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Daily Archives: February 17, 2022

Cohort study: Protection against SARS-CoV-2 after Covid-19 vaccination lasts longer in patients with previous infection.

17 Feb, 2022 | 10:11h | UTC

Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection – New England Journal of Medicine

 


RCT: Oral Nirmatrelvir for high-risk adults with Covid-19 reduces the risk of hospitalization by 89%.

17 Feb, 2022 | 10:14h | UTC

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 – New England Journal of Medicine

Audio Interview: A New Antiviral against Covid-19 – new England Journal of Medicine

Related:

[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.

 

Commentary on Twitter

 


Retrospective cohort study: Pfizer vaccine reduces the risk of reinfection after recovery from Covid-19.

17 Feb, 2022 | 10:13h | UTC

Effectiveness of the BNT162b2 Vaccine after Recovery from Covid-19 – New England Journal of Medicine

 

Commentary on Twitter

 


Meta-analysis finds the overall prevalence of statin intolerance is around 9% and identifies the most common risk factors.

17 Feb, 2022 | 10:07h | UTC

Prevalence of statin intolerance: a meta-analysis – European Heart Journal

Commentaries:

Study shows the true prevalence of statin intolerance worldwide is between 6 to 10% – News Medical / European Society of Cardiology

Expert reaction to study looking at statin intolerance – Science Media Centre

Related:

Side effect patterns in a crossover trial of statin, placebo, and no treatment – This N-of-1 trial, now published in full, suggests the nocebo effect causes most of statins muscle adverse effects.

#AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo

 

Commentary on Twitter

 


England to offer Covid jab to five to 11-year-olds.

17 Feb, 2022 | 10:09h | UTC

England to offer Covid jab to five to 11-year-olds – BBC

 


Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

17 Feb, 2022 | 09:58h | UTC

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year – Nature Medicine

Commentary: Studies detail risk of severe COVID-19, GI problems in kids – CIDRAP

 

Commentary on Twitter

 


Review: Diagnosis and treatment of acute coronary syndromes.

17 Feb, 2022 | 10:04h | UTC

Diagnosis and Treatment of Acute Coronary Syndromes: A Review – JAMA (free for a limited period)

Audio clinical review: Diagnosis and Treatment of Acute Coronary Syndromes – JAMA

 


How COVID-19 transformed genomics and changed the handling of disease outbreaks forever.

17 Feb, 2022 | 09:56h | UTC

How COVID-19 transformed genomics and changed the handling of disease outbreaks forever – The Conversation

 


Review | Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic.

17 Feb, 2022 | 09:54h | UTC

Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic – PLOS Global Public Health

Related:

Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.

CDC unveils its latest weapon in Covid-19 detection: wastewater.

CDC Report: Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021.

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus.

[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.

Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME

Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT

Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start – STAT

The myriad ways sewage surveillance is helping fight COVID around the world – Nature

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19 – The Conversation

It’s time to begin a national wastewater testing program for Covid-19 – STAT

Coronavirus: Testing sewage an ‘easy win’ – BBC

Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings – high sensitivity, but unable to distinguish new infectious cases from persistent convalescent shedding.

 


German Guidelines for the diagnosis, therapy and follow-up of cervical cancer – Part 1 with recommendations on epidemiology, screening, diagnostics and therapy.

17 Feb, 2022 | 08:47h | UTC

Diagnosis, Therapy and Follow-up of Cervical Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry No. 032/033OL, May 2021) – Part 1 with Recommendations on Epidemiology, Screening, Diagnostics and Therapy – Geburtshilfe und Frauenheilkunde

 


SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia.

17 Feb, 2022 | 10:01h | UTC

SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia – Internal and Emergency Medicine

Related:

RCT: CPAP improved outcomes in patients with acute hypoxemic respiratory failure due to COVID-19, but high-flow nasal oxygen was not better than conventional oxygen therapy.

RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.

 


ASCRS Guidelines for the management of colon cancer.

17 Feb, 2022 | 08:49h | UTC

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer – Diseases of the Colon & Rectum

 

Commentary on Twitter

 


Guidance for systematic integration of undernutrition in attributing cause of death in children.

17 Feb, 2022 | 08:46h | UTC

Guidance for Systematic Integration of Undernutrition in Attributing Cause of Death in Children – Clinical Infectious Diseases

 


Consensus Recommendations: Development of a swallowing risk screening tool and best practice recommendations for the management of oropharyngeal dysphagia following acute cervical spinal cord injury.

17 Feb, 2022 | 08:40h | UTC

Development of a swallowing risk screening tool and best practice recommendations for the management of oropharyngeal dysphagia following acute cervical spinal cord injury: an international multi-professional Delphi consensus – Disability and Rehabilitation

 


Perspective | The hidden epidemic: Antibiotic resistance is approaching a crisis point, and the world needs to act.

17 Feb, 2022 | 08:39h | UTC

The Hidden Epidemic – Vox

Related: Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.

 


Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments.

17 Feb, 2022 | 08:35h | UTC

Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments – Clinical Microbiology and Infection

 


Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomized evidence.

17 Feb, 2022 | 08:37h | UTC

Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence – Journal of Neurology

 


Supportive care needs of men with prostate cancer: A systematic review of qualitative studies.

17 Feb, 2022 | 08:34h | UTC

Supportive care needs of men with prostate cancer: A systematic review update – European Journal of Cancer Care

 


RCT: L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy.

17 Feb, 2022 | 08:35h | UTC

L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial – Hepatology (link to abstract – $ for full-text)

 


A novel diabetes typology: towards precision diabetology from pathogenesis to treatment.

17 Feb, 2022 | 08:31h | UTC

A novel diabetes typology: towards precision diabetology from pathogenesis to treatment – Diabetologia

 


Central vs. peripheral vision loss in emergency medicine.

17 Feb, 2022 | 08:32h | UTC

Central vs. Peripheral Vision Loss – emDocs

 


Treatment options after a diagnosis of early miscarriage: expectant, medical, and surgical.

17 Feb, 2022 | 08:24h | UTC

Treatment Options After a Diagnosis of Early Miscarriage: Expectant, Medical, and Surgical – Deutsches Ärzteblatt International

 


M-A: Impact of pharmacist-led antimicrobial stewardship on appropriate antibiotic prescribing in the emergency department.

17 Feb, 2022 | 08:23h | UTC

Impact of Pharmacist-Led Antimicrobial Stewardship on Appropriate Antibiotic Prescribing in the Emergency Department: A Systematic Review and Meta-Analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Dupuytren’s Disease—etiology and treatment.

17 Feb, 2022 | 08:25h | UTC

Dupuytren’s Disease—Etiology and Treatment – Deutsches Ärzteblatt International

 


Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis.

17 Feb, 2022 | 08:19h | UTC

Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis – Critical Care

 


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