-up care still falls far short – STAT

Original Study: Electronic Population-Based Depression Detection and Management Through Universal Screening in the Veterans Health Administration – JAMA Network Open

M-A: Tuberculosis screening among HIV-positive inpatients.

25 Mar, 2022 | 08:35h | UTC

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis – The Lancet HIV

Commentary on Twitter

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis https://t.co/DqTUr2JxHy In setting where TB prevalence is > 10%, WHO now strongly recommends molecular rapid diagnostic testing in all medical inpatient PWH.

— Carlos del Rio (@CarlosdelRio7) March 24, 2022

RCT: In patients with knee osteoarthritis, prehabilitation before total knee replacement did not improve functional outcomes.

25 Mar, 2022 | 08:32h | UTC

Effect of Prehabilitation Before Total Knee Replacement for Knee Osteoarthritis on Functional Outcomes: A Randomized Clinical Trial – JAMA Network Open

Commentary: Prehabilitation May Not Improve Knee Replacement Results – Medscape (free registration required)

Commentary on Twitter

In this randomized clinical trial that included 262 participants, prehabilitation for knee osteoarthritis did not improve functional outcomes in total knee replacement. Findings question the usefulness of prehabilitation before total knee replacement. https://t.co/vsMxQ8PYJ7

— JAMA Network Open (@JAMANetworkOpen) March 9, 2022